131-01-1 | Yohimban-16-carboxylic acid,17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester,(3b,16b,17a,18b,20a)-

Packsize	Purity	Availability	Price	Discounted Price
5mg	95%	in stock	$165.00	$116.00
10mg	95%	in stock	$270.00	$189.00
25mg	95%	in stock	$540.00	$378.00

Description

• Catalog Number: AW54147
• Chemical Name: Yohimban-16-carboxylic acid,17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester,(3b,16b,17a,18b,20a)-
• CAS Number: 131-01-1
• Molecular Formula: C32H38N2O8
• Molecular Weight: 578.6527
• MDL Number: MFCD00078228
• SMILES: COC(=O)[C@@H]1[C@@H](OC)[C@@H](C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c1[nH]c1c2cccc1)OC(=O)c1cc(OC)c(c(c1)OC)OC
• NSC Number: 72138

Computed Properties

• Complexity: 953
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 6
• Heavy Atom Count: 42
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 9
• XLogP3: 4.1

Literature

• [Application of recording SK2 current in human atrial myocytes by perforated patch clamp techniques with the mix of beta-escin and amphotericin B].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20120501

• Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells.

  The Journal of pharmacology and experimental therapeutics 20100701

• KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel.

  Life sciences 20100508

• Calcium sensitization induced by sodium fluoride in permeabilized rat mesenteric arteries.

  The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20100201

• Beta-escin has potent anti-allergic efficacy and reduces allergic airway inflammation.

  BMC immunology 20100101

• Brain Activation by Peptide Pro-Leu-Gly-NH(2) (MIF-1).

  International journal of peptides 20100101

• Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic Response.

  Journal of nucleic acids 20100101

• Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091001

• Beta-escin, a natural triterpenoid saponin from Chinese horse chestnut seeds, depresses HL-60 human leukaemia cell proliferation and induces apoptosis.

  The Journal of pharmacy and pharmacology 20080901

• Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor.

  Pflugers Archiv : European journal of physiology 20080501

• Intracellular calcium stores in beta-escin skinned rat and guinea-pig bladders.

  European journal of pharmacology 20070702

• Acylation with diangeloyl groups at C21-22 positions in triterpenoid saponins is essential for cytotoxicity towards tumor cells.

  Biochemical pharmacology 20070201

• The shikonin derivatives and pyrrolizidine alkaloids in hairy root cultures of Lithospermum canescens (Michx.) Lehm.

  Plant cell reports 20061001

• Involvement of Rho kinase and protein kinase C in carbachol-induced calcium sensitization in beta-escin skinned rat and guinea-pig bladders.

  British journal of pharmacology 20060601

• Beta-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21(waf1/cip1) in colon cancer cells.

  Molecular cancer therapeutics 20060601

• Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current.

  Journal of cardiovascular electrophysiology 20060501

• Synthesis of deserpidine from reserpine.

  Journal of natural products 20051101

• Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology.

  The Journal of biological chemistry 20050325

• Ca2+-independent hypoxic vasorelaxation in porcine coronary artery.

  The Journal of physiology 20050201

• Inhibition by cytoplasmic nucleotides of a new cation channel in freshly isolated human and rat type II pneumocytes.

  American journal of physiology. Lung cellular and molecular physiology 20041201

• Beta-escin diminishes voltage-gated calcium current rundown in perforated patch-clamp recordings from rat primary afferent neurons.

  Journal of neuroscience methods 20041015

• Nitric oxide relaxes rat tail artery smooth muscle by cyclic GMP-independent decrease in calcium sensitivity of myofilaments.

  Cell calcium 20040801

• Perforated patch recording of L-type calcium current with beta-escin in guinea pig ventricular myocytes.

  Acta pharmacologica Sinica 20031101

• Dependence of Ca2+-induced contraction on ATP in alpha-toxin-permeabilized preparations of rat femoral artery.

  Journal of pharmacological sciences 20031001

• Characterization of alpha-soluble N-ethylmaleimide-sensitive fusion attachment protein in alveolar type II cells: implications in lung surfactant secretion.

  American journal of respiratory cell and molecular biology 20030901

• Lowdenic acid: a new antifungal polyketide-derived metabolite from a new fungicolous Verticillium sp.

  Journal of natural products 20030901

• Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox.

  The Journal of clinical investigation 20030815

• Troponin I inhibitory peptide suppresses the force generation in smooth muscle by directly interfering with cross-bridge formation.

  Biochemical and biophysical research communications 20030725

• Measurement of the dissociation constant of Fluo-3 for Ca2+ in isolated rabbit cardiomyocytes using Ca2+ wave characteristics.

  Cell calcium 20030701

• CaM kinase IIalpha mediates norepinephrine-induced translocation of cytosolic phospholipase A2 to the nuclear envelope.

  Journal of cell science 20030115

• Pyrrolizidine alkaloids from Lithospermum canescens Lehm.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

• [Effect of inhibiting protein kinase C on calcium sensitivity of contractile apparatus of vascular smooth muscle during vasospasms of different origins].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20030101

• Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells.

  British journal of pharmacology 20020401

• Extensive skinning of cell membrane diminishes the force-inhibiting effect of okadaic acid on smooth muscles of Guinea pig hepatic portal vein.

  The Japanese journal of physiology 20020401

• Muscarinic excitation-contraction coupling mechanisms in tracheal and bronchial smooth muscles.

  Journal of applied physiology (Bethesda, Md. : 1985) 20010901

• Synexin and GTP increase surfactant secretion in permeabilized alveolar type II cells.

  American journal of physiology. Lung cellular and molecular physiology 20010501

• Inhibition of capacitative calcium entry is not obligatory for relaxation of the mouse anococcygeus by the NO/cyclic GMP signalling pathway.

  British journal of pharmacology 20010201

• Protein kinase C suppresses spontaneous, transient, outwards K+ currents through modulation of the Na/Ca exchanger in guinea-pig gastric myocytes.

  Pflugers Archiv : European journal of physiology 20010101

• Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

  Journal of natural products 19910101