129453-61-8 | Estra-1,3,5(10)-triene-3,17-diol, 7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-, (7α,17β)-

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥98%	in stock	$42.00	$29.00
5mg	98%(HPLC)	in stock	$44.00	$31.00
25mg	98%(HPLC)	in stock	$74.00	$52.00
100mg	97%	in stock	$218.00	$152.00
250mg	97%	in stock	$338.00	$236.00
1g	97%	in stock	$803.00	$562.00

Description

• Catalog Number: AA45334
• Chemical Name: Estra-1,3,5(10)-triene-3,17-diol, 7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-, (7α,17β)-
• CAS Number: 129453-61-8
• Molecular Formula: C32H47F5O3S
• Molecular Weight: 606.7708
• MDL Number: MFCD00903953
• SMILES: O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O
• NSC Number: 719276

Computed Properties

• Complexity: 854
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 6
• Heavy Atom Count: 41
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 14
• Undefined Atom Stereocenter Count: 1
• XLogP3: 9.2

Literature

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  Toxicological sciences : an official journal of the Society of Toxicology 20130101

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  Endocrinology 20130101

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• Environmental alkylphenols modulate cytokine expression in plasmacytoid dendritic cells.

  PloS one 20130101

• Assessment of cellular estrogenic activity based on estrogen receptor-mediated reduction of soluble-form catechol-O-methyltransferase (COMT) expression in an ELISA-based system.

  PloS one 20130101

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  PloS one 20130101

• Transactivating function (AF) 2-mediated AF-1 activity of estrogen receptor α is crucial to maintain male reproductive tract function.

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  Endocrinology 20121101

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  The Journal of steroid biochemistry and molecular biology 20121001

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  European journal of cancer (Oxford, England : 1990) 20120901

• Effects of 17β-estradiol on adiponectin regulation of the expression of osteoprotegerin and receptor activator of nuclear factor-κB ligand.

  Bone 20120901

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  Toxicology in vitro : an international journal published in association with BIBRA 20120901

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  Steroids 20120901

• Effects of bisphenol A on the proliferation and cell cycle of HBL-100 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

• Oral metronomic cyclophosphamide and methotrexate plus fulvestrant in advanced breast cancer patients: a mono-institutional case-cohort report.

  The breast journal 20120901

• Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity.

  Toxicology 20120816

• The endocrine disruptor diethylstilbestrol induces adipocyte differentiation and promotes obesity in mice.

  Toxicology and applied pharmacology 20120815

• Combination anastrozole and fulvestrant in metastatic breast cancer.

  The New England journal of medicine 20120802

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• Estrogen suppresses expression of the matrix metalloproteinase inhibitor reversion-inducing cysteine-rich protein with Kazal motifs (RECK) within the mouse uterus.

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  Toxicological sciences : an official journal of the Society of Toxicology 20120801

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• Preliminary experience with personalized and targeted therapy for pediatric brain tumors.

  Pediatric blood & cancer 20120715

• Neonatal phytoestrogen exposure alters oviduct mucosal immune response to pregnancy and affects preimplantation embryo development in the mouse.

  Biology of reproduction 20120701

• Combine therapy of gefitinib and fulvestrant enhances antitumor effects on NSCLC cell lines with acquired resistance to gefitinib.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120701

• Intrahypothalamic estradiol modulates hypothalamus-pituitary-adrenal-axis activity in female rats.

  Endocrinology 20120701

• 17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model.

  Japanese journal of ophthalmology 20120701

• Small-animal PET of steroid hormone receptors predicts tumor response to endocrine therapy using a preclinical model of breast cancer.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20120701

• Specific transcriptional response of four blockers of estrogen receptors on estradiol-modulated genes in the mouse mammary gland.

  Breast cancer research and treatment 20120701

• AKT-aro and HER2-aro, models for de novo resistance to aromatase inhibitors; molecular characterization and inhibitor response studies.

  Breast cancer research and treatment 20120701

• Mechanisms of FGFR3 actions in endocrine resistant breast cancer.

  International journal of cancer 20120615

• Wnt family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbestrol exposure in mice.

  Toxicology 20120614

• FACT: an open-label randomized phase III study of fulvestrant and anastrozole in combination compared with anastrozole alone as first-line therapy for patients with receptor-positive postmenopausal breast cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120601

• A randomized trial of combination anastrozole plus gefitinib and of combination fulvestrant plus gefitinib in the treatment of postmenopausal women with hormone receptor positive metastatic breast cancer.

  Breast cancer research and treatment 20120601

• Polyendocrine treatment in estrogen receptor-positive breast cancer: a 'FACT' yet to be proven.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120601

• 17β-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation/reperfusion.

  Free radical biology & medicine 20120601

• Differential expression and regulation of angiopoietin-3 in mouse uterus during preimplantation period.

  Journal of experimental zoology. Part B, Molecular and developmental evolution 20120601

• The pro-apoptotic effect of quercetin in cancer cell lines requires ERβ-dependent signals.

  Journal of cellular physiology 20120501

• Alteration of Y-box binding protein-1 expression modifies the response to endocrine therapy in estrogen receptor-positive breast cancer.

  Breast cancer research and treatment 20120501

• Dose-dependent change in biomarkers during neoadjuvant endocrine therapy with fulvestrant: results from NEWEST, a randomized Phase II study.

  Breast cancer research and treatment 20120501

• Insulin-like growth factor binding protein 7 modulates estrogen-induced trophoblast proliferation and invasion in HTR-8 and JEG-3 cells.

  Cell biochemistry and biophysics 20120501

• 17β-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects.

  American journal of respiratory and critical care medicine 20120501

• Estrogen stimulates leptin receptor expression in ATDC5 cells via the estrogen receptor and extracellular signal-regulated kinase pathways.

  The Journal of endocrinology 20120501

• Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters.

  Cancer research 20120501

• [Preliminary study of estrogen effects on calcium free smooth muscle cells at the endometrial-myometrial interface in uteri with adenomyosis].

  Zhonghua fu chan ke za zhi 20120501

• Nanomolar dose of bisphenol A rapidly modulates spinogenesis in adult hippocampal neurons.

  Molecular and cellular endocrinology 20120404

• 17α-Ethinylestradiol and nonylphenol affect the development of forebrain GnRH neurons through an estrogen receptors-dependent pathway.

  Reproductive toxicology (Elmsford, N.Y.) 20120401

• Diesel exhaust particulate extracts inhibit transcription of nuclear respiratory factor-1 and cell viability in human umbilical vein endothelial cells.

  Archives of toxicology 20120401

• 17β-Estradiol regulates cyclin A1 and cyclin B1 gene expression in adult rat seminiferous tubules.

  Journal of molecular endocrinology 20120401

• Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I.

  Steroids 20120401

• Regulation of leptin expression by 17beta-estradiol in human placental cells involves membrane associated estrogen receptor alpha.

  Biochimica et biophysica acta 20120401

• The terminal substituents of 7α, 6-hexanyl derivatives of estradiol determine their selective estrogen receptor modulator versus agonist activities.

  Steroids 20120401

• 2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition.

  Bioorganic & medicinal chemistry 20120401

• Phase II trial of exemestane in combination with fulvestrant in postmenopausal women with advanced, hormone-responsive breast cancer.

  Clinical breast cancer 20120401

• Identification of modulators of hair cell regeneration in the zebrafish lateral line.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120307

• Repeated and long-term treatment with physiological concentrations of resveratrol promotes NO production in vascular endothelial cells.

  The British journal of nutrition 20120301

• The role of estrogen receptor α and β in regulating vascular smooth muscle cell proliferation is based on sex.

  The Journal of surgical research 20120301

• Combining the multitargeted tyrosine kinase inhibitor vandetanib with the antiestrogen fulvestrant enhances its antitumor effect in non-small cell lung cancer.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20120301

• Cytoplasmic estrogen receptor β as a potential marker in human non-small cell lung carcinoma.

  Expert opinion on therapeutic targets 20120301

• Estrogen-related MxA transcriptional variation in hepatitis C virus-infected patients.

  Translational research : the journal of laboratory and clinical medicine 20120301

• Drug-targeted inhibition of peroxisome proliferator-activated receptor-gamma enhances the chemopreventive effect of anti-estrogen therapy.

  Oncotarget 20120301

• Ugonin K-stimulated osteogenesis involves estrogen receptor-dependent activation of non-classical Src signaling pathway and classical pathway.

  European journal of pharmacology 20120215

• Phthalate esters modulate the differentiation and maturation of mouse peripheral blood mononuclear cell-derived dendritic cells.

  Journal of applied toxicology : JAT 20120201

• Estrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growth.

  Breast cancer research and treatment 20120201

• Effect of pollen from Typha angustata on hydrogen peroxide induced toxicity in osteoblastic MC3T3-E1 cells.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20120201

• Synergistic effects of parabens on the induction of calbindin-D(9k) gene expression act via a progesterone receptor-mediated pathway in GH3 cells.

  Human & experimental toxicology 20120201

• Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice.

  Neuropharmacology 20120201

• Rapid estrogenic effects on TMJ-responsive brainstem neurons.

  Journal of dental research 20120201

• Nuclear estrogen receptor-mediated Notch signaling and GPR30-mediated PI3K/AKT signaling in the regulation of endometrial cancer cell proliferation.

  Oncology reports 20120201

• Bisphenol A exposure modifies methylation of imprinted genes in mouse oocytes via the estrogen receptor signaling pathway.

  Histochemistry and cell biology 20120201

• A comparative study of the effect of 17β-estradiol and estriol on peripheral pain behavior in rats.

  Steroids 20120201

• Central estrogenic pathways protect against the depressant action of acute nicotine on reflex tachycardia in female rats.

  Toxicology and applied pharmacology 20120201

• [Pharmacological and clinical profiles of Fulvestrant (Faslodex(®)) in the treatment of advanced or recurrenced breast cancer].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20120201

• Potential estrogenic activity of triclosan in the uterus of immature rats and rat pituitary GH3 cells.

  Toxicology letters 20120125

• Effects of nonylphenol on aldosterone release from rat zona glomerulosa cells.

  Chemico-biological interactions 20120105

• Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity.

  Molecular pharmacology 20120101

• Metalloestrogenic effects of quantum dots.

  Nanomedicine (London, England) 20120101

• Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20120101

• Estrogen and progesterone play pivotal roles in endothelial progenitor cell proliferation.

  Reproductive biology and endocrinology : RB&E 20120101

• Estrogen receptor-alpha 36 mediates mitogenic antiestrogen signaling in ER-negative breast cancer cells.

  PloS one 20120101

• Endocrine disruptor regulation of microRNA expression in breast carcinoma cells.

  PloS one 20120101

• Current approaches to the management of Her2-negative metastatic breast cancer.

  Breast cancer research : BCR 20120101

• Inhibition of ERβ induces resistance to cisplatin by enhancing Rad51-mediated DNA repair in human medulloblastoma cell lines.

  PloS one 20120101

• Molecular target based combinational therapeutic approaches in thyroid cancer.

  Journal of translational medicine 20120101

• The role of estrogen receptor alpha in mediating chemoresistance in breast cancer cells.

  Journal of experimental & clinical cancer research : CR 20120101

• Arsenic induces functional re-expression of estrogen receptor α by demethylation of DNA in estrogen receptor-negative human breast cancer.

  PloS one 20120101

• Effects of 4-nonylphenol and/or diisononylphthalate on THP-1 cells: impact of endocrine disruptors on human immune system parameters.

  International journal of immunopathology and pharmacology 20120101

• Genistein stimulates jejunal chloride secretion via sex-dependent, estrogen receptor or adenylate cyclase mechanisms.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Puerarin exerted anti-osteoporotic action independent of estrogen receptor-mediated pathway.

  Journal of nutritional science and vitaminology 20120101

• [The role of estrogen receptor alpha in breast cancer cell proliferation mediated by progestins].

  Medicina 20120101

• The antiestrogens tamoxifen and fulvestrant abolish estrogenic impacts of 17α-ethinylestradiol on male calling behavior of Xenopus laevis.

  PloS one 20120101

• Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer.

  PloS one 20120101

• Disruption of 3D MCF-12A breast cell cultures by estrogens--an in vitro model for ER-mediated changes indicative of hormonal carcinogenesis.

  PloS one 20120101

• Cajaninstilbene acid relaxes rat renal arteries: roles of Ca2+ antagonism and protein kinase C-dependent mechanism.

  PloS one 20120101

• The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.

  PloS one 20120101

• In vivo and in vitro evaluation of the estrogenic properties of the 17β-(butylamino)-1,3,5(10)-estratrien-3-ol (buame) related to 17β-estradiol.

  Pharmacological reports : PR 20120101

• Low concentrations of o,p'-DDT inhibit gene expression and prostaglandin synthesis by estrogen receptor-independent mechanism in rat ovarian cells.

  PloS one 20120101

• Dual IGF-1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer.

  Cancer research 20111215

• 17β-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor α.

  The Journal of biological chemistry 20111202

• Estradiol-mediated suppression of CYP1B1 expression in mouse MA-10 Leydig cells is independent of protein kinase A and estrogen receptor.

  Molecular and cellular biochemistry 20111201

• Low concentrations of bisphenol A induce mouse spermatogonial cell proliferation by G protein-coupled receptor 30 and estrogen receptor-α.

  Environmental health perspectives 20111201

• Estrogen upregulates hepatic apolipoprotein M expression via the estrogen receptor.

  Biochimica et biophysica acta 20111201

• Tamoxifen and its metabolites cause acute vasorelaxation of aortic rings by inducing vasodilator prostanoid synthesis.

  Journal of cardiovascular pharmacology 20111201

• Estrogen increases nitric-oxide production in human bronchial epithelium.

  The Journal of pharmacology and experimental therapeutics 20111201

• Effects of an estrogen receptor antagonist on proliferation, prolactin secretion and growth factor expression in the MMQ pituitary prolactinoma cell line.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20111201

• Nursing perspectives on fulvestrant for the treatment of postmenopausal women with metastatic breast cancer.

  Clinical journal of oncology nursing 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase.

  Toxicology and applied pharmacology 20111115

• Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells.

  Cancer biology & therapy 20111115

• Combination treatment with fulvestrant and various cytotoxic agents (doxorubicin, paclitaxel, docetaxel, vinorelbine, and 5-fluorouracil) has a synergistic effect in estrogen receptor-positive breast cancer.

  Cancer science 20111101

• Permanent oviduct posteriorization after neonatal exposure to the phytoestrogen genistein.

  Environmental health perspectives 20111101

• Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes.

  Arteriosclerosis, thrombosis, and vascular biology 20111101

• ERβ-specific agonists and genistein inhibit proliferation and induce apoptosis in the large and small intestine.

  Carcinogenesis 20111101

• A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer.

  Cancer research 20111101

• CEBPD suppresses prolactin expression and prolactinoma cell proliferation.

  Molecular endocrinology (Baltimore, Md.) 20111101

• [Hormone therapy and breast cancer].

  Bulletin du cancer 20111101

• Role of fulvestrant in the management of postmenopausal breast cancer.

  Expert review of anticancer therapy 20111101

• Effects of bisphenol A and triclocarban on brain-specific expression of aromatase in early zebrafish embryos.

  Proceedings of the National Academy of Sciences of the United States of America 20111025

• Endocrine disrupting effects of zearalenone, alpha- and beta-zearalenol at the level of nuclear receptor binding and steroidogenesis.

  Toxicology letters 20111010

• The anti-oestrogen fulvestrant (ICI 182,780) reduces the androgen receptor expression, ERK1/2 phosphorylation and cell proliferation in the rat ventral prostate.

  International journal of andrology 20111001

• Aroclor1254 interferes with estrogen receptor-mediated neuroprotection against beta-amyloid toxicity in cholinergic SN56 cells.

  Neurochemistry international 20111001

• Attenuation of atherogenesis via the anti-inflammatory effects of the selective estrogen receptor beta modulator 8β-VE2.

  Journal of cardiovascular pharmacology 20111001

• A phase II neoadjuvant trial of anastrozole, fulvestrant, and gefitinib in patients with newly diagnosed estrogen receptor positive breast cancer.

  Breast cancer research and treatment 20111001

• Progesterone and 17β-estradiol increase differentiation of mouse embryonic stem cells to motor neurons.

  IUBMB life 20111001

• Effect of conceptus secretions on HOXA10 and PTGS2 gene expression, and PGE2 release in co-cultured luminal epithelial and stromal cells of the porcine endometrium at the time of early implantation.

  Theriogenology 20110915

• Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators.

  Proceedings of the National Academy of Sciences of the United States of America 20110906

• Estrogen or estrogen receptor agonist inhibits lipopolysaccharide induced microglial activation and death.

  Neurochemical research 20110901

• Conserved aquaporin 4 levels associated with reduction of brain edema are mediated by estrogen in the ischemic brain after experimental stroke.

  Biochimica et biophysica acta 20110901

• Estrogen regulation of the dopamine-activated GIRK channel in pituitary lactotrophs: implications for regulation of prolactin release during the estrous cycle.

  American journal of physiology. Regulatory, integrative and comparative physiology 20110901

• Emerging data on the efficacy and safety of fulvestrant, a unique antiestrogen therapy for advanced breast cancer.

  Expert opinion on drug safety 20110901

• Phospholipid hydroperoxide glutathione peroxidase gene is regulated via an estrogen and estrogen receptor signaling in cultured mouse fetuses.

  In vitro cellular & developmental biology. Animal 20110901

• Bisphenol-A rapidly enhanced passive avoidance memory and phosphorylation of NMDA receptor subunits in hippocampus of young rats.

  Toxicology and applied pharmacology 20110901

• DNA site-specific N3-adenine methylation targeted to estrogen receptor-positive cells.

  Bioorganic & medicinal chemistry 20110901

• Management of patients with metastatic breast cancer.

  Advances in therapy 20110901

• Synergistic chemoprotective mechanisms of dietary phytoestrogens in a select combination against prostate cancer.

  The Journal of nutritional biochemistry 20110801

• The presence of a membrane-bound progesterone receptor sensitizes the estradiol-induced effect on the proliferation of human breast cancer cells.

  Menopause (New York, N.Y.) 20110801

• STX, a novel nonsteroidal estrogenic compound, induces rapid action in primate GnRH neuronal calcium dynamics and peptide release.

  Endocrinology 20110801

• Efficacy of pharmacological estrogen receptor antagonists in blocking activation of zebrafish estrogen receptors.

  General and comparative endocrinology 20110801

• Effect of ozonation on the estrogenicity and androgenicity of oil sands process-affected water.

  Environmental science & technology 20110801

• Fulvestrant revisited: efficacy and safety of the 500-mg dose.

  Clinical breast cancer 20110801

• Can the increase in breast cancer observed in the estrogen plus progestin arm of the Women's Health Initiative trial be explained by progesterone receptor membrane component 1?

  Menopause (New York, N.Y.) 20110801

• The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy.

  Biochemical pharmacology 20110715

• Fluoroestradiol positron emission tomography reveals differences in pharmacodynamics of aromatase inhibitors, tamoxifen, and fulvestrant in patients with metastatic breast cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110715

• Effects of PCB126 and 17β-oestradiol on endothelium-derived vasoactive factors in human endothelial cells.

  Toxicology 20110711

• Estradiol and progesterone modulate halothane-induced liver injury in mice.

  Toxicology letters 20110704

• Cytokeratin 5 positive cells represent a steroid receptor negative and therapy resistant subpopulation in luminal breast cancers.

  Breast cancer research and treatment 20110701

• Combined Src and ER blockade impairs human breast cancer proliferation in vitro and in vivo.

  Breast cancer research and treatment 20110701

• 17β-estradiol aggravates temporomandibular joint inflammation through the NF-κB pathway in ovariectomized rats.

  Arthritis and rheumatism 20110701

• Tamoxifen regulation of bone growth and endocrine function in the ovariectomized rat: discrimination of responses involving estrogen receptor α/estrogen receptor β, G protein-coupled estrogen receptor, or estrogen-related receptor γ using fulvestrant (ICI 182780).

  The Journal of pharmacology and experimental therapeutics 20110701

• An in vitro model showing adaptation to long-term oestrogen deprivation highlights the clinical potential for targeting kinase pathways in combination with aromatase inhibition.

  Steroids 20110701

• [Effect of estrogen on mismatch repair gene expression in colon cancer cells].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20110701

• Prolonged time to progression with fulvestrant for metastatic breast cancer.

  Medical oncology (Northwood, London, England) 20110601

• Duodenal and renal transient receptor potential vanilloid 6 is regulated by sex steroid hormones, estrogen and progesterone, in immature rats.

  The Journal of veterinary medical science 20110601

• BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas.

  Cellular signalling 20110601

• Costunolide stimulates the function of osteoblastic MC3T3-E1 cells.

  International immunopharmacology 20110601

• Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer.

  Endocrine-related cancer 20110601

• Activation of mutated K-ras in donor endometrial epithelium and stroma promotes lesion growth in an intact immunocompetent murine model of endometriosis.

  The Journal of pathology 20110601

• Antiproliferative effect of estrogen in vascular smooth muscle cells is mediated by Kruppel-like factor-4 and manganese superoxide dismutase.

  Basic research in cardiology 20110601

• The effects of wild ginger (Costus speciosus (Koen) Smith) rhizome extract and diosgenin on rat uterine contractions.

  Reproductive sciences (Thousand Oaks, Calif.) 20110601

• Hormonal therapy plus bevacizumab in postmenopausal patients who have hormone receptor-positive metastatic breast cancer: a phase II Trial of the Sarah Cannon Oncology Research Consortium.

  Clinical breast cancer 20110601

• Biomimetic syntheses and antiproliferative activities of racemic, natural (-), and unnnatural (+) glyceollin I.

  Journal of medicinal chemistry 20110526

• High content imaging-based assay to classify estrogen receptor-α ligands based on defined mechanistic outcomes.

  Gene 20110515

• Role of estrogen receptor-dependent upregulation of P38 MAPK/heme oxygenase 1 in resveratrol-mediated attenuation of intestinal injury after trauma-hemorrhage.

  Shock (Augusta, Ga.) 20110501

• Down-regulation of oestrogen receptor-β associates with transcriptional co-regulator PATZ1 delocalization in human testicular seminomas.

  The Journal of pathology 20110501

• Spinal estrogen receptor alpha mediates estradiol-induced pronociception in a visceral pain model in the rat.

  Pain 20110501

• Overcoming resistance to fulvestrant (ICI182,780) by downregulating the c-ABL proto-oncogene in breast cancer.

  Molecular carcinogenesis 20110501

• p53 status influences response to tamoxifen but not to fulvestrant in breast cancer cell lines.

  International journal of cancer 20110415

• Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a proapoptotic unfolded protein response.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110415

• Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5.

  Science signaling 20110412

• Estrogen receptor alpha pathway is involved in leptin-induced ovarian cancer cell growth.

  Carcinogenesis 20110401

• Resveratrol interacts with estrogen receptor-β to inhibit cell replicative growth and enhance stress resistance by upregulating mitochondrial superoxide dismutase.

  Free radical biology & medicine 20110401

• Notch/neurogenin 3 signalling is involved in the neuritogenic actions of oestradiol in developing hippocampal neurones.

  Journal of neuroendocrinology 20110401

• Estrogen receptor-β signaling modulates epithelial barrier function.

  American journal of physiology. Gastrointestinal and liver physiology 20110401

• Differential estrogenic effects of the persistent organochlorine pesticides dieldrin, endosulfan, and lindane in primary neuronal cultures.

  Toxicological sciences : an official journal of the Society of Toxicology 20110401

• Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines.

  Environmental research 20110401

• Cross talk between glucocorticoid and estrogen receptors occurs at a subset of proinflammatory genes.

  Journal of immunology (Baltimore, Md. : 1950) 20110401

• Fulvestrant for advanced male breast cancer patients: a case series.

  Annals of oncology : official journal of the European Society for Medical Oncology 20110401

• MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways.

  Oncogene 20110303

• The antidepressant-like effect of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane involves a regulation of β-type estrogen receptors.

  Psychopharmacology 20110301

• Genistein ameliorates learning and memory deficits in amyloid β(1-40) rat model of Alzheimer's disease.

  Neurobiology of learning and memory 20110301

• Regional genomic regulation of cardiac sodium-calcium exchanger by oestrogen.

  The Journal of physiology 20110301

• Estrogens promote invasion of prostate cancer cells in a paracrine manner through up-regulation of matrix metalloproteinase 2 in prostatic stromal cells.

  Endocrinology 20110301

• Fulvestrant: a review of its use in the management of hormone receptor-positive metastatic breast cancer in postmenopausal women.

  Drugs 20110212

• Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.

  Breast cancer research and treatment 20110201

• Testosterone and 17β-estradiol have opposite effects on podocyte apoptosis that precedes glomerulosclerosis in female estrogen receptor knockout mice.

  Kidney international 20110201

• Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line.

  Endocrine-related cancer 20110201

• Phase II study of fulvestrant in recurrent/metastatic endometrial carcinoma: a Gynecologic Oncology Group study.

  Gynecologic oncology 20110201

• Dual effects of estrogen on vascular smooth muscle cells: receptor-mediated proliferative vs. metabolite-induced pro-senescent actions.

  Steroids 20110201

• Complete estrogen receptor blocker ICI182,780 promotes the proliferation of vascular smooth muscle cells.

  Acta biochimica et biophysica Sinica 20110201

• Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer.

  Expert review of anticancer therapy 20110201

• Fulvestrant in the management of postmenopausal women with advanced, endocrine-responsive breast cancer.

  Future oncology (London, England) 20110201

• Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer.

  Cancer research 20110115

• The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine promotes invasive behaviour of breast cancer cells.

  Toxicology 20110111

• Estradiol-regulated proline-rich acid protein 1 is repressed by class I histone deacetylase and functions in peri-implantation mouse uterus.

  Molecular and cellular endocrinology 20110101

• In vivo treatments with fulvestrant and anastrozole differentially affect gene expression in the rat efferent ductules.

  Biology of reproduction 20110101

• Estrogen induces stromal cell-derived factor 1 (SDF-1/CXCL12) production in human endometrial stromal cells: a possible role of endometrial epithelial cell growth.

  Fertility and sterility 20110101

• Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells.

  Environmental pollution (Barking, Essex : 1987) 20110101

• Sex differences in the analgesic effects of ICI 182,780 and Flutamide on ureteral calculosis in rats.

  Hormones and behavior 20110101

• Fulvestrant 250 mg versus anastrozole for Chinese patients with advanced breast cancer: results of a multicentre, double-blind, randomised phase III trial.

  Cancer chemotherapy and pharmacology 20110101

• Benefits of early and prolonged fulvestrant treatment in 848 postmenopausal advanced breast cancer patients.

  Breast cancer research and treatment 20110101

• Estrogen receptor-α but not -β or GPER inhibits high glucose-induced human VSMC proliferation: potential role of ROS and ERK.

  The Journal of clinical endocrinology and metabolism 20110101

• SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20110101

• New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription.

  Bioorganic & medicinal chemistry 20110101

• Acquired endocrine resistance in breast cancer: implications for tumour metastasis.

  Frontiers in bioscience (Landmark edition) 20110101

• Bisphenol A induces otolith malformations during vertebrate embryogenesis.

  BMC developmental biology 20110101

• Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer.

  Breast cancer research : BCR 20110101

• Fulvestrant-induced expression of ErbB3 and ErbB4 receptors sensitizes oestrogen receptor-positive breast cancer cells to heregulin β1.

  Breast cancer research : BCR 20110101

• Assessing oestrogenic effects of brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on MCF-7 cells.

  Folia biologica 20110101

• Response of estrogen receptor-positive breast cancer tumorspheres to antiestrogen treatments.

  PloS one 20110101

• Tamoxifen in early-stage estrogen receptor-positive breast cancer: overview of clinical use and molecular biomarkers for patient selection.

  OncoTargets and therapy 20110101

• Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes.

  Breast cancer research : BCR 20110101

• Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay.

  PloS one 20110101

• Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library.

  PloS one 20110101

• Ki67 proliferation in core biopsies versus surgical samples - a model for neo-adjuvant breast cancer studies.

  BMC cancer 20110101

• Mechanisms of genistein protection on pancreas cell damage in high glucose condition.

  Internal medicine (Tokyo, Japan) 20110101

• Crosstalk between integrin αvβ3 and estrogen receptor-α is involved in thyroid hormone-induced proliferation in human lung carcinoma cells.

  PloS one 20110101

• Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression.

  PloS one 20110101

• PAX2 is activated by estradiol in breast cancer cells of the luminal subgroup selectively, to confer a low invasive phenotype.

  Molecular cancer 20110101

• Chronic leptin treatment sensitizes MCF-7 breast cancer cells to estrogen.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Inhibition of aryl hydrocarbon receptor-dependent transcription by resveratrol or kaempferol is independent of estrogen receptor α expression in human breast cancer cells.

  Cancer letters 20101228

• The effect of intra-locus coeruleus injection of 17beta-estradiol on inflammatory pain modulation in male rat.

  Behavioural brain research 20101225

• Loss of BRCA1 leads to an increased sensitivity to Bisphenol A.

  Toxicology letters 20101215

• Three dose regimens of fulvestrant in postmenopausal Japanese women with advanced breast cancer: results from a double-blind, phase II comparative study (FINDER1).

  Annals of oncology : official journal of the European Society for Medical Oncology 20101201

• Estradiol regulates expression of polysialated neural cell adhesion molecule by human vascular endothelial cells.

  Reproductive sciences (Thousand Oaks, Calif.) 20101201

• Effects and mechanisms of nonylphenol on corticosterone release in rat zona fasciculata-reticularis cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20101201

• Bisphenol-A rapidly promotes dynamic changes in hippocampal dendritic morphology through estrogen receptor-mediated pathway by concomitant phosphorylation of NMDA receptor subunit NR2B.

  Toxicology and applied pharmacology 20101201

• Mechanical loading-related bone gain is enhanced by tamoxifen but unaffected by fulvestrant in female mice.

  Endocrinology 20101201

• Trefoil factor 3 is oncogenic and mediates anti-estrogen resistance in human mammary carcinoma.

  Neoplasia (New York, N.Y.) 20101201

• Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities.

  Proceedings of the National Academy of Sciences of the United States of America 20101123

• Small proline-rich protein 2 family is a cluster of genes induced by estrogenic compounds through nuclear estrogen receptors in the mouse uterus.

  Reproductive toxicology (Elmsford, N.Y.) 20101101

• Progesterone increases systemic and local uterine proportions of CD4+CD25+ Treg cells during midterm pregnancy in mice.

  Endocrinology 20101101

• Research resource: estrogen-driven prolactin-mediated gene-expression networks in hormone-induced prostatic intraepithelial neoplasia.

  Molecular endocrinology (Baltimore, Md.) 20101101

• 17β-estradiol inhibits the production of infectious particles of hepatitis C virus.

  Microbiology and immunology 20101101

• The protective effect of 17beta-estradiol postconditioning against hypoxia/reoxygenation injury in human gastric epithelial cells.

  European journal of pharmacology 20101025

• Results of the CONFIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20101020

• Insights into the place of fulvestrant for the treatment of advanced endocrine responsive breast cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20101020

• Effects of estrogen on breast cancer development: Role of estrogen receptor independent mechanisms.

  International journal of cancer 20101015

• Bisphenol-A interferes with estradiol-mediated protection in osteoarthritic chondrocytes.

  Toxicology letters 20101005

• Progesterone is primary regulator of Cdk2ap1 gene expression and tissue-specific expression in the uterus.

  Journal of endocrinological investigation 20101001

• Efavirenz directly modulates the oestrogen receptor and induces breast cancer cell growth.

  HIV medicine 20101001

• Superinduction of estrogen receptor mediated gene expression in luciferase based reporter gene assays is mediated by a post-transcriptional mechanism.

  The Journal of steroid biochemistry and molecular biology 20101001

• Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function.

  Hepatology (Baltimore, Md.) 20101001

• Chrysoeriol isolated from Eurya cilliata leaves protects MC3T3-E1 cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation.

  Journal of applied toxicology : JAT 20101001

• ETAR antagonist ZD4054 exhibits additive effects with aromatase inhibitors and fulvestrant in breast cancer therapy, and improves in vivo efficacy of anastrozole.

  Breast cancer research and treatment 20100901

• 17beta-estradiol mediated protection against vascular leak after hemorrhagic shock: role of estrogen receptors and apoptotic signaling.

  Shock (Augusta, Ga.) 20100901

• Results of a phase II study comparing three dosing regimens of fulvestrant in postmenopausal women with advanced breast cancer (FINDER2).

  Breast cancer research and treatment 20100901

• 17 β-estradiol rapidly increases ATP-sensitive potassium channel activity in gonadotropin-releasing hormone neurons [corrected] via a protein kinase signaling pathway.

  Endocrinology 20100901

• Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells.

  Journal of medicinal chemistry 20100826

• Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation.

  Proceedings of the National Academy of Sciences of the United States of America 20100824

• Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation.

  Chemical research in toxicology 20100816

• Intratumoral localization of aromatase and interaction between stromal and parenchymal cells in the non-small cell lung carcinoma microenvironment.

  Cancer research 20100815

• Sensitive and rapid high-performance liquid chromatography tandem mass spectrometry method for estimation of fulvestrant in rabbit plasma.

  Biomedical chromatography : BMC 20100801

• The assessment of estrogenic or anti-estrogenic activity of chemicals by the human stably transfected estrogen sensitive MELN cell line: results of test performance and transferability.

  Reproductive toxicology (Elmsford, N.Y.) 20100801

• Optimization and prevalidation of the in vitro ERalpha CALUX method to test estrogenic and antiestrogenic activity of compounds.

  Reproductive toxicology (Elmsford, N.Y.) 20100801

• Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells.

  Biology of reproduction 20100801

• Estradiol-17beta stimulates specific receptor and endogenous nitric oxide-dependent dynamic endothelial protein S-nitrosylation: analysis of endothelial nitrosyl-proteome.

  Endocrinology 20100801

• 17α-Ethinylestradiol rapidly alters transcript levels of murine coagulation genes via estrogen receptor α.

  Journal of thrombosis and haemostasis : JTH 20100801

• Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-alpha.

  Bioorganic & medicinal chemistry 20100801

• Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780.

  Pharmacology 20100801

• Cardiac oxytocin receptor blockade stimulates adverse cardiac remodeling in ovariectomized spontaneously hypertensive rats.

  American journal of physiology. Heart and circulatory physiology 20100801

• A better injection site.

  The American journal of nursing 20100801

• Gender-specific reduction in contraction is associated with increased estrogen receptor expression in single vascular smooth muscle cells of female rat.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100801

• Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner.

  Brain research 20100723

• Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways.

  The Journal of nutritional biochemistry 20100701

• 17Beta-estradiol enhances leptin expression in human placental cells through genomic and nongenomic actions.

  Biology of reproduction 20100701

• Ciliary beat frequency controlled by oestradiol and progesterone during ovarian cycle in guinea-pig Fallopian tube.

  Experimental physiology 20100701

• ICI 182,780 induces P-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: a role for C/EBPbeta in CDH3 gene activation.

  Human molecular genetics 20100701

• Effect of Estradiol-17beta on protein synthesis and degradation rates in fused bovine satellite cell cultures.

  Domestic animal endocrinology 20100701

• Asymmetric regulation by estrogen at the cholinergic gene locus in differentiated NG108-15 neuronal cells.

  Life sciences 20100605

• In vitro effects of bisphenol A on developing hypothalamic neurons.

  Toxicology 20100604

• Artemin is estrogen regulated and mediates antiestrogen resistance in mammary carcinoma.

  Oncogene 20100603

• Fulvestrant (ICI 182,780) sensitizes breast cancer cells expressing estrogen receptor alpha to vinblastine and vinorelbine.

  Breast cancer research and treatment 20100601

• Breast cancer cells can switch between estrogen receptor alpha and ErbB signaling and combined treatment against both signaling pathways postpones development of resistance.

  Breast cancer research and treatment 20100601

• Breast cancer cell growth inhibition by phenethyl isothiocyanate is associated with down-regulation of oestrogen receptor-alpha36.

  Journal of cellular and molecular medicine 20100601

• Activity of fulvestrant in HER2-overexpressing advanced breast cancer.

  Annals of oncology : official journal of the European Society for Medical Oncology 20100601

• Effect of selective estrogen receptor modulator/raloxifene analogue on proliferation and collagen metabolism of tendon fibroblast.

  Connective tissue research 20100601

• Membrane-impermeable estrogen is involved in regulation of calbindin-D9k expression via non-genomic pathways in a rat pituitary cell line, GH3 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20100601

• Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens.

  Toxicology and applied pharmacology 20100601

• Intracellular, not membrane, estrogen receptors control vitellogenin synthesis in the rainbow trout.

  General and comparative endocrinology 20100601

• Optical redox ratio differentiates breast cancer cell lines based on estrogen receptor status.

  Cancer research 20100601

• FOXM1 is a transcriptional target of ERalpha and has a critical role in breast cancer endocrine sensitivity and resistance.

  Oncogene 20100520

• Rapid effects of phytoestrogens on human colonic smooth muscle are mediated by oestrogen receptor beta.

  Molecular and cellular endocrinology 20100514

• Activation of G protein-coupled receptor 30 modulates hormone secretion and counteracts cytokine-induced apoptosis in pancreatic islets of female mice.

  Molecular and cellular endocrinology 20100514

• Delayed activation of extracellular-signal-regulated kinase 1/2 is involved in genistein- and equol-induced cell proliferation and estrogen-receptor-alpha-mediated transcription in MCF-7 breast cancer cells.

  The Journal of nutritional biochemistry 20100501

• E-cadherin mediates the aggregation of breast cancer cells induced by tamoxifen and epidermal growth factor.

  Breast cancer research and treatment 20100501

• Experience with fulvestrant acetate in castration-resistant prostate cancer patients.

  Annals of oncology : official journal of the European Society for Medical Oncology 20100501

• Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation.

  Arteriosclerosis, thrombosis, and vascular biology 20100501

• Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1.

  Molecular endocrinology (Baltimore, Md.) 20100501

• Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization.

  Molecular endocrinology (Baltimore, Md.) 20100501

• Cadmium promotes breast cancer cell proliferation by potentiating the interaction between ERalpha and c-Jun.

  Molecular endocrinology (Baltimore, Md.) 20100501

• Steroidal regulation of Ihh and Gli1 expression in the rat uterus.

  Cell and tissue research 20100501

• Estradiol-induced proliferation of papillary and follicular thyroid cancer cells is mediated by estrogen receptors alpha and beta.

  International journal of oncology 20100501

• IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis.

  Molecular cancer therapeutics 20100501

• Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs).

  Journal of medicinal chemistry 20100422

• Estrogen receptor and Wnt signaling interact to regulate early gene expression in response to mechanical strain in osteoblastic cells.

  Biochemical and biophysical research communications 20100409

• Differential action of chlorinated polycyclic aromatic hydrocarbons on aryl hydrocarbon receptor-mediated signaling in breast cancer cells.

  Environmental toxicology 20100401

• Breast cancer-derived M543V mutation in helix 12 of estrogen receptor alpha inverts response to estrogen and SERMs.

  Breast cancer research and treatment 20100401

• Resveratrol prevents endothelial dysfunction and aortic superoxide production after trauma hemorrhage through estrogen receptor-dependent hemeoxygenase-1 pathway.

  Critical care medicine 20100401

• Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity.

  Molecular nutrition & food research 20100401

• Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20100401

• Estradiol inhibits chondrogenic differentiation of mesenchymal stem cells via nonclassic signaling.

  Arthritis and rheumatism 20100401

• Fulvestrant: a unique antiendocrine agent for estrogen-sensitive breast cancer.

  Expert opinion on pharmacotherapy 20100401

• The Wilms' tumor suppressor WT1 induces estrogen-independent growth and anti-estrogen insensitivity in ER-positive breast cancer MCF7 cells.

  Oncology reports 20100401

• Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins.

  Journal of vascular surgery 20100401

• Oestrogen receptor-beta signalling protects against transplanted skin tumour growth in the mouse.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20100401

• Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling.

  The Journal of biological chemistry 20100319

• 4-Hydroxytamoxifen inhibits K(+) currents in mouse ventricular myocytes.

  European journal of pharmacology 20100310

• Fulvestrant in the treatment of advanced breast cancer: a systematic review and meta-analysis of randomized controlled trials.

  Critical reviews in oncology/hematology 20100301

• Sex differences in estrogen receptor subcellular location and activity in lung adenocarcinoma cells.

  American journal of respiratory cell and molecular biology 20100301

• Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells.

  Endocrine-related cancer 20100301

• The effects of beta-blockers on endothelial nitric oxide synthase immunoreactivity in the rat corpus cavernosum.

  Urology 20100301

• The effects of pomegranate seed extract and beta-sitosterol on rat uterine contractions.

  Reproductive sciences (Thousand Oaks, Calif.) 20100301

• Estrogen-regulated expression and distribution of Id-1 in the mouse uterus.

  Placenta 20100301

• Estrogen receptor-alpha-interacting cytokeratins potentiate the antiestrogenic activity of fulvestrant.

  Cancer biology & therapy 20100301

• Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha.

  EMBO reports 20100301

• FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer.

  Cancer research 20100301

• Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance.

  Molecular cancer research : MCR 20100301

• Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells.

  The Journal of steroid biochemistry and molecular biology 20100227

• Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer.

  British journal of cancer 20100216

• Both nongenomic and genomic effects are involved in estradiol's enhancing the phenotype of smooth muscle cells in cultured prostate stromal cells.

  The Prostate 20100215

• Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications.

  Toxicology letters 20100215

• Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer.

  Cancer research 20100215

• Suppressive effect on MDC and IP-10 expression in monocytes by endocrine disruptor chemicals.

  Inflammation 20100201

• Zip6-attenuation promotes epithelial-to-mesenchymal transition in ductal breast tumor (T47D) cells.

  Experimental cell research 20100201

• Hexachlorobenzene induces cell proliferation and IGF-I signaling pathway in an estrogen receptor alpha-dependent manner in MCF-7 breast cancer cell line.

  Toxicology letters 20100201

• Effects of estrogen on synapsin I distribution in developing hypothalamic neurons.

  Neuroscience research 20100201

• Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effect of di(n-butyl) phthalate.

  Reproduction (Cambridge, England) 20100201

• FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy.

  Cancer research 20100201

• Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells.

  British journal of pharmacology 20100201

• Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet.

  Cancer research 20100115

• Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.

  Oncogene 20100114

• Cellular and molecular mechanisms of 17beta-estradiol postconditioning protection against gastric mucosal injury induced by ischemia/reperfusion in rats.

  Life sciences 20100102

• Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen.

  Breast cancer research and treatment 20100101

• Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-gamma-inducible protein-10 by astrocytes exposed to inflammatory challenge in vitro.

  Glia 20100101

• Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells.

  Toxicology and applied pharmacology 20100101

• Absence of ligand-independent transcriptional activation of the estrogen receptor via the estrogen response element in pituitary lactotrophs in primary culture.

  The Journal of steroid biochemistry and molecular biology 20100101

• Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators.

  Molecular endocrinology (Baltimore, Md.) 20100101

• Environmental endocrine disruptors promote invasion and metastasis of SK-N-SH human neuroblastoma cells.

  Oncology reports 20100101

• Modulation of cytokine expression in human myeloid dendritic cells by environmental endocrine-disrupting chemicals involves epigenetic regulation.

  Environmental health perspectives 20100101

• Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis.

  PloS one 20100101

• Estrogen receptor-dependent regulation of CYP2B6 in human breast cancer cells.

  Biochimica et biophysica acta 20100101

• Fulvestrant - a novel endocrine therapy for breast cancer.

  Current medicinal chemistry 20100101

• Do we really need new trials on fulvestrant in prostate cancer?

  Onkologie 20100101

• PSA decrease with fulvestrant acetate in a hormone-resistant metastatic prostate cancer patient.

  Onkologie 20100101

• Estrogenic in vitro assay on mouse embryonic Leydig cells.

  The International journal of developmental biology 20100101

• In vitro effects of oestrogens, antioestrogens and SERMs on pancreatic solid pseudopapillary neoplasm-derived primary cell culture.

  Cellular oncology : the official journal of the International Society for Cellular Oncology 20100101

• Selective estrogen receptor down-regulator and selective estrogen receptor modulators differentially regulate lactotroph proliferation.

  PloS one 20100101

• Estradiol suppresses tissue androgens and prostate cancer growth in castration resistant prostate cancer.

  BMC cancer 20100101

• Anterior gradient-2 plays a critical role in breast cancer cell growth and survival by modulating cyclin D1, estrogen receptor-alpha and survivin.

  Breast cancer research : BCR 20100101

• Cell cycle and anti-estrogen effects synergize to regulate cell proliferation and ER target gene expression.

  PloS one 20100101

• The estrogen receptor influences microtubule-associated protein tau (MAPT) expression and the selective estrogen receptor inhibitor fulvestrant downregulates MAPT and increases the sensitivity to taxane in breast cancer cells.

  Breast cancer research : BCR 20100101

• MYB suppresses differentiation and apoptosis of human breast cancer cells.

  Breast cancer research : BCR 20100101

• Effects of 17 β-estradiol on lipopolysacharride-induced intracellular adhesion molecule-1 mRNA expression and Ca²+ homeostasis alteration in human endothelial cells.

  Vascular pharmacology 20100101

• Genistein induced apoptotic cell death in adult T-cell leukemia cells through estrogen receptors.

  Bioscience, biotechnology, and biochemistry 20100101

• Ligands specify estrogen receptor alpha nuclear localization and degradation.

  BMC cell biology 20100101

• Estrogen stimulates proliferation and differentiation of neural stem/progenitor cells through different signal transduction pathways.

  International journal of molecular sciences 20100101

• 17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells.

  Aquatic toxicology (Amsterdam, Netherlands) 20091213

• Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.

  Journal of medicinal chemistry 20091210

• Estradiol-induced estrogen receptor-alpha trafficking.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20091202

• Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERalpha.

  Breast cancer research and treatment 20091201

• 17Beta-estradiol activates adenosine A(2a) receptor after subarachnoid hemorrhage.

  The Journal of surgical research 20091201

• Clinical use of selective estrogen receptor modulators and down regulators with the main focus on breast cancer.

  Minerva ginecologica 20091201

• Differential regulation of Akt phosphorylation in endometriosis.

  Reproductive biomedicine online 20091201

• Antiproliferative activity of brown Cuban propolis extract on human breast cancer cells.

  Natural product communications 20091201

• Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity.

  Journal of medicinal chemistry 20091112

• Interdependence between heme oxygenase-1 induction and estrogen-receptor-beta signaling mediates photoimmune protection by UVA radiation in mice.

  The Journal of investigative dermatology 20091101

• Predicting benefit from fulvestrant in pretreated metastatic breast cancer patients.

  Breast cancer research and treatment 20091101

• Aromatase promoter I.f is regulated by estrogen receptor alpha (ESR1) in mouse hypothalamic neuronal cell lines.

  Biology of reproduction 20091101

• Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells.

  Toxicology and applied pharmacology 20091101

• An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model.

  Toxicological sciences : an official journal of the Society of Toxicology 20091101

• Fulvestrant in advanced male breast cancer.

  Annals of oncology : official journal of the European Society for Medical Oncology 20091101

• Melatonin-induced estrogen receptor alpha-mediated calbindin-D9k expression plays a role in H2O2-mediated cell death in rat pituitary GH3 cells.

  Journal of pineal research 20091101

• The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.

  Journal of natural products 20091101

• Estrogenic activity of xanthorrhizol isolated from curcuma xanthorrhiza ROXB.

  Biological & pharmaceutical bulletin 20091101

• Dual activities of odorants on olfactory and nuclear hormone receptors.

  The Journal of biological chemistry 20091030

• Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20091014

• Comparison of chemical binding to recombinant fathead minnow and human estrogen receptors alpha in whole cell and cell-free binding assays.

  Environmental toxicology and chemistry 20091001

• Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival.

  Neurobiology of disease 20091001

• CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.

  Carcinogenesis 20091001

• Early regulation of brain aromatase (cyp19a1b) by estrogen receptors during zebrafish development.

  Developmental dynamics : an official publication of the American Association of Anatomists 20091001

• Activity of fulvestrant 500 mg versus anastrozole 1 mg as first-line treatment for advanced breast cancer: results from the FIRST study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090920

• [Fulvestrant in heavily pretreated postmenopausal women with advanced breast cancer].

  Medicina clinica 20090919

• Induction of cells differentiation and ABC transporters expression by a myco-estrogen, zearalenone, in human choriocarcinoma cell line (BeWo).

  Toxicology 20090919

• Activity of fulvestrant versus exemestane in advanced breast cancer patients with or without visceral metastases: data from the EFECT trial.

  Breast cancer research and treatment 20090901

• Prospective assessment of the endometrium in postmenopausal breast cancer patients treated with fulvestrant.

  Breast cancer research and treatment 20090901

• Cost-utility analysis for advanced breast cancer therapy in Germany: results of the fulvestrant sequencing model.

  Breast cancer research and treatment 20090901

• Estrogen regulation of thrombospondin-1 in human breast cancer cells.

  International journal of cancer 20090901

• Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1.

  Molecular endocrinology (Baltimore, Md.) 20090901

• Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells.

  Clinical biochemistry 20090901

• Estrogen can signal through multiple pathways to regulate oocyte cyst breakdown and primordial follicle assembly in the neonatal mouse ovary.

  The Journal of endocrinology 20090901

• Differential effects of steroids on the synthesis of polyunsaturated fatty acids by human neuroblastoma cells.

  Neurochemistry international 20090901

• Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter.

  Molecular and cellular biology 20090901

• HE3286: a novel synthetic steroid as an oral treatment for autoimmune disease.

  Annals of the New York Academy of Sciences 20090901

• Long-term potentiation in the rat medial vestibular nuclei depends on locally synthesized 17beta-estradiol.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090826

• Characterization of the weak estrogen receptor alpha agonistic activity of exemestane.

  Breast cancer research and treatment 20090801

• Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus.

  Hippocampus 20090801

• Blockade of estrogen action upregulates estrogen receptor-alpha mRNA in the fetal brain.

  Neonatology 20090801

• Estrogen rapidly activates the PI3K/AKT pathway and hypoxia-inducible factor 1 and induces vascular endothelial growth factor A expression in luminal epithelial cells of the rat uterus.

  Biology of reproduction 20090801

• Androgen- and estrogen-independent regulation of copulatory behavior following castration in male B6D2F1 mice.

  Hormones and behavior 20090801

• In vitro exposure to xenoestrogens induces growth hormone transcription and release via estrogen receptor-dependent pathways in rat pituitary GH3 cells.

  Steroids 20090801

• A novel mechanism of natural vitamin E tocotrienol activity: involvement of ERbeta signal transduction.

  American journal of physiology. Endocrinology and metabolism 20090801

• Direct chronic effect of steroid hormones in attenuating uterine arterial myogenic tone: role of protein kinase c/extracellular signal-regulated kinase 1/2.

  Hypertension (Dallas, Tex. : 1979) 20090801

• Fulvestrant treatment is associated with cholesterol plasma level reduction in hormone-receptor-positive metastatic breast cancer patients.

  Cancer biology & therapy 20090801

• The clinical relevance of endocrine-therapy-induced changes in lipid metabolism in breast cancer patients.

  Cancer biology & therapy 20090801

• Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1.

  Biochemical and biophysical research communications 20090724

• Multiple mechanisms of soy isoflavones against oxidative stress-induced endothelium injury.

  Free radical biology & medicine 20090715

• Positive feedback activation of estrogen receptors by the CXCL12-CXCR4 pathway.

  Cancer research 20090715

• A yeast assay based on the gilthead sea bream (teleost fish) estrogen receptor beta for monitoring estrogen mimics.

  Ecotoxicology and environmental safety 20090701

• Effects of 17beta-oestradiol on rat detrusor smooth muscle contractility.

  Experimental physiology 20090701

• Oestrogen inhibits human colonic motility by a non-genomic cell membrane receptor-dependent mechanism.

  The British journal of surgery 20090701

• Oestradiol decreases colonic permeability through oestrogen receptor beta-mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells.

  The Journal of physiology 20090701

• Beta3-tubulin is induced by estradiol in human breast carcinoma cells through an estrogen-receptor dependent pathway.

  Cell motility and the cytoskeleton 20090701

• Structure-activity relationships of resveratrol and derivatives in breast cancer cells.

  Molecular nutrition & food research 20090701

• Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor.

  Environmental health perspectives 20090701

• Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms.

  Environmental health perspectives 20090701

• Phytoestrogens regulate mRNA and protein levels of guanine nucleotide-binding protein, beta-1 subunit (GNB1) in MCF-7 cells.

  Journal of cellular physiology 20090601

• Essential role of the 90-kilodalton heat shock protein in mediating nongenomic estrogen signaling in coronary artery smooth muscle.

  The Journal of pharmacology and experimental therapeutics 20090601

• Estrogen receptor alpha (ERalpha) mediates stimulatory effects of estrogen on aromatase (CYP19) gene expression in human placenta.

  Molecular endocrinology (Baltimore, Md.) 20090601

• Cell death mechanisms in GT1-7 GnRH cells exposed to polychlorinated biphenyls PCB74, PCB118, and PCB153.

  Toxicology and applied pharmacology 20090601

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  Bulletin du cancer 20090601

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  Breast (Edinburgh, Scotland) 20090601

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  Anticancer research 20090601

• ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands.

  The EMBO journal 20090520

• Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer.

  Cancer research 20090515

• The Austrian fulvestrant registry: results from a prospective observation of fulvestrant in postmenopausal patients with metastatic breast cancer.

  Breast cancer research and treatment 20090501

• Fulvestrant for systemic therapy of locally advanced or metastatic breast cancer in postmenopausal women: a systematic review.

  Breast cancer research and treatment 20090501

• Mechanisms of resistance to structurally diverse antiestrogens differ under premenopausal and postmenopausal conditions: evidence from in vitro breast cancer cell models.

  Endocrinology 20090501

• A phase II study of fulvestrant in the treatment of multiply-recurrent epithelial ovarian cancer.

  Gynecologic oncology 20090501

• Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells.

  Nucleic acids research 20090501

• Sex differences and central protective effect of 17beta-estradiol in the development of aldosterone/NaCl-induced hypertension.

  American journal of physiology. Heart and circulatory physiology 20090501

• 17beta-Estradiol-induced enhancement of estrogen receptor biosynthesis via MAPK pathway in mouse skeletal muscle myoblasts.

  The journal of physiological sciences : JPS 20090501

• High Cks1 expression in transgenic and carcinogen-initiated mammary tumors is not always accompanied by reduction in p27Kip1.

  International journal of oncology 20090501

• Short-term prophylactic tamoxifen reduces the incidence of antiestrogen-resistant/estrogen receptor-positive/progesterone receptor-negative mammary tumors.

  Cancer prevention research (Philadelphia, Pa.) 20090501

• Targeting tumors using estrogen receptor ligand conjugates.

  Current cancer drug targets 20090501

• Relaxing effects of phytoestrogen alpha-zearalanol on rat thoracic aorta rings in vitro.

  The Chinese journal of physiology 20090430

• Estrogens and human papilloma virus oncogenes regulate human ether-à-go-go-1 potassium channel expression.

  Cancer research 20090415

• Pilot study of gefitinib and fulvestrant in the treatment of post-menopausal women with advanced non-small cell lung cancer.

  Lung cancer (Amsterdam, Netherlands) 20090401

• Nitric oxide sensitive-guanylyl cyclase subunit expression changes during estrous cycle in anterior pituitary glands.

  American journal of physiology. Endocrinology and metabolism 20090401

• Estrogen receptors are involved in xenoestrogen induction of growth hormone in the rat pituitary gland.

  The Journal of reproduction and development 20090401

• Phase II trial of the farnesyltransferase inhibitor tipifarnib plus fulvestrant in hormone receptor-positive metastatic breast cancer: New York Cancer Consortium Trial P6205.

  Annals of oncology : official journal of the European Society for Medical Oncology 20090401

• Growth-promoting effect of bisphenol A on neuroblastoma in vitro and in vivo.

  Journal of pediatric surgery 20090401

• Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds.

  Toxicology and applied pharmacology 20090401

• Oestrogenic regulation and differential expression of WNT4 in the bonnet monkey and rodent epididymis.

  Reproductive biomedicine online 20090401

• Estrogen and TCDD influence RLN2 gene activity in estrogen receptor-positive human breast cancer cells.

  Annals of the New York Academy of Sciences 20090401

• Activation of the unliganded estrogen receptor by prolactin in breast cancer cells.

  Oncogene 20090312

• Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant.

  Breast cancer research and treatment 20090301

• Point:Counterpoint: Estrogen and sex do/do not influence post-exercise indexes of muscle damage, inflammation, and repair.

  Journal of applied physiology (Bethesda, Md. : 1985) 20090301

• A potential role for caveolin-1 in estradiol-17beta-induced proliferation of mouse embryonic stem cells: involvement of Src, PI3K/Akt, and MAPKs pathways.

  The international journal of biochemistry & cell biology 20090301

• Involvement of estradiol-17beta and its membrane receptor, G protein coupled receptor 30 (GPR30) in regulation of oocyte maturation in zebrafish, Danio rario.

  General and comparative endocrinology 20090301

• Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma.

  Endocrinology 20090301

• Enhanced expression of ERalpha in astrocytes modifies the response of cortical neurons to beta-amyloid toxicity.

  Neurobiology of disease 20090301

• Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons.

  Molecular endocrinology (Baltimore, Md.) 20090301

• Use of global gene expression patterns in mechanistic studies of oestrogen action in MCF7 human breast cancer cells.

  The Journal of steroid biochemistry and molecular biology 20090301

• Effects of CH4893237, a new orally active estrogen receptor downregulator, on breast cancer xenograft models with low serum estrogen levels.

  Oncology reports 20090301

• Nebivolol decreases endothelial cell stiffness via the estrogen receptor beta: a nano-imaging study.

  Journal of hypertension 20090301

• Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells.

  The Journal of steroid biochemistry and molecular biology 20090301

• Effect of fluorination on the pharmacological profile of 11beta isomers of fulvestrant in breast carcinoma cells.

  Journal of medicinal chemistry 20090212

• Signal pathway of 17beta-estradiol-induced MUC5B expression in human airway epithelial cells.

  American journal of respiratory cell and molecular biology 20090201

• Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer.

  Journal of molecular endocrinology 20090201

• A cyp19a1b-gfp (aromatase B) transgenic zebrafish line that expresses GFP in radial glial cells.

  Genesis (New York, N.Y. : 2000) 20090201

• Androgen-induced human breast cancer cell proliferation is mediated by discrete mechanisms in estrogen receptor-alpha-positive and -negative breast cancer cells.

  The Journal of steroid biochemistry and molecular biology 20090201

• Rapid estrogen receptor-alpha activation improves ischemic tolerance in aged female rats through a novel protein kinase C epsilon-dependent mechanism.

  Endocrinology 20090201

• Endocrine therapy for the treatment of postmenopausal women with breast cancer.

  Expert review of anticancer therapy 20090201

• Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-alpha-positive and -negative breast cancer cells.

  Environmental health perspectives 20090201

• Estradiol attenuates EGF-induced rapid uPAR mobilization and cell migration via the G-protein-coupled receptor 30 in ovarian cancer cells.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20090201

• Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene.

  The Journal of steroid biochemistry and molecular biology 20090201

• Effects of cadmium on estrogen receptor mediated signaling and estrogen induced DNA synthesis in T47D human breast cancer cells.

  Toxicology letters 20090130

• Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation.

  Circulation research 20090130

• Resting intracellular calcium concentration, depolarizing Gamma-Aminobutyric Acid and possible role of local estradiol synthesis in the developing male and female hippocampus.

  Neuroscience 20090123

• Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line.

  Toxicology 20090108

• Tamoxifen-induced [Ca2+]i rise and apoptosis in corneal epithelial cells.

  Toxicology 20090108

• Enantioselective estrogenicity of o,p'-dichlorodiphenyltrichloroethane in the MCF-7 human breast carcinoma cell line.

  Environmental toxicology and chemistry 20090101

• Monitoring of hormonal drug effect in a single breast cancer cell using an estrogen responsive GFP reporter vector delivered by a nanoneedle.

  Biosensors & bioelectronics 20090101

• A bipartite recombinant yeast system for the identification of subtype-selective estrogen receptor ligands.

  Molecular biotechnology 20090101

• Increased SULT1E1 activity in HepG2 hepatocytes decreases growth hormone stimulation of STAT5b phosphorylation.

  Steroids 20090101

• Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity.

  Bone 20090101

• Effects of 17beta-estradiol on rat urinary bladder: gender differences in anoxia-glucopenia and reperfusion damage.

  Neurourology and urodynamics 20090101

• Estradiol promotes pituitary cell proliferation and gonadotroph differentiation at different doses and with different mechanisms in chick embryo.

  Steroids 20090101

• Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines.

  BMC cancer 20090101

• Cellular and regional distributions of ubiquitin-proteasome and endocytotic pathway components in the epithelium of rat efferent ductules and initial segment of the epididymis.

  Journal of andrology 20090101

• Estrogenic effects of herbal medicines from Costa Rica used for the management of menopausal symptoms.

  Menopause (New York, N.Y.) 20090101

• Fulvestrant in advanced breast cancer following tamoxifen and aromatase inhibition: a single center experience.

  The breast journal 20090101

• Estrogen-induced stromal cell-derived factor-1 (SDF-1/Cxcl12) expression is repressed by progesterone and by Selective Estrogen Receptor Modulators via estrogen receptor alpha in rat uterine cells and tissues.

  Steroids 20090101

• Effects of fulvestrant, an estrogen receptor antagonist, on MMQ cells and its mechanism.

  Neuro endocrinology letters 20090101

• Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ.

  BMC cancer 20090101

• Recent advances in systemic therapy. When HER2 is not the target: advances in the treatment of HER2-negative metastatic breast cancer.

  Breast cancer research : BCR 20090101

• Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion.

  PloS one 20090101

• Treatment with the specific estrogen receptor antagonist ICI 182,780 demasculinizes neuron soma size in the developing zebra finch brain.

  Brain research 20081230

• Economic evaluation of fulvestrant as an extra step in the treatment sequence for ER-positive advanced breast cancer.

  British journal of cancer 20081209

• Premarin can act via estrogen receptors to rescue mice from heatstroke-induced lethality.

  Shock (Augusta, Ga.) 20081201

• Laccase treatment impairs bisphenol A-induced cancer cell proliferation affecting estrogen receptor alpha-dependent rapid signals.

  IUBMB life 20081201

• 17-Beta-estradiol inhibits transforming growth factor-beta signaling and function in breast cancer cells via activation of extracellular signal-regulated kinase through the G protein-coupled receptor 30.

  Molecular pharmacology 20081201

• ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2.

  Endocrine-related cancer 20081201

• The influence of endocrine treatments for breast cancer on health-related quality of life.

  Cancer treatment reviews 20081101

• 17beta-estradiol activates estrogen receptor beta-signalling and inhibits transient receptor potential vanilloid receptor 1 activation by capsaicin in adult rat nociceptor neurons.

  Endocrinology 20081101

• In vivo profiling of estrogen receptor/specificity protein-dependent transactivation.

  Endocrinology 20081101

• Effects of estrogen receptor alpha- and beta-selective substances in the metaphysis of the tibia and on serum parameters of bone and fat tissue metabolism of ovariectomized rats.

  Bone 20081101

• Differential regulation of the inducible nitric oxide synthase gene by estrogen receptors 1 and 2.

  The Journal of endocrinology 20081101

• Estrogen prevents intestinal inflammation after trauma-hemorrhage via downregulation of angiotensin II and angiotensin II subtype I receptor.

  American journal of physiology. Gastrointestinal and liver physiology 20081101

• Ebenfurans IV-VIII from Onobrychis ebenoides: evidence that C-prenylation is the key determinant of the cytotoxicity of 3-formyl-2-arylbenzofurans.

  Journal of natural products 20081101

• Estrogens and genomic instability in human breast cancer cells--involvement of Src/Raf/Erk signaling in micronucleus formation by estrogenic chemicals.

  Carcinogenesis 20081001

• Fispemifene [Z-2-{2-[4-(4-chloro-1,2-diphenylbut-1-enyl)-phenoxy]ethoxy}-ethanol], a novel selective estrogen receptor modulator, attenuates glandular inflammation in an animal model of chronic nonbacterial prostatitis.

  The Journal of pharmacology and experimental therapeutics 20081001

• ICI 182,780 penetrates brain and hypothalamic tissue and has functional effects in the brain after systemic dosing.

  Endocrinology 20081001

• Comparative effects of estradiol, methyl-piperidino-pyrazole, raloxifene, and ICI 182 780 on gene expression in the murine uterus.

  Journal of molecular endocrinology 20081001

• Potential role of G-protein-coupled receptor 30 (GPR30) in estradiol-17beta-stimulated IGF-I mRNA expression in bovine satellite cell cultures.

  Domestic animal endocrinology 20081001

• mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels.

  Cancer science 20081001

• Hormonal regulation of cardiac KCNE2 gene expression.

  Molecular and cellular endocrinology 20080924

• Phase II study of fulvestrant (Faslodex) in castration resistant prostate cancer.

  The Prostate 20080915

• Development of resistance to targeted therapies transforms the clinically associated molecular profile subtype of breast tumor xenografts.

  Cancer research 20080915

• Resveratrol attenuates hepatic injury after trauma-hemorrhage via estrogen receptor-related pathway.

  Shock (Augusta, Ga.) 20080901

• Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90.

  Neurochemical research 20080901

• Oestrogen receptors mediate oestrogen-induced increases in post-exercise rat skeletal muscle satellite cells.

  Acta physiologica (Oxford, England) 20080901

• Oestrogen changed cardiomyocyte contraction and beta-adrenoceptor expression in rat hearts subjected to ischaemia-reperfusion.

  Experimental physiology 20080901

• Effects of the antiestrogen fulvestrant (ICI 182,780) on gene expression of the rat efferent ductules.

  Biology of reproduction 20080901

• Gender-specific protection of estrogen against gastric acid-induced duodenal injury: stimulation of duodenal mucosal bicarbonate secretion.

  Endocrinology 20080901

• Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells.

  Endocrinology 20080901

• Ethanolic extract of Actaea racemosa (black cohosh) potentiates bone nodule formation in MC3T3-E1 preosteoblast cells.

  Bone 20080901

• Central estrogen inhibition of angiotensin II-induced hypertension in male mice and the role of reactive oxygen species.

  American journal of physiology. Heart and circulatory physiology 20080901

• Fulvestrant--a novel estrogen receptor antagonist for the treatment of advanced breast cancer.

  Drugs of today (Barcelona, Spain : 1998) 20080901

• Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats.

  Toxicology letters 20080828

• Inhibitory effects of genistein and resveratrol on guinea pig gallbladder contractility in vitro.

  World journal of gastroenterology 20080821

• Broad modulation of neuropathic pain states by a selective estrogen receptor beta agonist.

  European journal of pharmacology 20080820

• Expression of the estrogen receptor during differentiation of human osteoclasts.

  Steroids 20080801

• The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation.

  Endocrinology 20080801

• Effects of fulvestrant alone or combined with different steroids in human breast cancer cells in vitro.

  Climacteric : the journal of the International Menopause Society 20080801

• Role of estrogen receptors and aromatase on brain protein synthesis rates in ovariectomized female rats fed genistein.

  Nutritional neuroscience 20080801

• Pharmacokinetic profile of the fulvestrant loading dose regimen in postmenopausal women with hormone receptor-positive advanced breast cancer.

  Clinical breast cancer 20080801

• The role of estrogen in the developmental appearance of sensory-motor behaviors in the zebrafish (Danio rerio): the characterization of the 'listless' model.

  Brain research 20080730

• Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway.

  European journal of pharmacology 20080728

• MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERalpha ligands and ERRalpha ligands.

  Biochemical pharmacology 20080715

• Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080701

• Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome.

  Molecular endocrinology (Baltimore, Md.) 20080701

• Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.

  Domestic animal endocrinology 20080701

• Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and -independent pathways.

  Diabetes 20080701

• Estradiol abolishes reduction in cell death by the opioid agonist Met5-enkephalin after oxygen glucose deprivation in isolated cardiomyocytes from both sexes.

  American journal of physiology. Heart and circulatory physiology 20080701

• Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms.

  Molecular cancer therapeutics 20080701

• Estrogen and the Ca2+-mobilizing agonist ATP evoke acute NO synthesis via distinct pathways in an individual human vascular endothelium-derived cell.

  American journal of physiology. Cell physiology 20080601

• Combining fulvestrant (Faslodex) with continued oestrogen suppression in endocrine-sensitive advanced breast cancer: the SoFEA trial.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20080601

• Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways.

  American journal of physiology. Cell physiology 20080601

• Genomic deletion of estrogen receptors ERalpha and ERbeta does not alter estrogen-mediated inhibition of Ca2+ influx and contraction in murine cardiomyocytes.

  American journal of physiology. Heart and circulatory physiology 20080601

• Activation of estrogen receptor-alpha by the anion nitrite.

  Cancer research 20080515

• Fulvestrant (Faslodex) in advanced breast cancer: clinical experience from a Belgian cooperative study.

  Breast cancer research and treatment 20080501

• Estrogen receptor beta increases the efficacy of antiestrogens by effects on apoptosis and cell cycling in breast cancer cells.

  Breast cancer research and treatment 20080501

• Tenascin is highly expressed in endometriosis and its expression is upregulated by estrogen.

  Fertility and sterility 20080501

• Effects of 17beta-estradiol on neuronal cell excitability and neurotransmission in the suprachiasmatic nucleus of rat.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080501

• Genistein and daidzein induced apoA-1 transactivation in hepG2 cells expressing oestrogen receptor-alpha.

  The British journal of nutrition 20080501

• Estrogen determines sex differences in airway responsiveness after allergen exposure.

  American journal of respiratory cell and molecular biology 20080501

• Suppression of NO production and 8-nitroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages: involvement of estrogen receptor-dependent or -independent pathways.

  Nitric oxide : biology and chemistry 20080501

• Relaxin (RLX) and estrogen affect estrogen receptor alpha, vascular endothelial growth factor, and RLX receptor expression in the neonatal porcine uterus and cervix.

  Reproduction (Cambridge, England) 20080501

• Fulvestrant (Faslodex), an estrogen selective receptor downregulator, in therapy of women with systemic lupus erythematosus. clinical, serologic, bone density, and T cell activation marker studies: a double-blind placebo-controlled trial.

  The Journal of rheumatology 20080501

• Combination of anastrozole with fulvestrant in the intratumoral aromatase xenograft model.

  Cancer research 20080501

• Hormone therapy for breast cancer, with an emphasis on the pure antiestrogen fulvestrant: mode of action, antitumor efficacy and effects on bone health.

  Expert opinion on drug safety 20080501

• Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk.

  Current drug metabolism 20080501

• Gene expression profiles in breast cancer to identify estrogen receptor target genes.

  Mini reviews in medicinal chemistry 20080501

• Contribution of alpha2-adrenoceptors to the mitogenic effect of catecholestrogen in human breast cancer MCF-7 cells.

  The Journal of steroid biochemistry and molecular biology 20080501

• The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance.

  Frontiers in bioscience : a journal and virtual library 20080501

• Fulvestrant in heavily pretreated metastatic breast cancer: is it still effective as a very advanced line of treatment?

  The Israel Medical Association journal : IMAJ 20080501

• Genistein potentiates protein kinase A activity in porcine coronary artery.

  Molecular and cellular biochemistry 20080401

• Analysis of the effects of oestrogen receptor alpha (ERalpha)- and ERbeta-selective ligands given in combination to ovariectomized rats.

  British journal of pharmacology 20080401

• The specific estrogen receptor antagonist ICI 182,780 masculinizes development of the zebra finch syrinx.

  General and comparative endocrinology 20080401

• Understanding the data, meeting patients' needs.

  Breast (Edinburgh, Scotland) 20080401

• Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080401

• Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.

  Chemical research in toxicology 20080401

• Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhage.

  Cytokine 20080401

• Fulvestrant: expanding the endocrine treatment options for patients with hormone receptor-positive advanced breast cancer.

  Breast (Edinburgh, Scotland) 20080401

• GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat.

  The European journal of neuroscience 20080401

• Estrogen regulates the localization and expression of calbindin-D9k in the pituitary gland of immature male rats via the ERalpha-pathway.

  Molecular and cellular endocrinology 20080326

• Estrogen induces estrogen-related receptor alpha gene expression and chromatin structural changes in estrogen receptor (ER)-positive and ER-negative breast cancer cells.

  The Journal of biological chemistry 20080314

• Transactivation of ERalpha by Rosiglitazone induces proliferation in breast cancer cells.

  Breast cancer research and treatment 20080301

• 17alpha-Estradiol is neuroprotective in male and female rats in a model of early brain injury.

  Experimental neurology 20080301

• 4-Alkylphenols and related chemicals show similar effect on the function of human and rat estrogen receptor alpha in reporter gene assay.

  Chemosphere 20080301

• Estradiol stimulates transcription of nuclear respiratory factor-1 and increases mitochondrial biogenesis.

  Molecular endocrinology (Baltimore, Md.) 20080301

• Rapid action of estrogens on intracellular calcium oscillations in primate luteinizing hormone-releasing hormone-1 neurons.

  Endocrinology 20080301

• The contributions of oestrogen receptor isoforms to the development of papillary and anaplastic thyroid carcinomas.

  The Journal of pathology 20080301

• Genistein, a plant-derived isoflavone, counteracts the antilipolytic action of insulin in isolated rat adipocytes.

  The Journal of steroid biochemistry and molecular biology 20080301

• ABCC11 expression is regulated by estrogen in MCF7 cells, correlated with estrogen receptor alpha expression in postmenopausal breast tumors and overexpressed in tamoxifen-resistant breast cancer cells.

  Endocrine-related cancer 20080301

• Effects of thyroid hormones on human breast cancer cell proliferation.

  The Journal of steroid biochemistry and molecular biology 20080301

• Role of the insulin-like growth factor system on an estrogen-dependent cancer phenotype in the MCF-7 human breast cancer cell line.

  The Journal of steroid biochemistry and molecular biology 20080301

• Induction of regulatory T cells by physiological level estrogen.

  Journal of cellular physiology 20080201

• Hormonal regulation of BCRP expression in human placental BeWo cells.

  Pharmaceutical research 20080201

• Estrogen-enhanced gene expression of lipoprotein lipase in heart is antagonized by progesterone.

  Endocrinology 20080201

• Human prolactin gene promoter regulation by estrogen: convergence with tumor necrosis factor-alpha signaling.

  Endocrinology 20080201

• Effects of fulvestrant 750mg in premenopausal women with oestrogen-receptor-positive primary breast cancer.

  European journal of cancer (Oxford, England : 1990) 20080201

• Soy isoflavones decrease the catechol-O-methyltransferase-mediated inactivation of 4-hydroxyestradiol in cultured MCF-7 cells.

  Carcinogenesis 20080201

• Xenoestrogens modulate vascular endothelial growth factor secretion in breast cancer cells through an estrogen receptor-dependent mechanism.

  The Journal of endocrinology 20080201

• Estradiol, tamoxifen and ICI 182,780 alter alpha3 and beta1 integrin expression and laminin-1 adhesion in oral squamous cell carcinoma cell cultures.

  Oral oncology 20080101

• Estrogen induces endothelial progenitor cells proliferation and migration by estrogen receptors and PI3K-dependent pathways.

  Microvascular research 20080101

• Comparison of the estrogenic potencies of standardized soy extracts by immature rat uterotrophic bioassay.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20080101

• 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.

  Molecular endocrinology (Baltimore, Md.) 20080101

• Blockade of estrogen receptors decreases CNS and pituitary prostaglandin synthase expression in fetal sheep.

  Neuroendocrinology 20080101

• Ginsenoside Rg1 exerts estrogen-like activities via ligand-independent activation of ERalpha pathway.

  The Journal of steroid biochemistry and molecular biology 20080101

• Topical fulvestrant solution has no effect on male and postmenopausal female androgenetic alopecia: results from two randomized, proof-of-concept studies.

  The British journal of dermatology 20080101

• The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells.

  Reproductive toxicology (Elmsford, N.Y.) 20080101

• Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids.

  Journal of cellular and molecular medicine 20080101

• Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARalpha and NF-kappaB.

  Vascular pharmacology 20080101

• [Research on phytoestrogenic effects and its mechanism of psoralen].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080101

• Pancreatic insulin content regulation by the estrogen receptor ER alpha.

  PloS one 20080101

• Role of estrogens and their receptors in adhesion and invasiveness of breast cancer cells.

  Advances in experimental medicine and biology 20080101

• Phytoestrogens modulate the expression of 17alpha-estradiol metabolizing enzymes in cultured MCF-7 cells.

  Advances in experimental medicine and biology 20080101

• Diethylstilbestrol-induced estrogen receptor-dependent [Ca2+]i rises and apoptosis in Chinese hamster ovary (CHO) cells.

  Journal of receptor and signal transduction research 20080101

• Estrogen receptor beta displays cell cycle-dependent expression and regulates the G1 phase through a non-genomic mechanism in prostate carcinoma cells.

  Cellular oncology : the official journal of the International Society for Cellular Oncology 20080101

• The effect of long-term resveratrol treatment on relaxation to estrogen in aortae from male and female rats: role of nitric oxide and superoxide.

  Vascular pharmacology 20080101

• 17Beta-estradiol prevents retinal ganglion cell loss induced by acute rise of intraocular pressure in rat.

  Progress in brain research 20080101

• Phytoestrogens induce differential estrogen receptor beta-mediated responses in transfected MG-63 cells.

  Endocrine 20080101

• Two estrogen response element sequences near the PCNA gene are not responsible for its estrogen-enhanced expression in MCF7 cells.

  PloS one 20080101

• The use of fulvestrant, a parenteral endocrine agent, in intestinal obstruction due to metastatic lobular breast carcinoma.

  World journal of surgical oncology 20080101

• Molecular imaging provides novel insights on estrogen receptor activity in mouse brain.

  Molecular imaging 20080101

• Distribution plasticity of the human estrogen receptor alpha in live cells: distinct imaging of consecutively expressed receptors.

  Journal of molecular biology 20071214

• Synthesis and evaluation of the antiproliferative activities of derivatives of carboxyalkyl isoflavones linked to N-t-Boc-hexylenediamine.

  Journal of medicinal chemistry 20071213

• A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer.

  Breast cancer research and treatment 20071201

• Mechanism involved in genistein activation of insulin-like growth factor 1 receptor expression in human breast cancer cells.

  The British journal of nutrition 20071201

• Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20071201

• Vasorelaxant action of 17 -estradiol in rat uterine arteries: role of nitric oxide synthases and estrogen receptors.

  American journal of physiology. Heart and circulatory physiology 20071201

• Ethanol-induced ligand-independent activation of ERalpha mediated by cyclic AMP/PKA signaling pathway: an in vitro study on MCF-7 breast cancer cells.

  International journal of oncology 20071201

• Anti-estrogenic actions of histone deacetylase inhibitors in MCF-7 breast cancer cells.

  Endocrine-related cancer 20071201

• Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20071201

• Cks1 regulates cdk1 expression: a novel role during mitotic entry in breast cancer cells.

  Cancer research 20071201

• Differential regulation of cyclic AMP synthesis by estrogen in MCF7 cells.

  Biochemical and biophysical research communications 20071123

• Estrogen receptors in BRCA1-mutant breast cancer: now you see them, now you don't.

  Journal of the National Cancer Institute 20071121

• Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.

  Journal of the National Cancer Institute 20071121

• Fulvestrant in heavily pre-treated patients with advanced breast cancer: results from a single compassionate use programme centre.

  Breast cancer research and treatment 20071101

• Fulvestrant ('Faslodex') in heavily pretreated postmenopausal patients with advanced breast cancer: single centre clinical experience from the compassionate use programme.

  Breast cancer research and treatment 20071101

• Influence of estrogen and xenoestrogens on basolateral uptake of tetraethylammonium by opossum kidney cells in culture.

  The Journal of pharmacology and experimental therapeutics 20071101

• Dynamic regulation of estrogen receptor-alpha isoform expression in the mouse fallopian tube: mechanistic insight into estrogen-dependent production and secretion of insulin-like growth factors.

  American journal of physiology. Endocrinology and metabolism 20071101

• Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds in U2OS human osteosarcoma cells.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20071101

• Expression and role of estrogen receptor alpha and beta in medullary thyroid carcinoma: different roles in cancer growth and apoptosis.

  The Journal of endocrinology 20071101

• Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT.

  Cancer letters 20071028

• Functional characterization of estrogen receptor subtypes, ERalpha and ERbeta, mediating vitellogenin production in the liver of rainbow trout.

  Toxicology and applied pharmacology 20071015

• Neonatal porcine endometrial development and epithelial proliferation affected by age and exposure to estrogen and relaxin.

  Domestic animal endocrinology 20071001

• Progesterone, but not luteal estrogen, is required for the establishment of pregnancy in the new world monkey Cebus apella.

  American journal of primatology 20071001

• Resveratrol-induced inhibition of insulin secretion from rat pancreatic islets: evidence for pivotal role of metabolic disturbances.

  American journal of physiology. Endocrinology and metabolism 20071001

• Increased level of cellular Bip critically determines estrogenic potency for a xenoestrogen kepone in the mouse uterus.

  Endocrinology 20071001

• Human CYP2A6 is induced by estrogen via estrogen receptor.

  Drug metabolism and disposition: the biological fate of chemicals 20071001

• Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation.

  Journal of leukocyte biology 20071001

• Peripheral estrogen receptor-alpha selectively modulates the waveform of GH secretory bursts in healthy women.

  American journal of physiology. Regulatory, integrative and comparative physiology 20071001

• Regulation of C-C motif chemokine ligand 2 and its receptor in human decidual stromal cells by pregnancy-associated hormones in early gestation.

  Human reproduction (Oxford, England) 20071001

• 17Beta-oestradiol partially attenuates the inhibition of nitric oxide synthase-3 by advanced glycation end-products in human platelets.

  Clinical and experimental pharmacology & physiology 20071001

• Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death.

  Steroids 20071001

• Oestrogen and progesterone reduce lipopolysaccharide-induced expression of tumour necrosis factor-alpha and interleukin-18 in midbrain astrocytes.

  Journal of neuroendocrinology 20071001

• 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.

  Nature medicine 20071001

• [Systemic therapy of male breast cancer].

  Zentralblatt fur Chirurgie 20071001

• Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators.

  Cancer research 20071001

• The cooked meat derived genotoxic carcinogen 2-amino-3-methylimidazo[4,5-b]pyridine has potent hormone-like activity: mechanistic support for a role in breast cancer.

  Cancer research 20071001

• Polychlorinated biphenyls alter the expression of endothelial nitric oxide synthase mRNA in human umbilical vein endothelial cells.

  Human & experimental toxicology 20071001

• Tamoxifen stimulates calcium entry into human platelets.

  Journal of cardiovascular pharmacology 20071001

• A novel molecular assay to discriminate transcriptional effects caused by xenoestrogens.

  Molecular and cellular endocrinology 20070930

• Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790.

  The Journal of biological chemistry 20070928

• Sex-dependent differences in the activity and modulation of N-methyl-d-aspartic acid receptors in rat dorsal root ganglia neurons.

  Neuroscience 20070921

• Progestins reinitiate cell cycle progression in antiestrogen-arrested breast cancer cells through the B-isoform of progesterone receptor.

  Cancer research 20070915

• Estrogen-mediated endothelial progenitor cell biology and kinetics for physiological postnatal vasculogenesis.

  Circulation research 20070914

• [Antiestrogen treatment in postmenopausal patients with metastatic breast cancer].

  Ugeskrift for laeger 20070910

• Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons.

  Journal of medicinal chemistry 20070906

• 17Beta-estradiol protects depletion of rat temporal cortex somatostatinergic system by beta-amyloid.

  Neurobiology of aging 20070901

• Estrogen receptor alpha (ERalpha) and insulin-like growth factor I receptor (IGF-IR) cross-talk in the gonadotropic alphaT3-1 cell line.

  Journal of cellular physiology 20070901

• Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway.

  Journal of leukocyte biology 20070901

• Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor.

  British journal of pharmacology 20070901

• Therapeutic concentrations of raloxifene augment nitric oxide-dependent coronary artery dilatation in vitro.

  British journal of pharmacology 20070901

• Delay of postnatal maturation sensitizes the mouse prostate to testosterone-induced pronounced hyperplasia: protective role of estrogen receptor-beta.

  The American journal of pathology 20070901

• Estrogen increases smooth muscle expression of alpha2C-adrenoceptors and cold-induced constriction of cutaneous arteries.

  American journal of physiology. Heart and circulatory physiology 20070901

• Up-regulation of Per1 expression by estradiol and progesterone in the rat uterus.

  The Journal of endocrinology 20070901

• A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction.

  The Journal of biological chemistry 20070831

• Membrane estrogen receptor-alpha interactions with metabotropic glutamate receptor 1a modulate female sexual receptivity in rats.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070829

• Loss of tumourigenicity of stably ERbeta-transfected MCF-7 breast cancer cells.

  Molecular and cellular endocrinology 20070815

• Raloxifene increases proliferation of human endothelial cells in association with increased gene expression of cyclins A and B1.

  Fertility and sterility 20070801

• Androgen receptor or estrogen receptor-beta blockade alters DHEA-, DHT-, and E(2)-induced proliferation and PSA production in human prostate cancer cells.

  The Prostate 20070801

• A calcium-binding protein, calbindin-D9k, is regulated through an estrogen-receptor mediated mechanism following xenoestrogen exposure in the GH3 cell line.

  Toxicological sciences : an official journal of the Society of Toxicology 20070801

• Estrogen-dependent regulation of Eg5 in breast cancer cells.

  Anti-cancer drugs 20070801

• Her2 and progesterone receptor status are not predictive of response to fulvestrant treatment.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070801

• Effect of nuclear export inhibition on estrogen receptor regulation in breast cancer cells.

  Journal of molecular endocrinology 20070801

• Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling.

  Annals of oncology : official journal of the European Society for Medical Oncology 20070801

• 17beta-estradiol inhibits angiotensin II-induced collagen synthesis of cultured rat cardiac fibroblasts via modulating angiotensin II receptors.

  European journal of pharmacology 20070719

• Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol.

  The Journal of biological chemistry 20070706

• Demonstration of mitochondrial oestrogen receptor beta and oestrogen-induced attenuation of cytochrome c oxidase subunit I expression in human periodontal ligament cells.

  Archives of oral biology 20070701

• Increase of carcinogenic risk via enhancement of cyclooxygenase-2 expression and hydroxyestradiol accumulation in human lung cells as a result of interaction between BaP and 17-beta estradiol.

  Carcinogenesis 20070701

• Uterine TRPV6 expression during the estrous cycle and pregnancy in a mouse model.

  American journal of physiology. Endocrinology and metabolism 20070701

• Estrogen inhibition of norepinephrine responsiveness is initiated at the plasma membrane of GnRH-producing GT1-7 cells.

  The Journal of endocrinology 20070701

• Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production.

  Journal of cardiovascular pharmacology 20070701

• Fulvestrant (Faslodex) -- how to make a good drug better.

  The oncologist 20070701

• Raloxifene acutely reduces glutamate-induced intracellular calcium increase in cultured rat cortical neurons via inhibition of high-voltage-activated calcium current.

  Neuroscience 20070629

• Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen.

  Circulation 20070626

• Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cells.

  Oncogene 20070614

• Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation.

  American journal of physiology. Heart and circulatory physiology 20070601

• Raloxifene inhibits transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes.

  European journal of pharmacology 20070601

• Tetrabromodiphenyl ether (BDE 47) evokes estrogenicity and calbindin-D9k expression through an estrogen receptor-mediated pathway in the uterus of immature rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20070601

• Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro.

  British journal of pharmacology 20070601

• Urodynamic changes in a noble rat model for nonbacterial prostatic inflammation.

  The Prostate 20070601

• The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage.

  Annals of surgery 20070601

• The effects of synthetic 19-norprogestins on osteoblastic cell function are mediated by their non-phenolic reduced metabolites.

  The Journal of endocrinology 20070601

• Estrogen receptor alpha mediates breast cancer cell resistance to paclitaxel through inhibition of apoptotic cell death.

  Cancer research 20070601

• The pathway-selective estrogen receptor ligand WAY-169916 reduces infarct size after myocardial ischemia and reperfusion by an estrogen receptor dependent mechanism.

  Journal of cardiovascular pharmacology 20070601

• Effects of a phytoestrogen-containing soy extract on the growth-inhibitory activity of ICI 182 780 in an experimental model of estrogen-dependent breast cancer.

  Endocrine-related cancer 20070601

• Influence of estrogens and antiestrogens on the expression of selected hormone-responsive genes.

  Maturitas 20070520

• The activation by estrogen receptor agonists of the BK(Ca)-channel in human cardiac fibroblasts.

  Biochemical pharmacology 20070501

• An inhibitory effect on cell proliferation by blockage of the MAPK/estrogen receptor/MDM2 signal pathway in gynecologic cancer.

  Gynecologic oncology 20070501

• Identification of a series of tetrahydroisoquinoline derivatives as potential therapeutic agents for breast cancer.

  Bioorganic & medicinal chemistry letters 20070501

• Evidence for an estradiol-agonistic action of nebivolol in spontaneously hypertensive rats.

  Journal of hypertension 20070501

• Effect of estrogen and inhibition of phosphatidylinositol-3 kinase on Akt and FOXO1 in rat uterus.

  Steroids 20070501

• Classification of anti-estrogens according to intramolecular FRET effects on phospho-mutants of estrogen receptor alpha.

  Molecular cancer therapeutics 20070501

• Evaluation of estrogenic/antiestrogenic activity of Onobrychis ebenoides extract - interaction with estrogen receptor subtypes ERalpha and ERbeta.

  Toxicology in vitro : an international journal published in association with BIBRA 20070401

• Estrogen receptor-alpha mediates estrogen protection from angiotensin II-induced hypertension in conscious female mice.

  American journal of physiology. Heart and circulatory physiology 20070401

• Expression of zebra fish aromatase cyp19a and cyp19b genes in response to the ligands of estrogen receptor and aryl hydrocarbon receptor.

  Toxicological sciences : an official journal of the Society of Toxicology 20070401

• DNA content and chromatin texture of human breast epithelial cells transformed with 17-beta-estradiol and the estrogen antagonist ICI 182,780 as assessed by image analysis.

  Mutation research 20070401

• Raloxifene and ICI182,780 increase estrogen receptor-alpha association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12.

  Molecular endocrinology (Baltimore, Md.) 20070401

• Astrocyte-like cells as a main target for estrogen action during neuronal differentiation.

  Molecular and cellular neurosciences 20070401

• Neuroprotection by estrogen against MPP+-induced dopamine neuron death is mediated by ERalpha in primary cultures of mouse mesencephalon.

  Experimental neurology 20070401

• Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity.

  Experimental neurology 20070401

• Dehydroepiandrosterone improves murine osteoblast growth and bone tissue morphometry via mitogen-activated protein kinase signaling pathway independent of either androgen receptor or estrogen receptor.

  Journal of molecular endocrinology 20070401

• Evaluation of fulvestrant in clinical practice: use of an electronic data registry.

  Clinical breast cancer 20070401

• Synthesis, structure, and estrogenic activity of 4-amino-3-(2-methylbenzyl)coumarins on human breast carcinoma cells.

  Bioorganic & medicinal chemistry 20070315

• Effect of genistein and raloxifene on vascular dependent platelet aggregation.

  Molecular and cellular endocrinology 20070315

• Estradiol-induced conditioned place preference may require actions at estrogen receptors in the nucleus accumbens.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070301

• SVEP1 expression is regulated in estrogen-dependent manner.

  Journal of cellular physiology 20070301

• The antiestrogen tamoxifen activates BK channels and stimulates proliferation of MCF-7 breast cancer cells.

  Molecular pharmacology 20070301

• Targeted salmon gene array (SalArray): a toxicogenomic tool for gene expression profiling of interactions between estrogen and aryl hydrocarbon receptor signalling pathways.

  Chemical research in toxicology 20070301

• Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen.

  Journal of veterinary science 20070301

• Effects of genistein, resveratrol, and quercetin on steroidogenesis and proliferation of MA-10 mouse Leydig tumor cells.

  The Journal of endocrinology 20070301

• Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070207

• Mechanisms of action of the carcinogenic heterocyclic amine PhIP.

  Toxicology letters 20070205

• Modulation by phenylacetate of early estrogen-mediated events in MCF-7 breast cancer cells.

  Cancer chemotherapy and pharmacology 20070201

• Paclitaxel induced apoptosis in breast cancer cells requires cell cycle transit but not Cdc2 activity.

  Cancer chemotherapy and pharmacology 20070201

• Does estrogen contribute to the hepatic regeneration following portal branch ligation in rats?

  American journal of physiology. Gastrointestinal and liver physiology 20070201

• 17beta-Estradiol differentially regulates androgen-responsive genes through estrogen receptor-beta- and extracellular-signal regulated kinase-dependent pathways in LNCaP human prostate cancer cells.

  Molecular carcinogenesis 20070201

• Neuroprotective effect of 17beta-estradiol against N-methyl-D-aspartate-induced retinal neurotoxicity via p-ERK induction.

  Journal of neuroscience research 20070201

• Estrogen receptor-alpha mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of Cyp17a1 (cytochrome P450, steroid 17alpha-hydroxylase/17,20 lyase) expression.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070201

• Effects of 4-hydroxytamoxifen, raloxifene and ICI 182 780 on survival of uterine cancer cell lines in the presence and absence of exogenous estrogens.

  International journal of oncology 20070201

• Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer.

  International journal of oncology 20070201

• Oestrogen receptor antagonist and hair regrowth in dogs with hair cycle arrest (alopecia X).

  Veterinary dermatology 20070201

• Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons.

  Journal of neurochemistry 20070201

• Modulation of the expression of bloom helicase by estrogenic agents.

  Biological & pharmaceutical bulletin 20070201

• Transforming growth factor-beta, estrogen, and progesterone converge on the regulation of p27Kip1 in the normal and malignant endometrium.

  Cancer research 20070201

• Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism.

  Molecular and cellular endocrinology 20070129

• Endothelium-independent relaxation to raloxifene in porcine coronary artery.

  European journal of pharmacology 20070126

• Induction of uterine calbindin-D9k through an estrogen receptor-dependent pathway following single injection with xenobiotic agents in immature rats.

  Journal of toxicology and environmental health. Part A 20070115

• Estradiol-17beta: tracing its metabolic significance in female fatbody of fifth instar larvae of silkworm, Bombyx mori L (race: Nistari).

  Life sciences 20070109

• Estrogen stimulates the neuronal differentiation of human umbilical cord blood mesenchymal stem cells (CD34-).

  Neuroreport 20070108

• Fulvestrant in advanced male breast cancer.

  Breast cancer research and treatment 20070101

• In silico prediction of pregnane X receptor activators by machine learning approaches.

  Molecular pharmacology 20070101

• Ligand-selective interdomain conformations of estrogen receptor-alpha.

  Molecular endocrinology (Baltimore, Md.) 20070101

• Clinical benefit of fulvestrant in postmenopausal women with advanced breast cancer and primary or acquired resistance to aromatase inhibitors: final results of phase II Swiss Group for Clinical Cancer Research Trial (SAKK 21/00).

  Annals of oncology : official journal of the European Society for Medical Oncology 20070101

• Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoids.

  Molecular pharmacology 20070101

• Effects of fulvestrant 250mg in premenopausal women with oestrogen receptor-positive primary breast cancer.

  European journal of cancer (Oxford, England : 1990) 20070101

• Effect of antiestrogens on EGF-mediated movement of human breast cancer cells.

  Pharmacology 20070101

• Differential effects of centrally-administered oestrogen antagonist ICI-182,780 on oestrogen-sensitive functions in the hypothalamus.

  Journal of neuroendocrinology 20070101

• Two unsuccessful clinical trials on endometriosis and a few lessons learned.

  Gynecologic and obstetric investigation 20070101

• Oestrogen formation and connective tissue growth factor expression in rat granulosa cells.

  The Journal of endocrinology 20070101

• Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil.

  Anticancer research 20070101

• Evidence to implicate early modulation of interleukin-1beta expression in the neuroprotection afforded by 17beta-estradiol in male rats undergone transient middle cerebral artery occlusion.

  International review of neurobiology 20070101

• Activation of estrogen receptor-beta by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds.

  The Journal of steroid biochemistry and molecular biology 20070101

• Determining the transrepression activity of xenoestrogen on nuclear factor-kappa B in Cos-1 cells by estrogen receptor-alpha.

  International journal of toxicology 20070101

• Induction of acquired resistance to antiestrogen by reversible mitochondrial DNA depletion in breast cancer cell line.

  International journal of cancer 20070101

• Mechanism of collagen biosynthesis up-regulation in cultured leiomyoma cells.

  Folia histochemica et cytobiologica 20070101

• An estrogen receptor-beta agonist is active in models of inflammatory and chemical-induced pain.

  European journal of pharmacology 20061228

• The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats.

  Toxicology and applied pharmacology 20061215

• Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant.

  Cancer research 20061215

• Hormonal activity of combinations of genistein, bisphenol A and 17beta-estradiol in the female Wistar rat.

  Archives of toxicology 20061201

• Effects of estradiol on phenylephrine contractility associated with intracellular calcium release in rat aorta.

  American journal of physiology. Cell physiology 20061201

• Raloxifene elicits combined rapid vasorelaxation and long-term anti-inflammatory actions in rat aorta.

  The Journal of pharmacology and experimental therapeutics 20061201

• Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile.

  The Journal of pharmacology and experimental therapeutics 20061201

• Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones.

  Molecular pharmacology 20061201

• Estrogen produced in cultured hippocampal neurons is a functional regulator of a GABAergic machinery.

  Journal of neuroscience research 20061201

• Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats.

  Journal of neurochemistry 20061201

• Emerging principles for the development of resistance to antihormonal therapy: implications for the clinical utility of fulvestrant.

  The Journal of steroid biochemistry and molecular biology 20061201

• Clinically occult cutaneous metastases.

  Journal of the American Academy of Dermatology 20061201

• Aromatase and breast cancer.

  The Journal of steroid biochemistry and molecular biology 20061201

• [Fulvestrant].

  Deutsche medizinische Wochenschrift (1946) 20061201

• Chronic exposure to fulvestrant promotes overexpression of the c-Met receptor in breast cancer cells: implications for tumour-stroma interactions.

  Endocrine-related cancer 20061201

• Endocrine therapy resistance can be associated with high estrogen receptor alpha (ERalpha) expression and reduced ERalpha phosphorylation in breast cancer models.

  Endocrine-related cancer 20061201

• Molecular cloning and characterization of the human WISP-2/CCN5 gene promoter reveal its upregulation by oestrogens.

  The Journal of endocrinology 20061201

• Aromatase activity of human mesenchymal stem cells is stimulated by early differentiation, vitamin D and leptin.

  The Journal of endocrinology 20061201

• Fulvestrant: a further treatment option for patients with metastatic uterine cancer?

  Onkologie 20061201

• Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes.

  Proceedings of the National Academy of Sciences of the United States of America 20061107

• Ovulation induction by antiestrogens in an Indian tropical vespertillionid bat, Scotophilus heathi.

  Life sciences 20061102

• Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

  Journal of molecular graphics & modelling 20061101

• The pure estrogen receptor antagonist ICI 182,780 promotes a novel interaction of estrogen receptor-alpha with the 3',5'-cyclic adenosine monophosphate response element-binding protein-binding protein/p300 coactivators.

  Molecular endocrinology (Baltimore, Md.) 20061101

• Estrogen regulates epithelial cell deformability by modulation of cortical actomyosin through phosphorylation of nonmuscle myosin heavy-chain II-B filaments.

  Endocrinology 20061101

• Estrogen modulates place learning through estrogen receptors in the hippocampus.

  Neurobiology of learning and memory 20061101

• Cooperative effect of gefitinib and fumitremorgin c on cell growth and chemosensitivity in estrogen receptor alpha negative fulvestrant-resistant MCF-7 cells.

  International journal of oncology 20061101

• Phytoestrogens regulate transcription and translation of vitamin D receptor in colon cancer cells.

  The Journal of endocrinology 20061101

• The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes.

  The Journal of endocrinology 20061101

• Effects of raloxifene on caveolin-1 mRNA and protein expressions in vascular smooth muscle cells.

  Acta biochimica et biophysica Sinica 20061101

• Crosstalk between EGFR and extranuclear steroid receptors.

  Annals of the New York Academy of Sciences 20061101

• Impact of 17beta-estradiol on cytokine-mediated apoptotic effects in primary hippocampal and neocortical cell cultures.

  Brain research 20061020

• [Effects of ICI182780 (Faslodex) on proliferation and apoptosis induced by 17beta-estradiol in endometrial carcinoma cells].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20061018

• Regulation of expression of BIK proapoptotic protein in human breast cancer cells: p53-dependent induction of BIK mRNA by fulvestrant and proteasomal degradation of BIK protein.

  Cancer research 20061015

• Decreased chicken ovalbumin upstream promoter transcription factor II expression in tamoxifen-resistant breast cancer cells.

  Cancer research 20061015

• Expression of Cystatin C in the rat endometrium during the peri-implantation period.

  Biochemical and biophysical research communications 20061013

• Postmenopausal advanced breast cancer: options for therapy after tamoxifen and aromatase inhibitors.

  Breast (Edinburgh, Scotland) 20061001

• 2-methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts.

  Journal of cellular biochemistry 20061001

• Flow cytometric cell cycle analysis allows for rapid screening of estrogenicity in MCF-7 breast cancer cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20061001

• Apoptotic and anti-proliferative effects of 17beta-estradiol and 17beta-estradiol-like compounds in the Hep3B cell line.

  Molecular and cellular biochemistry 20061001

• Characterisation of the relaxant response to raloxifene in porcine coronary arteries.

  European journal of pharmacology 20060918

• Hemodynamic effects of acute and repeated exposure to raloxifene in ovariectomized sheep.

  American journal of physiology. Heart and circulatory physiology 20060901

• Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20060901

• 17 beta-estradiol modifies nitric oxide-sensitive guanylyl cyclase expression and down-regulates its activity in rat anterior pituitary gland.

  Endocrinology 20060901

• Fulvestrant: pharmacologic profile versus existing endocrine agents for the treatment of breast cancer.

  The Annals of pharmacotherapy 20060901

• Enhanced formation of non-phenolic androgen metabolites with intrinsic oestrogen-like gene transactivation potency in human breast cancer cells: a distinctive metabolic pattern.

  The Journal of endocrinology 20060901

• Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells.

  Journal of cellular biochemistry 20060801

• Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells.

  Breast cancer research and treatment 20060801

• Distinct regulation by steroids of messenger RNAs for FSHR and CYP19A1 in bovine granulosa cells.

  Biology of reproduction 20060801

• Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells.

  Endocrinology 20060801

• Discovery of thiochroman derivatives bearing a carboxy-containing side chain as orally active pure antiestrogens.

  Bioorganic & medicinal chemistry letters 20060801

• Estrogen-like activity and prevention effect of bone loss in calcium deficient ovariectomized rats by the extract of Pleurotus eryngii.

  Phytotherapy research : PTR 20060801

• Insulin-like growth factor binding protein 2 is a marker for antiestrogen resistant human breast cancer cell lines but is not a major growth regulator.

  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20060801

• Mechanisms underlying nebivolol-induced endothelial nitric oxide synthase activation in human umbilical vein endothelial cells.

  Clinical and experimental pharmacology & physiology 20060801

• Time to response: comparison of fulvestrant and oral endocrine agents.

  Clinical breast cancer 20060801

• [Estrogenicity of adzuki bean Phaseolus angularis wight. and its effect on proesterone receptor level in human breast cancer MCF-7 cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060801

• Anti-estrogen ICI 182.780 and anti-androgen flutamide induce tyrosine phosphorylation of cortactin in the ectoplasmic specialization between the Sertoli cell and spermatids in the mouse testis.

  Biochemical and biophysical research communications 20060721

• Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome.

  Cancer research 20060715

• Progesterone receptor antagonist is effective in relieving neuropathic pain.

  European journal of pharmacology 20060710

• Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells.

  Molecular pharmacology 20060701

• Estrogens cross-talk to alpha1b-adrenergic receptors.

  Molecular pharmacology 20060701

• Prenatal estrogen and progesterone deprivation impairs alveolar formation and fluid clearance in newborn piglets.

  Pediatric research 20060701

• Hypoxic activation of unoccupied estrogen-receptor-alpha is mediated by hypoxia-inducible factor-1 alpha.

  The Journal of steroid biochemistry and molecular biology 20060701

• Administration of xenobiotics with anti-estrogenic effects results in mRNA induction of adult male-specific cytochrome P450 isozymes in the livers of adult female rats.

  Journal of pharmacological sciences 20060701

• Expression of estrogen receptors-alpha and -beta in bladder cancer cell lines and human bladder tumor tissue.

  Cancer 20060615

• Comparative assessment of lipid effects of endocrine therapy for breast cancer: implications for cardiovascular disease prevention in postmenopausal women.

  Breast (Edinburgh, Scotland) 20060601

• Dynamic changes in dopaminergic neurotransmission induced by a low concentration of bisphenol-A in neurones and astrocytes.

  Journal of neuroendocrinology 20060601

• The susceptibility of granulosa cells to apoptosis is influenced by oestradiol and the cell cycle.

  The Journal of endocrinology 20060601

• Genistein modulates the effects of parathyroid hormone in human osteoblastic SaOS-2 cells.

  The British journal of nutrition 20060601

• New therapies in the treatment of breast cancer.

  Seminars in oncology 20060601

• Fulvestrant (ICI 182,780) down-regulates androgen receptor expression and diminishes androgenic responses in LNCaP human prostate cancer cells.

  Molecular cancer therapeutics 20060601

• Estrogenic compounds inhibit gap junctional intercellular communication in mouse Leydig TM3 cells.

  Toxicology and applied pharmacology 20060501

• Regulation of BCRP/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cells.

  American journal of physiology. Endocrinology and metabolism 20060501

• Dioxin induces an estrogen-like, estrogen receptor-dependent gene expression response in the murine uterus.

  Molecular pharmacology 20060501

• Synthetic 19-nortestosterone derivatives as estrogen receptor alpha subtype-selective ligands induce similar receptor conformational changes and steroid receptor coactivator recruitment than natural estrogens.

  The Journal of steroid biochemistry and molecular biology 20060501

• Uterotrophic effects of relaxin related to age and estrogen receptor activation in neonatal pigs.

  Reproduction (Cambridge, England) 20060501

• [Regulatory effect of 17beta-estradiol on expression of orphan nuclear receptor ERRalpha in endometrial carcinoma cell lines].

  Ai zheng = Aizheng = Chinese journal of cancer 20060501

• [Estrogenic activity and its mechanism of ethanol extract from black soybean].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060501

• Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure.

  The Journal of biological chemistry 20060414

• Effects of oestrogens and anti-oestrogens on normal breast tissue from women bearing BRCA1 and BRCA2 mutations.

  British journal of cancer 20060410

• Fulvestrant (ICI 182,780)-dependent interacting proteins mediate immobilization and degradation of estrogen receptor-alpha.

  The Journal of biological chemistry 20060407

• Rapid action of pesticides on cytosolic calcium concentrations in cultures of human umbilical vein endothelial cells.

  Reproductive toxicology (Elmsford, N.Y.) 20060401

• Overexpression of estrogen receptor alpha increases hepatic cholesterogenesis, leading to biliary hypersecretion in mice.

  Journal of lipid research 20060401

• Participation of estrogen receptors in the enhancement of osteoblast differentiation by TAK-778.

  Molecular and cellular biochemistry 20060401

• Virtual and biomolecular screening converge on a selective agonist for GPR30.

  Nature chemical biology 20060401

• Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells--implications for neuroprotection against Ca-mediated excitotoxicity.

  Journal of neurochemistry 20060401

• Changes in oestrogen receptor-alpha and -beta during progression to acquired resistance to tamoxifen and fulvestrant (Faslodex, ICI 182,780) in MCF7 human breast cancer cells.

  The Journal of steroid biochemistry and molecular biology 20060401

• Estrogens modulate the gene expression of Wnt-7a in cultured endometrial adenocarcinoma cells.

  Molecular nutrition & food research 20060401

• Estradiol and its membrane-impermeable conjugate estradiol-BSA inhibit tamoxifen-stimulated prolactin secretion in incubated rat pituitaries.

  Reproduction (Cambridge, England) 20060401

• Development and therapeutic options for the treatment of raloxifene-stimulated breast cancer in athymic mice.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060401

• ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk.

  Neoplasia (New York, N.Y.) 20060401

• Prenylflavonoids as nonsteroidal phytoestrogens and related structure-activity relationships.

  ChemMedChem 20060401

• Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation.

  Molecular endocrinology (Baltimore, Md.) 20060301

• Estrogen receptor alpha mediates acute potassium channel stimulation in human coronary artery smooth muscle cells.

  The Journal of pharmacology and experimental therapeutics 20060301

• Inactivation of the pure antiestrogen fulvestrant and other synthetic estrogen molecules by UDP-glucuronosyltransferase 1A enzymes expressed in breast tissue.

  Molecular pharmacology 20060301

• Inhibition of MCF-7 breast cancer cell proliferation by MCF-10A breast epithelial cells in coculture.

  Cell biology international 20060301

• Estrogen induces death of tamoxifen-resistant MCF-7 cells: contrasting effect of the estrogen receptor downregulator fulvestrant.

  The Journal of steroid biochemistry and molecular biology 20060301

• Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF-7 human breast cancer cells.

  Oncology reports 20060301

• Fulvestrant ('Faslodex'): current and future role in breast cancer management.

  Critical reviews in oncology/hematology 20060301

• Fulvestrant in women with advanced breast cancer after progression on prior aromatase inhibitor therapy: North Central Cancer Treatment Group Trial N0032.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060301

• Endocrine response after prior treatment with fulvestrant in postmenopausal women with advanced breast cancer: experience from a single centre.

  Endocrine-related cancer 20060301

• 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha.

  Cancer research 20060215

• Fulvestrant, a new treatment option for advanced breast cancer: tolerability versus existing agents.

  Annals of oncology : official journal of the European Society for Medical Oncology 20060201

• Durable response of metastatic endometrial carcinoma to treatment with fulvestrant (Faslodex) after prior progestin and anastrozole therapy.

  Gynecologic oncology 20060201

• Effect of methoxychlor and estradiol on cytochrome p450 enzymes in the mouse ovarian surface epithelium.

  Toxicological sciences : an official journal of the Society of Toxicology 20060201

• Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1.

  Journal of leukocyte biology 20060201

• Estrogenic properties of isoflavones derived from Millettia griffoniana.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20060201

• Locally produced estrogen promotes fetal rat metatarsal bone growth; an effect mediated through increased chondrocyte proliferation and decreased apoptosis.

  The Journal of endocrinology 20060201

• DNA damage caused by bisphenol A and estradiol through estrogenic activity.

  Biological & pharmaceutical bulletin 20060201

• 17beta-estradiol potentiates the cardiac cystic fibrosis transmembrane conductance regulator chloride current in guinea-pig ventricular myocytes.

  The journal of physiological sciences : JPS 20060201

• Relaxin-induced reduction of infarct size in male rats receiving MCAO is dependent on nitric oxide synthesis and not estrogenic mechanisms.

  Neuroscience letters 20060130

• Effects of endocrine disrupters on the expression of growth hormone and prolactin mRNA in the rainbow trout pituitary.

  General and comparative endocrinology 20060115

• Characterization of estrogen receptor betab in sea bream (Sparus auratus): phylogeny, ligand-binding, and comparative analysis of expression.

  General and comparative endocrinology 20060115

• Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1.

  American journal of physiology. Heart and circulatory physiology 20060101

• Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-beta agonist: up-regulation of cardiac heat shock factor-1 and heat shock proteins.

  Journal of molecular and cellular cardiology 20060101

• Antiestrogens modulate MT1 melatonin receptor expression in breast and ovarian cancer cell lines.

  Oncology reports 20060101

• Additive growth inhibitory effects of ibandronate and antiestrogens in estrogen receptor-positive breast cancer cell lines.

  Breast cancer research : BCR 20060101

• The estrogen metabolite 17beta-dihydroequilenin counteracts interleukin-1alpha induced expression of inflammatory mediators in human endothelial cells in vitro via NF-kappaB pathway.

  Thrombosis and haemostasis 20060101

• Prognostic value of monitoring tumour markers CA 15-3 and CEA during fulvestrant treatment.

  BMC cancer 20060101

• DHEA-induced antiproliferative effect in MCF-7 cells is androgen- and estrogen receptor-independent.

  Cancer journal (Sudbury, Mass.) 20060101

• [Fulvestrant: a new agent in endocrine treatment for breast cancer].

  Lijecnicki vjesnik 20060101

• Rapid Ca(2+) signaling induced by Bisphenol A in cultured rat hippocampal neurons.

  Neuro endocrinology letters 20060101

• AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines.

  BMC cancer 20060101

• Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780.

  Gynecologic and obstetric investigation 20060101

• Estrogen and raloxifene inhibit the monocytic chemoattractant protein-1-induced migration of human monocytic cells via nongenomic estrogen receptor alpha.

  Menopause (New York, N.Y.) 20060101

• Is fulvestrant ('Faslodex') just another selective estrogen receptor modulator?

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101

• Metastatic breast cancer: sequencing hormonal therapy and positioning of fulvestrant.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101

• Estrogens, selective estrogen receptor modulators, and a selective estrogen receptor down-regulator inhibit endothelial production of tissue factor pathway inhibitor 1.

  BMC cardiovascular disorders 20060101

• Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women.

  Reproductive biology and endocrinology : RB&E 20060101

• ICI 182,780 has agonistic effects and synergizes with estradiol-17 beta in fish liver, but not in testis.

  Reproductive biology and endocrinology : RB&E 20060101

• ERE-independent ERalpha target genes differentially expressed in human breast tumors.

  Molecular and cellular endocrinology 20051221

• Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation.

  Journal of the National Cancer Institute 20051207

• Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR).

  Toxicology and applied pharmacology 20051201

• Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells.

  Molecular endocrinology (Baltimore, Md.) 20051201

• CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha.

  Molecular endocrinology (Baltimore, Md.) 20051201

• Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors.

  Endocrinology 20051201

• Adjuvant endocrine therapies for postmenopausal women with early breast cancer: standards and not.

  Breast (Edinburgh, Scotland) 20051201

• Role of mitochondria in tamoxifen-induced rapid death of MCF-7 breast cancer cells.

  Apoptosis : an international journal on programmed cell death 20051201

• Complex agonist-like properties of ICI 182,780 (Faslodex) in human breast cancer cells that predominantly express progesterone receptor-B: implications for treatment resistance.

  International journal of oncology 20051201

• Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20051201

• Multitargeted therapy in estrogen receptor-positive, human epidermal growth factor receptor-2-positive breast cancer.

  American journal of clinical oncology 20051201

• MCT-1 oncogene contributes to increased in vivo tumorigenicity of MCF7 cells by promotion of angiogenesis and inhibition of apoptosis.

  Cancer research 20051201

• The anti-oestrogen ICI 182,780, but not tamoxifen, inhibits the growth of MCF-7 breast cancer cells refractory to long-term oestrogen deprivation through down-regulation of oestrogen receptor and IGF signalling.

  Endocrine-related cancer 20051201

• Role of estrogen receptor (ER) alpha in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells.

  Journal of molecular endocrinology 20051201

• Tissue-specific modulation of cyclooxygenase-2 (Cox-2) expression in the uterus and the v. cava by estrogens and phytoestrogens.

  Molecular and cellular endocrinology 20051124

• Comparative effect of seeds of Rhynchosia volubilis and soybean on MG-63 human osteoblastic cell proliferation and estrogenicity.

  Life sciences 20051119

• Activation of estrogen receptor-alpha protects the in vivo rabbit heart from ischemia-reperfusion injury.

  American journal of physiology. Heart and circulatory physiology 20051101

• Estrogen receptor alpha increases basal and cigarette smoke extract-induced expression of CYP1A1 and CYP1B1, but not GSTP1, in normal human bronchial epithelial cells.

  Molecular carcinogenesis 20051101

• No estrogen-like effects of an isopropanolic extract of Rhizoma Cimicifugae racemosae on uterus and vena cava of rats after 17 day treatment.

  The Journal of steroid biochemistry and molecular biology 20051101

• Fulvestrant ('Faslodex') in pre-treated patients with advanced breast cancer: a single-centre experience.

  European journal of cancer (Oxford, England : 1990) 20051101

• Isopropanolic extract of black cohosh stimulates osteoprotegerin production by human osteoblasts.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20051101

• Estrogenic induction of spermatogenesis in the hypogonadal (hpg) mouse: role of androgens.

  Reproduction (Cambridge, England) 20051101

• Investigation of central versus peripheral effects of estradiol in ovariectomized mice.

  The Journal of endocrinology 20051101

• Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20051101

• 17beta-estradiol protects SH-SY5Y Cells against HIV-1 gp120-induced cell death: evidence for a role of estrogen receptors.

  Neurotoxicology 20051001

• The effects of blocking the actions of estrogen and progesterone on the rates of proliferation and apoptosis of cervical epithelial and stromal cells during the second half of pregnancy in rats.

  Biology of reproduction 20051001

• Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels.

  Molecular pharmacology 20051001

• Growth-plate chondrocytes respond to 17beta-estradiol with sex-specific increases in IP3 and intracellular calcium ion signalling via a capacitative entry mechanism.

  Steroids 20051001

• Differential effects of estrogen on DNA synthesis in human periodontal ligament and breast cancer cells.

  Journal of periodontal research 20051001

• Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin.

  Journal of the Society for Gynecologic Investigation 20051001

• The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system.

  Transplant immunology 20051001

• Differential effect of estrogen receptor alpha and beta agonists on the receptor for advanced glycation end product expression in human microvascular endothelial cells.

  Biochimica et biophysica acta 20050930

• Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity.

  The Journal of biological chemistry 20050923

• Estrogen receptor-alpha regulates SOCS-3 expression in human breast cancer cells.

  Biochemical and biophysical research communications 20050916

• Diffusion-time distribution analysis reveals characteristic ligand-dependent interaction patterns of nuclear receptors in living cells.

  Biochemistry 20050906

• The red wine polyphenol, resveratrol, exerts acute direct actions on guinea-pig ventricular myocytes.

  European journal of pharmacology 20050905

• Non-genomic action of estradiol and progesterone on cytosolic calcium concentrations in primary cultures of human granulosa-lutein cells.

  Human reproduction (Oxford, England) 20050901

• The estrogen receptor-alpha agonist 16alpha-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats.

  Cardiovascular research 20050901

• Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain.

  Bioorganic & medicinal chemistry letters 20050901

• Dehydroepiandrosterone sulfate induces acute vasodilation of porcine coronary arteries in vitro and in vivo.

  Journal of cardiovascular pharmacology 20050901

• Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy.

  FEBS letters 20050829

• Effect of follicle-stimulating hormone and estrogen on the expression of betaglycan messenger ribonucleic acid levels in cultured rat granulosa cells.

  Endocrinology 20050801

• Selective oestrogen receptor modulators, aromatase inhibitors and the female breast.

  Current opinion in obstetrics & gynecology 20050801

• Estrogen-induced growth inhibition of human seminoma cells expressing estrogen receptor beta and aromatase.

  Journal of molecular endocrinology 20050801

• A selective estrogen receptor modulator, tamoxifen, and membrane fluidity of erythrocytes in normotensive and hypertensive postmenopausal women: an electron paramagnetic resonance investigation.

  American journal of hypertension 20050801

• A short-incubation reporter-gene assay for high-throughput screening of estrogen receptor-alpha antagonists.

  Assay and drug development technologies 20050801

• Regulation of glutamate transporter GLAST and GLT-1 expression in astrocytes by estrogen.

  Brain research. Molecular brain research 20050729

• Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma: a prospectively planned combined survival analysis of two multicenter trials.

  Cancer 20050715

• Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release.

  Molecular and cellular endocrinology 20050715

• Opposite effects of estrogen receptors alpha and beta on MCF-7 sensitivity to the cytotoxic action of TNF and p53 activity.

  Oncogene 20050714

• A nongenomic action of 17beta-estradiol as the mechanism underlying the acute suppression of secretion of luteinizing hormone.

  Biology of reproduction 20050701

• Estrogen modulates endothelial and neuronal nitric oxide synthase expression via an estrogen receptor beta-dependent mechanism in hypothalamic slice cultures.

  Endocrinology 20050701

• Coplanar PCB congeners increase uterine weight and frontal cortical dopamine in the developing rat: implications for developmental neurotoxicity.

  Toxicological sciences : an official journal of the Society of Toxicology 20050701

• Sensitivity to further endocrine therapy is retained following progression on first-line fulvestrant.

  Breast cancer research and treatment 20050701

• Effects of 17beta-estradiol on chemically induced long-term depression.

  Neuropharmacology 20050701

• A paradoxical inhibitory effect of oestradiol-17beta on GnRH self-priming in pituitaries from tamoxifen-treated rats.

  The Journal of endocrinology 20050701

• Elevated ERK1/ERK2/estrogen receptor cross-talk enhances estrogen-mediated signaling during long-term estrogen deprivation.

  Endocrine-related cancer 20050701

• Estrogen therapy for experimental intracerebral hemorrhage in rats.

  Journal of neurosurgery 20050701

• Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer.

  Oncogene 20050630

• Estrogen-induced loss of progesterone receptor expression in normal and malignant ovarian surface epithelial cells.

  Oncogene 20050623

• [Regulation of orphan receptor ERR alpha by estrogen and progesterone in endometrial carcinoma cell line].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20050618

• Gene expression changes in rat prostate after activation or blocking of the androgen and estrogen receptor.

  Molecular and cellular endocrinology 20050615

• Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model.

  Cancer research 20050615

• Molecular and functional signature of heart hypertrophy during pregnancy.

  Circulation research 20050610

• Distinctive actions of membrane-targeted versus nuclear localized estrogen receptors in breast cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20050601

• Dose-dependent effects of 4-hydroxytamoxifen, the active metabolite of tamoxifen, on estrogen receptor-alpha expression in the rat uterus.

  Anti-cancer drugs 20050601

• Aquaporin-1 and -9 are differentially regulated by oestrogen in the efferent ductule epithelium and initial segment of the epididymis.

  Biology of the cell 20050601

• The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.

  International journal of oncology 20050601

• CSN5/Jab1 is involved in ligand-dependent degradation of estrogen receptor {alpha} by the proteasome.

  Molecular and cellular biology 20050601

• A comparison of fulvestrant and the third-generation aromatase inhibitors in the second-line treatment of postmenopausal women with advanced breast cancer.

  Cancer treatment reviews 20050601

• Oestrogen does not affect the restoration of spermatogenesis in the gonadotrophin-releasing hormone-immunised adult rat.

  The Journal of endocrinology 20050601

• Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells.

  The Journal of endocrinology 20050601

• Selected highlights from the 27th San Antonio Breast Cancer Symposium. San Antonio, TX, USA, 8-11 December 2004.

  Expert opinion on pharmacotherapy 20050601

• Fulvestrant in the treatment of postmenopausal women with advanced breast cancer.

  Expert review of anticancer therapy 20050601

• Gender differences in renal tubular taurocholate transport.

  Naunyn-Schmiedeberg's archives of pharmacology 20050601

• Estrogen induces vascular wall dilation: mediation through kinase signaling to nitric oxide and estrogen receptors alpha and beta.

  The Journal of biological chemistry 20050520

• Expression and estrogen-dependent regulation of the zebrafish brain aromatase gene.

  The Journal of comparative neurology 20050516

• Uterine blood flow responses to ICI 182 780 in ovariectomized oestradiol-17beta-treated, intact follicular and pregnant sheep.

  The Journal of physiology 20050515

• Suppression of ps20 expression in the rat uterus by tamoxifen and estrogens.

  Endocrinology 20050501

• Promoting insulin secretion in pancreatic islets by means of bisphenol A and nonylphenol via intracellular estrogen receptors.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050501

• Estrogen specifically stimulates expression and production of osteoprotegerin from rheumatoid synovial fibroblasts.

  International journal of molecular medicine 20050501

• Effect of oestradiol on mouse uterine epithelial cell tumour necrosis factor-alpha release is mediated through uterine stromal cells.

  Immunology 20050501

• Suppression of experimental autoimmune encephalomyelitis using estrogen receptor-selective ligands.

  The Journal of endocrinology 20050501

• Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis.

  Apoptosis : an international journal on programmed cell death 20050501

• Anti-inflammatory effect of selective estrogen receptor modulators (SERMs) in microglial cells.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050501

• Model systems: mechanisms involved in the loss of sensitivity to letrozole.

  The Journal of steroid biochemistry and molecular biology 20050501

• Aromatase inhibitors: combinations with fulvestrant or signal transduction inhibitors as a strategy to overcome endocrine resistance.

  The Journal of steroid biochemistry and molecular biology 20050501

• [Fulvestrant].

  Ugeskrift for laeger 20050418

• Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells.

  Journal of cellular physiology 20050401

• Estrogen receptor alpha pathway is involved in the regulation of Calbindin-D9k in the uterus of immature rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20050401

• Transcriptional activation of the oxytocin promoter by oestrogens uses a novel non-classical mechanism of oestrogen receptor action.

  Journal of neuroendocrinology 20050401

• Role of fulvestrant in sequential hormonal therapy for advanced, hormone receptor-positive breast cancer in postmenopausal women.

  Clinical breast cancer 20050401

• Current and future perspectives on fulvestrant.

  Clinical breast cancer 20050401

• Clinical value of fulvestrant in breast cancer.

  Clinical breast cancer 20050401

• The history and mechanism of action of fulvestrant.

  Clinical breast cancer 20050401

• Effectiveness and tolerability of fulvestrant in postmenopausal women with hormone receptor-positive breast cancer.

  Clinical breast cancer 20050401

• Molecular basis of estrogen-induced cyclooxygenase type 1 upregulation in endothelial cells.

  Circulation research 20050318

• Signal transduction. A new mediator for an old hormone?

  Science (New York, N.Y.) 20050311

• [New strategies against breast carcinoma. To outwit the resistance tendency of tumor cells].

  MMW Fortschritte der Medizin 20050310

• Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells.

  The Journal of biological chemistry 20050304

• Raloxifene relaxes rat pulmonary arteries and veins: roles of gender, endothelium, and antagonism of Ca2+ influx.

  The Journal of pharmacology and experimental therapeutics 20050301

• The putative tumor suppressor deleted in malignant brain tumors 1 is an estrogen-regulated gene in rodent and primate endometrial epithelium.

  Endocrinology 20050301

• Hair cycle control by estrogens: catagen induction via estrogen receptor (ER)-alpha is checked by ER beta signaling.

  Endocrinology 20050301

• Modulation of osteoclastogenesis in porcine bone marrow cultures by quercetin and rutin.

  Cell and tissue research 20050301

• Improvement of portal hypertension and hepatic blood flow in cirrhotic rats by oestrogen.

  European journal of clinical investigation 20050301

• Innovations in antineoplastic therapy.

  The Nursing clinics of North America 20050301

• Differential effects of estrogens and progestins on the anticoagulant tissue factor pathway inhibitor in the rat.

  The Journal of steroid biochemistry and molecular biology 20050301

• Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects.

  Cancer research 20050215

• Regulation of endogenous gene expression in human non-small cell lung cancer cells by estrogen receptor ligands.

  Cancer research 20050215

• ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line.

  The Journal of biological chemistry 20050204

• Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer model.

  Toxicological sciences : an official journal of the Society of Toxicology 20050201

• Methoxychlor induces proliferation of the mouse ovarian surface epithelium.

  Toxicological sciences : an official journal of the Society of Toxicology 20050201

• Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture.

  Journal of cellular biochemistry 20050201

• Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays.

  Toxicological sciences : an official journal of the Society of Toxicology 20050201

• Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.

  Endocrinology 20050201

• Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events.

  Toxicological sciences : an official journal of the Society of Toxicology 20050201

• The estrogen antagonist ICI-182-780 does not inhibit the transformation phenotypes induced by 17-beta-estradiol and 4-OH estradiol in human breast epithelial cells.

  International journal of oncology 20050201

• Fulvestrant--ready to start its journey in the breast cancer adjuvant endocrine world?

  European journal of cancer (Oxford, England : 1990) 20050201

• Endocrine treatment options for advanced breast cancer--the role of fulvestrant.

  European journal of cancer (Oxford, England : 1990) 20050201

• Basis of melengestrol acetate action as a progestin.

  Domestic animal endocrinology 20050201

• Estrogen receptor independent rapid non-genomic effects of environmental estrogens on [Ca2+]i in human breast cancer cells.

  Molecular and cellular endocrinology 20050131

• Estradiol and endocrine disrupting compounds adversely affect development of sea urchin embryos at environmentally relevant concentrations.

  Aquatic toxicology (Amsterdam, Netherlands) 20050126

• Therapeutic observations in MCF-7 aromatase xenografts.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050115

• 17beta-Estradiol rapidly stimulates c-fos expression via the MAPK pathway in T84 cells.

  Molecular and cellular endocrinology 20050114

• Cytochromes 1A1/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast.

  The Journal of clinical endocrinology and metabolism 20050101

• Novel progestogenic activity of environmental endocrine disruptors in the upregulation of calbindin-D9k in an immature mouse model.

  Toxicological sciences : an official journal of the Society of Toxicology 20050101

• Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells.

  Oncology reports 20050101

• The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells.

  Molecular cancer therapeutics 20050101

• AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner.

  Molecular cancer research : MCR 20050101

• TAS-108, a novel oral steroidal antiestrogenic agent, is a pure antagonist on estrogen receptor alpha and a partial agonist on estrogen receptor beta with low uterotrophic effect.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050101

• Effects of ICI 182780 on estrogen receptor expression, fluid absorption and sperm motility in the epididymis of the bonnet monkey.

  Reproductive biology and endocrinology : RB&E 20050101

• Preclinical and clinical experience with fulvestrant (Faslodex) in postmenopausal women with hormone receptor-positive advanced breast cancer.

  Cancer investigation 20050101

• Estrogen and growth factor receptor interactions in human breast and non-small cell lung cancer cells.

  Steroids 20050101

• Gonadal steroids differentially modulate neurotoxicity of HIV and cocaine: testosterone and ICI 182,780 sensitive mechanism.

  BMC neuroscience 20050101

• Receptor isoform and ligand-specific modulation of dihydrotestosterone-induced prostate specific antigen gene expression and prostate tumor cell growth by estrogens.

  Journal of andrology 20050101

• Endocrinology and hormone therapy in breast cancer: selective oestrogen receptor modulators and downregulators for breast cancer - have they lost their way?

  Breast cancer research : BCR 20050101

• Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands.

  BMC immunology 20050101

• Oestrogenic activity of p-hydroxybenzoic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines.

  Journal of applied toxicology : JAT 20050101

• Evidence that 17alpha-estradiol is biologically active in the uterine tissue: antiuterotonic and antiuterotrophic action.

  Reproductive biology and endocrinology : RB&E 20050101

• Expression and regulation of retinoid-inducible gene 1 (RIG1) in breast cancer.

  Anticancer research 20050101

• 17beta-estradiol inhibits outward potassium currents recorded in rat parabrachial nucleus cells in vitro.

  Neuroscience 20050101

• Estrogen synthesis in the central nucleus of the amygdala following middle cerebral artery occlusion: role in modulating neurotransmission.

  Neuroscience 20050101

• Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells.

  Breast cancer research : BCR 20050101

• Clinical development of fulvestrant ('Faslodex').

  Cancer treatment reviews 20050101

• The future of fulvestrant ('Faslodex').

  Cancer treatment reviews 20050101

• Fulvestrant ('Faslodex'): clinical experience from the Compassionate Use Programme.

  Cancer treatment reviews 20050101

• Case studies of fulvestrant ('Faslodex') in postmenopausal women with advanced breast cancer.

  Cancer treatment reviews 20050101

• Fulvestrant ('Faslodex'): extending the reach of endocrine therapy?

  Breast cancer research and treatment 20050101

• Endocrine therapy--current benefits and limitations.

  Breast cancer research and treatment 20050101

• Biological characteristics of the pure antiestrogen fulvestrant: overcoming endocrine resistance.

  Breast cancer research and treatment 20050101

• Life following aromatase inhibitors--where now for endocrine sequencing?

  Breast cancer research and treatment 20050101

• 17Beta-estradiol suppresses TLR3-induced cytokine and chemokine production in endometrial epithelial cells.

  Reproductive biology and endocrinology : RB&E 20050101

• Treatment of Postmenopausal Breast Cancer with Selective Estrogen Receptor Modulators (SERMs).

  Breast disease 20050101

• Insulin-like growth factor-I receptor and estrogen receptor crosstalk mediates hormone-induced neurite outgrowth in PC12 cells.

  Brain research 20041224

• Effect of anti-estrogens on the androgen receptor activity and cell proliferation in prostate cancer cells.

  Urological research 20041201

• The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity.

  Carcinogenesis 20041201

• Effect of genistein as a selective estrogen receptor beta agonist on the expression of Calbindin-D9k in the uterus of immature rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20041201

• Induction of the paraoxonase-1 gene expression by resveratrol.

  Arteriosclerosis, thrombosis, and vascular biology 20041201

• Recruitment of uterine NK cells: induction of CXC chemokine ligands 10 and 11 in human endometrium by estradiol and progesterone.

  Journal of immunology (Baltimore, Md. : 1950) 20041201

• Fulvestrant - a new treatment for postmenopausal women with hormone-sensitive advanced breast cancer.

  Expert opinion on pharmacotherapy 20041201

• Tamoxifen exerts agonistic effects on clusterin and complement C3 gene expression in RUCA-I primary xenografts and metastases but not normal uterus.

  Endocrine-related cancer 20041201

• Advances in endocrine therapy for breast cancer: considering efficacy, safety, and quality of life.

  Clinical journal of oncology nursing 20041201

• Selective estrogen receptor modulators prevent neointima formation after vascular injury.

  Molecular and cellular endocrinology 20041130

• Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells.

  European journal of pharmacology 20041119

• P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells.

  Cancer research 20041115

• Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor beta.

  Endocrinology 20041101

• Endocrine approaches for the treatment of early and advanced breast cancer in postmenopausal women.

  The international journal of biochemistry & cell biology 20041101

• Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells.

  British journal of cancer 20041101

• Tissue-specific effect of estradiol on endothelial cell-dependent lymphocyte recruitment.

  Microvascular research 20041101

• Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways.

  Environmental health perspectives 20041101

• Response to fulvestrant in heavily pretreated postmenopausal women: a single-center experience.

  Breast cancer research and treatment 20041101

• Is fulvestrant more effective than tamoxifen for treating ER-positive breast cancer in postmenopausal women?

  Nature clinical practice. Oncology 20041101

• Intracellular signaling involved in estrogen regulation of serotonin reuptake.

  Molecular and cellular endocrinology 20041029

• Estrogen induces nitric oxide production via activation of constitutive nitric oxide synthases in human neuroblastoma cells.

  Endocrinology 20041001

• Oestradiol rapidly inhibits Ca2+ signals in ciliary neurons through classical oestrogen receptors in cytoplasm.

  Pflugers Archiv : European journal of physiology 20041001

• Relaxant effects of estradiol through non-genomic pathways in male and female pig bladder smooth muscle.

  Pharmacology 20041001

• 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling.

  Circulation research 20041001

• Understanding the biologic mechanisms responsible for breast-cancer progression during tamoxifen or fulvestrant treatment.

  American journal of surgery 20041001

• Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041001

• Synthesis and biological evaluation of stilbene-based pure estrogen antagonists.

  Bioorganic & medicinal chemistry letters 20040920

• Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists.

  Toxicological sciences : an official journal of the Society of Toxicology 20040901

• Estrogen and mu-opioid receptor antagonists counteract the 17 beta-estradiol-induced licking increase and interferon-gamma reduction occurring during the formalin test in male rats.

  Pain 20040901

• Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors.

  The Journal of clinical endocrinology and metabolism 20040901

• Estrogen induced changes in Akt-dependent activation of endothelial nitric oxide synthase and vasodilation.

  Steroids 20040901

• Endogenous estrogen receptor beta is transcriptionally active in primary ovarian cells from estrogen receptor knockout mice.

  Steroids 20040901

• Fulvestrant: a new type of estrogen receptor antagonist for the treatment of advanced breast cancer.

  Drugs of today (Barcelona, Spain : 1998) 20040901

• Non-classical regulation of estrogen receptor-alpha by ICI182,780.

  The Journal of steroid biochemistry and molecular biology 20040901

• Genistein inhibits expressions of NADPH oxidase p22phox and angiotensin II type 1 receptor in aortic endothelial cells from stroke-prone spontaneously hypertensive rats.

  Hypertension research : official journal of the Japanese Society of Hypertension 20040901

• Estrogen and phytoestrogen regulate the mRNA expression of adrenomedullin and adrenomedullin receptor components in the rat uterus.

  Molecular and cellular endocrinology 20040831

• Estrogen induces expression of secretory leukocyte protease inhibitor in rat uterus.

  Biology of reproduction 20040801

• Effects of the pesticides prochloraz and methiocarb on human estrogen receptor alpha and beta mRNA levels analyzed by on-line RT-PCR.

  Toxicology in vitro : an international journal published in association with BIBRA 20040801

• A low dose of daidzein acts as an ERbeta-selective agonist in trabecular osteoblasts of young female piglets.

  Journal of cellular physiology 20040801

• Daidzein and 17 beta-estradiol enhance nitric oxide synthase activity associated with an increase in calmodulin and a decrease in caveolin-1.

  Journal of cardiovascular pharmacology 20040801

• Impact on estrogen receptor binding and target tissue uptake of [18F]fluorine substitution at the 16alpha-position of fulvestrant (faslodex; ICI 182,780).

  Nuclear medicine and biology 20040801

• Extracellular calcium downregulates estrogen receptor alpha and increases its transcriptional activity through calcium-sensing receptor in breast cancer cells.

  Bone 20040801

• Mifepristone induces growth arrest, caspase activation, and apoptosis of estrogen receptor-expressing, antiestrogen-resistant breast cancer cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040801

• Soybean isoflavones eliminate nifedipine-induced flushing of tail skin in ovariectomized mice.

  Journal of pharmacological sciences 20040801

• Direct action of estradiol on gonadotropin-releasing hormone-1 neuronal activity via a transcription-dependent mechanism.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040714

• Antiestrogens induce growth inhibition by sequential activation of p38 mitogen-activated protein kinase and transforming growth factor-beta pathways in human breast cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20040701

• Estrogen and neuroprotection: higher constitutive expression of glutaredoxin in female mice offers protection against MPTP-mediated neurodegeneration.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040701

• Prolonged extracellular signal-regulated kinase 1/2 activation during fibroblast growth factor 1- or heregulin beta1-induced antiestrogen-resistant growth of breast cancer cells is resistant to mitogen-activated protein/extracellular regulated kinase kinase inhibitors.

  Cancer research 20040701

• Estrogen receptor alpha, but not beta, plays a major role in 17beta-estradiol-induced murine cholesterol gallstones.

  Gastroenterology 20040701

• Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells.

  American journal of physiology. Endocrinology and metabolism 20040601

• Estradiol stimulation of pulsatile gonadotropin-releasing hormone secretion in vitro: correlation with perinatal exposure to sex steroids and induction of sexual precocity in vivo.

  Endocrinology 20040601

• The unusual binding properties of the third distinct teleost estrogen receptor subtype ERbetaa are accompanied by highly conserved amino acid changes in the ligand binding domain.

  Endocrinology 20040601

• Protein kinase A activation of estrogen receptor alpha transcription does not require proteasome activity and protects the receptor from ligand-mediated degradation.

  Endocrinology 20040601

• Synergistic effects of ICI 182,780 on the cytotoxicity of cisplatin in cervical carcinoma cell lines.

  Cancer chemotherapy and pharmacology 20040601

• Estrogen receptor-independent catechol estrogen binding activity: protein binding studies in wild-type, Estrogen receptor-alpha KO, and aromatase KO mice tissues.

  Biochemistry 20040601

• Oestrogen receptor beta is required for androgen-stimulated proliferation of LNCaP prostate cancer cells.

  Journal of molecular endocrinology 20040601

• Distinct effects of the antiestrogen Faslodex on the stability of estrogen receptors-alpha and -beta in the breast cancer cell line MCF-7.

  Journal of molecular endocrinology 20040601

• interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant).

  Cancer research 20040601

• Expression of iNOS gene in macrophages stimulated with 17beta-estradiol is regulated by free intracellular Ca2+.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20040601

• Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer.

  Cancer cell 20040601

• Effects of 17beta-estradiol on in vitro maturation of pig oocytes in protein-free medium.

  The Journal of reproduction and development 20040601

• A new MCF-7 breast cancer cell line resistant to the arzoxifene metabolite desmethylarzoxifene.

  Molecular and cellular endocrinology 20040531

• Exposure to 4-tert-octylphenol, an environmentally persistent alkylphenol, enhances interleukin-4 production in T cells via NF-AT activation.

  Toxicology and applied pharmacology 20040515

• Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells.

  International journal of cancer 20040510

• Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition.

  Proceedings of the National Academy of Sciences of the United States of America 20040504

• The neuroprotective effects of estrogen in SK-N-SH neuroblastoma cell cultures.

  Neurochemistry international 20040501

• Small nuclear RING finger protein expression during gonad development: regulation by gonadotropins and estrogen in the postnatal ovary.

  Endocrinology 20040501

• Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and evaluation of predictive markers for vitamin D treatment.

  Breast cancer research and treatment 20040501

• Estrogen receptor-mediated vascular responsiveness to nebivolol: a novel endothelium-related mechanism of therapeutic vasorelaxation.

  Journal of cardiovascular pharmacology 20040501

• 17beta-estradiol protects oligodendrocytes from cytotoxicity induced cell death.

  Journal of neurochemistry 20040501

• Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trial.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040501

• Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer.

  Cancer research 20040501

• Estrogen up-regulates cyclooxygenase-2 via estrogen receptor in human uterine microvascular endothelial cells.

  Fertility and sterility 20040501

• Isoflavones stimulate estrogen receptor-mediated core histone acetylation.

  Biochemical and biophysical research communications 20040423

• Estradiol down-regulates CD36 expression in human breast cancer cells.

  Cancer letters 20040415

• Re: Playing the old piano: another tune for endocrine therapy.

  Journal of the National Cancer Institute 20040407

• Estradiol represses prolactin-induced expression of Na+/taurocholate cotransporting polypeptide in liver cells through estrogen receptor-alpha and signal transducers and activators of transcription 5a.

  Endocrinology 20040401

• Re-expression of estrogen receptor alpha using a tetracycline-regulated gene expression system induced estrogen-mediated growth inhibition of the MDA-MB-231 breast cancer cell line.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20040401

• Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation.

  Journal of molecular endocrinology 20040401

• Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens.

  Journal of molecular endocrinology 20040401

• Identification of novel estrogen receptor alpha antagonists.

  The Journal of steroid biochemistry and molecular biology 20040401

• Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation.

  International journal of cancer 20040320

• Estrogenic activity of procymidone in rainbow trout (Oncorhynchus mykiss) hepatocytes: a possible mechanism of action.

  Chemico-biological interactions 20040315

• Progestin-dependent induction of vascular endothelial growth factor in human breast cancer cells: preferential regulation by progesterone receptor B.

  Cancer research 20040315

• Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol.

  Molecular cancer research : MCR 20040301

• Transcriptional regulation of a BMP-6 promoter by estrogen receptor alpha.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040301

• Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action.

  British journal of cancer 20040301

• Fulvestrant: pharmacokinetics and pharmacology.

  British journal of cancer 20040301

• Fulvestrant is an effective and well-tolerated endocrine therapy for postmenopausal women with advanced breast cancer: results from clinical trials.

  British journal of cancer 20040301

• Fulvestrant and the sequential endocrine cascade for advanced breast cancer.

  British journal of cancer 20040301

• Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells.

  Cancer research 20040215

• Estrogen elicits cytochrome P450--mediated flow-induced dilation of arterioles in NO deficiency: role of PI3K-Akt phosphorylation in genomic regulation.

  Circulation research 20040206

• Overexpression of estrogen receptor-alpha gene suppresses gap junctional intercellular communication in endometrial carcinoma cells.

  Oncogene 20040205

• Steroidal regulation of uterine edema and tissue inhibitors of metalloproteinase (TIMP)-3 messenger RNA expression is altered in TIMP-1-deficient mice.

  Biology of reproduction 20040201

• Inhibition of estrogen receptor alpha expression and function in MCF-7 cells by kaempferol.

  Journal of cellular physiology 20040201

• Involvement of protein kinase C-dependent mitogen-activated protein kinase p44/42 signaling pathway for cross-talk between estradiol and transforming growth factor-beta3 in increasing basic fibroblast growth factor in folliculostellate cells.

  Endocrinology 20040201

• Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1.

  Molecular endocrinology (Baltimore, Md.) 20040201

• Potent ligand-independent estrogen receptor activation by 3,3'-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways.

  Molecular endocrinology (Baltimore, Md.) 20040201

• Estrogen preferentially promotes the differentiation of CD11c+ CD11b(intermediate) dendritic cells from bone marrow precursors.

  Journal of immunology (Baltimore, Md. : 1950) 20040201

• Augmented endothelial nitric oxide synthase (eNOS) protein expression in human pregnant myometrium: possible involvement of eNOS promoter activation by estrogen via both estrogen receptor (ER)alpha and ERbeta.

  Molecular human reproduction 20040201

• 17beta-estradiol antagonizes cardiomyocyte hypertrophy by autocrine/paracrine stimulation of a guanylyl cyclase A receptor-cyclic guanosine monophosphate-dependent protein kinase pathway.

  Circulation 20040120

• Estrogen-independent activation of erbBs signaling and estrogen receptor alpha in the mouse vagina exposed neonatally to diethylstilbestrol.

  Oncogene 20040115

• Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (Faslodex, ICI 182,780) in breast cancer cells.

  British journal of cancer 20040112

• Spreading the word, but not too thinly.

  Lancet (London, England) 20040110

• Beneficial effects of estrogen treatment in the HLA-B27 transgenic rat model of inflammatory bowel disease.

  American journal of physiology. Gastrointestinal and liver physiology 20040101

• Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells.

  Endocrinology 20040101

• Comparison of proteomic and genomic analyses of the human breast cancer cell line T47D and the antiestrogen-resistant derivative T47D-r.

  Molecular & cellular proteomics : MCP 20040101

• Increases in estrogen receptor-alpha concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040101

• Inhibition of HER1 signaling pathway enhances antitumor effect of endocrine therapy in breast cancer.

  Breast cancer (Tokyo, Japan) 20040101

• Topical estrogen accelerates hair regrowth in mice after chemotherapy-induced alopecia by favoring the dystrophic catagen response pathway to damage.

  The Journal of investigative dermatology 20040101

• BMP7/ActRIIB regulates estrogen-dependent apoptosis: new biomarkers for environmental estrogens.

  Journal of biochemical and molecular toxicology 20040101

• Fulvestrant: a review of its use in hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following antiestrogen therapy.

  Drugs 20040101

• Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.

  The Journal of steroid biochemistry and molecular biology 20040101

• Fulvestrant for the treatment of advanced breast cancer in postmenopausal women: a Japanese study.

  Anticancer research 20040101

• Pharmacokinetic profile of intramuscular fulvestrant in advanced breast cancer.

  Clinical pharmacokinetics 20040101

• 17beta-Estradiol promotes striatal medium size spiny neuronal maturation in vitro.

  Neuroendocrinology 20040101

• Tamoxifen--what next?

  The oncologist 20040101

• Conference report--cancer research 2004--top of the class March 27-March 31, 2004; Orlando, Florida.

  MedGenMed : Medscape general medicine 20040101

• Dose- and photoperiod-dependent effects of 17beta-estradiol and the anti-estrogen ICI 182,780 on testicular structure, acceleration of spermatogenesis, and aromatase immunoexpression in immature bank voles.

  Acta histochemica 20040101

• Plant 2-arylobenzofurans demonstrate a selective estrogen receptor modulator profile.

  Steroids 20040101

• Fulvestrant ('Faslodex')--a new hormonal treatment for advanced breast cancer.

  European journal of oncology nursing : the official journal of European Oncology Nursing Society 20040101

• Clinical experience with fulvestrant ('Faslodex'): a nurse's perspective.

  European journal of oncology nursing : the official journal of European Oncology Nursing Society 20040101

• B-ring unsaturated estrogens: biological evaluation of 17alpha-Dihydroequilein and novel B-Nor-6-thiaequilenins as tissue selective estrogens.

  Bioorganic & medicinal chemistry letters 20031215

• Estrogen modulates xanthine dehydrogenase/xanthine oxidase activity by a receptor-independent mechanism.

  Antioxidants & redox signaling 20031201

• Resistance to different antiestrogens is caused by different multi-factorial changes and is associated with reduced expression of IGF receptor Ialpha.

  Endocrine-related cancer 20031201

• An ICI 182,780-sensitive, membrane-related estrogen receptor contributes to estrogenic neuroprotective actions against amyloid-beta toxicity.

  Annals of the New York Academy of Sciences 20031201

• Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK(Ca) channel activity in cultured endothelial cells of human coronary artery.

  Biochemical pharmacology 20031115

• Paradoxical action of fulvestrant in estradiol-induced regression of tamoxifen-stimulated breast cancer.

  Journal of the National Cancer Institute 20031105

• The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro.

  Endocrinology 20031101

• Steroid hormone regulation of the human kallikrein 10 (KLK10) gene in cancer cell lines and functional characterization of the KLK10 gene promoter.

  Clinica chimica acta; international journal of clinical chemistry 20031101

• Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.

  Toxicology and applied pharmacology 20031101

• 2-methoxyestradiol strongly inhibits human uterine sarcomatous cell growth.

  Gynecologic oncology 20031101

• Expression and mitogenic effect of fibroblast growth factor-9 in human endometriotic implant is regulated by aberrant production of estrogen.

  The Journal of clinical endocrinology and metabolism 20031101

• Tamoxifen induces vasorelaxation via inhibition of mitogen-activated protein kinase in rat aortic smooth muscle.

  The Journal of veterinary medical science 20031101

• The interaction of the steroidal antagonist faslodex and methotrexate.

  Cellular and molecular biology (Noisy-le-Grand, France) 20031101

• Vascular ECE-1 mRNA expression decreases in response to estrogens.

  Life sciences 20031024

• Fulvestrant: spreading the word, but not too thinly.

  Lancet (London, England) 20031018

• AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter.

  Cancer research 20031015

• 17 beta-Estradiol inhibits angiotensin II activation of area postrema neurons.

  American journal of physiology. Heart and circulatory physiology 20031001

• Various phosphorylation pathways, depending on agonist and antagonist binding to endogenous estrogen receptor alpha (ERalpha), differentially affect ERalpha extractability, proteasome-mediated stability, and transcriptional activity in human breast cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20031001

• Equivalent single-dose pharmacokinetics of two different dosing methods of prolonged-release fulvestrant ('Faslodex') in postmenopausal women with advanced breast cancer.

  Cancer chemotherapy and pharmacology 20031001

• Effect of 4-nonylphenol on cell proliferation and adipocyte formation in cultures of fully differentiated 3T3-L1 cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20031001

• 17Beta-estradiol as a receptor-mediated cardioprotective agent.

  The Journal of pharmacology and experimental therapeutics 20031001

• Tamoxifen and ICI 182,780 negatively influenced cardiac cell growth via an estrogen receptor-independent mechanism.

  Cardiovascular research 20031001

• Fulvestrant in postmenopausal women with advanced breast cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20031001

• Fulvestrant: an estrogen receptor antagonist that downregulates the estrogen receptor.

  Seminars in oncology 20031001

• Synthetic estrogen-mediated activation of ERK 2 intracellular signaling molecule.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20031001

• Regulation of uterine hsp90alpha, hsp72 and HSF-1 transcription in B6C3F1 mice by beta-estradiol and bisphenol A: involvement of the estrogen receptor and protein kinase C.

  Toxicology letters 20030930

• Induction of p53 expression and function by estrogen in osteoblasts.

  Calcified tissue international 20030901

• 2-Methoxyestradiol exhibits a biphasic effect on VEGF-A in tumor cells and upregulation is mediated through ER-alpha: a possible signaling pathway associated with the impact of 2-ME2 on proliferative cells.

  Neoplasia (New York, N.Y.) 20030901

• Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation.

  The Journal of biological chemistry 20030815

• Expression of calcitonin gene-related peptide receptor components, calcitonin receptor-like receptor and receptor activity modifying protein 1, in the rat placenta during pregnancy and their cellular localization.

  Molecular human reproduction 20030801

• Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland.

  Nature medicine 20030801

• Regulation of ovarian primordial follicle assembly and development by estrogen and progesterone: endocrine model of follicle assembly.

  Endocrinology 20030801

• 17Beta-eEstradiol stimulates arachidonate release from human amnion-like WISH cells through a rapid mechanism involving a membrane receptor.

  Endocrinology 20030801

• Alterations in the post-translational modification and intracellular trafficking of clusterin in MCF-7 cells during apoptosis.

  Cell death and differentiation 20030801

• Both estrogen and raloxifene cause G1 arrest of vascular smooth muscle cells.

  The Journal of endocrinology 20030801

• p27(Kip1) induces quiescence and growth factor insensitivity in tamoxifen-treated breast cancer cells.

  Cancer research 20030801

• Dehydroepiandrosterone sulfate causes proliferation of estrogen receptor-positive breast cancer cells despite treatment with fulvestrant.

  Archives of surgery (Chicago, Ill. : 1960) 20030801

• Expression of constitutively active Akt-3 in MCF-7 breast cancer cells reverses the estrogen and tamoxifen responsivity of these cells in vivo.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030801

• Estimation of estrogenic and anti-estrogenic activities of some phthalate diesters and monoesters by MCF-7 cell proliferation assay in vitro.

  Biological & pharmaceutical bulletin 20030801

• An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat.

  The European journal of neuroscience 20030801

• Effect of estrogen and antiestrogens on the estrogen receptor content in the cochlea of ovariectomized rats.

  Hearing research 20030801

• Effects of estriol on the proliferation and differentiation of human osteoblastic MG-63 cells.

  Endocrine research 20030801

• [Switching off the estrogen effect and approaches to its correction].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20030801

• Estrogenic and antiestrogenic regulation of MMP-2 and MMP-13 mRNA in RUCA-I endometrial tumor cells in vitro and in vivo.

  Cancer letters 20030730

• Modulation of antioxidant enzyme expression and function by estrogen.

  Circulation research 20030725

• Mutation of Leu-536 in human estrogen receptor-alpha alters the coupling between ligand binding, transcription activation, and receptor conformation.

  The Journal of biological chemistry 20030718

• Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: a prospective combined analysis of two multicenter trials.

  Cancer 20030715

• Inhibitory actions of genistein in human breast cancer (MCF-7) cells.

  Biochimica et biophysica acta 20030714

• Antiestrogens are pro-apoptotic in normal human breast epithelial cells.

  International journal of cancer 20030710

• Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains.

  Molecular endocrinology (Baltimore, Md.) 20030701

• Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.

  Molecular endocrinology (Baltimore, Md.) 20030701

• Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells.

  Endocrinology 20030701

• New drugs 2003, part II.

  Nursing 20030701

• Oestrogen receptor downregulation: an opportunity for extending the window of endocrine therapy in advanced breast cancer.

  Annals of oncology : official journal of the European Society for Medical Oncology 20030701

• H-ras dependent estrogenic effects of epidermal growth factor in the estrogen-independent breast cancer cell line MDA-MB-231.

  Breast cancer research and treatment 20030701

• Identification of estrogen receptor beta expression in Chinese hamster ovary (CHO) cells and comparison of estrogen-responsive gene transcription in cells adapted to serum-free media.

  The Journal of steroid biochemistry and molecular biology 20030701

• Down-regulation of inducible nitric oxide synthase and tumor necrosis factor-alpha expression by bisphenol A via nuclear factor-kappaB inactivation in macrophages.

  Cancer letters 20030630

• The differential effects of tamoxifen and ICI 182,780 on the reduction of Na+/K+ ATPase activity and spontaneous oscillations by 17beta-estradiol.

  The Chinese journal of physiology 20030630

• Estrogens and ICI182,780 (Faslodex) modulate mitosis and cell death in immature cerebellar neurons via rapid activation of p44/p42 mitogen-activated protein kinase.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615

• Estradiol exacerbates hippocampal damage in a model of preterm infant brain injury.

  Endocrinology 20030601

• Estrogen-like activity of metals in MCF-7 breast cancer cells.

  Endocrinology 20030601

• An oestrogen membrane receptor participates in estradiol actions for the prevention of amyloid-beta peptide1-40-induced toxicity in septal-derived cholinergic SN56 cells.

  Journal of neurochemistry 20030601

• Fulvestrant (Faslodex) versus anastrozole for the second-line treatment of advanced breast cancer in subgroups of postmenopausal women with visceral and non-visceral metastases: combined results from two multicentre trials.

  European journal of cancer (Oxford, England : 1990) 20030601

• Modulation of the folate receptor alpha gene by the estrogen receptor: mechanism and implications in tumor targeting.

  Cancer research 20030601

• A randomized, placebo-controlled, dose-ranging trial comparing fulvestrant with goserelin in premenopausal patients with uterine fibroids awaiting hysterectomy.

  Fertility and sterility 20030601

• Estrogen-induced autonomic effects are mediated by NMDA and GABAA receptors in the parabrachial nucleus.

  Brain research 20030530

• Impact of estrogen replacement on ventricular myocyte contractile function and protein kinase B/Akt activation.

  American journal of physiology. Heart and circulatory physiology 20030501

• Estradiol rapidly activates Akt via the ErbB2 signaling pathway.

  Molecular endocrinology (Baltimore, Md.) 20030501

• Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20030501

• Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20030501

• Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells stably transfected with ER alpha.

  International journal of cancer 20030501

• 17beta-estradiol activates ICI 182,780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030501

• Time- and dose-related effects of estradiol and diethylstilbestrol on the morphology and function of the fetal rat testis in culture.

  Toxicological sciences : an official journal of the Society of Toxicology 20030501

• Oxidative damage to human lens epithelial cells in culture: estrogen protection of mitochondrial potential, ATP, and cell viability.

  Investigative ophthalmology & visual science 20030501

• Studies on the development of resistance to the pure antiestrogen Faslodex in three human breast cancer cell lines.

  The Journal of steroid biochemistry and molecular biology 20030501

• Postmenopausal women who progress on fulvestrant ('Faslodex') remain sensitive to further endocrine therapy.

  Breast cancer research and treatment 20030501

• Pharmacokinetics of a single dose of fulvestrant prolonged-release intramuscular injection in postmenopausal women awaiting surgery for primary breast cancer.

  Clinical therapeutics 20030501

• Substance P in the uterine cervix, dorsal root ganglia and spinal cord during pregnancy and the effect of estrogen on SP synthesis.

  Peptides 20030501

• De novo design, synthesis, and evaluation of novel nonsteroidal phenanthrene ligands for the estrogen receptor.

  Journal of medicinal chemistry 20030410

• 17-epiestriol, an estrogen metabolite, is more potent than estradiol in inhibiting vascular cell adhesion molecule 1 (VCAM-1) mRNA expression.

  The Journal of biological chemistry 20030404

• Estrogen receptor, cyclic adenosine monophosphate, and protein kinase A are involved in the nongenomic pathway by which estradiol accelerates oviductal oocyte transport in cyclic rats.

  Biology of reproduction 20030401

• Differential effects of natural and environmental estrogens on endothelin synthesis in bovine oviduct cells.

  Biology of reproduction 20030401

• Uncoupling of 5-HT1A receptors in the brain by estrogens: regional variations in antagonism by ICI 182,780.

  Neuropharmacology 20030401

• Induction of an estrogen-responsive reporter gene in rainbow trout hepatoma cells (RTH 149) at 11 or 18 degrees C.

  Environmental toxicology and chemistry 20030401

• 17Beta-estradiol and anti-estrogen ICI:compound 182,780 regulate expression of lipoprotein lipase and hormone-sensitive lipase in isolated subcutaneous abdominal adipocytes.

  Metabolism: clinical and experimental 20030401

• The effect of estradiol in the striatum is blocked by ICI 182,780 but not tamoxifen: pharmacological and behavioral evidence.

  Neuroendocrinology 20030401

• The display of sexual behaviors by female rats administered ICI 182,780.

  Hormones and behavior 20030401

• The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20030301

• Estrogen regulates tyrosine hydroxylase expression in the neonate mouse midbrain.

  Journal of neurobiology 20030301

• Estradiol-induced vascular endothelial growth factor-A expression in breast tumor cells is biphasic and regulated by estrogen receptor-alpha dependent pathway.

  International journal of oncology 20030301

• Estrogen activation of cyclic adenosine 5'-monophosphate response element-mediated transcription requires the extracellularly regulated kinase/mitogen-activated protein kinase pathway.

  Endocrinology 20030301

• Soy-derived isoflavones exert opposing actions on Guinea pig ventricular myocytes.

  The Journal of pharmacology and experimental therapeutics 20030301

• The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes.

  Molecular and cellular biology 20030301

• Genistein inhibits vitamin D hydroxylases CYP24 and CYP27B1 expression in prostate cells.

  The Journal of steroid biochemistry and molecular biology 20030301

• The effects of estradiol and selective estrogen receptor modulators on gene expression and messenger RNA stability in immortalized sheep endometrial stromal cells and human endometrial adenocarcinoma cells.

  The Journal of steroid biochemistry and molecular biology 20030301

• Effect of antiestrogens and aromatase inhibitor on basal growth of the human breast cancer cell line MCF-7 in serum-free medium.

  The Journal of steroid biochemistry and molecular biology 20030301

• Idoxifene and estradiol enhance antiapoptotic activity through estrogen receptor-beta in cultured rat hepatocytes.

  Digestive diseases and sciences 20030301

• Differential SERM effects on corepressor binding dictate ERalpha activity in vivo.

  The Journal of biological chemistry 20030227

• Modulation of estrogen receptor alpha function and stability by tamoxifen and a critical amino acid (Asp-538) in helix 12.

  The Journal of biological chemistry 20030227

• The effects of the phytoestrogen, coumestrol, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 GnRH neurones.

  Journal of neuroendocrinology 20030201

• 17alpha-estradiol-induced VEGF-A expression in rat pituitary tumor cells is mediated through ER independent but PI3K-Akt dependent signaling pathway.

  Biochemical and biophysical research communications 20030103

• Estrogen receptor-alpha gene deficiency enhances androgen biosynthesis in the mouse Leydig cell.

  Endocrinology 20030101

• Estrogen receptor-mediated neuroprotection from oxidative stress requires activation of the mitogen-activated protein kinase pathway.

  Endocrinology 20030101

• Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium.

  Investigative ophthalmology & visual science 20030101

• Oestrogenic activity of benzylparaben.

  Journal of applied toxicology : JAT 20030101

• Role of the estrogen antagonist ICI 182,780 in vessel assembly and apoptosis of endothelial cells.

  Ultrastructural pathology 20030101

• Current status of selective estrogen receptor modulators (SERMs).

  Cancer journal (Sudbury, Mass.) 20030101

• WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferation.

  Neoplasia (New York, N.Y.) 20030101

• Fulvestrant antiestrogen for treatment of breast cancer.

  Clinical journal of oncology nursing 20030101

• Ovarian steroids reduce apoptosis induced by trophic insufficiency in nerve growth factor-differentiated PC12 cells and axotomized rat facial motoneurons.

  Neuroscience 20030101

• Estradiol inhibits atp-induced intracellular calcium concentration increase in dorsal root ganglia neurons.

  Neuroscience 20030101

• The effects of estrogen, its antagonist ICI 182, 780, and interferon-tau on the expression of estrogen receptors and integrin alphaV beta 3 on cycle day 16 in bovine endometrium.

  Reproductive biology and endocrinology : RB&E 20030101

• Effects of SERM (selective estrogen receptor modulator) treatment on growth and proliferation in the rat uterus.

  Reproductive biology and endocrinology : RB&E 20030101

• Hormonal therapy for breast cancer: focus on fulvestrant.

  Clinical journal of oncology nursing 20030101

• The antiestrogen ICI 182,780 induces early effects on the adult male mouse reproductive tract and long-term decreased fertility without testicular atrophy.

  Reproductive biology and endocrinology : RB&E 20030101

• [Perspectives for the hormonal therapy of breast cancer].

  Magyar onkologia 20030101

• 17beta-estradiol- and lipopolysaccharide-induced changes in nitric oxide, tumor necrosis factor-alpha and vascular endothelial growth factor release from RAW 264.7 macrophages.

  Gynecologic and obstetric investigation 20030101

• Future directions in the endocrine therapy of breast cancer.

  Breast cancer research and treatment 20030101

• Estrogen receptor beta in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone.

  Neuroscience 20030101

• Estrogenic compounds suppressed interferon-gamma production in mouse splenocytes through direct cell-cell interaction.

  In vitro cellular & developmental biology. Animal 20030101

• The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules.

  Reproductive biology and endocrinology : RB&E 20030101

• 17 beta -estradiol-mediated vessel assembly and stabilization in tumor angiogenesis requires TGF beta and EGFR crosstalk.

  Angiogenesis 20030101

• A phase I trial to assess the pharmacology of the new oestrogen receptor antagonist fulvestrant on the endometrium in healthy postmenopausal volunteers.

  British journal of cancer 20021202

• Acute effects of 17beta -estradiol on femoral veins from adult gonadally intact and ovariectomized female pigs.

  American journal of physiology. Heart and circulatory physiology 20021201

• Estradiol reduces F2alpha-isoprostane production in cultured human endothelial cells.

  American journal of physiology. Heart and circulatory physiology 20021201

• Estrogenic and antiproliferative properties of soy sapogenols in human breast cancer cells in vitro.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021201

• Modulation of estrogen receptor-dependent reporter construct activation and G0/G1-S-phase transition by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20021201

• Advances in endocrine therapy of metastatic breast cancer.

  The British journal of surgery 20021201

• Isomer-specific activity of dichlorodyphenyltrichloroethane with estrogen receptor in adult and suckling estrogen reporter mice.

  Endocrinology 20021201

• Constitutive overexpression of cyclin D1 but not cyclin E confers acute resistance to antiestrogens in T-47D breast cancer cells.

  Cancer research 20021201

• Fulvestrant ('Faslodex')--a new treatment option for patients progressing on prior endocrine therapy.

  Endocrine-related cancer 20021201

• Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17beta-estradiol in vitro requires protein kinases A and C.

  Neuroendocrinology 20021201

• Stimulation of alkaline phosphatase activity in Ishikawa cells induced by various phytoestrogens and synthetic estrogens.

  The Journal of steroid biochemistry and molecular biology 20021201

• Enhancing effects of estrogen on inhibitory avoidance performance may be in part independent of intracellular estrogen receptors in the hippocampus.

  Brain research 20021129

• Estrogen receptor-dependent and estrogen receptor-independent pathways for tamoxifen and 4-hydroxytamoxifen-induced programmed cell death.

  The Journal of biological chemistry 20021122

• Estrogen blocks 3-nitropropionic acid-induced Ca2+i increase and cell damage in cultured rat cerebral endothelial cells.

  Brain research 20021122

• Involvement of G1/S cyclins in estrogen-independent proliferation of estrogen receptor-positive breast cancer cells.

  Oncogene 20021121

• Cyr61 promotes breast tumorigenesis and cancer progression.

  Oncogene 20021121

• Fulvestrant versus anastrozole as second-line treatment of advanced breast cancer in postmenopausal women.

  European journal of cancer (Oxford, England : 1990) 20021101

• Selective oestrogen receptor downregulator.

  European journal of cancer (Oxford, England : 1990) 20021101

• Immature uterotrophic assay of estrogenic compounds in rats given diets of different phytoestrogen content and the ovarian changes with ICI 182,780 or antide.

  Archives of toxicology 20021101

• Effects of 17 alpha-methyltestosterone on uterine morphology and heat shock protein expression are mediated through estrogen and androgen receptors.

  The Journal of steroid biochemistry and molecular biology 20021101

• A role for TGF-beta in estrogen and retinoid mediated regulation of the nuclear receptor coactivator AIB1 in MCF-7 breast cancer cells.

  Oncogene 20021017

• Two antiestrogens affect differently chromatin remodeling of trefoil factor 1 (pS2) gene and the fate of estrogen receptor in MCF7 cells.

  Biochimica et biophysica acta 20021011

• Estrogenicity of organophosphorus and pyrethroid pesticides.

  Journal of toxicology and environmental health. Part A 20021011

• Calcitonin expression in rat anterior pituitary gland is regulated by ovarian steroid hormones.

  Endocrinology 20021001

• Expression and regulation of calcitonin gene-related Peptide receptor in rat placentas.

  Biology of reproduction 20021001

• A new estrogen receptor antagonist--an overview of available data.

  Breast cancer research and treatment 20021001

• A novel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: direct effects on gonadotropin-releasing hormone neurones.

  Journal of neuroendocrinology 20021001

• In vitro antiestrogenic effects of aryl methyl sulfone metabolites of polychlorinated biphenyls and 2,2-bis(4-chlorophenyl)-1,1-dichloroethene on 17beta-estradiol-induced gene expression in several bioassay systems.

  Toxicological sciences : an official journal of the Society of Toxicology 20021001

• Structure and regulation of expression of the mouse GH receptor.

  The Journal of endocrinology 20021001

• Effects of resveratrol-related hydroxystilbenes on the nitric oxide production in macrophage cells: structural requirements and mechanism of action.

  Life sciences 20020913

• Bisphenol A stimulates NO synthesis through a non-genomic estrogen receptor-mediated mechanism in mouse endothelial cells.

  Toxicology letters 20020905

• Genistein action in the prepubertal mammary gland in a chemoprevention model.

  Carcinogenesis 20020901

• Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020815

• Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020815

• Estradiol stimulates GDNF expression in developing hypothalamic neurons.

  Endocrinology 20020801

• Interactions of ATP, oestradiol, genistein and the anti-oestrogens, faslodex (ICI 182780) and tamoxifen, with the human erythrocyte glucose transporter, GLUT1.

  The Biochemical journal 20020801

• Intracellular pathways mediating estrogen-induced cholangiocyte proliferation in the rat.

  Hepatology (Baltimore, Md.) 20020801

• The pure anti-oestrogen ICI 182,780 (Faslodex) activates large conductance Ca(2+)-activated K(+) channels in smooth muscle.

  British journal of pharmacology 20020801

• Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes.

  The EMBO journal 20020801

• Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists.

  Molecular endocrinology (Baltimore, Md.) 20020801

• Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor.

  Cancer research 20020801

• Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng.

  The Journal of clinical endocrinology and metabolism 20020801

• Estrogen represses whereas the estrogen-antagonist ICI 182780 stimulates placental CRH gene expression.

  The Journal of clinical endocrinology and metabolism 20020801

• Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation.

  The Journal of steroid biochemistry and molecular biology 20020801

• Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera.

  Oncogene 20020725

• Fulvestrant (faslodex) for advanced breast cancer.

  The Medical letter on drugs and therapeutics 20020722

• Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a mouse ovarian cancer cell line.

  Toxicology 20020715

• Antiestrogen ICI 182,780 decreases proliferation of insulin-like growth factor I (IGF-I)-treated MCF-7 cells without inhibiting IGF-I signaling.

  Cancer research 20020715

• Inhibition of progesterone-induced VEGF production in human breast cancer cells by the pure antiestrogen ICI 182,780.

  Cancer letters 20020708

• 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta.

  Cancer research 20020701

• The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020701

• Regulation of matrix metalloproteinase expression by estrogen in fibroblasts that are derived from the pelvic floor.

  American journal of obstetrics and gynecology 20020701

• Effects of selective estrogen receptor modulators (SERMs) on coactivator nuclear receptor (NR) box binding to estrogen receptors.

  Molecular genetics and metabolism 20020701

• New alternative to tamoxifen.

  Harvard women's health watch 20020701

• Ligand-independent activation of steroid receptors.

  Domestic animal endocrinology 20020701

• Organochlorine pesticides directly regulate gonadotropin-releasing hormone gene expression and biosynthesis in the GT1-7 hypothalamic cell line.

  Molecular and cellular endocrinology 20020628

• Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha expression by 4-nonylphenol in macrophages.

  Biochemical and biophysical research communications 20020621

• Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780).

  Cancer research 20020615

• Triphenylethylene antiestrogen-induced acute relaxation of mouse duodenal muscle. Possible involvement of Ca2+ channels.

  European journal of pharmacology 20020612

• Gene expression profiling of testosterone and estradiol-17 beta-induced prostatic dysplasia in Noble rats and response to the antiestrogen ICI 182,780.

  Endocrinology 20020601

• ER function in the adult male rat: short- and long-term effects of the antiestrogen ICI 182,780 on the testis and efferent ductules, without changes in testosterone.

  Endocrinology 20020601

• Mechanisms of growth arrest by c-myc antisense oligonucleotides in MCF-7 breast cancer cells: implications for the antiproliferative effects of antiestrogens.

  Cancer research 20020601

• Estrogen increases endothelial nitric oxide synthase via estrogen receptors in rat cerebral blood vessels: effect preserved after concurrent treatment with medroxyprogesterone acetate or progesterone.

  Stroke 20020601

• Direct actions of estradiol on the anterior pituitary gland are required for hypothalamus-dependent lactotrope proliferation and secretory surges of luteinizing hormone but not of prolactin in female rats.

  Neuroendocrinology 20020601

• Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer.

  Annals of the New York Academy of Sciences 20020601

• A review of selective estrogen receptor modulators in the treatment of breast and endometrial cancer.

  Seminars in oncology 20020601

• Concept evaluation: an assay for receptor-mediated and biochemical antiestrogens using pubertal rats.

  Regulatory toxicology and pharmacology : RTP 20020601

• C-myc gene expression alone is sufficient to confer resistance to antiestrogen in human breast cancer cells.

  International journal of cancer 20020501

• Nongenomic regulation of the kinetics of exocytosis by estrogens.

  The Journal of pharmacology and experimental therapeutics 20020501

• Oestrogen action on the myocardium in vivo: specific and permissive for angiotensin-converting enzyme inhibition.

  Journal of hypertension 20020501

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Effect of prolonged hydroxytamoxifen treatment of MCF-7 cells on mitogen activated kinase cascade.

  International journal of cancer 20020410

• High glucose abolishes the antiproliferative effect of 17beta-estradiol in human vascular smooth muscle cells.

  American journal of physiology. Endocrinology and metabolism 20020401

• Ligand-specific regulation of proteasome-mediated proteolysis of estrogen receptor-alpha.

  American journal of physiology. Endocrinology and metabolism 20020401

• Estrogen attenuates the cardiovascular and ventilatory responses to central command in cats.

  Journal of applied physiology (Bethesda, Md. : 1985) 20020401

• Differential effects of sarcolemmal and mitochondrial K(ATP) channels activated by 17 beta-estradiol on reperfusion arrhythmias and infarct sizes in canine hearts.

  The Journal of pharmacology and experimental therapeutics 20020401

• Estrogen receptor isoform-specific induction of progesterone receptors in human osteoblasts.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020401

• Down-regulation of osteoclast differentiation by daidzein via caspase 3.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020401

• Human osteoblasts' proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020401

• 17-beta-oestradiol-induced vasorelaxation in vitro is mediated by eNOS through hsp90 and akt/pkb dependent mechanism.

  British journal of pharmacology 20020401

• Tamoxifen elicits its anti-estrogen effects in growth plate chondrocytes by inhibiting protein kinase C.

  The Journal of steroid biochemistry and molecular biology 20020401

• Reciprocal regulation by estradiol 17-beta of ezrin and cadherin-catenin complexes in pituitary GH3 cells.

  Endocrine 20020401

• Fulvestrant (Faslodex): current status in the therapy of breast cancer.

  Expert review of anticancer therapy 20020401

• Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk.

  The Journal of biological chemistry 20020308

• Comparative effects of testosterone propionate, oestradiol benzoate, ICI 182,780, tamoxifen and raloxifene on hypothalamic differentiation in the female rat.

  The Journal of endocrinology 20020301

• Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer.

  Molecular endocrinology (Baltimore, Md.) 20020301

• Stanniocalcin 2 is an estrogen-responsive gene coexpressed with the estrogen receptor in human breast cancer.

  Cancer research 20020301

• The estrogen receptor ligand ICI 182,780 does not impair the bone-sparing effects of testosterone in the young orchidectomized rat model.

  Calcified tissue international 20020301

• Estradiol stimulates gene expression of norepinephrine biosynthetic enzymes in rat locus coeruleus.

  Neuroendocrinology 20020301

• Effects of dietary phytoestrogens in vivo and in vitro in rainbow trout and Siberian sturgeon: interests and limits of the in vitro studies of interspecies differences.

  General and comparative endocrinology 20020301

• Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells.

  The Journal of steroid biochemistry and molecular biology 20020301

• The cyclin-dependent kinase inhibitor p21WAF1/Cip1 is an antiestrogen-regulated inhibitor of Cdk4 in human breast cancer cells.

  The Journal of biological chemistry 20020215

• Receptor-mediated ethinylestradiol-induced oxidative DNA damage in rat testicular cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020201

• Fulvestrant.

  Expert opinion on investigational drugs 20020201

• 2-methoxyestradiol induces interferon gene expression and apoptosis in osteosarcoma cells.

  Bone 20020201

• Fulvestrant (AstraZeneca).

  Current opinion in investigational drugs (London, England : 2000) 20020201

• Expression and regulation of Cyr61 in human breast cancer cell lines.

  Oncogene 20020131

• Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein.

  The Journal of biological chemistry 20020125

• Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta.

  Science (New York, N.Y.) 20020118

• Functional role of estrogen in pituitary tumor pathogenesis.

  The Journal of clinical investigation 20020115

• A+U-rich-element RNA-binding factor 1/heterogeneous nuclear ribonucleoprotein D gene expression is regulated by oestrogen in the rat uterus.

  The Biochemical journal 20020101

• Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis.

  Molecular endocrinology (Baltimore, Md.) 20020101

• Phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts.

  Journal of cellular biochemistry 20020101

• Oestrogenic activity of parabens in MCF7 human breast cancer cells.

  The Journal of steroid biochemistry and molecular biology 20020101

• Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7.

  The Journal of steroid biochemistry and molecular biology 20020101

• Toxicity of antiestrogens.

  The breast journal 20020101

• Fulvestrant: clinical application of an estrogen receptor downregulator.

  Clinical therapeutics 20020101

• Identification and characterization of a negative regulatory element within the epidermal growth factor receptor gene first intron in hormone-dependent breast cancer cells.

  Journal of cellular biochemistry 20020101

• The effect of antiestrogens on TGF-beta-mediated chemotaxis of human breast cancer cells.

  Anticancer research 20020101

• Reduction of post injury neointima formation due to 17beta-estradiol and phytoestrogen treatment is not influenced by the pure synthetic estrogen receptor antagonist ICI 182,780 in vitro.

  BMC cardiovascular disorders 20020101

• Critical parameters in the MCF-7 cell proliferation bioassay (E-Screen).

  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20020101

• Fulvestrant, an estrogen receptor downregulator, reduces cell turnover index more effectively than tamoxifen.

  Anticancer research 20020101

• New treatment for advanced breast cancer.

  FDA consumer 20020101

• In vitro regulation of vascular endothelial growth factor by estrogens and antiestrogens in estrogen-receptor positive breast cancer.

  Breast cancer (Tokyo, Japan) 20020101

• Oestrogenic activity of isobutylparaben in vitro and in vivo.

  Journal of applied toxicology : JAT 20020101

• Inhibition of low-density lipoprotein oxidation by the pure antiestrogens ICI 182780 and EM-652 (SCH 57068).

  Menopause (New York, N.Y.) 20020101

• Inhibition of E2-induced expression of BRCA1 by persistent organochlorines.

  Breast cancer research : BCR 20020101

• FDA drug approval summaries: fulvestrant.

  The oncologist 20020101

• Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha.

  Anticancer research 20020101

• Induction of endothelial nitric-oxide synthase phosphorylation by the raloxifene analog LY117018 is differentially mediated by Akt and extracellular signal-regulated protein kinase in vascular endothelial cells.

  The Journal of biological chemistry 20011214

• Selected contribution: Effects of gender on reduced-size liver ischemia and reperfusion injury.

  Journal of applied physiology (Bethesda, Md. : 1985) 20011201

• Identification of novel oestrogen receptor target genes in human ZR75-1 breast cancer cells by expression profiling.

  Journal of molecular endocrinology 20011201

• Stimulation of vascular protein synthesis by activation of oestrogen receptor beta.

  The Journal of endocrinology 20011201

• Estrogen increases CD40 ligand expression in T cells from women with systemic lupus erythematosus.

  The Journal of rheumatology 20011201

• Modulation of aromatase expression in human breast tissue.

  The Journal of steroid biochemistry and molecular biology 20011201

• Adaptive hypersensitivity to estradiol: potential mechanism for secondary hormonal responses in breast cancer patients.

  The Journal of steroid biochemistry and molecular biology 20011201

• Faslodex (ICI 182, 780), a novel estrogen receptor downregulator--future possibilities in breast cancer.

  The Journal of steroid biochemistry and molecular biology 20011201

• Prospects for combining hormonal and nonhormonal growth factor inhibition.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20011201

• Estrogen-induced recovery of autonomic function after middle cerebral artery occlusion in male rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20011101

• Estrogen regulation of ion transporter messenger RNA levels in mouse efferent ductules are mediated differentially through estrogen receptor (ER) alpha and ER beta.

  Biology of reproduction 20011101

• Adult tissue angiogenesis: evidence for negative regulation by estrogen in the uterus.

  Molecular endocrinology (Baltimore, Md.) 20011101

• Acute gender-specific hemodynamic and inotropic effects of 17beta-estradiol on rats.

  Hypertension (Dallas, Tex. : 1979) 20011101

• Oestrogen-mediated suppression of tumour necrosis factor alpha-induced apoptosis in MCF-7 cells: subversion of Bcl-2 by anti-oestrogens.

  The Journal of steroid biochemistry and molecular biology 20011101

• ICI 182,780 (Fulvestrant)--the first oestrogen receptor down-regulator--current clinical data.

  British journal of cancer 20011101

• A vision for the future?

  British journal of cancer 20011101

• Estrogen stimulates brain-derived neurotrophic factor expression in embryonic mouse midbrain neurons through a membrane-mediated and calcium-dependent mechanism.

  Journal of neuroscience research 20011015

• Effects of beta-estradiol and bisphenol A on heat shock protein levels and localization in the mouse uterus are antagonized by the antiestrogen ICI 182,780.

  Toxicological sciences : an official journal of the Society of Toxicology 20011001

• Co-administration of finasteride and the pure anti-oestrogen ICI 182,780 act synergistically in modulating the IGF system in rat prostate.

  The Journal of endocrinology 20011001

• Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells.

  Cancer research 20011001

• Novel antitumor effect of estradiol in athymic mice injected with a T47D breast cancer cell line overexpressing protein kinase Calpha.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20011001

• A new antiestrogen, 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indol-5-ol hydrochloride (ERA-923), inhibits the growth of tamoxifen-sensitive and -resistant tumors and is devoid of uterotropic effects in mice and rats.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20011001

• Hypoxia reduces hormone responsiveness of human breast cancer cells.

  Japanese journal of cancer research : Gann 20011001

• Comparison of the short-term biological effects of 7alpha-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17beta-diol (Faslodex) versus tamoxifen in postmenopausal women with primary breast cancer.

  Cancer research 20010915

• Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens.

  Toxicology 20010914

• Assessment of the oestrogenic activity of the contraceptive progestin levonorgestrel and its non-phenolic metabolites.

  European journal of pharmacology 20010914

• Hepatic stellate cells contain the functional estrogen receptor beta but not the estrogen receptor alpha in male and female rats.

  Biochemical and biophysical research communications 20010907

• Effects of chronic estrogen-receptor blockade on ovine perinatal pulmonary circulation.

  American journal of physiology. Heart and circulatory physiology 20010901

• Effects of dietary phytoestrogen on global myocardial ischemia-reperfusion injury in isolated female rat hearts.

  American journal of physiology. Heart and circulatory physiology 20010901

• Temporal effects of 17beta-estradiol on caveolin-1 mRNA and protein in bovine aortic endothelial cells.

  American journal of physiology. Heart and circulatory physiology 20010901

• Infertility and testicular atrophy in the antiestrogen-treated adult male rat.

  Biology of reproduction 20010901

• Enhancement of collagen-induced arthritis in female mice by estrogen receptor blockage.

  Arthritis and rheumatism 20010901

• Inhibitory effect of 17beta-estradiol in the parabrachial nucleus is mediated by GABA.

  Brain research 20010824

• Estrogen prevents destabilization of endothelial nitric oxide synthase mRNA induced by tumor necrosis factor alpha through estrogen receptor mediated system.

  Life sciences 20010824

• Activation of estrogen receptor beta is a prerequisite for estrogen-dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes.

  FEBS letters 20010803

• Induction of mammary epithelial cell differentiation and inhibition of dimethylbenz(A)anthracene-induced mammary tumour by co-administration of a pure antiestrogen ICI 182,780 and testosterone enanthate.

  International journal of oncology 20010801

• S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells.

  International journal of oncology 20010801

• Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20010801

• Inhibition of insulin-like growth factor signaling pathways in mammary gland by pure antiestrogen ICI 182,780.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010801

• Molecular identification of potential selective estrogen receptor modulator (SERM) like properties of phytoestrogens in the human breast cancer cell line MCF-7.

  Planta medica 20010801

• Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform.

  Journal of cellular biochemistry 20010801

• Mechanisms of estrogen receptor action in the myocardium. Rapid gene activation via the ERK1/2 pathway and serum response elements.

  The Journal of biological chemistry 20010727

• Estrogen protects neuronal cells from amyloid beta-induced apoptotic cell death.

  Neuroreport 20010703

• Cell-transforming activity and estrogenicity of bisphenol-A and 4 of its analogs in mammalian cells.

  International journal of cancer 20010701

• Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex).

  Endocrinology 20010701

• Induction of UO-44 gene expression by tamoxifen in the rat uterus and ovary.

  Endocrinology 20010701

• Production of steroids by human ovarian surface epithelial cells in culture: possible role of progesterone as growth inhibitor.

  Gynecologic oncology 20010701

• [Developments of hormonal agents for breast cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010701

• Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements.

  The Journal of steroid biochemistry and molecular biology 20010701

• Estrogenic influence on the regulation of hepatic estrogen receptor-alpha and serum level of angiotensinogen in female rats.

  The Journal of steroid biochemistry and molecular biology 20010701

• Induction of apoptosis in mammary gland by a pure anti-estrogen ICI 182780.

  Breast cancer research and treatment 20010701

• Estrogen receptor (ER)alpha and ERbeta exhibit unique pharmacologic properties when coupled to activation of the mitogen-activated protein kinase pathway.

  Endocrinology 20010601

• Identification and implantation stage-specific expression of an interferon-alpha-regulated gene in human and rat endometrium.

  Endocrinology 20010601

• Cyr61, a member of the CCN family, is required for MCF-7 cell proliferation: regulation by 17beta-estradiol and overexpression in human breast cancer.

  Endocrinology 20010601

• Phytoestrogens restore nitric oxide-mediated relaxation in isolated pulmonary arteries from chronically hypoxic rats.

  The Journal of pharmacology and experimental therapeutics 20010601

• Estradiol-regulated expression of the immunophilins cyclophilin 40 and FKBP52 in MCF-7 breast cancer cells.

  Biochemical and biophysical research communications 20010601

• Estrogen and neuroinflammation.

  Urology 20010601

• The Src signaling pathway regulates osteoclast lysosomal enzyme secretion and is rapidly modulated by estrogen.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010601

• ICI 182,780 acts as a partial agonist and antagonist of estradiol effects in specific cells of the sheep uterus.

  The Journal of steroid biochemistry and molecular biology 20010601

• Effects of estrogen on leptin gene promoter activation in MCF-7 breast cancer and JEG-3 choriocarcinoma cells: selective regulation via estrogen receptors alpha and beta.

  Molecular and cellular endocrinology 20010515

• Dexamethasone blocks antioestrogen- and oxidant-induced death of pituitary tumour cells.

  The Journal of endocrinology 20010501

• Effects of acute stanozolol treatment on puberty in female rats.

  Biology of reproduction 20010501

• Differential regulation of retinoblastoma protein by hormonal and antihormonal agents in T47D breast cancer cells.

  The Journal of steroid biochemistry and molecular biology 20010501

• Antagonism of oestrogen action in human breast and endometrial cells in vitro: potential novel antitumour agents.

  Cancer chemotherapy and pharmacology 20010501

• Estrogen receptor binding to DNA is not required for its activity through the nonclassical AP1 pathway.

  The Journal of biological chemistry 20010427

• Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease.

  The Journal of biological chemistry 20010427

• Neuroprotective effects of estrogen against beta-amyloid toxicity are mediated by estrogen receptors in cultured neuronal cells.

  Neuroscience letters 20010413

• Tamoxifen inhibits nerve growth factor-induced proliferation of the human breast cancerous cell line MCF-7.

  Cancer research 20010401

• Relaxant effects of 17-beta-estradiol in cerebral arteries through Ca(2+) entry inhibition.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010401

• Androgen-accelerated bone maturation in mice is not attenuated by Faslodex, an estrogen receptor blocker.

  Bone 20010401

• Synthetic estrogens-mediated activation of JNK intracellular signaling molecule.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20010401

• Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010315

• 17-beta estradiol elicits an autocrine leiomyoma cell proliferation: evidence for a stimulation of protein kinase-dependent pathway.

  Journal of cellular physiology 20010301

• Systemic ICI 182,780 alters the display of sexual behaviors in the female rat.

  Hormones and behavior 20010301

• Estrogens act in rat hippocampus and frontal cortex to produce rapid, receptor-mediated decreases in serotonin 5-HT(1A) receptor function.

  Neuroendocrinology 20010301

• Dehydroepiandrosterone stimulates proliferation and gene expression in MCF-7 cells after conversion to estradiol.

  Molecular and cellular endocrinology 20010227

• Testosterone inhibits osteoclast formation stimulated by parathyroid hormone through androgen receptor.

  FEBS letters 20010223

• Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists.

  Journal of molecular endocrinology 20010201

• Role of androgens in the growth of endometrial carcinoma: an in vivo animal model.

  American journal of obstetrics and gynecology 20010201

• Proliferative effects of combination estrogen and progesterone replacement therapy on the normal postmenopausal mammary gland in a murine model.

  American journal of obstetrics and gynecology 20010201

• Estradiol metabolites inhibit endothelin synthesis by an estrogen receptor-independent mechanism.

  Hypertension (Dallas, Tex. : 1979) 20010201

• Effects of estradiol and its metabolites on glomerular endothelial nitric oxide synthesis and mesangial cell growth.

  Hypertension (Dallas, Tex. : 1979) 20010201

• The phytoestrogen alpha-zearalenol reverses endothelial dysfunction induced by oophorectomy in rats.

  Laboratory investigation; a journal of technical methods and pathology 20010201

• Regulation of progesterone receptors and decidualization in uterine stroma of the estrogen receptor-alpha knockout mouse.

  Biology of reproduction 20010101

• FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent.

  Nature cell biology 20010101

• The PlA polymorphism of glycoprotein IIIa functions as a modifier for the effect of estrogen on platelet aggregation.

  Archives of pathology & laboratory medicine 20010101

• Inhibition of volume-regulated anion channels in cultured endothelial cells by the anti-oestrogens clomiphene and nafoxidine.

  British journal of pharmacology 20010101

• The Twenty-third Annual San Antonio Breast Cancer Symposium.

  Current medical research and opinion 20010101

• Relationship between expression of coactivators and corepressors of hormone receptors and resistance of ovarian cancers to growth regulation by steroid hormones.

  Journal of the Society for Gynecologic Investigation 20010101

• Estrogen downregulates the number of caveolae and the level of caveolin in uterine smooth muscle.

  Cell biology international 20010101

• Effects of oestradiol and the oestrogen antagonist Ici 182,780 on the delayed type hypersensitivity (DTH) index and on serum levels of IgM and IgG in ovariectomised Balb/C and MRL/Mp-Lpr/Lpr mice, a model of systemic lupus erythematosus (SLE).

  Autoimmunity 20010101

• Endometrial effects of pure antiestrogens.

  Tumori 20010101

• Pure antiestrogens and breast cancer.

  Current medical research and opinion 20010101

• Isoflavones inhibit proliferation of ovarian cancer cells in vitro via an estrogen receptor-dependent pathway.

  Nutrition and cancer 20010101

• TCDD elevates erbB2 expression and signaling in T47D cells by reversing serum potentiation of estrogen receptor activity, independent of estrogen levels and enhanced ER down-regulation.

  Molecular and cellular endocrinology 20001222

• Effects of arsenite on estrogen receptor-alpha expression and activity in MCF-7 breast cancer cells.

  Endocrinology 20001001

• Relative binding affinity does not predict biological response to xenoestrogens in rat endometrial adenocarcinoma cells.

  The Journal of steroid biochemistry and molecular biology 20001001

• WISP-2 as a novel estrogen-responsive gene in human breast cancer cells.

  Biochemical and biophysical research communications 20000818

• Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro.

  Toxicological sciences : an official journal of the Society of Toxicology 20000401

• A metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane, reduces testosterone biosynthesis in rat leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme.

  Biology of reproduction 20000301

• Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells.

  The Journal of biological chemistry 20000225

• High concentrations of bisphenol A induce cell growth and prolactin secretion in an estrogen-responsive pituitary tumor cell line.

  Toxicology and applied pharmacology 20000201

• Molecular analysis of the inhibition of monocyte chemoattractant protein-1 gene expression by estrogens and xenoestrogens in MCF-7 cells.

  Endocrinology 20000101

• Comparative analyses of mechanistic differences among antiestrogens.

  Endocrinology 19991201

• The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements.

  Molecular and cellular endocrinology 19991125

• Estrogen directly respresses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons.

  Endocrinology 19991101

• Effects of environmental estrogens on tumor necrosis factor alpha-mediated apoptosis in MCF-7 cells.

  Carcinogenesis 19991101

• Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.

  Molecular endocrinology (Baltimore, Md.) 19990901

• Methoxychlor stimulates estrogen-responsive messenger ribonucleic acids in mouse uterus through a non-estrogen receptor (non-ER) alpha and non-ER beta mechanism.

  Endocrinology 19990801

• Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status.

  Carcinogenesis 19990601

• Estrogenicity of bisphenol A in a human endometrial carcinoma cell line.

  Molecular and cellular endocrinology 19990425

• Perinatal exposure to estrogenic compounds and the subsequent effects on the prostate of the adult rat: evaluation of inflammation in the ventral and lateral lobes.

  Reproductive toxicology (Elmsford, N.Y.) 19990101

• Aryl hydrocarbon receptor-mediated antiestrogenicity in MCF-7 cells: modulation of hormone-induced cell cycle enzymes.

  Archives of biochemistry and biophysics 19980815

• Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse uterus by primary estrogen, catechol estrogen, and xenoestrogen.

  Endocrinology 19980601

• Estradiol induces C-type natriuretic peptide gene expression in mouse uterus.

  The American journal of physiology 19971201

• Effect of toxaphene on estrogen receptor functions in human breast cancer cells.

  Carcinogenesis 19970801

• Estrogen-induced cyclin D1 and D3 gene expressions during mouse uterine cell proliferation in vivo: differential induction mechanism of cyclin D1 and D3.

  Molecular reproduction and development 19970401

• Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.

  Endocrinology 19970301

• DDT mimicks estradiol stimulation of breast cancer cells to enter the cell cycle.

  Molecular carcinogenesis 19970201

• Superinduction of c-fos gene expression by estrogen in cultured guinea-pig endometrial cells requires priming by a cycloheximide-dependent mechanism.

  Endocrinology 19920901

• Placenta defects and embryonic lethality resulting from disruption of mouse hydroxysteroid (17-beta) dehydrogenase 2 gene.

  Molecular endocrinology (Baltimore, Md.)