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Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.
Toxicology and applied pharmacology 20170301
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Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action.
PloS one 20140101
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Bmi1 is required for regeneration of the exocrine pancreas in mice.
Gastroenterology 20120901
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Small-molecule inhibitors of the protein methyltransferase SET7/9 identified in a high-throughput screen.
Journal of biomolecular screening 20120901
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The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat.
Experimental and molecular pathology 20120801
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Prevention effects of ND-07, a novel drug candidate with a potent antioxidative action and anti-inflammatory action, in animal models of severe acute pancreatitis.
European journal of pharmacology 20120715
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Identification and characterization of genes related to the production of organic acids in yeast.
Journal of bioscience and bioengineering 20120501
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Role of bone marrow cells in the development of pancreatic fibrosis in a rat model of pancreatitis induced by a choline-deficient/ethionine-supplemented diet.
Biochemical and biophysical research communications 20120420
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Automated annotation and quantification of metabolites in 1H NMR data of biological origin.
Analytical and bioanalytical chemistry 20120401
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Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.
Nature medicine 20120304
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Importance of methionine metabolism in morula-to-blastocyst transition in bovine preimplantation embryos.
The Journal of reproduction and development 20120101
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
PLoS computational biology 20111201
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Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury.
The American journal of pathology 20111001
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Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice.
Laboratory investigation; a journal of technical methods and pathology 20110701
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Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice.
American journal of physiology. Gastrointestinal and liver physiology 20110601
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Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response.
Gut 20110401
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New short term prediction method for chemical carcinogenicity by hepatic transcript profiling following 28-day toxicity tests in rats.
Cancer informatics 20110101
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug metabolism and disposition: the biological fate of chemicals 20101201
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Age dependence of oval cell responses and bile duct carcinomas in male fischer 344 rats fed a cyclic choline-deficient, ethionine-supplemented diet.
Hepatology (Baltimore, Md.) 20101101
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Impaired liver glucose production in a murine model of steatosis and endotoxemia: protection by inducible nitric oxide synthase.
Antioxidants & redox signaling 20100701
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Effects of acute ethionine injection on plasma ghrelin and obestatin levels in trained male rats.
Metabolism: clinical and experimental 20100701
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Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells.
Hepatology (Baltimore, Md.) 20100701
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Imprinting: RNA expression for homocysteine recycling in the human oocyte.
Fertility and sterility 20100315
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Time-resolved biomarker discovery in 1H-NMR data using generalized fuzzy Hough transform alignment and parallel factor analysis.
Analytical and bioanalytical chemistry 20100301
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A medium-term, rapid rat bioassay model for the detection of carcinogenic potential of chemicals.
Toxicologic pathology 20100101
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Chronic pancreatitis in mice by treatment with choline-deficient ethionine-supplemented diet.
Experimental animals 20100101
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An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial.
Reproductive toxicology (Elmsford, N.Y.) 20091201
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Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database.
Toxicology 20091109
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Superoxide dismutase activity as a measure of hepatic oxidative stress in cattle following ethionine administration.
Veterinary journal (London, England : 1997) 20091101
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Ethionine-induced ATP depletion represses mTOR signaling in the absence of increases in AMP-activated protein kinase activity in the rat liver.
Bioscience, biotechnology, and biochemistry 20090901
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Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy.
The Journal of toxicological sciences 20090601
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Separation and determination of seleno amino acids using gas chromatography hyphenated with inductively coupled plasma mass spectrometry after hollow fiber liquid phase microextraction.
Journal of mass spectrometry : JMS 20090501
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Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury.
Hepatology (Baltimore, Md.) 20090501
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Expression of extracellular matrix genes in cultured hepatic oval cells: an origin of hepatic stellate cells through transforming growth factor beta?
Liver international : official journal of the International Association for the Study of the Liver 20090401
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Risperidone attenuates local and systemic inflammatory responses to ameliorate diet-induced severe necrotic pancreatitis in mice: it may provide a new therapy for acute pancreatitis.
The Journal of pharmacology and experimental therapeutics 20090101
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Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury.
Hepatology (Baltimore, Md.) 20090101
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Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats.
Clinics (Sao Paulo, Brazil) 20081201
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C-kit inhibition by imatinib mesylate attenuates progenitor cell expansion and inhibits liver tumor formation in mice.
Gastroenterology 20080901
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Bone marrow cells play only a very minor role in chronic liver regeneration induced by a choline-deficient, ethionine-supplemented diet.
Stem cell research 20080901
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Total glutathione and glutathione reductase in bovine erythrocytes and liver biopsy.
The Journal of veterinary medical science 20080801
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X-ray structure of the [FeFe]-hydrogenase maturase HydE from Thermotoga maritima.
The Journal of biological chemistry 20080704
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Random mutagenesis and recombination of sam1 gene by integrating error-prone PCR with staggered extension process.
Biotechnology letters 20080701
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Bone marrow-derived cells fuse with hepatic oval cells but are not involved in hepatic tumorigenesis in the choline-deficient ethionine-supplemented diet rat model.
Carcinogenesis 20080201
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Misincorporation of amino acid analogues into proteins by biosynthesis.
The international journal of biochemistry & cell biology 20080101
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Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice.
Laboratory investigation; a journal of technical methods and pathology 20071201
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Analysis of time-related metabolic fluctuations induced by ethionine in the rat.
Journal of proteome research 20071201
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The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.
The Journal of biological chemistry 20070824
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Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury.
British journal of pharmacology 20070801
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6His-Eco29kI methyltransferase methylation site and kinetic mechanism characterization.
Biochimica et biophysica acta 20070801
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Characteristics of methionine production by an engineered Corynebacterium glutamicum strain.
Metabolic engineering 20070701
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Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells.
Hepatology research : the official journal of the Japan Society of Hepatology 20070501
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Hepatotoxin-induced hypertyrosinemia and its toxicological significance.
Archives of toxicology 20070301
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Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
Plant & cell physiology 20070201
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Different effects of sulfur amino acids on prolidase and prolinase activity in normal and prolidase-deficient human erythrocytes.
Clinica chimica acta; international journal of clinical chemistry 20070101
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Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice.
Journal of hepatology 20070101
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Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet.
The international journal of biochemistry & cell biology 20070101
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An unusual S-adenosylmethionine synthetase gene from dinoflagellate is methylated.
BMC molecular biology 20070101
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Activation of nuclear factor kappa B and severe hepatic necrosis may mediate systemic inflammation in choline-deficient/ethionine-supplemented diet-induced pancreatitis.
Pancreas 20061001
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Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor.
Carcinogenesis 20060801
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Integrity of the methylation cycle is essential for mammalian neural tube closure.
Birth defects research. Part A, Clinical and molecular teratology 20060701
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Natural and directed biosynthesis of communesin alkaloids.
Phytochemistry 20060301
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Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels.
Bioorganic & medicinal chemistry letters 20060301
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Effect of amino acids containing sulfur on dithiolopyrrolone antibiotic productions by Saccharothrix algeriensis NRRL B-24137.
Journal of applied microbiology 20060201
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S-adenosyl methionine: A connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer's disease.
The journal of nutrition, health & aging 20060101
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Harnessing natural diversity to probe metabolic pathways.
PLoS genetics 20051201
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Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis.
European journal of pharmacology 20051003
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Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta.
Carcinogenesis 20051001
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Regional differences in gastrointestinal motility disturbances during acute necrotising pancreatitis.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20051001
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Single-gene knockout of a novel regulatory element confers ethionine resistance and elevates methionine production in Corynebacterium glutamicum.
Applied microbiology and biotechnology 20050801
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Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury.
Immunology and cell biology 20050801
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Natural disruption of group 2 phospholipase A2 gene protects against choline-deficient ethionine-supplemented diet-induced acute pancreatitis and lung injury.
Pancreas 20050701
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Experimental cell research 20050515
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Differential lymphotoxin-beta and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury.
Hepatology (Baltimore, Md.) 20050201
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TNF/LTalpha double knockout mice display abnormal inflammatory and regenerative responses to acute and chronic liver injury.
Cell and tissue research 20050101
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In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid.
Journal of medicinal food 20050101
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Selection and characterization of L-ethionine resistant mutants of Trichosporon cutaneum.
Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101
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Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis.
The American journal of pathology 20041201
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Nihon rinsho. Japanese journal of clinical medicine 20041101
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Decreases in serum apolipoprotein C-III concentration in cows with ethionine-induced fatty liver.
The Journal of veterinary medical science 20040901
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Suppression of 8-oxo-2'-deoxyguanosine formation and carcinogenesis induced by N-nitrosobis (2-oxopropyl)amine in hamsters by esculetin and esculin.
Free radical research 20040801
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Protective effect of soybean against hepatocarcinogenesis induced by DL-ethionine.
Journal of biochemistry and molecular biology 20040531
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Gene expression profiles in liver regeneration with oval cell induction.
Biochemical and biophysical research communications 20040430
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Activation, isolation, identification and in vitro proliferation of oval cells from adult rat livers.
Cell proliferation 20040401
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Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation.
Journal of cell science 20040401
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Direct effects of interleukin-6 on liver progenitor oval cells in culture.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20040101
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Enhancement of the primary flavor compound methional in potato by increasing the level of soluble methionine.
Journal of agricultural and food chemistry 20030910
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Cellular proliferation in the canine pancreas after d,l-ethionine dosage as detected by double immunohistochemical labelling.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030901
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S-adenosylmethionine (AdoMet) modulates endotoxin stimulated interleukin-10 production in monocytes.
American journal of physiology. Gastrointestinal and liver physiology 20030601
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Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese.
Biochemistry 20030506
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An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria.
Archives of toxicology 20030401
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Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis.
Gastroenterology 20030301
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Diminished lung injury with vascular adhesion molecule-1 blockade in choline-deficient ethionine diet-induced pancreatitis.
Surgery 20030201
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Pancreatic concentrations of cefepime in experimental necrotizing pancreatitis.
Journal of chemotherapy (Florence, Italy) 20030201
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Role of S-adenosylmethionine in two experimental models of pancreatitis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030101
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Effect of IS-741 on ethionine-induced acute pancreatitis in rats: relation to pancreatic acinar cell regeneration.
Journal of gastroenterology 20030101
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Pancreatic regeneration after ethionine-induced acute pancreatitis in rats lacking pancreatic CCK-A receptor gene expression.
Journal of gastroenterology 20030101
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Translational initiation regulators are hypophosphorylated in rat liver during ethionine-mediated ATP depletion.
Biochemical and biophysical research communications 20021025
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Ethanol interactions with a choline-deficient, ethionine-supplemented feeding regime potentiate pre-neoplastic cellular alterations in rat liver.
Carcinogenesis 20021001
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Identification of a short highly conserved amino acid sequence as the functional region required for posttranscriptional autoregulation of the cystathionine gamma-synthase gene in Arabidopsis.
The Journal of biological chemistry 20020927
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Isolation, cloning and expression of a multifunctional O-methyltransferase capable of forming 2,5-dimethyl-4-methoxy-3(2H)-furanone, one of the key aroma compounds in strawberry fruits.
The Plant journal : for cell and molecular biology 20020901
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Effect of d,l-ethionine administration on the histomorphology of canine pancreatic acinar and beta-cells.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20020801
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A single-nucleotide mutation in a gene encoding S-adenosylmethionine synthetase is associated with methionine over-accumulation phenotype in Arabidopsis thaliana.
Genes & genetic systems 20020401
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Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma.
Carcinogenesis 20020301
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Protein repair methyltransferase from the hyperthermophilic archaeon Pyrococcus furiosus. Unusual methyl-accepting affinity for D-aspartyl and N-succinyl-containing peptides.
The Journal of biological chemistry 20020111
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Constitutive overexpression of cystathionine gamma-synthase in Arabidopsis leads to accumulation of soluble methionine and S-methylmethionine.
Plant physiology 20020101
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Evaluation of d,l-ethionine as a mechanism for pancreatic islet regeneration in dogs.
Australian veterinary journal 20020101
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Methionine depletion induces transcription of the mRNA (N6-adenosine)methyltransferase.
The international journal of biochemistry & cell biology 20011101
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Methylation is involved in the Ustilago maydis mating response.
Fungal genetics and biology : FG & B 20011001
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A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver.
Hepatology (Baltimore, Md.) 20010901
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Adenoviral delivery of human and viral IL-10 in murine sepsis.
Journal of immunology (Baltimore, Md. : 1950) 20010715
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Biosynthesis of diaporthin and orthosporin by Aspergillus ochraceus.
Phytochemistry 20010501
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Evaluation of lysine and methionine production in some Lactobacilli and yeasts from ogi.
International journal of food microbiology 20010122
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Methionine deprivation and methionine analogs inhibit cell proliferation and growth of human xenografted gliomas.
Life sciences 19970101
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13-cis-retinoic acid and hepatic steatosis in rats.
Biochemical pharmacology 19930720
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Effects of the seleno-organic substance Ebselen in two different models of acute pancreatitis.
Pancreas 19910501
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Correlation between medium-term liver bioassay system data and results of long-term testing in rats.
Carcinogenesis 19900401
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Hepatic levels of cytosolic, microsomal and 'mitochondrial' epoxide hydrolases and other drug-metabolizing enzymes after treatment of mice with various xenobiotics and endogenous compounds.
Chemico-biological interactions 19870101
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Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver.
Environmental health perspectives 19830401
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Increased alpha1-fetoprotein production in rat liver injuries induced by various hepatotoxins.
Gan 19760401
