133407-82-6 | Mg-132

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$22.00	$15.00
5mg	98%	in stock	$38.00	$27.00
10mg	98%	in stock	$60.00	$42.00
25mg	98%	in stock	$115.00	$81.00
50mg	98%	in stock	$194.00	$136.00
100mg	98%	in stock	$306.00	$214.00
250mg	98%	in stock	$436.00	$305.00

Description

• Catalog Number: AD30012
• Chemical Name: Mg-132
• CAS Number: 133407-82-6
• Molecular Formula: C26H41N3O5
• Molecular Weight: 475.62083999999993
• MDL Number: MFCD00674886
• SMILES: O=C[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(C)C)CC(C)C)CC(C)C

Computed Properties

• Complexity: 644
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 3
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 15
• XLogP3: 4.8

Literature

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  Experimental cell research 20120801

• Apolipoprotein A-I mimetic peptides inhibit expression and activity of hypoxia-inducible factor-1α in human ovarian cancer cell lines and a mouse ovarian cancer model.

  The Journal of pharmacology and experimental therapeutics 20120801

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  Endocrinology 20120801

• Infrasonic noise induces axonal degeneration of cultured neurons via a Ca²⁺ influx pathway.

  Toxicology letters 20120720

• Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms.

  The Journal of biological chemistry 20120706

• MG132 alleviates liver injury induced by intestinal ischemia/reperfusion in rats: involvement of the AhR and NFκB pathways.

  The Journal of surgical research 20120701

• Noxa/Mcl-1 balance influences the effect of the proteasome inhibitor MG-132 in combination with anticancer agents in pancreatic cancer cell lines.

  Anti-cancer drugs 20120701

• SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β-catenin.

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• Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression.

  Cancer letters 20120628

• Activity-dependent growth of new dendritic spines is regulated by the proteasome.

  Neuron 20120621

• Sodium arsenite down-regulates the expression of X-linked inhibitor of apoptosis protein via translational and post-translational mechanisms in hepatocellular carcinoma.

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• Degradation of mouse NTE-related esterase by macroautophagy and the proteasome.

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• Sustained intrahepatic glutathione depletion causes proteasomal degradation of multidrug resistance-associated protein 2 in rat liver.

  Biochimica et biophysica acta 20120601

• Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis.

  Journal of biomolecular screening 20120601

• Androgen deprivation causes truncation of the C-terminal region of androgen receptor in human prostate cancer LNCaP cells.

  Cancer science 20120601

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• Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance.

  Cell research 20120601

• ω-6 lipids regulate PPAR turnover via reciprocal switch between PGC-1 alpha and ubiquitination.

  Atherosclerosis 20120601

• Auxin activates the plasma membrane H+-ATPase by phosphorylation during hypocotyl elongation in Arabidopsis.

  Plant physiology 20120601

• N- and C-terminal degradation of ecdysteroid receptor isoforms, when transiently expressed in mammalian CHO cells, is regulated by the proteasome and cysteine and threonine proteases.

  Insect molecular biology 20120601

• Diphenylarsinic acid promotes degradation of glutaminase C by mitochondrial Lon protease.

  The Journal of biological chemistry 20120525

• Potential role of 20S proteasome in maintaining stem cell integrity of human bone marrow stromal cells in prolonged culture expansion.

  Biochemical and biophysical research communications 20120525

• Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-κB-mediated matrix metalloproteinase-9 expression.

  Toxicology and applied pharmacology 20120515

• RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation.

  Cellular signalling 20120501

• Neddylation positively regulates the ubiquitin E3 ligase activity of parkin.

  Journal of neuroscience research 20120501

• Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes.

  Biochemical pharmacology 20120501

• The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult.

  IUBMB life 20120501

• Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.

  Molecular & cellular proteomics : MCP 20120501

• Quercetin enhancement of arsenic-induced apoptosis via stimulating ROS-dependent p53 protein ubiquitination in human HaCaT keratinocytes.

  Experimental dermatology 20120501

• High sensitivity of embryonic stem cells to proteasome inhibitors correlates with low expression of heat shock protein and decrease of pluripotent cell marker expression.

  BMB reports 20120501

• p38γ mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription.

  The Journal of biological chemistry 20120427

• Peroxynitrite donor SIN-1 alters high-affinity choline transporter activity by modifying its intracellular trafficking.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120418

• A role for the calmodulin kinase II-related anchoring protein (αkap) in maintaining the stability of nicotinic acetylcholine receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120411

• Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation.

  The Biochemical journal 20120401

• MG132, a proteasome inhibitor, induces human pulmonary fibroblast cell death via increasing ROS levels and GSH depletion.

  Oncology reports 20120401

• SUMO-2/3 conjugates accumulating under heat shock or MG132 treatment result largely from new protein synthesis.

  Biochimica et biophysica acta 20120401

• Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes.

  International immunopharmacology 20120401

• Ubiquitin/proteasome-mediated proteolysis is involved in the response to flooding stress in soybean roots, independent of oxygen limitation.

  Plant science : an international journal of experimental plant biology 20120401

• Rapid downregulation of cyclin D1 induced by geranylgeranoic acid in human hepatoma cells.

  Nutrition and cancer 20120401

• Effects of phosphatase and proteasome inhibitors on Borealin phosphorylation and degradation.

  Journal of biochemistry 20120401

• HSPA2 overexpression protects V79 fibroblasts against bortezomib-induced apoptosis.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20120401

• The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions.

  Cell cycle (Georgetown, Tex.) 20120315

• The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis.

  Experimental cell research 20120310

• Androgen regulated HN1 leads proteosomal degradation of androgen receptor (AR) and negatively influences AR mediated transactivation in prostate cells.

  Molecular and cellular endocrinology 20120305

• Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1).

  The Journal of biological chemistry 20120302

• Sodium arsenite and cadmium chloride induction of proteasomal inhibition and HSP accumulation in Xenopus laevis A6 kidney epithelial cells.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120301

• Identification of HSP90 as a new GABARAPL1 (GEC1)-interacting protein.

  Biochimie 20120301

• Type I interferons directly down-regulate BCL-6 in primary and transformed germinal center B cells: differential regulation in B cell lines derived from endemic or sporadic Burkitt's lymphoma.

  Cytokine 20120301

• The Ubiquitin ligase Ubr11 is essential for oligopeptide utilization in the fission yeast Schizosaccharomyces pombe.

  Eukaryotic cell 20120301

• Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase.

  Journal of cell science 20120301

• 4-Hydroxynonenal differentially regulates adiponectin gene expression and secretion via activating PPARγ and accelerating ubiquitin-proteasome degradation.

  Molecular and cellular endocrinology 20120226

• Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3β.

  Biochemical and biophysical research communications 20120224

• Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120222

• Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide.

  Bioorganic & medicinal chemistry letters 20120215

• Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence.

  Journal of hepatology 20120201

• c-Myc down-regulation is involved in proteasome inhibitor-mediated enhancement of radiotherapeutic efficacy in non-small cell lung cancer.

  International journal of oncology 20120201

• The F-box protein CPR1/CPR30 negatively regulates R protein SNC1 accumulation.

  The Plant journal : for cell and molecular biology 20120201

• Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120201

• Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120201

• PP2A phosphatase suppresses function of the mesenchymal invasion regulator NEDD9.

  Biochimica et biophysica acta 20120201

• Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases.

  Carcinogenesis 20120201

• Synergism between arsenite and proteasome inhibitor MG132 over cell death in myeloid leukaemic cells U937 and the induction of low levels of intracellular superoxide anion.

  Toxicology and applied pharmacology 20120201

• Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection.

  Cell cycle (Georgetown, Tex.) 20120201

• Regulated expression and role of c-Myb in the cardiovascular-directed differentiation of mouse embryonic stem cells.

  Circulation research 20120120

• Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol.

  Toxicology letters 20120105

• Involvement of suppressor of cytokine signalling-1-mediated degradation of MyD88-adaptor-like protein in the suppression of Toll-like receptor 2-mediated signalling by the murine C-type lectin SIGNR1-mediated signalling.

  Cellular microbiology 20120101

• Janus kinase 2--a novel negative regulator of estrogen receptor α function.

  Cellular signalling 20120101

• CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL.

  Cellular signalling 20120101

• Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells.

  Haematologica 20120101

• Characterization of the Cullin7 E3 ubiquitin ligase--heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity.

  Cellular signalling 20120101

• The origin of proteasome-inhibitor resistant HLA class I peptidomes: a study with HLA-A*68:01.

  Molecular & cellular proteomics : MCP 20120101

• gp130 cytokines stimulate proteasomal degradation of tyrosine hydroxylase via extracellular signal regulated kinases 1 and 2.

  Journal of neurochemistry 20120101

• Suppression of pain and joint destruction by inhibition of the proteasome system in experimental osteoarthritis.

  Pain 20120101

• Inhibition of proteasomal proteolysis affects expression of extracellular matrix components and steroidogenesis in porcine oocyte-cumulus complexes.

  Domestic animal endocrinology 20120101

• MG132 treatment during oocyte maturation improves embryonic development after somatic cell nuclear transfer and alters oocyte and embryo transcript abundance in pigs.

  Molecular reproduction and development 20120101

• Effects of proteasome inhibitors on the nucleolar size of porcine oocytes.

  The Journal of reproduction and development 20120101

• Ubiquitin-proteasomal degradation of COX-2 in TGF-β stimulated human endometrial cells is mediated through endoplasmic reticulum mannosidase I.

  Endocrinology 20120101

• Establishment of a microplate-formatted cell-based immunoassay for rapid analysis of nucleotide excision repair ability in human primary cells.

  Photochemistry and photobiology 20120101

• Tyrosine nitration of PA700 links proteasome activation to endothelial dysfunction in mouse models with cardiovascular risk factors.

  PloS one 20120101

• Transforming growth factor-β1 suppresses hepatitis B virus replication by the reduction of hepatocyte nuclear factor-4α expression.

  PloS one 20120101

• Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development.

  BMC cancer 20120101

• Down-regulation of glucose-regulated protein (GRP) 78 potentiates cytotoxic effect of celecoxib in human urothelial carcinoma cells.

  PloS one 20120101

• Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation.

  PloS one 20120101

• MUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activation.

  PloS one 20120101

• Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.

  PloS one 20120101

• Skp2 expression unfavorably impacts survival in resectable esophageal squamous cell carcinoma.

  Journal of translational medicine 20120101

• Mechanism of chemical activation of Nrf2.

  PloS one 20120101

• Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat.

  PloS one 20120101

• In vivo ubiquitination assay by agroinfiltration.

  Methods in molecular biology (Clifton, N.J.) 20120101

• Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome.

  PloS one 20120101

• Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells.

  PloS one 20120101

• M-opsin protein degradation is inhibited by MG-132 in Rpe65⁻/⁻ retinal explant culture.

  Molecular vision 20120101

• Low molecular weight heparin ablates lung cancer cisplatin-resistance by inducing proteasome-mediated ABCG2 protein degradation.

  PloS one 20120101

• Phenazine methosulfate decreases HIF-1α accumulation during the exposure of cells to hypoxia.

  Bioscience, biotechnology, and biochemistry 20120101

• Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research.

  PloS one 20120101

• Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation.

  PloS one 20120101

• Withaferin A induces proteasome inhibition, endoplasmic reticulum stress, the heat shock response and acquisition of thermotolerance.

  PloS one 20120101

• Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun.

  ASN neuro 20120101

• Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells.

  Experimental & molecular medicine 20111231

• Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase-3 β/β-catenin pathway.

  International journal of cancer 20111215

• Autophagy is increased in laminin α2 chain-deficient muscle and its inhibition improves muscle morphology in a mouse model of MDC1A.

  Human molecular genetics 20111215

• NF-kappaB p65 modulates the telomerase reverse transcriptase in the HepG₂ hepatoma cell line.

  European journal of pharmacology 20111215

• p53-Independent up-regulation of a TRAIL receptor DR5 by proteasome inhibitors: a mechanism for proteasome inhibitor-enhanced TRAIL-induced apoptosis.

  Biochemical and biophysical research communications 20111209

• Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells.

  Biochemical and biophysical research communications 20111202

• Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells.

  Investigational new drugs 20111201

• Mitogen-activated protein kinase inhibitors differently affect the growth inhibition and death of a proteasome inhibitor, MG132-treated human pulmonary fibroblast cells.

  Human & experimental toxicology 20111201

• E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.

  Cell death and differentiation 20111201

• SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis.

  Cell death and differentiation 20111201

• Inhibition of ubiquitin proteasome function suppresses proliferation of pulmonary artery smooth muscle cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20111201

• Involvement of IRAKs and TRAFs in anti-β₂GPI/β₂GPI-induced tissue factor expression in THP-1 cells.

  Thrombosis and haemostasis 20111201

• Posttranslational regulation of the iron deficiency basic helix-loop-helix transcription factor FIT is affected by iron and nitric oxide.

  Plant physiology 20111201

• Clusterin is a critical downstream mediator of stress-induced YB-1 transactivation in prostate cancer.

  Molecular cancer research : MCR 20111201

• Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1.

  Molecular endocrinology (Baltimore, Md.) 20111201

• Comparative study of the influence of proteasome inhibitor MG132 and ganciclovir on the cytomegalovirus-specific CD8(+) T-cell immune response.

  Viral immunology 20111201

• Proteasome inhibitors improve the function of mutant lysosomal α-glucosidase in fibroblasts from Pompe disease patient carrying c.546G>T mutation.

  Biochemical and biophysical research communications 20111118

• Proteasome inhibitors suppress expression of NPM and ARF proteins.

  Cell cycle (Georgetown, Tex.) 20111115

• A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.

  Cancer cell 20111115

• Muscle actin is polyubiquitinylated in vitro and in vivo and targeted for breakdown by the E3 ligase MuRF1.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111101

• Proteasome inhibitor MG132-induced apoptosis via ER stress-mediated apoptotic pathway and its potentiation by protein tyrosine kinase p56lck in human Jurkat T cells.

  Biochemical pharmacology 20111101

• Relative contribution of different l-arginine sources to the substrate supply of endothelial nitric oxide synthase.

  Journal of molecular and cellular cardiology 20111101

• New aldehyde and vinylsulfone proteasome inhibitors for targeted melanoma therapy.

  European journal of medicinal chemistry 20111101

• Down-regulation of peroxisome proliferator-activated receptor γ coactivator-1α expression in fatty acid-induced pancreatic beta-cell apoptosis involves nuclear factor-κB pathway.

  Chinese medical journal 20111101

• Gastrodia elata prevents huntingtin aggregations through activation of the adenosine A₂A receptor and ubiquitin proteasome system.

  Journal of ethnopharmacology 20111031

• Synthesis and biological activity of optimized belactosin C congeners.

  Organic & biomolecular chemistry 20111026

• Agrobacterium counteracts host-induced degradation of its effector F-box protein.

  Science signaling 20111018

• N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)-glycyrrhetinamide (6b): a novel anticancer glycyrrhetinic acid derivative that targets the proteasome and displays anti-kinase activity.

  Journal of medicinal chemistry 20111013

• OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability.

  Experimental cell research 20111001

• An anti-HIV-1 compound that increases steady-state expression of apoplipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G.

  International journal of molecular medicine 20111001

• E3 ubiquitin-protein ligases in rat kidney collecting duct: response to vasopressin stimulation and withdrawal.

  American journal of physiology. Renal physiology 20111001

• Increased glucose concentration results in reduced proteasomal activity and the formation of glycogen positive aggresomal structures.

  The FEBS journal 20111001

• Assessing ubiquitination of viral proteins: Lessons from flavivirus NS5.

  Methods (San Diego, Calif.) 20111001

• Celecoxib promotes c-FLIP degradation through Akt-independent inhibition of GSK3.

  Cancer research 20111001

• Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase.

  Nature cell biology 20111001

• Involvement of Arabidopsis NAC transcription factor in the regulation of 20S and 26S proteasomes.

  Plant science : an international journal of experimental plant biology 20111001

• A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.

  Molecular & cellular proteomics : MCP 20111001

• Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways.

  Journal of cell science 20111001

• FoxM1 knockdown sensitizes human cancer cells to proteasome inhibitor-induced apoptosis but not to autophagy.

  Cell cycle (Georgetown, Tex.) 20111001

• SCAR mediates light-induced root elongation in Arabidopsis through photoreceptors and proteasomes.

  The Plant cell 20111001

• Cigarette smoke induces Akt protein degradation by the ubiquitin-proteasome system.

  The Journal of biological chemistry 20110916

• Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.

  Toxicology and applied pharmacology 20110915

• PEST motif sequence regulating human NANOG for proteasomal degradation.

  Stem cells and development 20110901

• Constitutive ERK activity induces downregulation of tristetraprolin, a major protein controlling interleukin8/CXCL8 mRNA stability in melanoma cells.

  American journal of physiology. Cell physiology 20110901

• An IκBα phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-κB-independent mechanism.

  Cellular signalling 20110901

• Hunterian Lecture. Characterisation of human prostate epithelial progenitor differentiation in response to androgens.

  Annals of the Royal College of Surgeons of England 20110901

• Novel interactions between actin and the proteasome revealed by complex haploinsufficiency.

  PLoS genetics 20110901

• A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbα.

  Nature neuroscience 20110828

• A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases.

  Current biology : CB 20110823

• Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.

  The Journal of biological chemistry 20110819

• A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair.

  The EMBO journal 20110817

• Proteomic signatures in thapsigargin-treated hepatoma cells.

  Chemical research in toxicology 20110815

• The effect of nNOS inhibitors on toxin-induced cell death in dopaminergic cell lines depends on the extent of enzyme expression.

  Brain research 20110802

• RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury.

  Kidney international 20110801

• Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions.

  Cellular signalling 20110801

• Chemical chaperones protect epidermolysis bullosa simplex keratinocytes from heat stress-induced keratin aggregation: involvement of heat shock proteins and MAP kinases.

  The Journal of investigative dermatology 20110801

• Inhibition of HSP90-dependent telomerase activity in amyloid β-induced apoptosis of cerebral endothelial cells.

  Journal of cellular physiology 20110801

• Uraemic serum induces dysfunction of vascular endothelial cells: role of ubiquitin-proteasome pathway.

  Experimental physiology 20110801

• Apoptotic effect of MG-132 on human tongue squamous cell carcinoma.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110801

• Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase.

  Parasitology 20110801

• Inhibition of NF-κB by MG132 through ER stress-mediated induction of LAP and LIP.

  FEBS letters 20110721

• The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy.

  Biochemical pharmacology 20110715

• The tyrosine kinase inhibitor sorafenib sensitizes hepatocellular carcinoma cells to taxol by suppressing the HURP protein.

  Biochemical pharmacology 20110715

• Intracellular colocalization of HAP1/STBs with steroid hormone receptors and its enhancement by a proteasome inhibitor.

  Experimental cell research 20110715

• Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation.

  British journal of cancer 20110712

• Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells.

  The Journal of biological chemistry 20110708

• Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies.

  Cell biochemistry and biophysics 20110701

• Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells.

  The Journal of pharmacology and experimental therapeutics 20110701

• An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110701

• Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells.

  Journal of cellular physiology 20110701

• Aldo-keto reductase 1C15 as a quinone reductase in rat endothelial cell: its involvement in redox cycling of 9,10-phenanthrenequinone.

  Free radical research 20110701

• [The effect of RhoA and proteasome inhibitor MG132 on angiogenesis in tumors].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20110701

• Sesquiterpene and norsesquiterpene derivatives from Sanicula lamelligera and their biological evaluation.

  Journal of natural products 20110624

• Bim protein degradation contributes to cisplatin resistance.

  The Journal of biological chemistry 20110624

• MG132 enhances neurite outgrowth in neurons overexpressing mutant TAR DNA-binding protein-43 via increase of HO-1.

  Brain research 20110623

• Comparative proteomic analysis identifies a role for SUMO in protein quality control.

  Science signaling 20110621

• A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation.

  Nature genetics 20110619

• JWA regulates chronic morphine dependence via the delta opioid receptor.

  Biochemical and biophysical research communications 20110610

• Constitutive activation of metalloproteinase ADAM10 in mantle cell lymphoma promotes cell growth and activates the TNFα/NFκB pathway.

  Blood 20110609

• Prefoldin subunits are protected from ubiquitin-proteasome system-mediated degradation by forming complex with other constituent subunits.

  The Journal of biological chemistry 20110603

• Interactive expressions of HtrA1 and VEGF in human vitreous humors and fetal RPE cells.

  Investigative ophthalmology & visual science 20110601

• Classical swine fever virus NS2 protein promotes interleukin-8 expression and inhibits MG132-induced apoptosis.

  Virus genes 20110601

• Proteasome inhibition by MG132 induces growth inhibition and death of human pulmonary fibroblast cells in a caspase-independent manner.

  Oncology reports 20110601

• Garlic constituent diallyl trisulfide suppresses x-linked inhibitor of apoptosis protein in prostate cancer cells in culture and in vivo.

  Cancer prevention research (Philadelphia, Pa.) 20110601

• Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteasome pathway and effective checkpoint response to replication blocks.

  Biochimica et biophysica acta 20110601

• Arabidopsis G1 cell cycle proteins undergo proteasome-dependent degradation during sucrose starvation.

  Plant physiology and biochemistry : PPB 20110601

• Caffeine can be used for oocyte enucleation.

  Cellular reprogramming 20110601

• Offspring from intracytoplasmic sperm injection of aged mouse oocytes treated with caffeine or MG132.

  Genesis (New York, N.Y. : 2000) 20110601

• The HSP90 molecular chaperone cycle regulates cyclical transcriptional dynamics of the glucocorticoid receptor and its coregulatory molecules CBP/p300 during ultradian ligand treatment.

  Molecular endocrinology (Baltimore, Md.) 20110601

• Regulation of Notch1 signaling by the APP intracellular domain facilitates degradation of the Notch1 intracellular domain and RBP-Jk.

  Journal of cell science 20110601

• Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29.

  Chemico-biological interactions 20110530

• Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression.

  The Journal of biological chemistry 20110520

• MG132 treatment attenuates cardiac remodeling and dysfunction following aortic banding in rats via the NF-κB/TGFβ1 pathway.

  Biochemical pharmacology 20110515

• Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals.

  Molecular & cellular proteomics : MCP 20110501

• Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways.

  Cell death and differentiation 20110501

• N-Glycans mutations rule oligomeric assembly and functional expression of P2X3 receptor for extracellular ATP.

  Glycobiology 20110501

• The proteasome inhibitor MG-132 induces AIF nuclear translocation through down-regulation of ERK and Akt/mTOR pathway.

  Neurochemical research 20110501

• Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.

  Nucleic acids research 20110501

• Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment.

  Experimental cell research 20110501

• Proteasome inhibitors induce the presentation of an Epstein-Barr virus nuclear antigen 1-derived cytotoxic T lymphocyte epitope in Burkitt's lymphoma cells.

  Immunology 20110501

• Prevention of muscle disuse atrophy by MG132 proteasome inhibitor.

  Muscle & nerve 20110501

• Proteasome inhibitor MG-132 induces C6 glioma cell apoptosis via oxidative stress.

  Acta pharmacologica Sinica 20110501

• Interaction between the bHLH transcription factor FIT and ETHYLENE INSENSITIVE3/ETHYLENE INSENSITIVE3-LIKE1 reveals molecular linkage between the regulation of iron acquisition and ethylene signaling in Arabidopsis.

  The Plant cell 20110501

• APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells.

  Protein & cell 20110501

• Ubiquitin proteasomal pathway mediated degradation of p53 in melanoma.

  Archives of biochemistry and biophysics 20110415

• Intracellular rescue of the uroporphyrinogen III synthase activity in enzymes carrying the hotspot mutation C73R.

  The Journal of biological chemistry 20110415

• Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells.

  Cell biology and toxicology 20110401

• Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.

  The Journal of biological chemistry 20110401

• Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism.

  Cell death & disease 20110401

• Contribution of hypoxia-inducible factor-1α to transcriptional regulation of vascular endothelial growth factor in bovine developing luteal cells.

  Animal science journal = Nihon chikusan Gakkaiho 20110401

• Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation.

  The Journal of biological chemistry 20110318

• Prevention of diabetic nephropathy in rats through enhanced renal antioxidative capacity by inhibition of the proteasome.

  Life sciences 20110314

• Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8.

  The Journal of biological chemistry 20110311

• Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk.

  The Journal of biological chemistry 20110311

• Involvement of protein kinase D in expression and trafficking of ATP7B (copper ATPase).

  The Journal of biological chemistry 20110304

• LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.

  Cell stem cell 20110304

• Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20110301

• Role of the ubiquitin-proteasome system in Bombyx mori nucleopolyhedrovirus infection.

  The Journal of general virology 20110301

• Reactivation of L1 retrotransposon by benzo(a)pyrene involves complex genetic and epigenetic regulation.

  Epigenetics 20110301

• The enhancement of propyl gallate-induced apoptosis in HeLa cells by a proteasome inhibitor MG132.

  Oncology reports 20110301

• Proteasome inhibitor sensitizes oral squamous cell carcinoma cells to TRAIL-mediated apoptosis.

  Oncology reports 20110301

• HSP90 is crucial for regulation of LAT expression in activated T cells.

  Molecular immunology 20110301

• Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism.

  Diabetes 20110301

• Rapid and quantitative assessment of cell quality, identity, and functionality for cell-based assays using real-time cellular analysis.

  Journal of biomolecular screening 20110301

• Proteasome inhibition causes epithelial-mesenchymal transition upon TM4SF5 expression.

  Journal of cellular biochemistry 20110301

• Nerve growth factor-induced neurite outgrowth is potentiated by stabilization of TrkA receptors.

  BMB reports 20110301

• Gambogic acid enhances proteasome inhibitor-induced anticancer activity.

  Cancer letters 20110227

• Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.

  Oncogene 20110217

• Calsenilin is degraded by the ubiquitin-proteasome pathway.

  Biochemical and biophysical research communications 20110211

• Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin.

  The EMBO journal 20110202

• Opioid-induced chemokine expression requires NF-κB activity: the role of PKCζ.

  Journal of leukocyte biology 20110201

• NFκB inhibitors induce cell death in glioblastomas.

  Biochemical pharmacology 20110201

• Carbamazepine promotes Her-2 protein degradation in breast cancer cells by modulating HDAC6 activity and acetylation of Hsp90.

  Molecular and cellular biochemistry 20110201

• Proteasome inhibition improves the muscle of laminin α2 chain-deficient mice.

  Human molecular genetics 20110201

• Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells.

  Toxicology and applied pharmacology 20110201

• Activation of brain endothelium by soluble aggregates of the amyloid-β protein involves nuclear factor-κB.

  Current Alzheimer research 20110201

• Bortezomib induces nuclear translocation of IκBα resulting in gene-specific suppression of NF-κB--dependent transcription and induction of apoptosis in CTCL.

  Molecular cancer research : MCR 20110201

• [Apoptosis induced by MG-132 in Tca-8113 cells].

  Shanghai kou qiang yi xue = Shanghai journal of stomatology 20110201

• Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis.

  Developmental biology 20110115

• Tripeptidyl peptidase II serves as an alternative to impaired proteasome to maintain viral growth in the host cells.

  FEBS letters 20110103

• The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.

  Cell death and differentiation 20110101

• Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes.

  Cell death and differentiation 20110101

• Proteasome inhibition induces developmentally deregulated programs of apoptotic and autophagic cell death during Drosophila melanogaster oogenesis.

  Cell biology international 20110101

• Inhibition of all-trans-retinoic acid-induced proteasome activation potentiates the differentiating effect of retinoid in acute myeloid leukemia cells.

  Molecular carcinogenesis 20110101

• The mammalian target of rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre-B acute lymphocytic leukemia.

  Haematologica 20110101

• MG132, a proteasome inhibitor-induced calf pulmonary arterial endothelial cell growth and death, are changed by MAPK inhibitors.

  Drug and chemical toxicology 20110101

• Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells.

  Journal of biomedicine & biotechnology 20110101

• Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway.

  The FEBS journal 20110101

• Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos.

  Nature cell biology 20110101

• Effects of proteasome inhibitors on rat renal fibrosis in vitro and in vivo.

  Nephrology (Carlton, Vic.) 20110101

• Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression.

  Molecular cancer 20110101

• Modulation of TRAIL resistance in colon carcinoma cells: different contributions of DR4 and DR5.

  BMC cancer 20110101

• Proteasome inhibition alleviates prolonged moderate compression-induced muscle pathology.

  BMC musculoskeletal disorders 20110101

• Quantitative proteomics identifies the Myb-binding protein p160 as a novel target of the von Hippel-Lindau tumor suppressor.

  PloS one 20110101

• Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.

  PloS one 20110101

• Effect of inhibition of the ubiquitin-proteasome-system and IκB kinase on airway inflammation and hyperresponsiveness in a murine model of asthma.

  International journal of immunopathology and pharmacology 20110101

• Production of free methylarginines via the proteasome and autophagy pathways in cultured cells.

  Molecular medicine reports 20110101

• Structure-function analysis of STRUBBELIG, an Arabidopsis atypical receptor-like kinase involved in tissue morphogenesis.

  PloS one 20110101

• Staphylococcus aureus regulates secretion of interleukin-6 and monocyte chemoattractant protein-1 through activation of nuclear factor kappaB signaling pathway in human osteoblasts.

  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101

• Systemic analysis of heat shock response induced by heat shock and a proteasome inhibitor MG132.

  PloS one 20110101

• [Critical amino acids of ornitin decarboxylase degron: the presence and C-terminal arrangement is insufficient for alfa-fetoprotein degradation].

  Molekuliarnaia biologiia 20110101

• Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.

  PloS one 20110101

• The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice.

  BMC musculoskeletal disorders 20110101

• Eukaryotic cells producing ribosomes deficient in Rpl1 are hypersensitive to defects in the ubiquitin-proteasome system.

  PloS one 20110101

• The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR.

  PloS one 20110101

• The docking protein p130Cas regulates cell sensitivity to proteasome inhibition.

  BMC biology 20110101

• Possible linkage of SP6 transcriptional activity with amelogenesis by protein stabilization.

  Journal of biomedicine & biotechnology 20110101

• Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in β-cells.

  PloS one 20110101

• A single bivalent efficiently inhibits cyclin B1 degradation and polar body extrusion in mouse oocytes indicating robust SAC during female meiosis I.

  PloS one 20110101

• Postnatal proteasome inhibition induces neurodegeneration and cognitive deficiencies in adult mice: a new model of neurodevelopment syndrome.

  PloS one 20110101

• Adriamycin enhances proteasome-mediated generation of the proapoptotic processed form of MAGE-A4 in hepatoma cells.

  Oncology 20110101

• A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor {alpha}.

  The Journal of biological chemistry 20101231

• Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner.

  The Journal of biological chemistry 20101224

• Regulation of PTEN stability and activity by Plk3.

  The Journal of biological chemistry 20101217

• Regulation of ΔNp63α by NFκΒ.

  Cell cycle (Georgetown, Tex.) 20101215

• Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect.

  The Journal of biological chemistry 20101210

• Tumor necrosis factor alpha-induced inflammation is increased but apoptosis is inhibited by common food additive carrageenan.

  The Journal of biological chemistry 20101210

• An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs.

  Oncogene 20101209

• 1α, 25-Dihydroxyvitamin D regulates hypoxia-inducible factor-1α in untransformed and Harvey-ras transfected breast epithelial cells.

  Cancer letters 20101208

• Oxaliplatin down-regulates survivin by p38 MAP kinase and proteasome in human colon cancer cells.

  Chemico-biological interactions 20101205

• Lysine 419 targets human glucocorticoid receptor for proteasomal degradation.

  Steroids 20101201

• Modulation of hypoxia-inducible factor-1α expression by mitochondrial NADP+-dependent isocitrate dehydrogenase.

  Biochimie 20101201

• Physiological levels of ATP negatively regulate proteasome function.

  Cell research 20101201

• Inhibition of the ubiquitin-proteasome system leads to delay of the onset of ZGA gene expression.

  The Journal of reproduction and development 20101201

• Metabolism and action of proteasome inhibitors in primary human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses.

  Biochimica et biophysica acta 20101201

• Mineralocorticoid receptor degradation is promoted by Hsp90 inhibition and the ubiquitin-protein ligase CHIP.

  American journal of physiology. Renal physiology 20101201

• Nuclear remodeling in bovine somatic cell nuclear transfer embryos using MG132-treated recipient oocytes.

  Cellular reprogramming 20101201

• Radioimmunotherapy with an antibody to the HPV16 E6 oncoprotein is effective in an experimental cervical tumor expressing low levels of E6.

  Cancer biology & therapy 20101115

• Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27.

  The Journal of biological chemistry 20101112

• Cadmium impairs albumin reabsorption by down-regulating megalin and ClC5 channels in renal proximal tubule cells.

  Environmental health perspectives 20101101

• Combined chemical and genetic approach to inhibit proteolysis by the proteasome.

  Yeast (Chichester, England) 20101101

• Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes.

  Glia 20101101

• Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NF-κB signaling.

  Journal of cellular biochemistry 20101101

• Regulation of intracellular decorin via proteasome degradation in rat mesangial cells.

  Journal of cellular biochemistry 20101101

• Selective vulnerability of neurons to acute toxicity after proteasome inhibitor treatment: implications for oxidative stress and insolubility of newly synthesized proteins.

  Free radical biology & medicine 20101101

• NF-kappaB regulates the expression of Nucling, a novel apoptosis regulator, with involvement of proteasome and caspase for its degradation.

  Journal of biochemistry 20101101

• Insulin stimulation of PKCδ triggers its rapid degradation via the ubiquitin-proteasome pathway.

  Biochimica et biophysica acta 20101101

• Implication of oxygen-regulated protein 150 (ORP150) in apoptosis induced by proteasome inhibitors in human thyroid cancer cells.

  The Journal of clinical endocrinology and metabolism 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Regulation of human carbonyl reductase 3 (CBR3; SDR21C2) expression by Nrf2 in cultured cancer cells.

  Biochemistry 20101005

• Reactive oxygen species and glutathione level changes by a proteasome inhibitor, MG132, partially affect calf pulmonary arterial endothelial cell death.

  Drug and chemical toxicology 20101001

• Treatment with p38 inhibitor intensifies the death of MG132-treated As4.1 juxtaglomerular cells via the enhancement of GSH depletion.

  Drug and chemical toxicology 20101001

• p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.

  Cellular signalling 20101001

• Proteasome inhibition modeling nigral neuron degeneration in Parkinson's disease.

  Journal of neurochemistry 20101001

• Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging.

  American journal of physiology. Heart and circulatory physiology 20101001

• Butein suppresses the expression of nuclear factor-kappa B-mediated matrix metalloproteinase-9 and vascular endothelial growth factor in prostate cancer cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20101001

• Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines.

  International journal of oncology 20101001

• Programmed cell death of the megagametophyte during post-germinative growth of white spruce (Picea glauca) seeds is regulated by reactive oxygen species and the ubiquitin-mediated proteolytic system.

  Plant & cell physiology 20101001

• Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor γ co-activator-1α protein.

  British journal of pharmacology 20101001

• Short hairpin RNA-mediated fibronectin knockdown delays tumor growth in a mouse glioma model.

  Neoplasia (New York, N.Y.) 20101001

• Murine double minute 2 as a modulator of retroviral restrictions mediated by TRIM5alpha.

  Virology 20100930

• Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis.

  Current biology : CB 20100928

• Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth.

  Chemical research in toxicology 20100920

• Alpha,beta-unsaturated N-acylpyrrole peptidyl derivatives: new proteasome inhibitors.

  Journal of medicinal chemistry 20100909

• Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1.

  Biochemical and biophysical research communications 20100903

• The Ski protein negatively regulates Siah2-mediated HDAC3 degradation.

  Biochemical and biophysical research communications 20100903

• Suppression of MG132-mediated cell death by peroxiredoxin 1 through influence on ASK1 activation in human thyroid cancer cells.

  Endocrine-related cancer 20100901

• Proteasome inhibitor MG132 reduces growth of As4.1 juxtaglomerular cells via caspase-independent apoptosis.

  Archives of toxicology 20100901

• The silencing suppressor P25 of Potato virus X interacts with Argonaute1 and mediates its degradation through the proteasome pathway.

  Molecular plant pathology 20100901

• Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.

  Nature cell biology 20100901

• Recruitment of phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugates.

  Cancer research 20100901

• Activation of specific apoptotic caspases with an engineered small-molecule-activated protease.

  Cell 20100820

• Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients.

  Human molecular genetics 20100815

• Inhibition of connexin 43 gap junction channels by the endocrine disruptor ioxynil.

  Toxicology and applied pharmacology 20100815

• Protection against cellular stress by 25-hydroxyvitamin D3 in breast epithelial cells.

  Journal of cellular biochemistry 20100815

• A novel Ca2+/calmodulin antagonist HBC inhibits angiogenesis and down-regulates hypoxia-inducible factor.

  The Journal of biological chemistry 20100813

• Effect of proteasome inhibition by MG-132 on HSP27 oligomerization, phosphorylation, and aggresome formation in the OLN-93 oligodendroglia cell line.

  Journal of neurochemistry 20100801

• Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells.

  Journal of periodontal research 20100801

• Light-induced degradation of phyA is promoted by transfer of the photoreceptor into the nucleus.

  Plant molecular biology 20100801

• Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress.

  The Journal of biological chemistry 20100716

• Glucose is necessary for stabilization of hypoxia-inducible factor-1alpha under hypoxia: contribution of the pentose phosphate pathway to this stabilization.

  FEBS letters 20100716

• Temperature-sensitive post-translational regulation of plant omega-3 fatty-acid desaturases is mediated by the endoplasmic reticulum-associated degradation pathway.

  The Journal of biological chemistry 20100709

• HSP27 controls GATA-1 protein level during erythroid cell differentiation.

  Blood 20100708

• Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells.

  FEBS letters 20100702

• MG132 as a proteasome inhibitor induces cell growth inhibition and cell death in A549 lung cancer cells via influencing reactive oxygen species and GSH level.

  Human & experimental toxicology 20100701

• Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells.

  Biochemical pharmacology 20100701

• Characterization of BAG3 cleavage during apoptosis of pancreatic cancer cells.

  Journal of cellular physiology 20100701

• Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.

  European journal of medicinal chemistry 20100701

• PCB-153 exposure coordinates cell cycle progression and cellular metabolism in human mammary epithelial cells.

  Toxicology letters 20100701

• Attenuation of pain and inflammation in adjuvant-induced arthritis by the proteasome inhibitor MG132.

  Arthritis and rheumatism 20100701

• Akt associates with nuclear factor kappaB and plays an important role in chemoresistance of gastric cancer cells.

  Oncology reports 20100701

• Quercetin potentiates UVB-Induced c-Fos expression: implications for its use as a chemopreventive agent.

  Cancer prevention research (Philadelphia, Pa.) 20100701

• Mitochondrial dynamics and its responds to proteasome defection during Picea wilsonii pollen tube development.

  Cell biochemistry and function 20100701

• [Protected effects of MG-132 on apoptosis induced by deltamethrin in rat's hippocampus].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20100701

• Calcium-sensing receptor biosynthesis includes a cotranslational conformational checkpoint and endoplasmic reticulum retention.

  The Journal of biological chemistry 20100625

• Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells.

  American journal of respiratory cell and molecular biology 20100601

• Breast cancer cell growth inhibition by phenethyl isothiocyanate is associated with down-regulation of oestrogen receptor-alpha36.

  Journal of cellular and molecular medicine 20100601

• MG132, a proteasome inhibitor decreased the growth of Calu-6 lung cancer cells via apoptosis and GSH depletion.

  Toxicology in vitro : an international journal published in association with BIBRA 20100601

• Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20100601

• EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway.

  Molecular pharmacology 20100601

• Treatment with p38 inhibitor partially prevents Calu-6 lung cancer cell death by a proteasome inhibitor, MG132.

  Cancer genetics and cytogenetics 20100601

• Functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis.

  Cell biochemistry and function 20100601

• Clioquinol independently targets NF-kappaB and lysosome pathways in human cancer cells.

  Anticancer research 20100601

• Attenuation of MG132-induced HeLa cell death by N-acetyl cysteine via reducing reactive oxygen species and preventing glutathione depletion.

  Anticancer research 20100601

• Hypopigmentary action of dihydropyranocoumarin D2, a decursin derivative, as a MITF-degrading agent.

  Journal of natural products 20100528

• Increased protein hydrophobicity in response to aging and Alzheimer disease.

  Free radical biology & medicine 20100515

• Proteasome inhibition induces hsp30 and hsp70 gene expression as well as the acquisition of thermotolerance in Xenopus laevis A6 cells.

  Cell stress & chaperones 20100501

• Zinc mesoporphyrin induces rapid proteasomal degradation of hepatitis C nonstructural 5A protein in human hepatoma cells.

  Gastroenterology 20100501

• Mechanical stretch enhances NF-kappaB-dependent gene expression and poly(ADP-ribose) synthesis in synovial cells.

  Journal of biochemistry 20100501

• Cdc20 proteolysis requires p38 MAPK signaling and Cdh1-independent APC/C ubiquitination during spindle assembly checkpoint activation by cadmium.

  Journal of cellular physiology 20100501

• Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.

  Gastroenterology 20100501

• MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes.

  Arthritis and rheumatism 20100501

• Novel exon nucleotide substitution at the splice junction causes a neonatal Marfan syndrome.

  Clinical genetics 20100501

• A novel sphingosine kinase inhibitor induces autophagy in tumor cells.

  The Journal of pharmacology and experimental therapeutics 20100501

• Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein.

  Molecular nutrition & food research 20100501

• Prolonged endoplasmic reticulum stress promotes mislocalization of immunoglobulins to the cytoplasm.

  Molecular immunology 20100501

• Lipopolysaccharide induced connective tissue growth factor gene expression in human bronchial epithelial cells.

  Respirology (Carlton, Vic.) 20100501

• Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling.

  The Biochemical journal 20100414

• Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells.

  Molecular cell 20100409

• TNF-NF-kappaB signaling mediates excessive somnolence in hemiparkinsonian rats.

  Behavioural brain research 20100402

• AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes.

  Circulation research 20100402

• Proteasome inhibitor MG132 inhibits angiogenesis in pancreatic cancer by blocking NF-kappaB activity.

  Digestive diseases and sciences 20100401

• Proteasome inhibitor-induced apoptosis in acute myeloid leukemia: a correlation with the proteasome status.

  Leukemia research 20100401

• Role of the ubiquitin-proteasome pathway in downregulation of the gap-junction protein Connexin43 by TNF-{alpha} in human corneal fibroblasts.

  Investigative ophthalmology & visual science 20100401

• Defective TPA signalling compromises HaCat cells as a human in vitro skin carcinogenesis model.

  Toxicology in vitro : an international journal published in association with BIBRA 20100401

• Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-kappaB signaling pathways and augmented by ubiquitin-proteasome inhibition.

  Toxicology in vitro : an international journal published in association with BIBRA 20100401

• A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and methylmercury in mouse embryonic fibroblast.

  Toxicological sciences : an official journal of the Society of Toxicology 20100401

• alphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells.

  Pigment cell & melanoma research 20100401

• Decreased replication of human respiratory syncytial virus treated with the proteasome inhibitor MG-132.

  Virus research 20100401

• Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1.

  Journal of neurochemistry 20100401

• (-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100401

• The effects of N-acetyl cysteine on the MG132 proteasome inhibitor-treated lung cancer cells in relation to cell growth, reactive oxygen species and glutathione.

  International journal of molecular medicine 20100401

• N-terminal residues regulate proteasomal degradation of AANAT.

  Journal of pineal research 20100401

• Novel combination of celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells.

  Cell cycle (Georgetown, Tex.) 20100401

• Sulindac metabolites induce proteosomal and lysosomal degradation of the epidermal growth factor receptor.

  Cancer prevention research (Philadelphia, Pa.) 20100401

• MG132, a proteasome inhibitor, attenuates pressure-overload-induced cardiac hypertrophy in rats by modulation of mitogen-activated protein kinase signals.

  Acta biochimica et biophysica Sinica 20100401

• [Effect of proteasome inhibitor MG-132 on L1210 cell apoptosis and its mechanism].

  Zhongguo shi yan xue ye xue za zhi 20100401

• Motexafin gadolinium enhances p53-Mdm2 interactions, reducing p53 and downstream targets in lymphoma cell lines.

  Anticancer research 20100401

• Imidazole inhibits B16 melanoma cell migration via degradation of beta-catenin.

  The Journal of pharmacy and pharmacology 20100401

• Proteasome activity correlates with male BMI and contributes to the differentiation of adipocyte in hADSC.

  Endocrine 20100401

• The changes of reactive oxygen species and glutathione by MG132, a proteasome inhibitor affect As4.1 juxtaglomerular cell growth and death.

  Chemico-biological interactions 20100330

• [Effect of MG-132 upon the expression of intercellular adhesion molecule-1 in cerulein-induced acute pancreatitis in mice].

  Zhonghua yi xue za zhi 20100330

• Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.

  The Journal of biological chemistry 20100326

• Formation of parkin aggregates and enhanced PINK1 accumulation during the pathogenesis of Parkinson's disease.

  Biochemical and biophysical research communications 20100319

• Enhanced vulnerability of PARK6 patient skin fibroblasts to apoptosis induced by proteasomal stress.

  Neuroscience 20100317

• Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.

  Biochemistry 20100316

• Novel findings on endoribonuclease activity of proteasomes.

  Cell cycle (Georgetown, Tex.) 20100315

• In vitro and in vivo interaction of AtRma2 E3 ubiquitin ligase and auxin binding protein 1.

  Biochemical and biophysical research communications 20100312

• Combination therapy for hepatitis C virus with heat-shock protein 90 inhibitor 17-AAG and proteasome inhibitor MG132.

  Antiviral chemistry & chemotherapy 20100309

• Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation.

  Carcinogenesis 20100301

• Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis.

  Cancer science 20100301

• Antidepressants increase β-arrestin 2 ubiquitinylation and degradation by the proteasomal pathway in C6 rat glioma cells.

  The Journal of pharmacology and experimental therapeutics 20100301

• Proteasomal inhibition upregulates the endogenous MAPK deactivator MKP-1 in human airway smooth muscle: mechanism of action and effect on cytokine secretion.

  Biochimica et biophysica acta 20100301

• Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression.

  The American journal of pathology 20100301

• Proteasome inhibitor MG132 suppresses number and function of endothelial progenitor cells: involvement of nitric oxide synthase inhibition.

  International journal of molecular medicine 20100301

• The 26S proteasome function and Hsp90 activity involved in the regulation of HsfA2 expression in response to oxidative stress.

  Plant & cell physiology 20100301

• MG132, a proteasome inhibitor, induced death of calf pulmonary artery endothelial cells via caspase-dependent apoptosis and GSH depletion.

  Anticancer research 20100301

• The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation.

  Cancer letters 20100227

• Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach.

  Journal of medicinal chemistry 20100225

• The influence of proteasome inhibitor MG132, external radiation, and unlabeled antibody on the tumor uptake and biodistribution of (188)re-labeled anti-E6 C1P5 antibody in cervical cancer in mice.

  Cancer 20100215

• ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.

  The Journal of biological chemistry 20100212

• A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100203

• The effect of the time interval between injection and parthenogenetic activation on the spindle formation and the in vitro developmental potential of somatic cell nuclear-transferred rat oocytes.

  Zygote (Cambridge, England) 20100201

• Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage.

  Cellular signalling 20100201

• Post-fusion treatment with MG132 increases transcription factor expression in somatic cell nuclear transfer embryos in pigs.

  Molecular reproduction and development 20100201

• The effects of MAPK inhibitors on a proteasome inhibitor, MG132-induced HeLa cell death in relation to reactive oxygen species and glutathione.

  Toxicology letters 20100201

• Cholera toxin-sensitive GTP-binding protein-coupled activation of augmenter of liver regeneration (ALR) receptor and its function in rat kupffer cells.

  Journal of cellular physiology 20100201

• Preventive effect of a proteasome inhibitor on the formation of accelerated atherosclerosis in rabbits with uremia.

  Journal of cardiovascular pharmacology 20100201

• Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells.

  Autophagy 20100201

• ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy.

  Autophagy 20100201

• [Tumor stem cells and their impact on the concept of cancer treatment].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20100201

• Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system.

  Neuroscience letters 20100118

• Multiple cardiac proteasome subtypes differ in their susceptibility to proteasome inhibitors.

  Cardiovascular research 20100115

• Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase.

  The Journal of biological chemistry 20100108

• Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation.

  Oncogene 20100107

• Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin.

  DNA repair 20100102

• TLR3 in human eosinophils: functional effects and decreased expression during allergic rhinitis.

  International archives of allergy and immunology 20100101

• MG-132 inhibits carcinoid growth and alters the neuroendocrine phenotype.

  The Journal of surgical research 20100101

• The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway.

  Experimental cell research 20100101

• Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing.

  Experimental cell research 20100101

• Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage.

  The Journal of pharmacology and experimental therapeutics 20100101

• Mutations in NOTCH3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation.

  Human molecular genetics 20100101

• Activation of PERK kinase in neural cells by proteasome inhibitor treatment.

  Journal of neurochemistry 20100101

• Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.

  Biochemical and biophysical research communications 20100101

• Effect of overexpression of Arabidopsis damaged DNA-binding protein 1A on de-etiolated 1.

  Planta 20100101

• Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells.

  The American journal of pathology 20100101

• Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.

  Journal of cell science 20100101

• Interferon-alpha2b induces p21cip1/waf1 degradation and cell proliferation in HeLa cells.

  Cell cycle (Georgetown, Tex.) 20100101

• Tumor necrosis factor-a augments lipopolysaccharide-induced suppressor of cytokine signalling 3 (SOCS-3) protein expression by preventing the degradation.

  Immunology 20100101

• The inhibitory mechanisms of the tyrosine kinase inhibitors herbimycin a, genistein, and tyrphostin B48 with regard to the function of the aryl hydrocarbon receptor in Caco-2 cells.

  Bioscience, biotechnology, and biochemistry 20100101

• Processing of autophagic protein LC3 by the 20S proteasome.

  Autophagy 20100101

• Neuroprotective effects of the drug GVT (monosodium luminol) are mediated by the stabilization of Nrf2 in astrocytes.

  Neurochemistry international 20100101

• The attenuation of MG132, a proteasome inhibitor, induced A549 lung cancer cell death by p38 inhibitor in ROS-independent manner.

  Oncology research 20100101

• Selective estrogen receptor down-regulator and selective estrogen receptor modulators differentially regulate lactotroph proliferation.

  PloS one 20100101

• Angiotensin I-converting enzyme Gln1069Arg mutation impairs trafficking to the cell surface resulting in selective denaturation of the C-domain.

  PloS one 20100101

• Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.

  PloS one 20100101

• p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells.

  Molecular vision 20100101

• Amino acid deprivation decreases intracellular levels of reactive oxygen species in hepatic stellate cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Investigation of the eIF2alpha phosphorylation mechanism in response to proteasome inhibition in melanoma and breast cancer cells.

  Molekuliarnaia biologiia 20100101

• Involvement of BMPs/Smad signaling pathway in mechanical response in osteoblasts.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency.

  The Biochemical journal 20091214

• Covalent complexes of proteasome model with peptide aldehyde inhibitors MG132 and MG101: docking and molecular dynamics study.

  Journal of molecular modeling 20091201

• Proteasome inhibition suppresses Schwann cell dedifferentiation in vitro and in vivo.

  Glia 20091201

• Lysosome-dependent degradation of Notch3.

  The international journal of biochemistry & cell biology 20091201

• Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells.

  Journal of cellular physiology 20091201

• Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin-proteasome system in PC12D cells.

  Journal of neural transmission (Vienna, Austria : 1996) 20091201

• Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells.

  Free radical biology & medicine 20091201

• Zn2+ mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus.

  Journal of neurochemistry 20091201

• NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation.

  Molecular pharmacology 20091201

• Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins.

  American journal of physiology. Heart and circulatory physiology 20091201

• Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2.

  The FEBS journal 20091201

• Effects of inhibiting the proteasomal degradation of estrogen receptor alpha on estrogen receptor alpha activation under hypoxic conditions.

  Biological & pharmaceutical bulletin 20091201

• Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction.

  Experimental cell research 20091115

• The small heat shock protein HSP25 protects astrocytes against stress induced by proteasomal inhibition.

  Glia 20091101

• Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival.

  Journal of neuroscience research 20091101

• Skp2 enhances polyubiquitination and degradation of TIS21/BTG2/PC3, tumor suppressor protein, at the downstream of FoxM1.

  Experimental cell research 20091101

• Capillary electrophoresis for screening of 20S proteasome inhibitors.

  Analytical biochemistry 20091101

• Inhibition of the JNK signalling pathway enhances proteasome inhibitor-induced apoptosis of kidney cancer cells by suppression of BAG3 expression.

  British journal of pharmacology 20091101

• BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution.

  Journal of neurochemistry 20091101

• TDP-43 is recruited to stress granules in conditions of oxidative insult.

  Journal of neurochemistry 20091101

• Cdh1 controls the stability of TACC3.

  Cell cycle (Georgetown, Tex.) 20091101

• Downregulation of DeltaNp63alpha in keratinocytes by p14ARF-mediated SUMO-conjugation and degradation.

  Cell cycle (Georgetown, Tex.) 20091101

• Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization.

  Cancer research 20091101

• Proteasome inhibitors induce apoptosis in human lung cancer cells through a positive feedback mechanism and the subsequent Mcl-1 protein cleavage.

  Oncogene 20091029

• Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress- and calpain-mediated mitochondrial cell death pathways.

  Toxicology 20091029

• The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume.

  Blood 20091029

• Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks.

  The Journal of biological chemistry 20091009

• Nitric oxide regulates lung carcinoma cell anoikis through inhibition of ubiquitin-proteasomal degradation of caveolin-1.

  The Journal of biological chemistry 20091009

• Perturbation of DNA repair pathways by proteasome inhibitors corresponds to enhanced chemosensitivity of cells to DNA damage-inducing agents.

  Cancer chemotherapy and pharmacology 20091001

• Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.

  Molecular & cellular proteomics : MCP 20091001

• Genome-wide comparative analysis of type-A Arabidopsis response regulator genes by overexpression studies reveals their diverse roles and regulatory mechanisms in cytokinin signaling.

  Cell research 20091001

• The DOUBLETIME protein kinase regulates phosphorylation of the Drosophila PDP1epsilon.

  Journal of neurochemistry 20091001

• Regulation of stathmin phosphorylation in mouse liver progenitor-29 cells during proteasome inhibition.

  Proteomics 20091001

• Aurora-C: the youngest of 'the three (Aurora kinase) tenors' of mitotic symphony.

  Cell cycle (Georgetown, Tex.) 20091001

• Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.

  Proceedings of the National Academy of Sciences of the United States of America 20090929

• Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.

  The Journal of biological chemistry 20090925

• Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis.

  Genes & development 20090915

• Repression of protein translation and mTOR signaling by proteasome inhibitor in colon cancer cells.

  Biochemical and biophysical research communications 20090904

• Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells.

  Journal of cellular and molecular medicine 20090901

• Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms.

  Molecular carcinogenesis 20090901

• alpha-Synuclein promotes the recruitment of tau to protein inclusions in oligodendroglial cells: effects of oxidative and proteolytic stress.

  Journal of molecular neuroscience : MN 20090901

• Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: a consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase (PERK) and general control nonderepressible-2 eIF2alpha kinase (GCN2), and global translational shutoff.

  Molecular pharmacology 20090901

• Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance.

  Molecular pharmacology 20090901

• Follicular thyroid cancer cell growth inhibition by proteosome inhibitor MG132.

  The Journal of surgical research 20090901

• Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension.

  Hypertension (Dallas, Tex. : 1979) 20090901

• Evaluation of in vitro cultured rat oocytes, from different strains, by spindle morphology and maturation-promoting-factor activity combined with nuclear-transfer experiments.

  Cloning and stem cells 20090901

• Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca(2+)-evoked activation of p38alpha MAPK and JNK1.

  Toxicology 20090821

• Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins.

  The Journal of biological chemistry 20090821

• A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel.

  Structure (London, England : 1993) 20090812

• Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascades.

  Journal of cellular physiology 20090801

• Potent anti-inflammatory effects of low-dose proteasome inhibition in the vascular system.

  Journal of molecular medicine (Berlin, Germany) 20090801

• Ectodomain shedding and generation of two carboxy-terminal fragments of human complement receptor 2/CD21.

  Molecular immunology 20090801

• Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation.

  Nature cell biology 20090801

• BAX/BAK-independent mitoptosis during cell death induced by proteasome inhibition?

  Molecular cancer research : MCR 20090801

• Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure.

  The European journal of neuroscience 20090801

• Cytosolic prion protein induces apoptosis in human neuronal cell SH-SY5Y via mitochondrial disruption pathway.

  BMB reports 20090731

• Proteasome inhibitors block HIV-1 replication by affecting both cellular and viral targets.

  Biochemical and biophysical research communications 20090717

• Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection.

  Cardiovascular research 20090715

• Ubiquitination of HEXIM1 by HDM2.

  Cell cycle (Georgetown, Tex.) 20090715

• Determining time of death: temperature-dependent postmortem changes in calcineurin A, MARCKS, CaMKII, and protein phosphatase 2A in mouse.

  International journal of legal medicine 20090701

• Diclofenac enhances proinflammatory cytokine-induced nitric oxide production through NF-kappaB signaling in cultured astrocytes.

  Toxicology and applied pharmacology 20090701

• Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol.

  Archives of biochemistry and biophysics 20090701

• The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH.

  Oncology reports 20090701

• Proteasome inhibitor MG-132 mediated expression of p27Kip1 via S-phase kinase protein 2 degradation induces cell cycle coupled apoptosis in primary effusion lymphoma cells.

  Leukemia & lymphoma 20090701

• Inhibition of autophagy induced by proteasome inhibition increases cell death in human SHG-44 glioma cells.

  Acta pharmacologica Sinica 20090701

• TGF-beta induces degradation of TAL1/SCL by the ubiquitin-proteasome pathway through AKT-mediated phosphorylation.

  Blood 20090625

• Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-induced nitric oxide production through stimulating iNOS protein ubiquitination.

  Toxicology and applied pharmacology 20090615

• Synthesis and biological evaluation of boron peptide analogues of Belactosin C as proteasome inhibitors.

  Bioorganic & medicinal chemistry letters 20090615

• Proteasome inhibitor differentially regulates expression of the major immediate early genes of human cytomegalovirus in human central nervous system-derived cell lines.

  Virus research 20090601

• Novel cytostatic activity of the trypanocidal drug Benznidazole.

  International immunopharmacology 20090601

• Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction.

  American journal of physiology. Lung cellular and molecular physiology 20090601

• The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.

  Nature cell biology 20090601

• Cellular calcium deficiency plays a role in neuronal death caused by proteasome inhibitors.

  Journal of neurochemistry 20090601

• Long-term suppression of tyrosinase by terrein via tyrosinase degradation and its decreased expression.

  Experimental dermatology 20090601

• [Effect of proteasome inhibitors MG-132 at different doses on cultured K562 cell apoptosis].

  Zhongguo shi yan xue ye xue za zhi 20090601

• Comprehensive proteomic and transcriptomic analysis reveals early induction of a protective anti-oxidative stress response by low-dose proteasome inhibition.

  Proteomics 20090601

• Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle.

  The Journal of biological chemistry 20090529

• Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription.

  Virology 20090525

• A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.

  Cancer research 20090515

• Method of oocyte activation affects cloning efficiency in pigs.

  Molecular reproduction and development 20090501

• Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells.

  Journal of cellular physiology 20090501

• Participation of the human sperm proteasome in the capacitation process and its regulation by protein kinase A and tyrosine kinase.

  Biology of reproduction 20090501

• SCA8 repeat expansion: large CTA/CTG repeat alleles in neurological disorders and functional implications.

  Human genetics 20090501

• Investigation of a role for lysine residues in non-structural proteins 2 and 2/3 of the hepatitis C virus for their degradation and virus assembly.

  The Journal of general virology 20090501

• Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated.

  Haematologica 20090501

• Transcriptional and posttranslational regulation of clusterin by the two main cellular proteolytic pathways.

  Free radical biology & medicine 20090501

• Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.

  Nature cell biology 20090501

• Rapid proteasomal degradation of transcription factor IIB in accordance with F9 cell differentiation.

  Gene 20090501

• Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy.

  Journal of neurotrauma 20090501

• Dynamic behavior of Arabidopsis eIF4A-III, putative core protein of exon junction complex: fast relocation to nucleolus and splicing speckles under hypoxia.

  The Plant cell 20090501

• [Effect of the proteasome inhibitor MG-132 on hyperoxic lung injury and its mechanism in rats].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090501

• Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.

  PLoS pathogens 20090501

• D-glucosamine down-regulates HIF-1alpha through inhibition of protein translation in DU145 prostate cancer cells.

  Biochemical and biophysical research communications 20090424

• Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease.

  Neuroscience letters 20090424

• The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins.

  The Journal of biological chemistry 20090417

• BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis.

  The Journal of investigative dermatology 20090401

• Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes.

  Endocrinology 20090401

• Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells.

  The Journal of pharmacology and experimental therapeutics 20090401

• ARC is a critical cardiomyocyte survival switch in doxorubicin cardiotoxicity.

  Journal of molecular medicine (Berlin, Germany) 20090401

• Mechanisms targeting apolipoprotein B100 to proteasomal degradation: evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminus.

  Arteriosclerosis, thrombosis, and vascular biology 20090401

• Low molecular mass polypeptide-2 in human trophoblast: over-expression in hydatidiform moles and possible role in trophoblast cell invasion.

  Placenta 20090401

• The effect of proteasome inhibitor MG132 on experimental inflammatory bowel disease.

  Clinical and experimental immunology 20090401

• New cyclic peptide proteasome inhibitors.

  Bioorganic & medicinal chemistry letters 20090401

• Dopamine (DA) induced irreversible proteasome inhibition via DA derived quinones.

  Free radical research 20090401

• Regulation of Cdh1-APC function in axon growth by Cdh1 phosphorylation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090401

• [Induction of apoptosis by proteasome inhibitor MG-132 in human erythroleukemia cell line K562].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090401

• The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition.

  Blood 20090326

• Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.

  The Journal of biological chemistry 20090320

• COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis.

  The Journal of biological chemistry 20090320

• Disulfide and thioether linked cytochrome c-oligoarginine conjugates in HeLa cells.

  International journal of pharmaceutics 20090318

• Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome system.

  FEBS letters 20090318

• Manganese (II) induces chemical hypoxia by inhibiting HIF-prolyl hydroxylase: implication in manganese-induced pulmonary inflammation.

  Toxicology and applied pharmacology 20090315

• Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes.

  Toxicology 20090304

• Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells.

  Parkinsonism & related disorders 20090301

• Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane.

  The Journal of nutritional biochemistry 20090301

• Proteasome inhibition induces neurite outgrowth through posttranslational modification of TrkA receptor.

  The international journal of biochemistry & cell biology 20090301

• Proteasome inhibitor MG132 induces BAG3 expression through activation of heat shock factor 1.

  Journal of cellular physiology 20090301

• Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations.

  Cell death and differentiation 20090301

• HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells.

  Journal of molecular and cellular cardiology 20090301

• West Nile virus genome amplification requires the functional activities of the proteasome.

  Virology 20090301

• Stable protein, unstable plaque?

  Journal of molecular and cellular cardiology 20090301

• Protective effect against Parkinson's disease-related insults through the activation of XBP1.

  Brain research 20090227

• Degradation of transglutaminase 2 by calcium-mediated ubiquitination responding to high oxidative stress.

  FEBS letters 20090218

• Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation.

  Bioorganic & medicinal chemistry letters 20090215

• Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy.

  Cancer research 20090215

• Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23.

  Biochemical and biophysical research communications 20090206

• Inhibition of rat liver cathepsins B and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-leucinal and its analogues.

  Journal of enzyme inhibition and medicinal chemistry 20090201

• Intracellular zinc increase inhibits p53(-/-) pancreatic adenocarcinoma cell growth by ROS/AIF-mediated apoptosis.

  Biochimica et biophysica acta 20090201

• Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations.

  Pharmaceutical research 20090201

• Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis.

  Experimental cell research 20090201

• Proteasome regulation of dynamic transcription factor occupancy on the GnRH-stimulated luteinizing hormone beta-subunit promoter.

  Molecular endocrinology (Baltimore, Md.) 20090201

• Dyclonine and alverine citrate enhance the cytotoxic effects of proteasome inhibitor MG132 on breast cancer cells.

  International journal of molecular medicine 20090201

• A histone deacetylase inhibitor LBH589 downregulates XIAP in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20090201

• Thalidomide inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production via down-regulation of MyD88 expression.

  Innate immunity 20090201

• Estrogen and hypoxia regulate estrogen receptor alpha in a synergistic manner.

  Biochemical and biophysical research communications 20090123

• Isolation of human proteasomes and putative proteasome-interacting proteins using a novel affinity chromatography method.

  Experimental cell research 20090115

• Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'.

  The Plant journal : for cell and molecular biology 20090101

• Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation.

  Journal of cellular physiology 20090101

• Phenethyl isothiocyanate induces cell cycle arrest and reduction of alpha- and beta-tubulin isotypes in human prostate cancer cells.

  Cell biology international 20090101

• Substrate selection by the proteasome during degradation of protein complexes.

  Nature chemical biology 20090101

• Protection against amyloid beta cytotoxicity by sulforaphane: role of the proteasome.

  Archives of pharmacal research 20090101

• The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome.

  PloS one 20090101

• Changes in proteasome structure and function caused by HAMLET in tumor cells.

  PloS one 20090101

• Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells.

  PloS one 20090101

• GSK3beta is involved in JNK2-mediated beta-catenin inhibition.

  PloS one 20090101

• Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha.

  PloS one 20090101

• Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders.

  PloS one 20090101

• Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.

  PloS one 20090101

• Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells (NCI-ADR-RES) and placental cells (JAR).

  Molecular pharmaceutics 20090101

• Notch versus the proteasome: what is the target of gamma-secretase inhibitor-I?

  Breast cancer research : BCR 20090101

• TRIM5alpha and TRIMCyp form apparent hexamers and their multimeric state is not affected by exposure to restriction-sensitive viruses or by treatment with pharmacological inhibitors.

  Retrovirology 20090101

• Mechanisms of c-myc degradation by nickel compounds and hypoxia.

  PloS one 20090101

• Dual regulation of TERT activity through transcription and splicing by DeltaNP63alpha.

  Aging 20090101

• Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells.

  Biochemical and biophysical research communications 20081226

• Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation.

  Journal of cellular biochemistry 20081215

• The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition.

  Journal of cell science 20081215

• p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner.

  Journal of cell science 20081215

• Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation.

  Journal of cellular and molecular medicine 20081201

• TNF-alpha stimulates Akt by a distinct aPKC-dependent pathway in premalignant keratinocytes.

  Experimental dermatology 20081201

• The expression of tubulin polymerization promoting protein TPPP/p25alpha is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress.

  Glia 20081201

• Treatment with proteasome inhibitor MG132 during cloning improves survival and pronuclear number of reconstructed rat embryos.

  Cloning and stem cells 20081201

• A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome.

  American journal of physiology. Heart and circulatory physiology 20081201

• Inhibition of the ubiquitin-proteasome activity prevents glutamate transporter degradation and morphine tolerance.

  Pain 20081201

• The developmental potential of parthenogenetic and somatic cell nuclear-transferred rat oocytes in vitro.

  Cloning and stem cells 20081201

• MG-132 inhibits telomerase activity, induces apoptosis and G(1) arrest associated with upregulated p27kip1 expression and downregulated survivin expression in gastric carcinoma cells.

  Cancer investigation 20081201

• Binding of MG132 or deletion of the Thr active sites in HslV subunits increases the affinity of HslV protease for HslU ATPase and makes this interaction nucleotide-independent.

  The Journal of biological chemistry 20081128

• The Arabidopsis receptor-like kinase STRUBBELIG mediates inter-cell-layer signaling during floral development.

  Developmental biology 20081115

• MG-132 inhibits the TCDD-mediated induction of Cyp1a1 at the catalytic activity but not the mRNA or protein levels in Hepa 1c1c7 cells.

  Toxicology letters 20081110

• Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells.

  Breast cancer research and treatment 20081101

• Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid apigenin in pancreatic cancer cell lines.

  Molecular carcinogenesis 20081101

• The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle.

  Molecular & cellular proteomics : MCP 20081101

• Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance.

  Leukemia 20081101

• MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation.

  American journal of physiology. Renal physiology 20081101

• Proteasome-dependent degradation of Chk1 kinase induced by the topoisomerase II inhibitor R16 contributes to its anticancer activity.

  Cancer biology & therapy 20081101

• Peroxynitrite augments fibroblast-mediated tissue remodeling via myofibroblast differentiation.

  American journal of physiology. Lung cellular and molecular physiology 20081101

• Interaction between cFLIP and Itch, a ubiquitin ligase, is obstructed in Trypanosoma cruzi-infected human cells.

  Microbiology and immunology 20081101

• Stress and IGF-I differentially control cell fate through mammalian target of rapamycin (mTOR) and retinoblastoma protein (pRB).

  The Journal of biological chemistry 20081017

• Compromised proteasome degradation elevates neuronal nitric oxide synthase levels and induces apoptotic cell death.

  Archives of biochemistry and biophysics 20081015

• Proteasome inhibition compromises direct retention of cytochrome P450 2C2 in the endoplasmic reticulum.

  Experimental cell research 20081015

• Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20081015

• In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis.

  American journal of respiratory cell and molecular biology 20081001

• The AAA-ATPase p97 facilitates degradation of apolipoprotein B by the ubiquitin-proteasome pathway.

  Journal of lipid research 20081001

• Quercetin-induced ubiquitination and down-regulation of Her-2/neu.

  Journal of cellular biochemistry 20081001

• Mesenchymal stem cells therapy exerts neuroprotection in a progressive animal model of Parkinson's disease.

  Journal of neurochemistry 20081001

• NF-kappaB-dependency and consequent regulation of IL-8 in echinomycin-induced apoptosis of HT-29 colon cancer cells.

  Cell biology international 20081001

• Caspase-3 activation as a key factor for HBx-transformed cell death.

  Cell proliferation 20081001

• Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.

  Journal of proteome research 20081001

• Troglitazone increases IL-1beta induced cyclooxygenase-2 and inducible nitric oxide synthase expression via enhanced phosphorylation of IkappaBalpha in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats.

  Biological & pharmaceutical bulletin 20081001

• TNF alpha-induced down-regulation of estrogen receptor alpha in MCF-7 breast cancer cells.

  Molecules and cells 20080930

• Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells.

  Biochemical and biophysical research communications 20080919

• A robust ex vivo model for evaluation of induction of apoptosis by rhTRAIL in combination with proteasome inhibitor MG132 in human premalignant cervical explants.

  International journal of cancer 20080915

• Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo.

  Cancer research 20080915

• Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells.

  The Journal of biological chemistry 20080912

• Chemical and biological approaches synergize to ameliorate protein-folding diseases.

  Cell 20080905

• Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2.

  American journal of respiratory cell and molecular biology 20080901

• A p38-p65 transcription complex induced by endothelin-1 mediates signal transduction in cancer cells.

  Biochimica et biophysica acta 20080901

• Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition.

  Cardiovascular research 20080901

• Proteasome inhibition and stress compromise the heart in chemotherapy.

  Cardiovascular research 20080901

• Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway.

  Molecular cancer therapeutics 20080901

• Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization.

  Molecular cell 20080822

• BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite.

  The Journal of biological chemistry 20080815

• Antitumor activity of bis-indole derivatives.

  Journal of medicinal chemistry 20080814

• Cystic fibrosis transmembrane regulator missing the first four transmembrane segments increases wild type and DeltaF508 processing.

  The Journal of biological chemistry 20080808

• MG132 proteasome inhibitor modulates proinflammatory cytokines production and expression of their receptors in U937 cells: involvement of nuclear factor-kappaB and activator protein-1.

  Immunology 20080801

• Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults.

  Free radical biology & medicine 20080801

• Cadmium-induced activation of stress signaling pathways, disruption of ubiquitin-dependent protein degradation and apoptosis in primary rat Sertoli cell-gonocyte cocultures.

  Toxicological sciences : an official journal of the Society of Toxicology 20080801

• Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina.

  Diabetes 20080801

• Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation.

  The Journal of biological chemistry 20080801

• Transient membrane recruitment of IRAK-1 in response to LPS and IL-1beta requires TNF R1.

  American journal of physiology. Cell physiology 20080801

• Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.

  American journal of physiology. Cell physiology 20080801

• EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1.

  Cell cycle (Georgetown, Tex.) 20080801

• Proteasome inhibitors induce apoptosis of prostate cancer cells by inducing nuclear translocation of IkappaBalpha.

  Archives of biochemistry and biophysics 20080715

• Laminin activates NF-kappaB in Schwann cells to enhance neurite outgrowth.

  Neuroscience letters 20080704

• C-terminal constrained phenylalanine as a pharmacophoric unit in peptide-based proteasome inhibitors.

  European journal of medicinal chemistry 20080701

• Proteasome inhibition reduces avian reovirus replication and apoptosis induction in cultured cells.

  Journal of virological methods 20080701

• Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanism.

  Journal of neurochemistry 20080701

• Jasmonate-induced nicotine formation in tobacco is mediated by tobacco COI1 and JAZ genes.

  Plant & cell physiology 20080701

• Activation of Nrf2 in defense against cadmium-induced oxidative stress.

  Chemical research in toxicology 20080701

• Inhibition of proteasome activity promotes the correct localization of disease-causing alpha-sarcoglycan mutants in HEK-293 cells constitutively expressing beta-, gamma-, and delta-sarcoglycan.

  The American journal of pathology 20080701

• Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol.

  Metabolism: clinical and experimental 20080701

• Phosphoinositide 3-kinase/AKT signaling can promote AIB1 stability independently of GSK3 phosphorylation.

  Cancer research 20080701

• Proteasome inhibitor MG-132 lowers gastric adenocarcinoma TMK1 cell proliferation via bone morphogenetic protein signaling.

  Biochemical and biophysical research communications 20080627

• Increased cytoplasmic levels of CIS, SOCS1, SOCS2, or SOCS3 are required for nuclear translocation.

  FEBS letters 20080625

• Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: involvement of NF-kappa B and reactive oxygen species-mediated p53 activation.

  Journal of immunology (Baltimore, Md. : 1950) 20080615

• Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis.

  European journal of pharmacology 20080610

• Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion.

  The Journal of biological chemistry 20080606

• The ubiquitin-conjugating enzymes, Ubc4 and Cdc34, mediate cadmium resistance in budding yeast through different mechanisms.

  Life sciences 20080606

• Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease.

  Journal of neurochemistry 20080601

• In vitro toxicity evaluation of diesel exhaust particles on human eosinophilic cell.

  Toxicology in vitro : an international journal published in association with BIBRA 20080601

• NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).

  EMBO reports 20080601

• Bone morphogenetic protein signalling is required for the anti-mitogenic effect of the proteasome inhibitor MG-132 on colon cancer cells.

  British journal of pharmacology 20080601

• Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells.

  Molecular cancer therapeutics 20080601

• Proteasome inhibitor ameliorates severe acute pancreatitis and associated lung injury of rats.

  World journal of gastroenterology 20080528

• RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage.

  The Journal of biological chemistry 20080516

• Caspase-dependent cleavage of BAG3 in proteasome inhibitors-induced apoptosis in thyroid cancer cells.

  Biochemical and biophysical research communications 20080509

• Regulation of bim in glucocorticoid-mediated osteoblast apoptosis.

  Journal of cellular physiology 20080501

• Degradation of caspase-activated DNase by the ubiquitin-proteasome system.

  Biochimica et biophysica acta 20080501

• Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2.

  The Biochemical journal 20080501

• Mannosidase I inhibition rescues the human alpha-sarcoglycan R77C recurrent mutation.

  Human molecular genetics 20080501

• Proteasome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells.

  Cancer science 20080501

• CD28 ligation in the absence of TCR promotes RelA/NF-kappaB recruitment and trans-activation of the HIV-1 LTR.

  European journal of immunology 20080501

• Cytokinin inhibits the proteasome-mediated degradation of carbonylated proteins in Arabidopsis leaves.

  Plant & cell physiology 20080501

• Steroidogenic acute regulatory protein gene expression, steroid-hormone secretion and proliferative activity of adrenocortical cells in the presence of proteasome inhibitors: in vivo studies on the regenerating rat adrenal cortex.

  International journal of molecular medicine 20080501

• The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-induced cell cycle arrest.

  DNA and cell biology 20080501

• Endogenous dopamine (DA) renders dopaminergic cells vulnerable to challenge of proteasome inhibitor MG132.

  Free radical research 20080501

• CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cells.

  Oncogene 20080417

• Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron.

  Journal of cellular biochemistry 20080415

• Involvement of mitogen-activated protein kinases and NFkappaB in LPS-induced CD40 expression on human monocytic cells.

  Toxicology and applied pharmacology 20080415

• Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity.

  Toxicology and applied pharmacology 20080415

• Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622.

  The Journal of pharmacology and experimental therapeutics 20080401

• Effects of proteasome inhibitor, MG132, on proteasome activity and oxidative status of rat liver.

  Cell biochemistry and function 20080401

• Proteasome inhibitor MG132 reverses multidrug resistance of gastric cancer through enhancing apoptosis and inhibiting P-gp.

  Cancer biology & therapy 20080401

• Proteasome inhibitor MG-132 modifies coxsackie and adenovirus receptor expression in colon cancer cell line lovo.

  Cell cycle (Georgetown, Tex.) 20080401

• CITED2 mediates the paradoxical responses of HIF-1alpha to proteasome inhibition.

  Oncogene 20080320

• Vinyl ester-based cyclic peptide proteasome inhibitors.

  Bioorganic & medicinal chemistry letters 20080315

• Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner.

  Oncogene 20080306

• Proteasome inhibitor MG132 blocks viral DNA replication and assembly of human cytomegalovirus.

  FEBS letters 20080305

• Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling.

  The Journal of surgical research 20080301

• The two isoforms of the Na+/Ca2+ exchanger, NCX1 and NCX3, constitute novel additional targets for the prosurvival action of Akt/protein kinase B pathway.

  Molecular pharmacology 20080301

• The role of sperm proteasomes during sperm aster formation and early zygote development: implications for fertilization failure in humans.

  Human reproduction (Oxford, England) 20080301

• A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization.

  Apoptosis : an international journal on programmed cell death 20080301

• Decreased epithelial barrier function evoked by exposure to metabolic stress and nonpathogenic E. coli is enhanced by TNF-alpha.

  American journal of physiology. Gastrointestinal and liver physiology 20080301

• Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells.

  Neoplasia (New York, N.Y.) 20080301

• Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1.

  Biochimica et biophysica acta 20080301

• Secretory products from human adipocytes impair endothelial function via nuclear factor kappaB.

  Atherosclerosis 20080201

• The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes.

  Atherosclerosis 20080201

• Defective protein folding and intracellular retention of thyroglobulin-R19K mutant as a cause of human congenital goiter.

  Molecular endocrinology (Baltimore, Md.) 20080201

• XND1, a member of the NAC domain family in Arabidopsis thaliana, negatively regulates lignocellulose synthesis and programmed cell death in xylem.

  The Plant journal : for cell and molecular biology 20080201

• Proteasomal degradation of human release factor eRF3a regulates translation termination complex formation.

  RNA (New York, N.Y.) 20080201

• Suppression of cardiomyocyte hypertrophy by inhibition of the ubiquitin-proteasome system.

  Hypertension (Dallas, Tex. : 1979) 20080201

• Antioxidants block proteasome inhibitor function in endometrial carcinoma cells.

  Anti-cancer drugs 20080201

• Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1.

  Oncogene 20080131

• Inefficient glycosylation leads to high steady-state levels of actively degrading cardiac triadin-1.

  The Journal of biological chemistry 20080125

• Characterization of a short isoform of human Tgs1 hypermethylase associating with small nucleolar ribonucleoprotein core proteins and produced by limited proteolytic processing.

  The Journal of biological chemistry 20080125

• Characterization of the cell membrane-associated products of the Neuregulin 4 gene.

  Oncogene 20080124

• Differential GATA factor stabilities: implications for chromatin occupancy by structurally similar transcription factors.

  Biochemistry 20080122

• Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.

  The Journal of biological chemistry 20080118

• Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase.

  The Journal of biological chemistry 20080118

• The ubiquitin-mediated degradation of Jak1 modulates osteoclastogenesis by limiting interferon-beta-induced inhibitory signaling.

  Blood 20080115

• Tbx6, Thylacine1, and E47 synergistically activate bowline expression in Xenopus somitogenesis.

  Developmental biology 20080115

• Pyruvate dehydrogenase complex deficiency caused by ubiquitination and proteasome-mediated degradation of the E1 subunit.

  The Journal of biological chemistry 20080104

• Diminished feedback regulation of proteasome expression and resistance to proteasome inhibitors in breast cancer cells.

  Breast cancer research and treatment 20080101

• Tristetraprolin regulates TNF TNF-alpha mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways.

  Molecular immunology 20080101

• Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha.

  International journal of cancer 20080101

• Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells.

  Acta oncologica (Stockholm, Sweden) 20080101

• Proteolytic activity of the 26S proteasome is required for the meiotic resumption, germinal vesicle breakdown, and cumulus expansion of porcine cumulus-oocyte complexes matured in vitro.

  Biology of reproduction 20080101

• Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation.

  Bioorganic & medicinal chemistry letters 20080101

• A novel class of intrinsic proteasome inhibitory gene transfer peptides.

  Bioconjugate chemistry 20080101

• Involvement of two distinct ubiquitin E3 ligase systems for p27 degradation in corneal endothelial cells.

  Investigative ophthalmology & visual science 20080101

• Down-regulation of brain-pancreas relative protein in diabetic rats and by high glucose in PC12 cells: prevention by calpain inhibitors.

  Journal of pharmacological sciences 20080101

• Expression of K6W-ubiquitin in lens epithelial cells leads to upregulation of a broad spectrum of molecular chaperones.

  Molecular vision 20080101

• The proteasome inhibitor MG132 induces nuclear translocation of erythroid transcription factor Nrf2 and cyclooxygenase-2 expression in human vascular endothelial cells.

  Thrombosis research 20080101

• Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication.

  PloS one 20080101

• Identification and characterization of two splicing variants of human Noxa.

  Anticancer research 20080101

• APOBEC3G-UBA2 fusion as a potential strategy for stable expression of APOBEC3G and inhibition of HIV-1 replication.

  Retrovirology 20080101

• Regulation of the Arabidopsis GSK3-like kinase BRASSINOSTEROID-INSENSITIVE 2 through proteasome-mediated protein degradation.

  Molecular plant 20080101

• The application and relevance of ex vivo culture systems for assessment of IBD treatment in murine models of colitis.

  Pharmacological research 20080101

• A single mutation at lysine 241 alters expression and trafficking of the D2 dopamine receptor.

  Journal of receptor and signal transduction research 20080101

• Local induction of heat shock protein 70 (Hsp70) by proteasome inhibition confers chondroprotection during surgically induced osteoarthritis in the rat knee.

  Bio-medical materials and engineering 20080101

• tabAnti-HER2 (erbB-2) oncogene effects of phenolic compounds directly isolated from commercial Extra-Virgin Olive Oil (EVOO).

  BMC cancer 20080101

• c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1.

  Molecular cell 20071214

• Reduction of infectious bursal disease virus replication in cultured cells by proteasome inhibitors.

  Virus genes 20071201

• Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis.

  Traffic (Copenhagen, Denmark) 20071201

• PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.

  British journal of pharmacology 20071201

• Absence of Bax switched MG132-induced apoptosis to non-apoptotic cell death that could be suppressed by transcriptional or translational inhibition.

  Apoptosis : an international journal on programmed cell death 20071201

• Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells.

  Basic & clinical pharmacology & toxicology 20071201

• A mutation in CHN-1/CHIP suppresses muscle degeneration in Caenorhabditis elegans.

  Developmental biology 20071201

• The complete removal of cohesin from chromosome arms depends on separase.

  Journal of cell science 20071201

• The protein degradation response of Saccharomyces cerevisiae to classical DNA-damaging agents.

  Chemical research in toxicology 20071201

• NKp30 ligation induces rapid activation of the canonical NF-kappaB pathway in NK cells.

  Journal of immunology (Baltimore, Md. : 1950) 20071201

• Viral control of the SUMO pathway: Gam1, a model system.

  Biochemical Society transactions 20071201

• [Protective effect of proteasome inhibitor MG-132 in rats with severe acute pancreatitis and lung injury].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20071201

• Hsp70B' regulation and function.

  Cell stress & chaperones 20071201

• Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing.

  The Journal of biological chemistry 20071123

• Ubiquitin-conjugating enzyme Cdc34 mediates cadmium resistance in budding yeast through ubiquitination of the transcription factor Met4.

  Biochemical and biophysical research communications 20071123

• Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells.

  International journal of cancer 20071115

• NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis.

  Biochemical pharmacology 20071115

• Aryl hydrocarbon receptor signaling in rainbow trout hepatocytes: role of hsp90 and the proteasome.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20071101

• Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases.

  American journal of physiology. Cell physiology 20071101

• Identification of ubiquitin target proteins using cell-based arrays.

  Journal of proteome research 20071101

• Inhibition of paclitaxel-induced proteasome activation influences paclitaxel cytotoxicity in breast cancer cells in a sequence-dependent manner.

  Cell cycle (Georgetown, Tex.) 20071101

• Mutant and misfolded human growth hormone is rapidly degraded through the proteasomal degradation pathway in a cellular model for isolated growth hormone deficiency type II.

  Journal of neuroendocrinology 20071101

• The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.

  Cell metabolism 20071101

• Heat Shock Protein 90 regulates the stability of c-Jun in HEK293 Cells.

  Molecules and cells 20071031

• Inhibition of estrogen action by 2-phenylchromone as AhR agonist in MCF-7 cells.

  Life sciences 20071027

• Regulation of repp86 stability by human Siah2.

  Biochemical and biophysical research communications 20071019

• Caspase-8 dependent osteosarcoma cell apoptosis induced by proteasome inhibitor MG132.

  Cell biology international 20071001

• Human GCIP interacts with CT847, a novel Chlamydia trachomatis type III secretion substrate, and is degraded in a tissue-culture infection model.

  Cellular microbiology 20071001

• Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells.

  Carcinogenesis 20071001

• Hypoxia stabilizes type 2 deiodinase activity in rat astrocytes.

  Endocrinology 20071001

• Cell cycle-and proteasome-dependent formation of etoposide-induced replication protein A (RPA) or Mre11/Rad50/Nbs1 (MRN) complex repair foci.

  Cell cycle (Georgetown, Tex.) 20071001

• PERK-dependent compartmentalization of ERAD and unfolded protein response machineries during ER stress.

  Experimental cell research 20071001

• Ascorbate (vitamin C) induces cell death through the apoptosis-inducing factor in human breast cancer cells.

  Oncology reports 20071001

• The proteasome and intracellular redox status: implications for apoptotic regulation in lens epithelial cells.

  Current eye research 20071001

• House dust mite induces expression of intercellular adhesion molecule-1 in EoL-1 human eosinophilic leukemic cells.

  Journal of Korean medical science 20071001

• EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression.

  The Journal of biological chemistry 20070928

• Hsp70-GlcNAc-binding activity is released by stress, proteasome inhibition, and protein misfolding.

  Biochemical and biophysical research communications 20070921

• Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein.

  The Journal of biological chemistry 20070921

• Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.

  Cancer research 20070915

• Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane.

  Cancer research 20070915

• Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex.

  The Journal of biological chemistry 20070907

• Therapeutic proteasome inhibition in experimental acute pancreatitis.

  World journal of gastroenterology 20070907

• SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.

  Cell 20070907

• Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers.

  The Journal of clinical investigation 20070904

• Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070901

• The role of androgen in determining differentiation and regulation of androgen receptor expression in the human prostatic epithelium transient amplifying population.

  Journal of cellular physiology 20070901

• Increased wild-type p53-induced phosphatase 1 (Wip1 or PPM1D) expression correlated with downregulation of checkpoint kinase 2 in human gastric carcinoma.

  Pathology international 20070901

• Oriental herbs as a source of novel anti-androgen and prostate cancer chemopreventive agents.

  Acta pharmacologica Sinica 20070901

• HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates.

  Genes & development 20070901

• DBC2 resistance is achieved by enhancing 26S proteasome-mediated protein degradation.

  Biochemical and biophysical research communications 20070831

• Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.

  Circulation 20070821

• NAC1 regulates the recruitment of the proteasome complex into dendritic spines.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070815

• Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation.

  The Journal of biological chemistry 20070803

• Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite.

  Journal of cellular physiology 20070801

• COX-2 expression induced by diesel particles involves chromatin modification and degradation of HDAC1.

  American journal of respiratory cell and molecular biology 20070801

• Maspin augments proteasome inhibitor-induced apoptosis in prostate cancer cells.

  Journal of cellular physiology 20070801

• Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics.

  The Journal of pharmacology and experimental therapeutics 20070801

• A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132.

  Journal of neurochemistry 20070801

• Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling.

  Human reproduction (Oxford, England) 20070801

• Sperm proteasomes are responsible for the acrosome reaction and sperm penetration of the vitelline envelope during fertilization of the sea urchin Pseudocentrotus depressus.

  Developmental biology 20070801

• Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium.

  Toxicology letters 20070801

• Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.

  The American journal of pathology 20070801

• Control of chronic pain by the ubiquitin proteasome system in the spinal cord.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070801

• An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070801

• Proteasome function is required for DNA damage response and fanconi anemia pathway activation.

  Cancer research 20070801

• Hsp70B' regulation and function.

  Cell stress & chaperones 20070801

• The Cdc25A is involved in S-phase checkpoint induced by benzo(a)pyrene.

  Toxicology 20070731

• ABA modulates the degradation of phosphoenolpyruvate carboxylase kinase in sorghum leaves.

  FEBS letters 20070724

• Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?

  Biochemistry 20070703

• Different induction of GRP78 and CHOP as a predictor of sensitivity to proteasome inhibitors in thyroid cancer cells.

  Endocrinology 20070701

• Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1.

  American journal of physiology. Cell physiology 20070701

• Effects of proteasome inhibitors on fertilization of the sea urchin Anthocidaris crassispina.

  Biological & pharmaceutical bulletin 20070701

• Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture.

  American journal of physiology. Gastrointestinal and liver physiology 20070701

• A proteomic approach towards the Hsp90-dependent ubiquitinylated proteome.

  Proteomics 20070701

• Specific blockage of ligand-induced degradation of the Ah receptor by proteasome but not calpain inhibitors in cell culture lines from different species.

  Biochemical pharmacology 20070630

• Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus.

  Neuroscience 20070615

• Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs.

  Cancer research 20070615

• The co-chaperone CHIP is induced in various stresses and confers protection to cells.

  Biochemical and biophysical research communications 20070608

• Liver-X-receptor activator prevents homocysteine-induced production of IgG antibodies from murine B lymphocytes via the ROS-NF-kappaB pathway.

  Biochemical and biophysical research communications 20070608

• Involvement of the betaTrCP in the ubiquitination and stability of the HIV-1 Vpu protein.

  Biochemical and biophysical research communications 20070608

• CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells.

  Oncogene 20070607

• TNF-alpha upregulates VCAM-1 and NF-kappaB in fibroblasts from nasal polyps.

  Auris, nasus, larynx 20070601

• Induction of cyclooxygenase-2 expression by manganese in cultured astrocytes.

  Neurochemistry international 20070601

• p45, an ATPase subunit of the 19S proteasome, targets the polyglutamine disease protein ataxin-3 to the proteasome.

  Journal of neurochemistry 20070601

• Retrodifferentiation and rejuvenation of senescent monocytic cells requires PARP-1.

  Experimental gerontology 20070601

• Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture.

  Laboratory investigation; a journal of technical methods and pathology 20070601

• BubR1 and CENP-E have antagonistic effects upon the stability of microtubule-kinetochore attachments in Drosophila S2 cell mitosis.

  Cell cycle (Georgetown, Tex.) 20070601

• Adrenoleukodystrophy: subcellular localization and degradation of adrenoleukodystrophy protein (ALDP/ABCD1) with naturally occurring missense mutations.

  Journal of neurochemistry 20070601

• Differential regulation of estrogen receptor alpha turnover and transactivation by Mdm2 and stress-inducing agents.

  Cancer research 20070601

• In vivo effects of an inhibitor of nuclear factor-kappa B on thrombogenic properties of antiphospholipid antibodies.

  Annals of the New York Academy of Sciences 20070601

• Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus.

  Oncogene 20070531

• Role of epidermal growth factor receptor degradation in gemcitabine-mediated cytotoxicity.

  Oncogene 20070517

• The proteasome function is required for Mycobacterium leprae-induced apoptosis and cytokine secretion.

  Immunology letters 20070515

• The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells.

  Cancer research 20070515

• Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression.

  Journal of medicinal chemistry 20070503

• Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells.

  Carcinogenesis 20070501

• Expression of islet inducible nitric oxide synthase and inhibition of glucose-stimulated insulin release after long-term lipid infusion in the rat is counteracted by PACAP27.

  American journal of physiology. Endocrinology and metabolism 20070501

• Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling.

  Journal of leukocyte biology 20070501

• Hydroxyurea increases eNOS protein levels through inhibition of proteasome activity.

  Nitric oxide : biology and chemistry 20070501

• Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells.

  Journal of cellular physiology 20070501

• Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease.

  Journal of cell science 20070501

• Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol.

  Traffic (Copenhagen, Denmark) 20070501

• Mouse homologue of yeast Prp19 interacts with mouse SUG1, the regulatory subunit of 26S proteasome.

  Biochemical and biophysical research communications 20070427

• Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction.

  Virology 20070410

• Action spectrum of Drosophila cryptochrome.

  The Journal of biological chemistry 20070406

• Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.

  Toxicological sciences : an official journal of the Society of Toxicology 20070401

• Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.

  Molecular carcinogenesis 20070401

• Proteasome inhibitors sensitize ovarian cancer cells to TRAIL induced apoptosis.

  Apoptosis : an international journal on programmed cell death 20070401

• CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism.

  Human molecular genetics 20070401

• Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment.

  Human molecular genetics 20070401

• Interleukin-1beta inhibits the hypoxic inducibility of the erythropoietin enhancer by suppressing hepatocyte nuclear factor-4alpha.

  Cellular and molecular life sciences : CMLS 20070401

• Proteasome inhibition specifically sensitizes leukemic cells to anthracyclin-induced apoptosis through the accumulation of Bim and Bax pro-apoptotic proteins.

  Cancer biology & therapy 20070401

• Peroxisome proliferator-activated receptor gamma-independent suppression of androgen receptor expression by troglitazone mechanism and pharmacologic exploitation.

  Cancer research 20070401

• Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor.

  The Journal of biological chemistry 20070323

• Synthesis, structure, and estrogenic activity of 4-amino-3-(2-methylbenzyl)coumarins on human breast carcinoma cells.

  Bioorganic & medicinal chemistry 20070315

• Expression, protein stability and transcriptional activity of retinoic acid receptors are affected by microtubules interfering agents and all-trans-retinoic acid in primary rat hepatocytes.

  Molecular and cellular endocrinology 20070315

• [Role of MG132, a proteasome inhibitor, in inducing expression of costimulatory molecules CD86 in leukemic cells and its effect on allogeneic mixed lymphocyte reaction].

  Zhonghua yi xue za zhi 20070313

• [The effect of selectively inhibiting the nuclear factor kappaB activation on survivin expression in leukemic cells].

  Zhonghua yi xue za zhi 20070313

• A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity.

  The Journal of biological chemistry 20070309

• Proteasome function is required for activation of programmed cell death in heat shocked tobacco Bright-Yellow 2 cells.

  FEBS letters 20070306

• Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes.

  The Journal of biological chemistry 20070302

• Glutamate stimulates glutamate receptor interacting protein 1 degradation by ubiquitin-proteasome system to regulate surface expression of GluR2.

  Neuroscience 20070302

• Activation of non-canonical NF-kappaB pathway mediated by STP-A11, an oncoprotein of Herpesvirus saimiri.

  Virology 20070301

• Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells.

  American journal of physiology. Gastrointestinal and liver physiology 20070301

• Defective hepatocyte aquaporin-8 expression and reduced canalicular membrane water permeability in estrogen-induced cholestasis.

  American journal of physiology. Gastrointestinal and liver physiology 20070301

• Inhibition of agonist-induced down-regulation of the delta-opioid receptor with a proteasome inhibitor attenuates opioid tolerance in human embryonic kidney 293 cells.

  The Journal of pharmacology and experimental therapeutics 20070301

• p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease.

  Journal of neurochemistry 20070301

• Accumulation of retinoid X receptor-alpha in uterine leiomyomas is associated with a delayed ligand-dependent proteasome-mediated degradation and an alteration of its transcriptional activity.

  Molecular endocrinology (Baltimore, Md.) 20070301

• Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding.

  Biochimica et biophysica acta 20070301

• p27 degradation by an ellipticinium series of compound via ubiquitin-proteasome pathway.

  Cancer biology & therapy 20070301

• A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells.

  Molecular cancer therapeutics 20070301

• Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease.

  The Journal of biological chemistry 20070216

• Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors.

  Cancer research 20070215

• Absence of reciprocal feedback between MPF and ERK2 MAP kinase in mitotic Xenopus laevis embryo cell-free extract.

  Cell cycle (Georgetown, Tex.) 20070215

• Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells.

  World journal of gastroenterology 20070214

• Proteomic expression analysis of cardiomyocytes subjected to proteasome inhibition.

  Biochemical and biophysical research communications 20070209

• Involvement of Ca2+-dependent proteasome in the degradation of both cyclin B1 and Mos during spontaneous activation of matured rat oocytes.

  Theriogenology 20070201

• Differential involvement of NF-kappaB and MAP kinase pathways in the generation of inflammatory cytokines by human neutrophils.

  Journal of leukocyte biology 20070201

• Turnover of StAR protein: roles for the proteasome and mitochondrial proteases.

  Molecular and cellular endocrinology 20070201

• A novel interaction between N-myristoylation and the 26S proteasome during cell morphogenesis.

  Molecular microbiology 20070201

• Transforming growth factor-beta, estrogen, and progesterone converge on the regulation of p27Kip1 in the normal and malignant endometrium.

  Cancer research 20070201

• NF-kappaB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition.

  Oncogene 20070125

• Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes.

  The Journal of biological chemistry 20070112

• Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells.

  Cancer letters 20070108

• The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells.

  The Journal of biological chemistry 20070105

• Proteasome dysfunction inhibits surfactant protein gene expression in lung epithelial cells: mechanism of inhibition of SP-B gene expression.

  American journal of physiology. Lung cellular and molecular physiology 20070101

• Purification and characterization of C-terminal truncated forms of histone H2A in monocytic THP-1 cells.

  The international journal of biochemistry & cell biology 20070101

• Proteasome activator enhances survival of Huntington's disease neuronal model cells.

  PloS one 20070101

• Amino acids and insulin act additively to regulate components of the ubiquitin-proteasome pathway in C2C12 myotubes.

  BMC molecular biology 20070101

• A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity.

  Molecular systems biology 20070101

• Effect of enucleation on inactivation of cytostatic factor activity in matured rat oocytes.

  Cloning and stem cells 20070101

• Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2.

  Neuro-degenerative diseases 20070101

• Degradation of the non-palmitoylated invertebrate visual guanine-nucleotide binding protein, iGq alpha(C3,4A), by the ubiquitin-proteasomal pathway is regulated by its activation and translocation to the cytoplasm.

  Visual neuroscience 20070101

• The effects of delayed activation and MG132 treatment on nuclear remodeling and preimplantation development of embryos cloned by electrofusion are correlated with the age of recipient cytoplasts.

  Cloning and stem cells 20070101

• Ubiquitin-dependent distribution of the transcriptional coactivator p300 in cytoplasmic inclusion bodies.

  Epigenetics 20070101

• Knockdown of NHERF1 enhances degradation of temperature rescued DeltaF508 CFTR from the cell surface of human airway cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• Proteasome inhibition potentiates the cytotoxic effects of hyperthermia in HT-29 colon cancer cells through inhibition of heat shock protein 27.

  Oncology 20070101

• Effect of proteasome inhibition on toxicity and CYP3A23 induction in cultured rat hepatocytes: comparison with arsenite.

  Toxicology and applied pharmacology 20061215

• NF-kB inhibition as a strategy to enhance etoposide-induced apoptosis in K562 cell line.

  American journal of hematology 20061201

• Ligand-dependent and -independent degradation of the human aryl hydrocarbon receptor (hAHR) in cell culture models.

  Chemico-biological interactions 20061201

• Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression.

  Arteriosclerosis, thrombosis, and vascular biology 20061201

• Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells.

  Cancer research 20061201

• Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells.

  Molecular cancer therapeutics 20061201

• The proteasome inhibitor MG-132 protects hypoxic SiHa cervical carcinoma cells after cyclic hypoxia/reoxygenation from ionizing radiation.

  Neoplasia (New York, N.Y.) 20061201

• Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2.

  The Journal of biological chemistry 20061124

• Proteasome inhibition induces both pro- and anti-cell death pathways in prostate cancer cells.

  Cancer letters 20061118

• The internalization and degradation of human copper transporter 1 following cisplatin exposure.

  Cancer research 20061115

• Phosphorylation-independent ubiquitylation and endocytosis of Fc gammaRIIA.

  The Journal of biological chemistry 20061103

• Coupling caspase cleavage and ubiquitin-proteasome-dependent degradation of SSRP1 during apoptosis.

  Cell death and differentiation 20061101

• Taxol and tau overexpression induced calpain-dependent degradation of the microtubule-destabilizing protein SCG10.

  Experimental neurology 20061101

• The interleukin 1beta-induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial-derived ULTR cells requires the transcription factor, NFkappaB.

  Biology of reproduction 20061101

• Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis.

  Cell biology international 20061101

• Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition.

  Molecular pharmacology 20061101

• Calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor.

  Molecular pharmacology 20061101

• Inhibition of Aurora kinases perturbs chromosome alignment and spindle checkpoint signaling in rat spermatocytes.

  Experimental cell research 20061101

• Heat induced release of Hsp70 from prostate carcinoma cells involves both active secretion and passive release from necrotic cells.

  International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20061101

• Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A.

  Oncogene 20061019

• Regulation of expression of BIK proapoptotic protein in human breast cancer cells: p53-dependent induction of BIK mRNA by fulvestrant and proteasomal degradation of BIK protein.

  Cancer research 20061015

• Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome.

  Oncogene 20061012

• Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate.

  Carcinogenesis 20061001

• Modulation of inflammatory response in sepsis by proteasome inhibition.

  International journal of experimental pathology 20061001

• Suppression of human lens epithelial cell proliferation by proteasome inhibition, a potential defense against posterior capsular opacification.

  Investigative ophthalmology & visual science 20061001

• Nitric oxide-induced down-regulation of beta-catenin in colon cancer cells by a proteasome-independent specific pathway.

  Gastroenterology 20061001

• Aspirin induces apoptosis through the inhibition of proteasome function.

  The Journal of biological chemistry 20060929

• Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060915

• The tyrosine phosphatase HD-PTP is regulated by FGF-2 through proteasome degradation.

  Frontiers in bioscience : a journal and virtual library 20060901

• Multilevel regulation of leptin storage, turnover, and secretion by feeding and insulin in rat adipose tissue.

  Journal of lipid research 20060901

• Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models.

  Neurotoxicology 20060901

• Akt and Mammalian target of rapamycin regulate separate systems of proteolysis in renal tubular cells.

  Journal of the American Society of Nephrology : JASN 20060901

• Local sharing as a predominant determinant of synaptic matrix molecular dynamics.

  PLoS biology 20060901

• Pressure-induced regulation of IL-6 in retinal glial cells: involvement of the ubiquitin/proteasome pathway and NFkappaB.

  Investigative ophthalmology & visual science 20060901

• Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells.

  Cancer research 20060901

• UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation.

  The Journal of endocrinology 20060901

• Proteolytic turnover of the Gal4 transcription factor is not required for function in vivo.

  Nature 20060831

• Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression.

  Neuron 20060817

• Novel covalent modifications of alpha-synuclein during the recovery from proteasomal dysfunction.

  Biochemical and biophysical research communications 20060811

• Photoactivated phytochrome induces rapid PIF3 phosphorylation prior to proteasome-mediated degradation.

  Molecular cell 20060804

• The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8.

  Molecular and cellular biochemistry 20060801

• Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteins.

  Journal of lipid research 20060801

• Roles of the ubiquitin/proteasome pathway in pollen tube growth with emphasis on MG132-induced alterations in ultrastructure, cytoskeleton, and cell wall components.

  Plant physiology 20060801

• Apoptotic effect of ethyl-4-isothiocyanatobutanoate is associated with DNA damage, proteasomal activity and induction of p53 and p21cip1/waf1.

  Apoptosis : an international journal on programmed cell death 20060801

• Cloning and characterization of a novel isoform of iodotyrosine dehalogenase 1 (DEHAL1) DEHAL1C from human thyroid: comparisons with DEHAL1 and DEHAL1B.

  Thyroid : official journal of the American Thyroid Association 20060801

• Cyclin B dissociation from CDK1 precedes its degradation upon MPF inactivation in mitotic extracts of Xenopus laevis embryos.

  Cell cycle (Georgetown, Tex.) 20060801

• [Inhibitory effect of carbamazepine on proliferation of estrogen-dependent breast cancer cells].

  Ai zheng = Aizheng = Chinese journal of cancer 20060801

• A CK2-dependent mechanism for degradation of the PML tumor suppressor.

  Cell 20060728

• Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development.

  Genes & development 20060715

• CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels.

  Biochemical and biophysical research communications 20060714

• Specific positive and negative effects of FLIP on cell survival in human prostate cancer.

  Carcinogenesis 20060701

• Modulation of IgE-dependent COX-2 gene expression by reactive oxygen species in human neutrophils.

  Journal of leukocyte biology 20060701

• The TRAIL apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary chronic lymphocytic leukemia cells.

  Apoptosis : an international journal on programmed cell death 20060701

• Cannabinoid signalling in TNF-alpha induced IL-8 release.

  European journal of pharmacology 20060701

• Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4.

  Journal of cell science 20060701

• In vivo heteromer formation. Expression of soluble betaA4-crystallin requires coexpression of a heteromeric partner.

  The FEBS journal 20060701

• IL-25 regulates the expression of adhesion molecules on eosinophils: mechanism of eosinophilia in allergic inflammation.

  Allergy 20060701

• Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress.

  Journal of neurochemistry 20060701

• Acetylcholine inhibits the hypoxia-induced reduction of connexin43 protein in rat cardiomyocytes.

  Journal of pharmacological sciences 20060701

• Dipeptidyl peptidase II and leukocyte cell death.

  Biochemical pharmacology 20060628

• Proteasome inhibitor MG-132 enhances whole-body protein turnover in rat.

  Biochemical and biophysical research communications 20060623

• Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132.

  Cancer research 20060615

• Nontoxic proteasome inhibition activates a protective antioxidant defense response in endothelial cells.

  Free radical biology & medicine 20060615

• Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB.

  The Journal of biological chemistry 20060602

• Mitogen-activated protein kinases mediate arsenic-induced down-regulation of survivin in human lung adenocarcinoma cells.

  Archives of toxicology 20060601

• Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation.

  American journal of physiology. Endocrinology and metabolism 20060601

• Knockdown of Skp2 by siRNA inhibits melanoma cell growth in vitro and in vivo.

  Journal of dermatological science 20060601

• Proteasome inhibition by MG-132 induces apoptotic cell death and mitochondrial dysfunction in cultured rat brain oligodendrocytes but not in astrocytes.

  Glia 20060601

• Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo.

  Leukemia 20060601

• Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase.

  Journal of cell science 20060601

• Cytokines differentially regulate ICAM-1 and VCAM-1 expression on human gingival fibroblasts.

  Clinical and experimental immunology 20060601

• [Leukemic stem cell targeting therapy].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20060601

• Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM.

  Cancer letters 20060518

• TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27(KIP1) protein.

  Oncogene 20060518

• Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors.

  Journal of medicinal chemistry 20060518

• Glucocorticoid hormones decrease proliferation of embryonic neural stem cells through ubiquitin-mediated degradation of cyclin D1.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060517

• c-Jun NH(2)-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells.

  Cancer research 20060515

• Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC.

  The Journal of biological chemistry 20060512

• Mutations affecting beta-tubulin folding and degradation.

  The Journal of biological chemistry 20060512

• Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells.

  The Journal of biological chemistry 20060505

• Involvement of protein synthesis and degradation in long-term potentiation of Schaffer collateral CA1 synapses.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060503

• SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells.

  Journal of cellular physiology 20060501

• Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures.

  Journal of neuroimmunology 20060501

• Selectively enhanced radiation sensitivity in prostate cancer cells associated with proteasome inhibition.

  Oncology reports 20060501

• Role of the proteasome in TGF-beta signaling in lens epithelial cells.

  Investigative ophthalmology & visual science 20060501

• [Proteomic analysis of G2/M arrest of HL-60 cells induced by MG132].

  Ai zheng = Aizheng = Chinese journal of cancer 20060501

• Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts.

  Annals of the New York Academy of Sciences 20060501

• Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin.

  The Journal of biological chemistry 20060428

• Proteasome inhibitor-induced cyclooxygenase-2 expression in Raw264.7 cells is potentiated by inhibition of c-Jun N-terminal kinase activation.

  Biochemical and biophysical research communications 20060421

• Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis.

  International journal of cancer 20060415

• Nuclear factor-kappaB p65 and upregulation of interleukin-6 in retinal ischemia/reperfusion injury in rats.

  Brain research 20060407

• The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus.

  Oncogene 20060406

• Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen.

  The Journal of pharmacology and experimental therapeutics 20060401

• Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes.

  The Biochemical journal 20060401

• Chemokine gene activation in human bone marrow-derived osteoblasts following exposure to particulate wear debris.

  Journal of biomedical materials research. Part A 20060401

• Inhibition of cardiac hypertrophy by triflusal (4-trifluoromethyl derivative of salicylate) and its active metabolite.

  Molecular pharmacology 20060401

• C-peptide signals via Galpha i to protect against TNF-alpha-mediated apoptosis of opossum kidney proximal tubular cells.

  Journal of the American Society of Nephrology : JASN 20060401

• Lysocellin, a metabolite of the novel drug 'alopestatin', induces G1 arrest and prevents cytotoxicity induced by etoposide.

  International journal of oncology 20060401

• Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis.

  Cancer research 20060401

• MG132 induced apoptosis is associated with p53-independent induction of pro-apoptotic Noxa and transcriptional activity of beta-catenin.

  Apoptosis : an international journal on programmed cell death 20060401

• Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism.

  The Journal of biological chemistry 20060331

• Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons.

  The Journal of biological chemistry 20060317

• Expression of the ubiquitin variant ubR48 decreases proteolytic activity in Arabidopsis and induces cell death.

  Planta 20060301

• Prolonged activation of NF-kappaB by human cytomegalovirus promotes efficient viral replication and late gene expression.

  Virology 20060301

• Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

• A novel mouse Smad4 mutation reduces protein stability and wild-type protein levels.

  Mammalian genome : official journal of the International Mammalian Genome Society 20060301

• Proteasome inhibition sensitizes hepatocellular carcinoma cells to TRAIL by suppressing caspase inhibitors and AKT pathway.

  Anti-cancer drugs 20060301

• The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis.

  The Journal of biological chemistry 20060224

• Merlin facilitates ubiquitination and degradation of transactivation-responsive RNA-binding protein.

  Oncogene 20060223

• P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription.

  The EMBO journal 20060222

• Function and subcellular location of Ro52beta.

  Biochemical and biophysical research communications 20060217

• Inefficient proteasomal-degradation pathway stabilizes AP-2alpha and activates HER-2/neu gene in breast cancer.

  International journal of cancer 20060215

• Intracellular composition of fatty acid affects the processing and function of tyrosinase through the ubiquitin-proteasome pathway.

  The Biochemical journal 20060215

• Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis.

  Experimental cell research 20060215

• Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.

  Journal of cellular biochemistry 20060201

• Pharmacological rescue of the dystrophin-glycoprotein complex in Duchenne and Becker skeletal muscle explants by proteasome inhibitor treatment.

  American journal of physiology. Cell physiology 20060201

• Dynamics of lipid droplet-associated proteins during hormonally stimulated lipolysis in engineered adipocytes: stabilization and lipid droplet binding of adipocyte differentiation-related protein/adipophilin.

  Molecular endocrinology (Baltimore, Md.) 20060201

• Lack of direct role of parkin in the steady-state level and aggregation of alpha-synuclein and the clearance of pre-formed aggregates.

  Experimental neurology 20060201

• Roles of Ras and extracellular signal-regulated kinase-dependent IkappaBalpha degradation in oridonin-enhanced phagocytosis of apoptotic cells by human macrophage-like U937 cells.

  International immunopharmacology 20060201

• Proteasome inhibition induces hepatic stellate cell apoptosis.

  Hepatology (Baltimore, Md.) 20060201

• Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells.

  Molecular cancer research : MCR 20060201

• E6AP and calmodulin reciprocally regulate estrogen receptor stability.

  The Journal of biological chemistry 20060127

• Dominant-negative effect of mutant valosin-containing protein in aggresome formation.

  FEBS letters 20060123

• Chemical blockage of the proteasome inhibitory function of bortezomib: impact on tumor cell death.

  The Journal of biological chemistry 20060113

• Transcriptional regulation of the NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and copper.

  Drug metabolism and disposition: the biological fate of chemicals 20060101

• Two different stages of epidermal growth factor (EGF) receptor endocytosis are sensitive to free ubiquitin depletion produced by proteasome inhibitor MG132.

  Cell biology international 20060101

• Oxidative stress response results in increased p21WAF1/CIP1 degradation in cystic fibrosis lung epithelial cells.

  Free radical biology & medicine 20060101

• The kinase p38 regulates peroxisome proliferator activated receptor-gamma in human trophoblasts.

  Placenta 20060101

• Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons.

  Molecular cancer therapeutics 20060101

• Degradation of perilipin is mediated through ubiquitination-proteasome pathway.

  Biochimica et biophysica acta 20060101

• The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines.

  Molecular cancer 20060101

• Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.

  Molecular cancer 20060101

• Peroxynitrite induces an alternative NF-kappaB activation pathway in L8 rat myoblasts.

  Antioxidants & redox signaling 20060101

• Opposite effects of proteasome inhibitors in the adrenergic induction of arylalkylamine N-acetyltransferase in rat pinealocytes.

  Chronobiology international 20060101

• Presenilin 1 forms aggresomal deposits in response to heat shock.

  Journal of molecular neuroscience : MN 20060101

• Apoptosis induced by proteasome inhibition in human myoblast cultures.

  European journal of histochemistry : EJH 20060101

• Proteasome inhibitors eliminate protective effect of postconditioning in cultured neonatal cardiomyocytes.

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20060101

• Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels.

  BMC cell biology 20060101

• The dynamic instability of microtubules is required for aggresome formation in oligodendroglial cells after proteolytic stress.

  Journal of molecular neuroscience : MN 20060101

• Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria.

  Pathology oncology research : POR 20060101

• P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity.

  Molecular cancer 20060101

• Effect of proteasome inhibitors on expression of HLA-G isoforms.

  Neoplasma 20060101

• [Artifitial increase of HIV-1 reverse transcriptase turnover through proteasome pathway].

  Molekuliarnaia biologiia 20060101

• Antiviral activity of proteasome inhibitors in herpes simplex virus-1 infection: role of nuclear factor-kappaB.

  Antiviral therapy 20060101

• Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway.

  The Journal of biological chemistry 20051230

• hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage.

  Cell 20051216

• Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase.

  Brain research. Molecular brain research 20051207

• Role of protein turnover in the activation of p38 mitogen-activated protein kinase in rat pinealocytes.

  Biochemical pharmacology 20051205

• Comparison of the SUMO1 and ubiquitin conjugation pathways during the inhibition of proteasome activity with evidence of SUMO1 recycling.

  The Biochemical journal 20051201

• Advanced glycation end-product induces fractalkine gene upregulation in normal rat glomeruli.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20051201

• The proteasome inhibitor MG132 induces apoptosis in human pancreatic cancer cells.

  Oncology reports 20051201

• Combination of proteasomal inhibitors lactacystin and MG132 induced synergistic apoptosis in prostate cancer cells.

  Neoplasia (New York, N.Y.) 20051201

• Evidence for proteasomal degradation of Kv1.5 channel protein.

  Biochemical and biophysical research communications 20051111

• The proteasome metabolizes peptide-mediated nonviral gene delivery systems.

  Gene therapy 20051101

• Regulatory mechanisms modulating the expression of cytochrome P450 1A1 gene by heavy metals.

  Toxicological sciences : an official journal of the Society of Toxicology 20051101

• Proteasomal proteolysis in the adrenergic induction of arylalkylamine-N-acetyltransferase in rat pinealocytes.

  Endocrinology 20051101

• Induction and attenuation of neuronal apoptosis by proteasome inhibitors in murine cortical cell cultures.

  Journal of neurochemistry 20051101

• UV-A light regulation of arylalkylamine N-acetyltransferase activity in the chick pineal gland: role of cAMP and proteasomal proteolysis.

  Journal of pineal research 20051101

• The proteasome inhibitor MG132 protects against acute pancreatitis.

  Free radical biology & medicine 20051101

• Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial nitric oxide synthase.

  Toxicology and applied pharmacology 20051101

• Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation.

  The Journal of biological chemistry 20051021

• Preliminary studies of new proteasome inhibitors in the tumor targeting approach: synthesis and in vitro cytotoxicity.

  Journal of medicinal chemistry 20051020

• Differential effect of calmodulin antagonists on MG132-induced mitochondrial dysfunction and cell death in PC12 cells.

  Brain research bulletin 20051015

• Low-level expression of proapoptotic Bcl-2-interacting mediator in leukemic cells in patients with chronic myeloid leukemia: role of BCR/ABL, characterization of underlying signaling pathways, and reexpression by novel pharmacologic compounds.

  Cancer research 20051015

• Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway.

  The Journal of biological chemistry 20051014

• Adeno-associated virus (AAV)-7 and -8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation.

  Gene therapy 20051001

• The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients.

  Experimental neurology 20051001

• Proteasome inhibition improves fractionated radiation treatment against non-small cell lung cancer: an antioxidant connection.

  International journal of oncology 20051001

• The proteasomal inhibitor MG132 increases the efficiency of mouse embryo production after cloning by electrofusion.

  Reproduction (Cambridge, England) 20051001

• Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival.

  Cancer research 20051001

• Degradation of the sodium taurocholate cotransporting polypeptide (NTCP) by the ubiquitin-proteasome system.

  Biological chemistry 20051001

• [The protective effect of MG132 on post-ischemia reperfusion injury of rat livers by activation of nuclear factor kappa B].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20051001

• Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress.

  Free radical research 20051001

• Exogenous auxin enhances the degradation of a light down-regulated and nuclear-localized OsiIAA1, an Aux/IAA protein from rice, via proteasome.

  Biochimica et biophysica acta 20050925

• Regulation of elastin gene transcription by proteasome dysfunction.

  American journal of physiology. Cell physiology 20050901

• Spindle pole fragmentation due to proteasome inhibition.

  Journal of cellular physiology 20050901

• Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP.

  American journal of physiology. Renal physiology 20050901

• Depressant effect of mitochondrial respiratory complex inhibitors on proteasome inhibitor-induced mitochondrial dysfunction and cell death in PC12 cells.

  Neurochemical research 20050901

• Proteasome comprising a beta1 inducible subunit acts as a negative regulator of NADPH oxidase during elicitation of plant defense reactions.

  FEBS letters 20050829

• Protein phosphatase 2A regulates estrogen receptor alpha (ER) expression through modulation of ER mRNA stability.

  The Journal of biological chemistry 20050819

• Functional analysis of six human aryl hydrocarbon receptor variants in a Japanese population.

  Drug metabolism and disposition: the biological fate of chemicals 20050801

• Distinct IkappaB kinase regulation in adult T cell leukemia and HTLV-I-transformed cells.

  Experimental cell research 20050801

• Polyamine depletion reduces TNFalpha/MG132-induced apoptosis in bone marrow stromal cells.

  Stem cells (Dayton, Ohio) 20050801

• TGF-beta1 enhances degradation of IFN-gamma-induced iNOS protein via proteasomes in RAW 264.7 cells.

  Nitric oxide : biology and chemistry 20050801

• Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis.

  Journal of neurochemistry 20050801

• Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol.

  Nature cell biology 20050801

• Inhibition of the proteasome strongly affects cadmium stimulated laccase activity in Trametes versicolor.

  Biochimie 20050801

• Cross talk in hormonally regulated gene transcription through induction of estrogen receptor ubiquitylation.

  Molecular and cellular biology 20050801

• [Effects of MG132 , an inhibitor of proteasome , on the pollen germination and tube growth of Pecea wilsonii].

  Shi yan sheng wu xue bao 20050801

• FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.

  The Journal of biological chemistry 20050729

• Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function.

  Biochemical and biophysical research communications 20050722

• Synergic action of insulin and genistein on Na+/K+/2Cl- cotransporter in renal epithelium.

  Biochemical and biophysical research communications 20050715

• Deubiquitination by proteasome is coordinated with substrate translocation for proteolysis in vivo.

  Experimental cell research 20050715

• Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors.

  The Journal of biological chemistry 20050701

• Eukaryotic translation initiation factor 4E is a cellular target for toxicity and death due to exposure to cadmium chloride.

  The Journal of biological chemistry 20050701

• Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway.

  Genes to cells : devoted to molecular & cellular mechanisms 20050701

• Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein.

  Cancer research 20050701

• Mechanisms of deregulation of IFN regulatory factor-1 in ras-transformed fibroblasts.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20050701

• Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma.

  Neoplasia (New York, N.Y.) 20050701

• Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of Aplysia.

  Learning & memory (Cold Spring Harbor, N.Y.) 20050701

• Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation.

  Cancer biology & therapy 20050701

• Increasing expression of heme oxygenase-1 by proteasome inhibition protects astrocytes from heme-mediated oxidative injury.

  Current neurovascular research 20050701

• Ubiquitin-dependent degradation of interferon regulatory factor-8 mediated by Cbl down-regulates interleukin-12 expression.

  The Journal of biological chemistry 20050624

• Degradation of glyceraldehyde-3-phosphate dehydrogenase triggered by 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal.

  Archives of biochemistry and biophysics 20050615

• Membrane insertion of betaine/GABA transporter during hypertonic stress correlates with nuclear accumulation of TonEBP.

  Biochimica et biophysica acta 20050615

• Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.

  Cancer research 20050615

• Degradation of Saccharomyces cervisiae Rck2 upon exposure of cells to high levels of zinc is dependent on Pep4.

  Molecular genetics and genomics : MGG 20050601

• Effects of mechanistically distinct NF-kappaB inhibitors on glial inducible nitric-oxide synthase expression.

  Nitric oxide : biology and chemistry 20050601

• Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells.

  International immunology 20050601

• Upregulation of heat shock protein expression by proteasome inhibition: an antiapoptotic mechanism in the lens.

  Investigative ophthalmology & visual science 20050601

• Cooperative cytotoxicity of proteasome inhibitors and tumor necrosis factor-related apoptosis-inducing ligand in chemoresistant Bcl-2-overexpressing cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050601

• [Reversal of chemoresistance to vincristine in gastric cancer cells by NF-kappaB inhibitor].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20050601

• PKCalpha is involved in phorbol ester TPA-mediated stabilization of p14ARF.

  Biochemical and biophysical research communications 20050520

• Activation of hypoxia-induced transcription in normoxia.

  Experimental cell research 20050515

• Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron.

  Experimental cell research 20050515

• Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.

  The Journal of biological chemistry 20050513

• Cdk2-dependent phosphorylation of homeobox transcription factor CDX2 regulates its nuclear translocation and proteasome-mediated degradation in human intestinal epithelial cells.

  The Journal of biological chemistry 20050506

• Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity.

  Oncogene 20050505

• Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050501

• Recombinant adeno-associated virus type 2-mediated gene transfer into human keratinocytes is influenced by both the ubiquitin/proteasome pathway and epidermal growth factor receptor tyrosine kinase.

  Archives of dermatological research 20050501

• Differential roles of constitutively activated ERK1/2 and NF-kappa B in cytotoxicity and proliferation by human NK cell lines.

  International immunopharmacology 20050501

• Death receptor-mediated apoptosis in human malignant glioma cells: modulation by the CD40/CD40L system.

  Journal of neuroimmunology 20050501

• Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib.

  Nature methods 20050501

• The regulation of pro-inflammatory gene expression induced by pigment epithelium-derived factor in rat cultured microglial cells.

  Neuroscience letters 20050501

• [Inhibiting expression of human telomerase reverse transcriptase promotes degradation of survivin protein].

  Ai zheng = Aizheng = Chinese journal of cancer 20050501

• Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.

  Blood 20050415

• Schistosoma mansoni: functional proteasomes are required for development in the vertebrate host.

  Experimental parasitology 20050401

• Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells.

  Molecular and cellular biology 20050401

• Proteasome inhibition enhances AAV-mediated transgene expression in human synoviocytes in vitro and in vivo.

  Molecular therapy : the journal of the American Society of Gene Therapy 20050401

• Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations.

  The Journal of biological chemistry 20050325

• Inhibitory effect of dicationic diphenylfurans on production of type I collagen by human fibroblasts and activated hepatic stellate cells.

  Life sciences 20050311

• Proteasome inhibitors induce peroxisome proliferator-activated receptor transactivation through RXR accumulation and a protein kinase C-dependent pathway.

  Experimental cell research 20050310

• Inhibition of MG132-induced mitochondrial dysfunction and cell death in PC12 cells by 3-morpholinosydnonimine.

  Brain research 20050302

• Growth-associated protein-43 is degraded via the ubiquitin-proteasome system.

  Journal of neuroscience research 20050301

• Regulation of Wallerian degeneration and nerve growth factor withdrawal-induced pruning of axons of sympathetic neurons by the proteasome and the MEK/Erk pathway.

  Molecular and cellular neurosciences 20050301

• Does proteasome [corrected] inhibition decrease or accelerate toxin-induced dopaminergic neurodegeneration?

  Journal of pharmacological sciences 20050301

• Inhibition of the 26S proteasome blocks progesterone receptor-dependent transcription through failed recruitment of RNA polymerase II.

  The Journal of steroid biochemistry and molecular biology 20050301

• Role of the proteasome in the regulation of estrogen receptor alpha turnover and function in MCF-7 breast carcinoma cells.

  The Journal of steroid biochemistry and molecular biology 20050301

• DET1 regulates the proteasomal degradation of LHY, a component of the Arabidopsis circadian clock.

  Plant molecular biology 20050301

• 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins.

  Blood 20050215

• L-dopa and dopamine enhance the formation of aggregates under proteasome inhibition in PC12 cells.

  FEBS letters 20050214

• E1AF degradation by a ubiquitin-proteasome pathway.

  Biochemical and biophysical research communications 20050211

• Proteasomal degradation of human CYP1B1: effect of the Asn453Ser polymorphism on the post-translational regulation of CYP1B1 expression.

  Molecular pharmacology 20050201

• Disruption of microtubules leads to glucocorticoid receptor degradation in HeLa cell line.

  Cellular signalling 20050201

• Herpes virus proteins ICP0 and BICP0 can activate NF-kappaB by catalyzing IkappaBalpha ubiquitination.

  Cellular signalling 20050201

• Protease inhibitor MG132 in cloning: no end to the nightmare.

  Trends in biotechnology 20050201

• Intercellular communication via gap junctions in activated rat hepatic stellate cells.

  Gastroenterology 20050201

• Contribution of high p34cdc2 kinase activity to premature chromosome condensation of injected somatic cell nuclei in rat oocytes.

  Reproduction (Cambridge, England) 20050201

• The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation.

  Oncogene 20050120

• Proteasome inhibition and Tau proteolysis: an unexpected regulation.

  FEBS letters 20050103

• Butyrate-induced apoptosis and cell cycle arrest in bovine kidney epithelial cells: involvement of caspase and proteasome pathways.

  Journal of animal science 20050101

• Adenosine kinase inhibitor attenuates the expression of inducible nitric oxide synthase in glial cells.

  Neuropharmacology 20050101

• Hypertonic upregulation of betaine transport in renal cells is blocked by a proteasome inhibitor.

  Cell biochemistry and function 20050101

• The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism.

  BMC cancer 20050101

• Proteasome inhibitors abolish cell death downstream of caspase activation during anti-microtubule drug-induced apoptosis in leukemia cells.

  Anticancer research 20050101

• Anthracyclines, proteasome activity and multi-drug-resistance.

  BMC cancer 20050101

• Cell-specific inhibition of paramyxovirus maturation by proteasome inhibitors.

  Microbiology and immunology 20050101

• Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor induce adhesion and chemotaxis of human eosinophils via p38 mitogen-activated protein kinase and nuclear factor kappaB.

  Immunopharmacology and immunotoxicology 20050101

• Osmotic regulation of MG-132-induced MAP-kinase phosphatase MKP-1 expression in H4IIE rat hepatoma cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20050101

• Proteomic analysis of ubiquitinated proteins from human MCF-7 breast cancer cells by immunoaffinity purification and mass spectrometry.

  Journal of proteome research 20050101

• Nuclear localization destabilizes the stress-regulated transcription factor Msn2.

  The Journal of biological chemistry 20041231

• c-Myc localization within the nucleus: evidence for association with the PML nuclear body.

  Journal of cellular biochemistry 20041215

• Aggresome formation and pharmacogenetics: sulfotransferase 1A3 as a model system.

  Biochemical and biophysical research communications 20041210

• Epidermal growth factor and interleukin-1beta utilize divergent signaling pathways to synergistically upregulate cyclooxygenase-2 gene expression in human amnion-derived WISH cells.

  Biology of reproduction 20041201

• Degradation of survival motor neuron (SMN) protein is mediated via the ubiquitin/proteasome pathway.

  Neurochemistry international 20041201

• A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs.

  The Biochemical journal 20041201

• Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF-2 activation and iNOS stability.

  Free radical biology & medicine 20041201

• Effects of proteasome inhibitors MG132, ZL3VS and AdaAhx3L3VS on protein metabolism in septic rats.

  International journal of experimental pathology 20041201

• Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041201

• Troglitazone inhibits cyclin D1 expression and cell cycling independently of PPARgamma in normal mouse skin keratinocytes.

  The Journal of investigative dermatology 20041201

• Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways.

  Molecular and cellular endocrinology 20041130

• cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1.

  The Journal of biological chemistry 20041119

• Effects of a redox-active agent on lymphocyte activation and early gene expression patterns.

  Free radical biology & medicine 20041115

• Proteasomal interference prevents zona pellucida penetration and fertilization in mammals.

  Biology of reproduction 20041101

• Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activation.

  Molecular endocrinology (Baltimore, Md.) 20041101

• Proteasomes act in the pre-mitochondrial signal transduction route towards roscovitine-induced apoptosis.

  International journal of oncology 20041101

• Retinoic acid induces neuroblastoma cell death by inhibiting proteasomal degradation of retinoic acid receptor alpha.

  Cancer research 20041101

• A proteasomal stress response: pre-treatment with proteasome inhibitors increases proteasome activity and reduces neuronal vulnerability to oxidative injury.

  Journal of neurochemistry 20041101

• Inhibition of proteasome by MG-132 treatment causes extra phragmoplast formation and cortical microtubule disorganization during M/G1 transition in synchronized tobacco cells.

  Plant & cell physiology 20041101

• Ectopic expression of nonliganded retinoic acid receptor beta abrogates AP-1 activity by selective degradation of c-Jun in cervical carcinoma cells.

  The Journal of biological chemistry 20041029

• The Rac1 C-terminal polybasic region regulates the nuclear localization and protein degradation of Rac1.

  The Journal of biological chemistry 20041015

• Ubiquitin-proteasome pathway modulates mouse oocyte meiotic maturation and fertilization via regulation of MAPK cascade and cyclin B1 degradation.

  Mechanisms of development 20041001

• Inhibitory effect of ubiquitin-proteasome pathway on proliferation of esophageal carcinoma cells.

  World journal of gastroenterology 20041001

• Downregulation of matrix metalloproteinases and collagens and suppression of cardiac fibrosis by inhibition of the proteasome.

  Hypertension (Dallas, Tex. : 1979) 20041001

• Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions.

  Journal of neurochemistry 20041001

• Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: a process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome.

  Molecular pharmacology 20041001

• Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.

  Nature cell biology 20041001

• GSK-3beta sets Snail's pace.

  Nature cell biology 20041001

• [Mechanism of G2/M cell cycle arrest before apoptosis in leukemia cell line HL-60 induced by proteasome inhibitor MG132].

  Ai zheng = Aizheng = Chinese journal of cancer 20041001

• Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells.

  Toxicology and applied pharmacology 20040915

• Proteasome-dependent degradation of cyclin D1 in 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell cycle arrest.

  The Journal of biological chemistry 20040910

• In situ dynamically monitoring the proteolytic function of the ubiquitin-proteasome system in cultured cardiac myocytes.

  American journal of physiology. Heart and circulatory physiology 20040901

• Regulation of ubiquitin-proteasome pathway on pig oocyte meiotic maturation and fertilization.

  Biology of reproduction 20040901

• Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040901

• Inhibition of the ubiquitin-proteasome pathway activates stress kinases and induces apoptosis in renal cancer cells.

  International journal of oncology 20040901

• The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex.

  European journal of biochemistry 20040901

• Ceramide, an apoptotic rheostat, inhibits CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 activation: the role in glutathione S-transferase A2 gene repression.

  Drug metabolism and disposition: the biological fate of chemicals 20040901

• Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals.

  Journal of immunology (Baltimore, Md. : 1950) 20040901

• Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis.

  The Journal of laboratory and clinical medicine 20040901

• Differential response of MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents.

  Biochemical pharmacology 20040815

• Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins.

  The Journal of biological chemistry 20040813

• c-Fos phosphorylation induced by H2O2 prevents proteasomal degradation of c-Fos in cardiomyocytes.

  The Journal of biological chemistry 20040806

• Fertilization and InsP3-induced Ca2+ release stimulate a persistent increase in the rate of degradation of cyclin B1 specifically in mature mouse oocytes.

  Developmental biology 20040801

• Regulation of IFN regulatory factor-7 and IFN-alpha production by enveloped virus and lipopolysaccharide in human plasmacytoid dendritic cells.

  Journal of immunology (Baltimore, Md. : 1950) 20040801

• Inhibition of constitutively activated nuclear factor-kappaB radiosensitizes human melanoma cells.

  Molecular cancer therapeutics 20040801

• The Ah receptor inhibits estrogen-induced estrogen receptor beta in breast cancer cells.

  Biochemical and biophysical research communications 20040716

• HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function.

  Oncogene 20040701

• Human hRad1 but not hRad9 protects hHus1 from ubiquitin-proteasomal degradation.

  Oncogene 20040701

• Reactive oxygen species mediate chloroquine-induced expression of chemokines by human astroglial cells.

  Glia 20040701

• The ubiquitin-proteasome machinery is essential for nuclear translocation of incoming minute virus of mice.

  Virology 20040701

• Glial cell line-derived neurotrophic factor enhances nuclear factor-kappaB activity and invasive potential in human pancreatic cancer cells.

  Pancreas 20040701

• Estrogen responsiveness of IBEP-2, a new human cell line derived from breast carcinoma.

  Breast cancer research and treatment 20040701

• Mechanism of NF-kappaB inactivation induced by survival signal withdrawal in cerebellar granule neurons.

  The European journal of neuroscience 20040701

• Down-regulation of melanogenesis by phospholipase D2 through ubiquitin proteasome-mediated degradation of tyrosinase.

  The Journal of biological chemistry 20040625

• Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1.

  The Journal of biological chemistry 20040625

• Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex.

  The Journal of biological chemistry 20040625

• High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin 43 by a proteasome-dependent mechanism.

  The Journal of biological chemistry 20040625

• Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson's disease.

  Brain research 20040625

• Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR, PI3K, Akt, IKK, and NF-kappaB.

  Biochemical and biophysical research communications 20040625

• Proteolytic stress causes heat shock protein induction, tau ubiquitination, and the recruitment of ubiquitin to tau-positive aggregates in oligodendrocytes in culture.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040623

• Endosome disruption enhances the functional nuclear delivery of Tat-fusion proteins.

  Biochemical and biophysical research communications 20040618

• Transcriptional repression of E2F gene by proteasome inhibitors in human osteosarcoma cells.

  Biochemical and biophysical research communications 20040611

• Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway.

  Journal of lipid research 20040601

• Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation.

  Obesity research 20040601

• 15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts.

  The Journal of biological chemistry 20040521

• Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine: a mechanism for the slow acetylator phenotype and substrate-dependent down-regulation.

  The Journal of biological chemistry 20040521

• Hereditary early-onset Parkinson's disease caused by mutations in PINK1.

  Science (New York, N.Y.) 20040521

• Proteasome inhibitors up-regulate haem oxygenase-1 gene expression: requirement of p38 MAPK (mitogen-activated protein kinase) activation but not of NF-kappaB (nuclear factor kappaB) inhibition.

  The Biochemical journal 20040501

• CDDO induces apoptosis via the intrinsic pathway in lymphoid cells.

  Leukemia 20040501

• Induction of apoptosis by the proteasome inhibitor MG132 in human HCC cells: Possible correlation with specific caspase-dependent cleavage of beta-catenin and inhibition of beta-catenin-mediated transactivation.

  International journal of molecular medicine 20040501

• Effect of proteasome inhibitor MG132 on in vitro maturation of pig oocytes.

  Zygote (Cambridge, England) 20040501

• A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor.

  Molecular cell 20040423

• Cardiac myocytes activated by septic plasma promote neutrophil transendothelial migration: role of platelet-activating factor and the chemokines LIX and KC.

  Circulation research 20040416

• HIV-1 auxiliary regulatory protein Vpr promotes ubiquitination and turnover of Vpr mutants containing the L64P mutation.

  FEBS letters 20040409

• AP-1-independent sensitization to oxidative stress-induced apoptosis by proteasome inhibitors.

  Biochemical and biophysical research communications 20040402

• Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells.

  Oncogene 20040401

• Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors.

  International journal of oncology 20040401

• Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation.

  The Journal of reproduction and development 20040401

• Involvement of suppressor for Gal 1 in the ubiquitin/proteasome-mediated degradation of estrogen receptors.

  The Journal of biological chemistry 20040326

• Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation.

  International journal of cancer 20040320

• Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions.

  The Journal of biological chemistry 20040312

• Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells.

  Blood 20040301

• Proteasome inhibition increases HuR level, restores heat-inducible HSP72 expression and thermotolerance in WI-38 senescent human fibroblasts.

  Experimental gerontology 20040301

• Degradation of AP2 during reticulocyte maturation enhances binding of hsc70 and Alix to a common site on TFR for sorting into exosomes.

  Traffic (Copenhagen, Denmark) 20040301

• Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway.

  The Journal of biological chemistry 20040227

• Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1.

  The Journal of biological chemistry 20040220

• Glucocorticoids regulate mRNA levels for subunits of the 19 S regulatory complex of the 26 S proteasome in fast-twitch skeletal muscles.

  The Biochemical journal 20040215

• Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viability.

  Cancer letters 20040210

• Proteasome inhibition and aggregation in Parkinson's disease: a comparative study in untransfected and transfected cells.

  Journal of neurochemistry 20040201

• Overexpression of torsinA in PC12 cells protects against toxicity.

  Journal of neurochemistry 20040201

• Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040201

• Laminar shear stress up-regulates inducible nitric oxide synthase in the endothelium.

  Hypertension research : official journal of the Japanese Society of Hypertension 20040201

• p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells.

  Neuroscience letters 20040116

• Estradiol binding to maxi-K channels induces their down-regulation via proteasomal degradation.

  The Journal of biological chemistry 20040109

• Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1beta-induced gene expression.

  The Journal of biological chemistry 20040109

• The ubiquitin-proteasome pathway is required for the function of the viral VP16 transcriptional activation domain.

  FEBS letters 20040102

• Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap 'n' collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction.

  The Biochemical journal 20040101

• The role of [beta]-transducin repeat-containing protein ([beta]-TrCP) in the regulation of NF-[kappa]B in vascular smooth muscle cells.

  Arteriosclerosis, thrombosis, and vascular biology 20040101

• Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival.

  Human molecular genetics 20040101

• Activation of the Raf-1/MEK/Erk kinase pathway by a novel Cdc25 inhibitor in human prostate cancer cells.

  The Prostate 20040101

• Altered proteasome function and subunit composition in aged muscle.

  Archives of biochemistry and biophysics 20040101

• Interferon-gamma induces apoptosis of lens alphaTN4-1 cells and proteasome inhibition has an antiapoptotic effect.

  Investigative ophthalmology & visual science 20040101

• Degradation of poly(A)-binding protein in apoptotic cells and linkage to translation regulation.

  Apoptosis : an international journal on programmed cell death 20040101

• Contribution of the constitutive and inducible degradation of Smad3 by the ubiquitin-proteasome pathway to transforming growth factor-beta signaling.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20040101

• The proteosome inhibitor MG132 attenuates retinoic acid receptor trans-activation and enhances trans-repression of nuclear factor kappaB. Potential relevance to chemo-preventive interventions with retinoids.

  Molecular cancer 20040101

• Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures.

  Biogerontology 20040101

• Inhibition of the proteasome reduces transfer-induced diabetes in nonobese diabetic mice.

  Scandinavian journal of immunology 20040101

• Proteasome inhibitors: their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cells.

  BMC pharmacology 20040101

• Induction of heat shock protein 70 (Hsp70) by proteasome inhibitor MG 132 protects articular chondrocytes from cellular death in vitro and in vivo.

  Biorheology 20040101

• [Effect of synthetic proteasomal inhibitor MG132 on dynamics of EGF-receptor complexes endocytosis in A431 cells].

  Tsitologiia 20040101

• The co-repressor hairless protects RORalpha orphan nuclear receptor from proteasome-mediated degradation.

  The Journal of biological chemistry 20031226

• Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B.

  The Journal of biological chemistry 20031219

• Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha.

  Science (New York, N.Y.) 20031212

• Coordinate expression of the alpha and beta subunits of heterotrimeric G proteins involves regulation of protein degradation in CHO cells.

  FEBS letters 20031204

• Ubiquitin-mediated proteasome activity is required for agonist-induced endocytosis of GluRs.

  Current biology : CB 20031202

• The ubiquitin-vacuolar protein sorting system is selectively required during entry of influenza virus into host cells.

  Traffic (Copenhagen, Denmark) 20031201

• SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases.

  Journal of cellular biochemistry 20031201

• Cysteine proteases and cell differentiation: excystment of the ciliated protist Sterkiella histriomuscorum.

  Eukaryotic cell 20031201

• Proteasome inhibitors: a novel tool to suppress human cytomegalovirus replication and virus-induced immune modulation.

  Antiviral therapy 20031201

• NF-kappaB inhibition restores sensitivity to Fas-mediated apoptosis in lymphoma cell lines.

  Annals of the New York Academy of Sciences 20031201

• Homogeneous assays for cellular protein degradation using beta-galactosidase complementation: NF-kappaB/IkappaB pathway signaling.

  Assay and drug development technologies 20031201

• Upregulation of the truncated basic hair keratin 1(hHb1-DeltaN) in carcinoma cells by Epstein-Barr virus (EBV).

  International journal of cancer 20031120

• Generation of fertile cloned rats by regulating oocyte activation.

  Science (New York, N.Y.) 20031114

• Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.

  Cytokine 20031107

• Lipopolysaccharide and proinflammatory cytokines stimulate interleukin-6 expression in C2C12 myoblasts: role of the Jun NH2-terminal kinase.

  American journal of physiology. Regulatory, integrative and comparative physiology 20031101

• Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts.

  Experimental cell research 20031101

• Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors.

  Free radical biology & medicine 20031101

• Inhibition of proteasome function leads to NF-kappaB-independent IL-8 expression in human hepatocytes.

  Hepatology (Baltimore, Md.) 20031101

• Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells.

  Laboratory investigation; a journal of technical methods and pathology 20031101

• Cks1 is degraded via the ubiquitin-proteasome pathway in a cell cycle-dependent manner.

  Genes to cells : devoted to molecular & cellular mechanisms 20031101

• Chlamydia pneumoniae induces the expression of inhibitor of apoptosis 2 (c-IAP2) in a human monocytic cell line by an NF-kappaB-dependent pathway.

  International journal of medical microbiology : IJMM 20031101

• Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.

  Neuron 20031030

• Proteasome inhibition induces nuclear translocation of the dioxin receptor through an Sp1 and protein kinase C-dependent pathway.

  Journal of molecular biology 20031017

• Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process.

  Oncogene 20031016

• The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity.

  Current biology : CB 20031014

• Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation.

  The Journal of biological chemistry 20031003

• Regulation of follitropin receptor cell surface residency by the ubiquitin-proteasome pathway.

  Endocrinology 20031001

• Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins.

  The American journal of pathology 20031001

• Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20031001

• Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells.

  Cancer research 20031001

• Proteasome-mediated degradation of RNase L in response to phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 cells.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20031001

• Regulation of nuclear factor-kappaB in intestinal epithelial cells in a cell model of inflammation.

  Mediators of inflammation 20031001

• Degradation of retinoid X receptor alpha by TPA through proteasome pathway in gastric cancer cells.

  World journal of gastroenterology 20030915

• Copper modulates the degradation of copper chaperone for Cu,Zn superoxide dismutase by the 26 S proteosome.

  The Journal of biological chemistry 20030912

• Involvement of the proteasome in activation of endothelial nitric oxide synthase.

  Life sciences 20030912

• Protein kinase C inhibition induces DNA fragmentation in COLO 205 cells which is blocked by cysteine protease inhibition but not mediated through caspase-3.

  Experimental cell research 20030910

• Conditions associated with ER dysfunction activate homer 1a expression.

  Journal of neurochemistry 20030901

• A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives.

  Bioorganic & medicinal chemistry 20030901

• Sulindac metabolites induce caspase- and proteasome-dependent degradation of beta-catenin protein in human colon cancer cells.

  Molecular cancer therapeutics 20030901

• Transforming growth factor-beta inhibition of proteasomal activity: a potential mechanism of growth arrest.

  American journal of physiology. Cell physiology 20030801

• Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1.

  The Journal of biological chemistry 20030801

• Induction of apoptosis in human osteosarcoma Saos-2 cells by the proteasome inhibitor MG132 and the protective effect of pRb.

  Cell death and differentiation 20030801

• A transgenic mouse model of the ubiquitin/proteasome system.

  Nature biotechnology 20030801

• The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling events.

  Journal of immunology (Baltimore, Md. : 1950) 20030801

• Thiopental inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappaB through suppression of kappaB kinase activity.

  Anesthesiology 20030801

• Stimulation of protein degradation by low pH in L6G8C5 skeletal muscle cells is independent of apoptosis but dependent on differentiation state.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20030801

• Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A.

  Oncogene 20030731

• Development of an in vitro assay for the proteolytic processing of the CDP/Cux transcription factor.

  Journal of biochemistry and molecular biology 20030731

• Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.

  The Journal of biological chemistry 20030725

• Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration.

  Neuron 20030717

• BCL6 overexpression prevents increase in reactive oxygen species and inhibits apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells.

  Oncogene 20030717

• UVB irradiation reduces the half-life and transactivation potential of the human papillomavirus 16 E2 protein.

  Oncogene 20030717

• The C-terminal T peptide of acetylcholinesterase enhances degradation of unassembled active subunits through the ERAD pathway.

  The EMBO journal 20030715

• Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor-induced adhesion molecule expression on eosinophils by p38 mitogen-activated protein kinase and nuclear factor-[kappa] B.

  American journal of respiratory cell and molecular biology 20030701

• Specific ubiquitin-conjugating enzymes promote degradation of specific nuclear receptor coactivators.

  Molecular endocrinology (Baltimore, Md.) 20030701

• Recovery of gap junctional intercellular communication after phorbol ester treatment requires proteasomal degradation of protein kinase C.

  Carcinogenesis 20030701

• Characterization of the expression of the hepatitis C virus F protein.

  The Journal of general virology 20030701

• Imaging 26S proteasome activity and inhibition in living mice.

  Nature medicine 20030701

• Platelet-type 12-lipoxygenase activates NF-kappaB in prostate cancer cells.

  Prostaglandins & other lipid mediators 20030701

• The cleavage product deltaPML-RARalpha contributes to all-trans retinoic acid-mediated differentiation in acute promyelocytic leukemia cells.

  Oncogene 20030626

• Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation.

  Genes & development 20030615

• Suppression of cytochrome P450 3A protein levels by proteasome inhibitors.

  The Journal of pharmacology and experimental therapeutics 20030601

• Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells.

  Hepatology (Baltimore, Md.) 20030601

• Vanadate and rapamycin synergistically enhance insulin-stimulated glucose uptake.

  Metabolism: clinical and experimental 20030601

• Inhibition of the proteasome by lactacystin enhances oligodendroglial cell differentiation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030601

• Cellular senescence in human keratinocytes: unchanged proteolytic capacity and increased protein load.

  Experimental gerontology 20030601

• Apoptosis meets proteasome, an invaluable therapeutic target of anticancer drugs.

  The Italian journal of biochemistry 20030601

• Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts.

  Biochemical and biophysical research communications 20030530

• Early degradation of paternal mitochondria in domestic pig (Sus scrofa) is prevented by selective proteasomal inhibitors lactacystin and MG132.

  Biology of reproduction 20030501

• Assessment of proteasome activity in cell lysates and tissue homogenates using peptide substrates.

  The international journal of biochemistry & cell biology 20030501

• Diminished NF-kappaB activation and PDGF-B expression in glomerular endothelial cells subjected to chronic shear stress.

  Microvascular research 20030501

• Concomitant differentiation and partial proteasome inhibition trigger apoptosis in neuroblastoma cells.

  Journal of neuro-oncology 20030501

• Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells.

  The Journal of biological chemistry 20030425

• p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells.

  Oncogene 20030417

• P53 facilitates degradation of human T-cell leukaemia virus type I Tax-binding protein through a proteasome-dependent pathway.

  The Journal of general virology 20030401

• NF-kappaB regulates intestinal epithelial cell and bile salt-induced migration after injury.

  Annals of surgery 20030401

• Oxidized low-density lipoprotein sensitizes human vascular smooth muscle cells to FAS (CD95)-mediated apoptosis.

  Clinical and experimental pharmacology & physiology 20030401

• Cacospongionolide B suppresses the expression of inflammatory enzymes and tumour necrosis factor-alpha by inhibiting nuclear factor-kappa B activation.

  British journal of pharmacology 20030401

• Stress-induced release of HSC70 from human tumors.

  Cellular immunology 20030401

• Bio-effectiveness of Tat-catalase conjugate: a potential tool for the identification of H2O2-dependent cellular signal transduction pathways.

  Biochemical and biophysical research communications 20030328

• Methyl-CpG-DNA binding proteins in human prostate cancer: expression of CXXC sequence containing MBD1 and repression of MBD2 and MeCP2.

  Biochemical and biophysical research communications 20030321

• Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor.

  Science (New York, N.Y.) 20030314

• Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

  Oncogene 20030313

• C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer.

  Oncogene 20030306

• The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation.

  Blood 20030301

• RNA polymerase II stalled on a DNA template during transcription elongation is ubiquitinated and the ubiquitination facilitates displacement of the elongation complex.

  International journal of oncology 20030301

• Functional analysis of murine aryl hydrocarbon (AH) receptors defective in nuclear import: impact on AH receptor degradation and gene regulation.

  Molecular pharmacology 20030301

• Facilitation of fas mediated apoptosis of human chondrocytes by the proteasome inhibitor and actinomycin D.

  The Journal of rheumatology 20030301

• The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes.

  Molecular and cellular biology 20030301

• Inhibition of the NF-kappaB signaling pathway mediates the anti-inflammatory effects of petrosaspongiolide M.

  Biochemical pharmacology 20030301

• Inducible p27(Kip1) expression inhibits proliferation of K562 cells and protects against apoptosis induction by proteasome inhibitors.

  Cell death and differentiation 20030301

• EphA2 overexpression correlates with poor prognosis in esophageal squamous cell carcinoma.

  International journal of cancer 20030220

• Activation of multiple caspases and modification of cell surface fas (CD95) in proteasome inhibitor-induced apoptosis of rat natural killer cells.

  Journal of cellular biochemistry 20030215

• Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome.

  The Journal of biological chemistry 20030214

• Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome.

  The Journal of biological chemistry 20030207

• C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation.

  Archives of biochemistry and biophysics 20030201

• Tumour necrosis factor-alpha-induced expression of intercellular adhesion molecule-1 on human eosinophilic leukaemia EoL-1 cells is mediated by the activation of nuclear factor-kappaB pathway.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20030201

• Enhancement of TNF-alpha-mediated cell death in vascular smooth muscle cells through cytochrome c-independent pathway by the proteasome inhibitor.

  FEBS letters 20030130

• Phosphorylation of connexin 43 acts as a stimuli for proteasome-dependent degradation of the protein in lens epithelial cells.

  Molecular vision 20030130

• Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium.

  The Journal of biological chemistry 20030124

• Endoproteolytic activity of the proteasome.

  Science (New York, N.Y.) 20030117

• Interleukin-6 induces thermotolerance in cultured Caco-2 cells independent of the heat shock response.

  Cytokine 20030107

• p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction.

  Cellular signalling 20030101

• Increased proteasome-dependent degradation of estrogen receptor-alpha by TGF-beta1 in breast cancer cell lines.

  Journal of cellular biochemistry 20030101

• The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity.

  Genes & development 20030101

• Antineoplastic therapy in colorectal cancer through proteasome inhibition.

  The American surgeon 20030101

• Ubiquitinylation and proteasome-dependent degradation of the phosphoinositide-specific phospholipase C gamma 1 in A-431 cells.

  Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20030101

• [Effect of EGF on ubiquitination and proteasome-dependent degradation of phospholipase C gamma1 in A431 cells].

  Tsitologiia 20030101

• Involvement of proteasome in the dynamic assembly of the androgen receptor transcription complex.

  The Journal of biological chemistry 20021213

• TGF-beta induced G(1) cell cycle arrest requires the activity of the proteasome pathway. Transforming growth factor.

  Experimental cell research 20021210

• Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells.

  The Biochemical journal 20021201

• Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation.

  Gastroenterology 20021201

• Attenuation of glucocorticoid signaling through targeted degradation of p300 via the 26S proteasome pathway.

  Molecular endocrinology (Baltimore, Md.) 20021201

• TNF-alpha protects human primary articular chondrocytes from nitric oxide-induced apoptosis via nuclear factor-kappaB.

  Laboratory investigation; a journal of technical methods and pathology 20021201

• Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol.

  Science (New York, N.Y.) 20021129

• Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.

  Science (New York, N.Y.) 20021129

• Removal of Pex3p is an important initial stage in selective peroxisome degradation in Hansenula polymorpha.

  The Journal of biological chemistry 20021108

• A novel phenoxazine derivative suppresses surface IgM expression in DT40 B cell line.

  British journal of pharmacology 20021101

• Human chorionic gonadotropin (HCG) activates monocytes to produce interleukin-8 via a different pathway from luteinizing hormone/HCG receptor system.

  The Journal of clinical endocrinology and metabolism 20021101

• Sustained activation of N-WASP through phosphorylation is essential for neurite extension.

  Developmental cell 20021101

• The life cycle of the steroidogenic acute regulatory (StAR) protein: from transcription through proteolysis.

  Endocrine research 20021101

• Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop.

  Science (New York, N.Y.) 20021025

• Regulation of Egr-1 by association with the proteasome component C8.

  Biochimica et biophysica acta 20021021

• Jak2 is involved in c-Myc induction by Bcr-Abl.

  Oncogene 20021017

• Orthovanadate decreases the leptin content in isolated mouse fat pads via proteasome activation.

  Archives of biochemistry and biophysics 20021015

• Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53.

  Biochemical and biophysical research communications 20021011

• Ligand-dependent and independent modulation of aryl hydrocarbon receptor localization, degradation, and gene regulation.

  Molecular pharmacology 20021001

• Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production, expression of Bcl-XS and activation of caspase-3.

  International journal of oncology 20021001

• Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20021001

• Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival.

  Journal of neurochemistry 20021001

• Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes.

  Archives of biochemistry and biophysics 20020915

• Proteasomal activity modulates TGF-ss signaling in a gene-specific manner.

  FEBS letters 20020911

• Proteasome inhibitors regulate tyrosine phosphorylation of IRS-1 and insulin signaling in adipocytes.

  Biochemical and biophysical research communications 20020906

• Glucocorticoid-mediated attenuation of the hsp70 response in trout hepatocytes involves the proteasome.

  American journal of physiology. Regulatory, integrative and comparative physiology 20020901

• Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle.

  American journal of physiology. Regulatory, integrative and comparative physiology 20020901

• c-Cbl is a negative regulator of GH-stimulated STAT5-mediated transcription.

  Endocrinology 20020901

• Glucocorticoid receptors in hippocampal neurons that do not engage proteasomes escape from hormone-dependent down-regulation but maintain transactivation activity.

  Molecular endocrinology (Baltimore, Md.) 20020901

• Proteasome inhibitors induce apoptosis in growth hormone- and prolactin-secreting rat pituitary tumor cells.

  The Journal of endocrinology 20020901

• Proteasome-dependent downregulation of p21(Waf1/Cip1) induced by reactive oxygen species.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20020901

• Proteasome inhibitors stimulate activator protein-1 pathway via reactive oxygen species production.

  FEBS letters 20020828

• Induction and superinduction of 2,3,7,8-tetrachlorodibenzo-rho-dioxin-inducible poly(ADP-ribose) polymerase: role of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator transcription activation domains and a labile transcription repressor.

  Archives of biochemistry and biophysics 20020815

• Proteasome inhibitors stimulate interleukin-8 expression via Ras and apoptosis signal-regulating kinase-dependent extracellular signal-related kinase and c-Jun N-terminal kinase activation.

  American journal of respiratory cell and molecular biology 20020801

• Nuclear factor-kappa B is required for tumor necrosis factor-alpha-induced manganese superoxide dismutase expression in human endometrial stromal cells.

  The Journal of clinical endocrinology and metabolism 20020801

• TNF-alpha-mediated apoptosis in chondrocytes sensitized by MG132 or actinomycin D.

  Biochemical and biophysical research communications 20020726

• E3 ubiquitin ligase that recognizes sugar chains.

  Nature 20020725

• Cellular steady-state levels of 'high risk' but not 'low risk' human papillomavirus (HPV) E6 proteins are increased by inhibition of proteasome-dependent degradation independent of their p53- and E6AP-binding capabilities.

  Virology 20020720

• Expression of kinin B(1) receptor in fresh or cultured rabbit aortic smooth muscle: role of NF-kappa B.

  American journal of physiology. Heart and circulatory physiology 20020701

• NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020701

• The effect of proteasome inhibitors on mammalian erythroid terminal differentiation.

  Experimental hematology 20020701

• Cell adhesion protects c-Raf-1 against ubiquitin-dependent degradation by the proteasome.

  Biochemical and biophysical research communications 20020628

• Localization and roles in fertilization of sperm proteasomes in the ascidian Halocynthia roretzi.

  Molecular reproduction and development 20020601

• The role of the proteasome in apoptosis induced by anthracycline anticancer agents.

  International journal of oncology 20020601

• Further pharmacological evidence of nuclear factor-kappa B pathway involvement in bradykinin B1 receptor-sensitized responses in human umbilical vein.

  The Journal of pharmacology and experimental therapeutics 20020601

• Interleukin-17 stimulates the expression of interleukin-8, growth-related oncogene-alpha, and granulocyte-colony-stimulating factor by human airway epithelial cells.

  American journal of respiratory cell and molecular biology 20020601

• Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase.

  Cancer research 20020601

• The expression of decorin in human ovarian tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020601

• Activation of p38 mitogen-activated protein kinase and nuclear factor-kappaB in tumour necrosis factor-induced eotaxin release of human eosinophils.

  Clinical and experimental immunology 20020601

• Proteasome inhibitor MG-132 enhances the expression of interleukin-6 in human umbilical vein endothelial cells: Involvement of MAP/ERK kinase.

  Immunology and cell biology 20020601

• Cell-cycle dependent dynamic change of 26S proteasome distribution in tobacco BY-2 cells.

  Plant & cell physiology 20020601

• Proteasome inhibitors in the treatment of B-cell malignancies.

  Clinical lymphoma 20020601

• A gene trap Dissociation insertion line, associated with a RING-H2 finger gene, shows tissue specific and developmental regulated expression of the gene in Arabidopsis.

  Gene 20020515

• Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020501

• Divergence of apoptosis-inducing and preventing signals in bacteria-faced macrophages through myeloid differentiation factor 88 and IL-1 receptor-associated kinase members.

  Journal of immunology (Baltimore, Md. : 1950) 20020501

• Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.

  Cancer research 20020501

• Nuclear factor (NF)-kappa B blockade attenuates but does not abrogate LPS-mediated interleukin (IL)-1 beta biosynthesis in alveolar epithelial cells.

  Biochemical and biophysical research communications 20020426

• Inhibition of mu and delta opioid receptor ligand binding by the peptide aldehyde protease inhibitor, leupeptin.

  Regulatory peptides 20020415

• Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells.

  American journal of physiology. Regulatory, integrative and comparative physiology 20020401

• Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes.

  Journal of biochemistry 20020401

• PDTC and Mg132, inhibitors of NF-kappaB, block endotoxin induced vasodilation of isolated rat skeletal muscle arterioles.

  Shock (Augusta, Ga.) 20020401

• A proteasome inhibitor confers cardioprotection.

  Cardiovascular research 20020401

• Hypoxia enhances the expression of plasminogen activator inhibitor-1 in human lung cancer cells, EBC-1.

  The Tohoku journal of experimental medicine 20020401

• Nuclear factor-kappa B-independent regulation of lipopolysaccharide-mediated interleukin-6 biosynthesis.

  Biochemical and biophysical research communications 20020308

• Inhibition of the ubiquitin-proteasome pathway induces differential heat-shock protein response in cardiomyocytes and renders early cardiac protection.

  Biochemical and biophysical research communications 20020301

• Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions.

  Archives of biochemistry and biophysics 20020301

• A cycloheximide-sensitive factor regulates TCDD-induced degradation of the aryl hydrocarbon receptor.

  Chemosphere 20020301

• A possible intermediate step during apoptotic execution.

  Human cell 20020301

• The susceptibility to Fas-induced apoptosis in normal enterocytes is regulated on the level of cIAP1 and 2.

  Biochemical and biophysical research communications 20020201

• Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis.

  European journal of immunology 20020201

• Translocation of small heat shock proteins to the actin cytoskeleton upon proteasomal inhibition.

  Journal of molecular and cellular cardiology 20020201

• Intracellular mechanisms mediating the inhibition of apoB-containing lipoprotein synthesis and secretion in HepG2 cells by avasimibe (CI-1011), a novel acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor.

  Biochemical pharmacology 20020201

• Ubiquitin, proteasome, and restenosis: a brave new world for cardiovascular research.

  Circulation 20020129

• Ubiquitin-proteasome pathway as a new target for the prevention of restenosis.

  Circulation 20020129

• Proteasome inhibitors activate the transcription factors C/EBP-beta and delta in human intestinal epithelial cells.

  Biochemical and biophysical research communications 20020111

• Arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1 beta-stimulated Caco-2 cells independent of the heat shock response.

  Journal of cellular biochemistry 20020101

• Evidence for a pre-restriction point Cdk3 activity.

  Journal of cellular biochemistry 20020101

• The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator.

  BMC biochemistry 20020101

• Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine.

  Nutrition and cancer 20020101

• Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins.

  Brain research. Molecular brain research 20011230

• Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells.

  Brain research. Molecular brain research 20011216

• Combined modulation of the mesangial machinery for monocyte recruitment by inhibition of NF-kappaB.

  American journal of physiology. Cell physiology 20011201

• Possible new role for NF-kappaB in the resolution of inflammation.

  Nature medicine 20011201

• Regulation of functional nuclear pore size in fibroblasts.

  Journal of cell science 20011201

• 6-Hydroxydopamine increases ubiquitin-conjugates and protein degradation: implications for the pathogenesis of Parkinson's disease.

  Cellular and molecular neurobiology 20011201

• The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.

  The Journal of biological chemistry 20011130

• Role of ATP in influenza virus budding.

  Virology 20011125

• Redundancy of mammalian proteasome beta subunit function during endoplasmic reticulum associated degradation.

  Biochemistry 20011106

• Nuclear factor-kappa B augments beta(2)-adrenergic receptor expression in human airway epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20011101

• Regulation of rheumatoid synoviocyte proliferation by endogenous p53 induction.

  Clinical and experimental immunology 20011101

• Leukemia stem cells and constitutive activation of NF-kappaB.

  Blood 20011015

• Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells.

  Blood 20011015

• Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-alpha.

  Biochemical pharmacology 20011001

• Regulation and distribution of MAdCAM-1 in endothelial cells in vitro.

  American journal of physiology. Cell physiology 20011001

• Proteasome-mediated degradation of BRCA1 protein in MCF-7 human breast cancer cells.

  International journal of oncology 20011001

• Proteasome inhibitors differentially affect heat shock protein response in cancer cells.

  International journal of molecular medicine 20011001

• Enhanced proteolysis of IkappaBalpha and IkappaBbeta proteins in astrocytes by Moloney murine leukemia virus (MoMuLV)-ts1 infection: a potential mechanism of NF-kappaB activation.

  Journal of neurovirology 20011001

• Inflammatory gene transcription in human astrocytes exposed to hypoxia: roles of the nuclear factor-kappaB and autocrine stimulation.

  Journal of neuroimmunology 20011001

• Molecular pathways that modify tumor radiation response.

  American journal of clinical oncology 20011001

• Proteasome activity is critical for the cAMP-induced differentiation of neuroblastoma cells.

  Cellular and molecular neurobiology 20011001

• The deubiquitinating enzyme DUB-2 prolongs cytokine-induced signal transducers and activators of transcription activation and suppresses apoptosis following cytokine withdrawal.

  Blood 20010915

• Proteasome inhibitor enhances growth hormone-binding protein release.

  Molecular and cellular endocrinology 20010901

• Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex.

  Leukemia 20010901

• Role of the proteasome in the regulation of fetal fibronectin secretion in human placenta.

  Annals of the New York Academy of Sciences 20010901

• Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines.

  FEBS letters 20010817

• Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

  Oncogene 20010816

• Inhibition of proteasome function induced apoptosis in gastric cancer.

  International journal of cancer 20010815

• The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.

  The Journal of biological chemistry 20010810

• Both Rb and E7 are regulated by the ubiquitin proteasome pathway in HPV-containing cervical tumor cells.

  Oncogene 20010802

• Removal of oxidatively damaged proteins from lens cells by the ubiquitin-proteasome pathway.

  Experimental eye research 20010801

• Unexpected transcriptional induction of monocyte chemoattractant protein 1 by proteasome inhibition: involvement of the c-Jun N-terminal kinase-activator protein 1 pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20010801

• Effects of arachidonic and docosahexaenoic acids on secretion and degradation of bile salt-dependent lipase in AR4-2J cells.

  Journal of lipid research 20010801

• Nuclear factor-kappa B is upregulated in colorectal cancer.

  Surgery 20010801

• Reversion of temperature-sensitive mutation by inhibition of proteasome-mediated degradation of mutated D123 protein.

  Cell structure and function 20010801

• Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway.

  Biochemical and biophysical research communications 20010720

• Heat-induced proteasomic degradation of HSF1 in serum-starved human fibroblasts aging in vitro.

  Experimental cell research 20010715

• PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.

  Biochemical and biophysical research communications 20010713

• Tumor necrosis factor alpha induces expression of genes for matrix degradation in human chondrocyte-like HCS-2/8 cells through activation of NF-kappaB: abrogation of the tumor necrosis factor alpha effect by proteasome inhibitors.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010701

• Inhibition of proteasome activity strongly affects kiwifruit pollen germination. Involvement of the ubiquitin/proteasome pathway as a major regulator.

  Plant physiology 20010701

• Trehalose accumulation during cellular stress protects cells and cellular proteins from damage by oxygen radicals.

  The Journal of biological chemistry 20010629

• Secretase targets for Alzheimer's disease: identification and therapeutic potential.

  Journal of medicinal chemistry 20010621

• Cyclic AMP-independent activation of protein kinase A by vasoactive peptides.

  The Journal of biological chemistry 20010615

• Involvement of proteasomes in gene induction by interferon and double-stranded RNA.

  Cytokine 20010607

• Involvement of all-trans-retinoic acid in the breakdown of retinoic acid receptors alpha and gamma through proteasomes in MCF-7 human breast cancer cells.

  Biochemical pharmacology 20010601

• Differential degradation of the three fibrinogen chains by proteasomes: involvement of Sec61p and cytosolic Hsp70.

  Archives of biochemistry and biophysics 20010601

• Effect of NF-kappa B Inhibition on TNF-alpha-induced apoptosis and downstream pathways in cardiomyocytes.

  Journal of molecular and cellular cardiology 20010601

• The effect of hydrogen peroxide on the cyclin D expression in fibroblasts.

  Cellular and molecular life sciences : CMLS 20010601

• Potential role of nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in apoptosis and oxidative stress.

  Journal of cell science 20010501

• Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress.

  Journal of cell science 20010501

• Differentiation-dependent sensitivity to cell death induced in the developing retina by inhibitors of the ubiquitin-proteasome proteolytic pathway.

  The European journal of neuroscience 20010501

• Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides.

  Biochemistry 20010424

• Enac degradation in A6 cells by the ubiquitin-proteosome proteolytic pathway.

  The Journal of biological chemistry 20010420

• IFNalpha sensitizes ME-180 human cervical cancer cells to TNFalpha-induced apoptosis by inhibiting cytoprotective NF-kappaB activation.

  FEBS letters 20010420

• Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression.

  Biochemical pharmacology 20010401

• Characterization of NF-kappaB expression in Hodgkin's disease: inhibition of constitutively expressed NF-kappaB results in spontaneous caspase-independent apoptosis in Hodgkin and Reed-Sternberg cells.

  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20010401

• Relationship of fiber surface iron and active oxygen species to expression of procollagen, PDGF-A, and TGF-beta(1) in tracheal explants exposed to amosite asbestos.

  American journal of respiratory cell and molecular biology 20010401

• Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five cells.

  BioTechniques 20010401

• Roles of NF-kappaB and 26 S proteasome in apoptotic cell death induced by topoisomerase I and II poisons in human nonsmall cell lung carcinoma.

  The Journal of biological chemistry 20010316

• Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cells.

  Hepatology (Baltimore, Md.) 20010301

• Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors.

  Cell death and differentiation 20010301

• Impairment of bile salt-dependent lipase secretion in AR4-2J rat pancreatic cells induces its degradation by the proteasome.

  Biochimica et biophysica acta 20010226

• Proteasome inhibitors sensitize human vascular smooth muscle cells to Fas (CD95)-mediated death.

  Biochemical and biophysical research communications 20010223

• Ubiquitin-mediated degradation of hepatitis C virus core protein is regulated by processing at its carboxyl terminus.

  Virology 20010215

• Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin.

  Oncogene 20010215

• The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase.

  The Journal of biological chemistry 20010209

• The proteasome inhibitor MG132 promotes accumulation of the steroidogenic acute regulatory protein (StAR) and steroidogenesis.

  FEBS letters 20010209

• Proteasome inhibitor induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5.

  The Journal of general virology 20010201

• Double-stranded RNA-dependent protein kinase is not required for double-stranded RNA-induced nitric oxide synthase expression or nuclear factor-kappaB activation by islets.

  Diabetes 20010201

• Relationship between NF-kappaB and trypsinogen activation in rat pancreas after supramaximal caerulein stimulation.

  Biochemical and biophysical research communications 20010112

• The proteasome regulates receptor-mediated endocytosis of interleukin-2.

  The Journal of biological chemistry 20010105

• Expression of the NF-kappa B target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cells.

  Oncogene 20010104

• FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent.

  Nature cell biology 20010101

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  Placenta 20010101

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  Anticancer research 20010101

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  Anticancer research 20010101

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  Prostaglandins, leukotrienes, and essential fatty acids 20010101

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  Proceedings of the National Academy of Sciences of the United States of America 20001121

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  FEBS letters 20000728

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  The Journal of biological chemistry 20000428

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  Journal of the American Society of Nephrology : JASN 19991101

• The apoptotic effects and synergistic interaction of sodium butyrate and MG132 in human retinoblastoma Y79 cells.

  Cancer research 19991101

• Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytosplasmic proteasome following nuclear export.

  The Journal of biological chemistry 19991001

• Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K(+)-ATPase through proteasomal and endo-/lysosomal proteolytic pathways.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19991001

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  Bioorganic & medicinal chemistry letters 19980217

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  Biochemical and biophysical research communications 19931115

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  Molecular endocrinology (Baltimore, Md.)

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  Molecular endocrinology (Baltimore, Md.)