1314978-36-3 | 5-Chloropyridazin-3-amine

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$45.00	$32.00
250mg	98%	in stock	$76.00	$54.00
1g	98%	in stock	$155.00	$109.00

Description

• Catalog Number: AA41718
• Chemical Name: 5-Chloropyridazin-3-amine
• CAS Number: 1314978-36-3
• Molecular Formula: C4H4ClN3
• Molecular Weight: 129.5477
• MDL Number: MFCD19214495
• SMILES: Clc1cnnc(c1)N

Upstream Synthesis Route

The upstream synthesis of 5-chloropyridazin-3-amine would typically involve the following steps:

1. **Diazotization Reaction**: Starting with 3-amino pyridazine, a diazotization reaction is performed using sodium nitrite (NaNO2) and hydrochloric acid (HCl) at low temperatures to form the corresponding diazonium salt.

2. **Sandmeyer Reaction**: The resulting diazonium salt is then subjected to a Sandmeyer reaction where it is reacted with copper(I) chloride (CuCl) to introduce the chloro substituent at the 5-position of the pyridazine ring, yielding 5-chloropyridazin-3-amine.

Handling and reaction conditions must be carefully controlled due to the reactive nature of diazonium intermediates and potential to form hazardous byproducts. The choice of solvents, temperatures, and reaction times are critical for the successful synthesis of the target compound.