1312309-63-9 | Azido-PEG2-acid

Packsize	Purity	Availability	Price	Discounted Price
100mg	96%	in stock	$25.00	$17.00
250mg	96%	in stock	$36.00	$25.00
500mg	96%	in stock	$58.00	$40.00
1g	96%	in stock	$93.00	$65.00
5g	96%	in stock	$278.00	$195.00
10g	96%	in stock	$462.00	$324.00

Description

• Catalog Number: AB53614
• Chemical Name: Azido-PEG2-acid
• CAS Number: 1312309-63-9
• Molecular Formula: C7H13N3O4
• Molecular Weight: 203.19582000000005
• MDL Number: MFCD20926378
• SMILES: [N-]=[N+]=NCCOCCOCCC(=O)O

Computed Properties

• Complexity: 203
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 9
• XLogP3: 0.3

Upstream Synthesis Route

The upstream synthesis route of Azido-PEG2-acid (where PEG stands for polyethylene glycol) involves the following key steps:

1. **Starting Material**: The synthesis typically begins with the commercially available monomethyl ether of PEG (mPEG) with two ethylene glycol units, known as mPEG2-OH.

2. **Activation of Carboxylic Acid**: The terminal hydroxyl group of mPEG2-OH is first activated using a suitable reagent such as DCC (dicyclohexylcarbodiimide) in the presence of a catalyst like DMAP (4-dimethylaminopyridine) to form the active ester intermediate.

3. **Azide Introduction**: The active ester is then reacted with sodium azide (NaN3) in a solvent like DMF (dimethylformamide) or DMSO (dimethyl sulfoxide) to substitute the leaving group with the azide functionality, yielding mPEG2-N3.

4. **Hydrolysis to Acid**: The azide-terminated PEG is finally hydrolyzed using a strong acid like hydrochloric acid or through base-catalyzed hydrolysis to introduce the carboxylic acid group, resulting in Azido-PEG2-acid.

Throughout each step of the synthesis, purification is typically performed via column chromatography, dialysis, or precipitation, and the identity and purity of the intermediates and final product are confirmed using techniques such as NMR (nuclear magnetic resonance), HPLC (high-performance liquid chromatography), and mass spectrometry.