130-16-5 | 5-Chloro-8-hydroxyquinoline

Packsize	Purity	Availability	Price	Discounted Price
25g	98%	in stock	$9.00	$6.00
100g	98%	in stock	$28.00	$19.00
500g	98%	in stock	$109.00	$76.00

Description

• Catalog Number: AA38491
• Chemical Name: 5-Chloro-8-hydroxyquinoline
• CAS Number: 130-16-5
• Molecular Formula: C9H6ClNO
• Molecular Weight: 179.60304
• MDL Number: MFCD00006788
• SMILES: Clc1ccc(c2c1cccn2)O

Computed Properties

• Complexity: 165
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 2.9

Literature

• Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.

  Journal of medicinal chemistry 20130328

• Synthesis and characterization of 8-hydroxyquinoline complexes of tin(IV) and their application in organic light emitting diode.

  Journal of fluorescence 20120901

• Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.

  The Journal of antimicrobial chemotherapy 20120201

• Investigation on the pharmacological profile of antimony(III) complexes with hydroxyquinoline derivatives: anti-trypanosomal activity and cytotoxicity against human leukemia cell lines.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20110801

• Supramolecular synthon pattern in solid clioquinol and cloxiquine (APIs of antibacterial, antifungal, antiaging and antituberculosis drugs) studied by ³⁵Cl NQR, ¹H-¹⁷O and ¹H-¹⁴N NQDR and DFT/QTAIM.

  Journal of molecular modeling 20110701

• Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

  Journal of medicinal chemistry 20110127

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Grafting aluminum(III) 8-hydroxyquinoline derivatives on MCM-41 mesoporous silica for tuning of the light emitting color.

  Journal of colloid and interface science 20100615

• 5-Chloro-8-hydroxy-quinolinium nitrate.

  Acta crystallographica. Section E, Structure reports online 20090601

• Vibrational spectroscopic investigations, ab initio and DFT studies on 7-bromo-5-chloro-8-hydroxyquinoline.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090501

• Bis(μ-5-chloro-quinolin-8-olato)-κN,O:O;κO:N,O-bis-[(acetato-κO,O')lead(II)].

  Acta crystallographica. Section E, Structure reports online 20090301

• Outlook on Thailand's genomics and computational biology research and development.

  PLoS computational biology 20080701

• Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

  The Biochemical journal 20071101

• In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.

  Antimicrobial agents and chemotherapy 20070301

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• The evaluation of liposome-water partitioning of 8-hydroxyquinolines and their copper complexes.

  Environmental science & technology 20060315