127910-31-0 | 3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-

Packsize	Purity	Availability	Price	Discounted Price
25mg	95%	in stock	$266.00	$186.00
50mg	95%	in stock	$463.00	$324.00
100mg	95%	in stock	$793.00	$555.00

Description

• Catalog Number: AA22132
• Chemical Name: 3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-
• CAS Number: 127910-31-0
• Molecular Formula: C6H12NO5P
• Molecular Weight: 209.1369
• MDL Number: MFCD00153906
• SMILES: C/C(=C\C(C(=O)O)N)/CP(=O)(O)O

Computed Properties

• Complexity: 268
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 4
• Undefined Atom Stereocenter Count: 1
• XLogP3: -4.1

Literature

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  Biological psychiatry 20110601

• Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208

• Reduced effect of NMDA glutamate receptor antagonist on ethanol-induced ataxia and striatal glutamate levels in mice lacking ENT1.

  Neuroscience letters 20100802

• Lack of NMDA-AMPA interaction in antidepressant-like effect of CGP 37849, an antagonist of NMDA receptor, in the forced swim test.

  Journal of neural transmission (Vienna, Austria : 1996) 20081101

• Impact of postnatal blockade of N-methyl-D-aspartate receptors on rat behavior: a search for a new developmental model of schizophrenia.

  Neuroscience 20080602

• NMDA/glutamate mechanism of magnesium-induced anxiolytic-like behavior in mice.

  Pharmacological reports : PR 20080101

• Detrimental effect of postnatal blockade of N-methyl-D-aspartate receptors on sensorimotor gating is reversed by neuroleptic drugs.

  Pharmacological reports : PR 20080101

• NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice.

  Pharmacology, biochemistry, and behavior 20071201

• Enhanced glutamatergic transmission reduces the anticonvulsant potential of lamotrigine but not of felbamate against tonic-clonic seizures.

  Pharmacological reports : PR 20070101

• Activation of the NMDA/glutamate receptor complex antagonizes the NMDA antagonist-induced antidepressant-like effects in the forced swim test.

  Pharmacological reports : PR 20070101

• Alterations in the dendritic morphology of prefrontal pyramidal neurons in adult rats after blockade of NMDA receptors in the postnatal period.

  Brain research 20051116

• Development of a three-dimensional model for the N-methyl-D-aspartate NR2A subunit.

  Journal of medicinal chemistry 20050825

• Functional roles of NMDA receptor NR2A and NR2B subunits in the acute intoxicating effects of ethanol in mice.

  Synapse (New York, N.Y.) 20050615

• Blockade of NMDA receptors in postnatal period decreased density of tyrosine hydroxylase immunoreactive axonal arbors in the medial prefrontal cortex of adult rats.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050601

• Cortical epileptic afterdischarges in immature rats are differently influenced by NMDA receptor antagonists.

  European journal of pharmacology 20050523

• GSA: behavioral, histological, electrophysiological and neurochemical effects.

  Physiology & behavior 20050215

• Involvement of a glutamergic mechanism in gamma-dendrotoxin-induced hippocampal neuronal cell loss in the rat.

  Basic & clinical pharmacology & toxicology 20040301

• Competitive NMDA receptor antagonists and agonists: effects on spontaneous alternation in mice exposed to cerebral oligemia.

  Polish journal of pharmacology 20040101

• Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.

  Kidney international 20030501

• Effects of clozapine, haloperidol and iloperidone on neurotransmission and synaptic plasticity in prefrontal cortex and their accumulation in brain tissue: an in vitro study.

  Neuroscience 20030101

• A competitive antagonist of NMDA receptors CGP 40116 attenuates experimental symptoms of schizophrenia evoked by MK-801.

  Polish journal of pharmacology 20030101

• NMDA receptor antagonists impair motor performance in immature rats.

  Psychopharmacology 20020801

• Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.

  Neuroscience 20010101

• Repeated imipramine administration enhances the effects of NMDA receptor ligands on synchronous activity in rat frontal cortex in vitro.

  Polish journal of pharmacology 20010101

• Morphine-induced catalepsy is augmented by NMDA receptor antagonists, but is partially attenuated by an AMPA receptor antagonist.

  European journal of pharmacology 19960111

• The AMPA receptor antagonist GYKI 52466 reverses the anti-cataleptic effects of the competitive NMDA receptor antagonist CGP 37849.

  European journal of pharmacology 19940502

• The new competitive NMDA receptor antagonist CGP 40116 inhibits pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse.

  Pharmacology, biochemistry, and behavior 19940101

• Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats.

  European journal of pharmacology 19930406

• Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.

  Journal of neural transmission. Parkinson's disease and dementia section 19930101

• Central effects of repeated treatment with CGP 37849, a competitive NMDA receptor antagonist with potential antidepressant activity.

  Polish journal of pharmacology 19930101

• Central effects of SL 82.0715, an antagonist of polyamine site of the NMDA receptor complex.

  Polish journal of pharmacology 19930101