131865-88-8 | Adenosine, 2-[2-(4-chlorophenyl)ethoxy]-

Packsize	Purity	Availability	Price	Discounted Price
10mg		4 weeks	$250.00	$175.00
25mg		4 weeks	$322.00	$225.00
50mg		4 weeks	$465.00	$325.00
100mg		4 weeks	$643.00	$450.00
250mg		4 weeks	$1,304.00	$913.00

Description

• Catalog Number: AA46267
• Chemical Name: Adenosine, 2-[2-(4-chlorophenyl)ethoxy]-
• CAS Number: 131865-88-8
• Molecular Formula: C18H20ClN5O5
• Molecular Weight: 421.8349
• MDL Number: MFCD16621070
• SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(OCCc1ccc(cc1)Cl)nc2N

Computed Properties

• Complexity: 543
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 6
• XLogP3: 1.8

Literature

• Adenosine A2A receptor as a drug discovery target.

  Journal of medicinal chemistry 20140508

• Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor.

  Journal of medicinal chemistry 20120112

• Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis.

  British journal of pharmacology 20060801

• Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages.

  Journal of leukocyte biology 20040901

• Adenosine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Becaplermin gel).

  Inflammation 20020201

• Design, synthesis, and evaluation of novel A2A adenosine receptor agonists.

  Journal of medicinal chemistry 20010215