133081-24-0 | 6-Hydrazinonicotinic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$6.00	$4.00
1g	95%	in stock	$17.00	$12.00
5g	95%	in stock	$20.00	$14.00
25g	95%	in stock	$61.00	$43.00

Description

• Catalog Number: AA51928
• Chemical Name: 6-Hydrazinonicotinic acid
• CAS Number: 133081-24-0
• Molecular Formula: C6H7N3O2
• Molecular Weight: 153.1387
• MDL Number: MFCD03788692
• SMILES: NNc1ccc(cn1)C(=O)O

Computed Properties

• Complexity: 151
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: -2.3

Literature

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  Dalton transactions (Cambridge, England : 2003) 20110621

• Preparation of catalytically active, covalent α-polylysine-enzyme conjugates via UV/vis-quantifiable bis-aryl hydrazone bond formation.

  Biomacromolecules 20110110

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  Nuclear medicine and biology 20110101

• Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20101201

• Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques.

  European journal of nuclear medicine and molecular imaging 20101101

• Gd-EDDA/HYNIC-RGD as an MR molecular probe imaging integrin alphanubeta3 receptor-expressed tumor-MR molecular imaging of angiogenesis.

  European journal of radiology 20100201

• Changes in vascular permeability and expression of different angiogenic factors following anti-angiogenic treatment in rat glioma.

  PloS one 20100101

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  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20091001

• Development of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase on malignant tumors.

  Biological & pharmaceutical bulletin 20090701

• Clinical evaluation of antimicrobial peptide [(99m)Tc/Tricine/HYNIC(0)]ubiquicidin 29-41 as a human-specific infection imaging agent.

  Nuclear medicine and biology 20090201

• Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20081001

• Breast tumor targeting with (99m)Tc-HYNIC-PR81 complex as a new biologic radiopharmaceutical.

  Nuclear medicine and biology 20081001

• 99mTc-labeled duramycin as a novel phosphatidylethanolamine-binding molecular probe.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080801

• Radiolabeling of annexin A5 with (99m)Tc: comparison of HYNIC-Tc vs. iminothiolane-Tc-tricarbonyl conjugates.

  Nuclear medicine and biology 20080801

• Initial direct comparison of 99mTc-TOC and 99mTc-TATE in identifying sites of disease in patients with proven GEP NETs.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080701

• A technetium intermediate specifically promotes deprotection of trifluoroacetyl HYNIC during radiolabelling under mild conditions.

  Dalton transactions (Cambridge, England : 2003) 20080614

• Label-free detection of biomolecular interactions in real time with a nano-porous silicon-based detection method.

  Proteome science 20080101

• Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20071101

• Two peptide receptor ligands (99m)Tc-EDDA/HYNIC-Tyr(3)-octreotide and (99m)Tc-EDDA/HYNIC-(D)Glu-octagastrin for scintigraphy of medullary thyroid carcinoma.

  Cancer biotherapy & radiopharmaceuticals 20071001

• Preclinical evaluation of [99mTc/EDDA/tricine/HYNIC0, 1-Nal3, Thr8]-octreotide as a new analogue in the detection of somatostatin-receptor-positive tumors.

  Nuclear medicine and biology 20070801

• Confirmation of hydrazone formation in HYNIC-peptide conjugate preparation, and its hydrolysis during labeling with (99m)Tc.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20070701

• Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging.

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  Anti-cancer agents in medicinal chemistry 20070501

• Trifluoroacetyl-HYNIC peptides: synthesis and 99mTc radiolabeling.

  Journal of medicinal chemistry 20070322

• 99mTc-EDDA/HYNIC-octreotate in detection of atypical bronchial carcinoid.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20070101

• Synthesis of oxytocin HYNIC derivatives as potential diagnostic agents for breast cancer.

  Bioconjugate chemistry 20070101

• Labelling of the anti-III-neurotubulin monoclonal antibody by 99mTc and its binding to responsible antigen.

  Nuclear medicine review. Central & Eastern Europe 20070101

• The effect of Tc-99m-labeled MDM2 antisense oligonucleotide on gene expression in human breast cancer MCF-7 cells.

  Journal of experimental therapeutics & oncology 20070101

• Development of a novel 99mTc-chelate-conjugated bisphosphonate with high affinity for bone as a bone scintigraphic agent.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20061201

• [99mTc]HYNIC-RGD for imaging integrin alphavbeta3 expression.

  Nuclear medicine and biology 20061101

• An improved method of 18F peptide labeling: hydrazone formation with HYNIC-conjugated c(RGDyK).

  Nuclear medicine and biology 20060701

• Annexin V SPECT imaging of phosphatidylserine expression in patients with dementia.

  Neurology 20060425

• Radiolabeled melanin-binding peptides are safe and effective in treatment of human pigmented melanoma in a mouse model of disease.

  Cancer biotherapy & radiopharmaceuticals 20060401

• Chemoselective hydrazone formation between HYNIC-functionalized peptides and (18)F-fluorinated aldehydes.

  Nuclear medicine and biology 20060201

• A novel ternary ligand system useful for preparation of cationic (99m)Tc-diazenido complexes and (99m)Tc-labeling of small biomolecules.

  Bioconjugate chemistry 20060101

• Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci.

  Journal of medicinal chemistry 20051006

• Evaluation of [99mTc/EDDA/HYNIC0]octreotide derivatives compared with [111In-DOTA0,Tyr3, Thr8]octreotide and [111In-DTPA0]octreotide: does tumor or pancreas uptake correlate with the rate of internalization?

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050901

• [99mTc] HYNIC-hEGF, a potential agent for imaging of EGF receptors in vivo: preparation and pre-clinical evaluation.

  Oncology reports 20050601

• Annexin A5 scintigraphy of forearm as a novel in vivo model of skeletal muscle preconditioning in humans.

  Circulation 20050118

• 99mTc-labeled mannosyl-neoglycoalbumin for sentinel lymph node identification.

  Nuclear medicine and biology 20041001

• Intratumoral injection of 188Re labeled cationic polyethylenimine conjugates: a preliminary report.

  Journal of Korean medical science 20041001

• Intraobserver, interobserver, and day-to-day reproducibility of quantitative 99mTc-HYNIC annexin-V imaging in head and neck carcinoma.

  Cancer biotherapy & radiopharmaceuticals 20040401

• 99mTc-Hynic-Annexin V. North American Scientific.

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• 99mTc-labeling and in vitro and in vivo evaluation of HYNIC- and (Nalpha-His)acetic acid-modified [D-Glu1]-minigastrin.

  Bioconjugate chemistry 20040101

• Lys and Arg in UBI: a specific site for a stable Tc-99m complex?

  Nuclear medicine and biology 20030801

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  Journal of medicinal chemistry 20030424

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  Nuclear medicine and biology 20030201

• Phosphine-containing HYNIC derivatives as potential bifunctional chelators for (99m)Tc-labeling of small biomolecules.

  Bioconjugate chemistry 20030101

• Nitriles form mixed-coligand complexes with (99m)Tc-HYNIC-peptide.

  Nuclear medicine and biology 20020101

• Control of radioactivity pharmacokinetics of 99mTc-HYNIC-labeled polypeptides derivatized with ternary ligand complexes.

  Bioconjugate chemistry 20020101

• In vitro and in vivo evaluation of a Technetium-99m-labeled cyclic RGD peptide as a specific marker of alpha(V)beta(3) integrin for tumor imaging.

  Bioconjugate chemistry 20020101

• Specific and rapid scintigraphic detection of infection with 99mTc-labeled interleukin-8.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20010101