130641-38-2 | Bindarit

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥98%	in stock	$33.00	$23.00
5mg	≥98%	in stock	$121.00	$85.00
10mg	≥98%	in stock	$193.00	$135.00
25mg	≥98%	in stock	$322.00	$225.00
200mg		in stock	$2,022.00	$1,416.00

Description

• Catalog Number: AA39636
• Chemical Name: Bindarit
• CAS Number: 130641-38-2
• Molecular Formula: C19H20N2O3
• Molecular Weight: 324.3737
• MDL Number: MFCD00866723
• SMILES: OC(=O)C(OCc1nn(c2c1cccc2)Cc1ccccc1)(C)C

Computed Properties

• Complexity: 434
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 6
• XLogP3: 3

Literature

• Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1 [corrected].

  Annals of the New York Academy of Sciences 20120401

• Protective effects of MCP-1 inhibitor on a rat model of severe acute pancreatitis.

  Hepatobiliary & pancreatic diseases international : HBPD INT 20100401

• The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice.

  Cardiovascular research 20091201

• The chemokine monocyte chemoattractant protein-1 contributes to renal dysfunction in swine renovascular hypertension.

  Journal of hypertension 20091001

• Treatment with bindarit, an inhibitor of MCP-1 synthesis, protects mice against trinitrobenzene sulfonic acid-induced colitis.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20081001

• Impact of the anti-inflammatory agent bindarit on the chemokinome: selective inhibition of the monocyte chemotactic proteins.

  European cytokine network 20080901

• Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft.

  The Journal of investigative dermatology 20070801

• Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis.

  American journal of physiology. Gastrointestinal and liver physiology 20050601

• Amelioration of rat adjuvant arthritis by therapeutic treatment with bindarit, an inhibitor of MCP-1 and TNF-alpha production.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020501

• Advances in the treatment of lupus nephritis.

  Annual review of medicine 20010101