133550-30-8 | Ag-490

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$28.00	$19.00
20mg	98%	in stock	$41.00	$29.00
250mg	98%	in stock	$478.00	$335.00

Description

• Catalog Number: AB51372
• Chemical Name: Ag-490
• CAS Number: 133550-30-8
• Molecular Formula: C17H14N2O3
• Molecular Weight: 294.3047
• MDL Number: MFCD00236452
• SMILES: N#CC(=Cc1ccc(c(c1)O)O)C(=O)NCc1ccccc1

Computed Properties

• Complexity: 460
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 22
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 4
• XLogP3: 2.4

Literature

• Silicon dioxide nanoparticles induce COX-2 expression through activation of STAT3 signaling pathway in HaCaT cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20181001

• Hormesis of mercuric chloride-human serum albumin adduct on N9 microglial cells via the ERK/MAPKs and JAK/STAT3 signaling pathways.

  Toxicology 20180901

• IL-6 knockout mice are protected from cocaine-induced kindling behaviors; possible involvement of JAK2/STAT3 and PACAP signalings.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180601

• PKA/CREB and NF-κB pathway regulates AKNA transcription: A novel insight into T-2 toxin-induced inflammation and GH deficiency in GH3 cells.

  Toxicology 20171201

• Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170801

• Galectin-3 contributes to vascular fibrosis in monocrotaline-induced pulmonary arterial hypertension rat model.

  Journal of biochemical and molecular toxicology 20170501

• Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38/JNK MAPK/STAT3 pathway.

  Toxicology and applied pharmacology 20160715

• Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways.

  Acta biochimica et biophysica Sinica 20150301

• Inhibition of STAT3 signaling as critical molecular event in resveratrol-suppressed ovarian cancer cells.

  Journal of ovarian research 20150101

• Development of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo.

  The Journal of biological chemistry 20141205

• Upregulation of the large conductance voltage- and Ca2+-activated K+ channels by Janus kinase 2.

  American journal of physiology. Cell physiology 20140601

• Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells.

  Genes & cancer 20140501

• Developmental defects in zebrafish for classification of EGF pathway inhibitors.

  Toxicology and applied pharmacology 20140115

• Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells.

  PloS one 20140101

• Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells.

  Toxicology and applied pharmacology 20131101

• Cooperation of bisphenol A and leptin in inhibition of caspase-3 expression and activity in OVCAR-3 ovarian cancer cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20130901

• The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death.

  Cell death & disease 20130801

• A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

  The Biochemical journal 20130415

• Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway.

  Toxicology 20130208

• A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors.

  PloS one 20130101

• Prolactin regulates luminal bicarbonate secretion in the intestine of the sea bream (Sparus aurata L.).

  The Journal of experimental biology 20121101

• Tyrphostin AG490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor.

  Journal of clinical immunology 20121001

• Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK/STAT signaling activation.

  Shock (Augusta, Ga.) 20121001

• Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2/STAT3 survival pathway.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120901

• Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells.

  The Journal of clinical investigation 20120702

• Interleukin 6 protects H(2)O(2)-induced cardiomyocytes injury through upregulation of prohibitin via STAT3 phosphorylation.

  Cell biochemistry and function 20120701

• A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures.

  International journal of oncology 20120601

• Involvement of intracellular oxidative stress-sensitive pathway in phloxine B-induced photocytotoxicity in human T lymphocytic leukemia cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601

• JAK/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin.

  Toxicological sciences : an official journal of the Society of Toxicology 20120601

• Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells.

  Cancer biology & therapy 20120601

• Site-specific regulation of ion transport by prolactin in rat colon epithelium.

  American journal of physiology. Gastrointestinal and liver physiology 20120515

• Regulation of interferon-inducible proteins by doxorubicin via interferon γ-Janus tyrosine kinase-signal transducer and activator of transcription signaling in tumor cells.

  Molecular pharmacology 20120501

• The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway.

  Basic research in cardiology 20120501

• Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt-induced NF-κB and STAT/GAS activity.

  Journal of pineal research 20120401

• Up-regulation of the betaine/GABA transporter BGT1 by JAK2.

  Biochemical and biophysical research communications 20120330

• Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis.

  Journal of cellular physiology 20120301

• Downregulation of the creatine transporter SLC6A8 by JAK2.

  The Journal of membrane biology 20120301

• IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis.

  Molecular immunology 20120201

• The Jak/STAT pathway is involved in synaptic plasticity.

  Neuron 20120126

• A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

  Toxicology and applied pharmacology 20120115

• Prolactin-induced activation of phagocyte NADPH oxidase in the teleost fish gilthead seabream involves the phosphorylation of p47phox by protein kinase C.

  Developmental and comparative immunology 20120101

• Mutual regulation of growth hormone and bone morphogenetic protein system in steroidogenesis by rat granulosa cells.

  Endocrinology 20120101

• Primary effusion lymphoma cell death induced by bortezomib and AG 490 activates dendritic cells through CD91.

  PloS one 20120101

• Identification of JAK2 as a mediator of FIP1L1-PDGFRA-induced eosinophil growth and function in CEL.

  PloS one 20120101

• The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice.

  PloS one 20120101

• AG490 promotes HIF-1α accumulation by inhibiting its hydroxylation.

  Current medicinal chemistry 20120101

• MAPK and JAK-STAT signaling pathways are involved in the oxidative stress-induced decrease in expression of surfactant protein genes.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Hyperglycaemia exacerbates choroidal neovascularisation in mice via the oxidative stress-induced activation of STAT3 signalling in RPE cells.

  PloS one 20120101

• STAT1 mediates oroxylin a inhibition of iNOS and pro-inflammatory cytokines expression in microglial BV-2 cells.

  PloS one 20120101

• Chronic perinatal hypoxia reduces glutamate-aspartate transporter function in astrocytes through the Janus kinase/signal transducer and activator of transcription pathway.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20111207

• AG490: an inhibitor of hepcidin expression in vivo.

  World journal of gastroenterology 20111207

• STAT3 does not regulate acute liver injury after ischemia/reperfusion.

  The Journal of surgical research 20111201

• A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination.

  Cellular signalling 20111201

• Transcription suppression of SARI (suppressor of AP-1, regulated by IFN) by BCR-ABL in human leukemia cells.

  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20111201

• Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke.

  Stroke 20111201

• Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell.

  Placenta 20111201

• Tyrphostin-like compounds with ubiquitin modulatory activity as possible therapeutic agents for multiple myeloma.

  Bioorganic & medicinal chemistry 20111201

• Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion.

  Circulation research 20111111

• The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats.

  Cytokine 20111101

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• Human gastrin mRNA expression up-regulated by Helicobacter pylori CagA through MEK/ERK and JAK2-signaling pathways in gastric cancer cells.

  Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20111001

• Erythropoietin protects retinal pigment epithelial cells against the increase of permeability induced by diabetic conditions: essential role of JAK2/ PI3K signaling.

  Cellular signalling 20111001

• Angiotensin II utilizes Janus kinase 2 in hypertension, but not in the physiological control of blood pressure, during low-salt intake.

  American journal of physiology. Regulatory, integrative and comparative physiology 20111001

• [Effect of homoharringtonine combined with AG490 on JAK2-STAT5 associated signal pathway in HEL cells].

  Zhongguo shi yan xue ye xue za zhi 20111001

• Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN.

  Cancer letters 20110901

• Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1.

  American journal of physiology. Cell physiology 20110901

• Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway.

  International immunopharmacology 20110801

• Potential role of NADPH oxidase-mediated activation of Jak2/Stat3 and mitogen-activated protein kinases and expression of TGF-β1 in the pathophysiology of acute pancreatitis.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110801

• Interferon-gamma-induced MD-2 protein expression and lipopolysaccharide (LPS) responsiveness in corneal epithelial cells is mediated by Janus tyrosine kinase-2 activation and direct binding of STAT1 protein to the MD-2 promoter.

  The Journal of biological chemistry 20110708

• Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats.

  Neuroscience letters 20110708

• Reactive oxygen species scavenger inhibits STAT3 activation after transient focal cerebral ischemia-reperfusion injury in rats.

  Anesthesia and analgesia 20110701

• Effects of leukemia inhibitory factor on proliferation and odontoblastic differentiation of human dental pulp cells.

  Journal of endodontics 20110601

• Stimulation of the glucose carrier SGLT1 by JAK2.

  Biochemical and biophysical research communications 20110506

• The antagonist of the JAK-1/STAT-1 signaling pathway improves the severity of cerulein-stimulated pancreatic injury via inhibition of NF-κB activity.

  International journal of molecular medicine 20110501

• Cortex Dictamni extract induces apoptosis of activated hepatic stellate cells via STAT1 and attenuates liver fibrosis in mice.

  Journal of ethnopharmacology 20110426

• [Effects of blocking activation of IGF-1-Stat3 signaling pathway in guinea pig sclera fibroblast by AG490 on expression of MMP-2 and Integrinβ(1)].

  [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20110401

• Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells.

  Journal of neuro-oncology 20110201

• JAK2 is an important signal transducer in IL-33-induced NF-κB activation.

  Cellular signalling 20110201

• In vitro leptin treatment of rainbow trout hypothalamus and hindbrain affects glucosensing and gene expression of neuropeptides involved in food intake regulation.

  Peptides 20110201

• Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesis.

  American journal of physiology. Gastrointestinal and liver physiology 20110201

• JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPβ transcription.

  Journal of cellular biochemistry 20110201

• Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors.

  Bioorganic & medicinal chemistry 20110115

• α4β2 nicotinic receptors partially mediate anti-inflammatory effects through Janus kinase 2-signal transducer and activator of transcription 3 but not calcium or cAMP signaling.

  Molecular pharmacology 20110101

• LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease.

  Nature cell biology 20110101

• Tyrphostin AG490 reduces NAPDH oxidase activity and expression in the aorta of hypercholesterolemic apolipoprotein E-deficient mice.

  Vascular pharmacology 20110101

• Rosuvastatin treatment activates JAK-STAT pathway and increases efficacy of allogeneic mesenchymal stem cell transplantation in infarcted hearts.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• Postconditioning inhibits myocardial apoptosis during prolonged reperfusion via a JAK2-STAT3-Bcl-2 pathway.

  Journal of biomedical science 20110101

• Non-nuclear activation of signal transducer and activator of transcription 3 by 17β- estradiol in endometrial cancer cells.

  Neoplasma 20110101

• Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies.

  PloS one 20110101

• p22phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation.

  Cell death and differentiation 20101201

• Rhizoctonia bataticola lectin (RBL) induces mitogenesis and cytokine production in human PBMC via p38 MAPK and STAT-5 signaling pathways.

  Biochimica et biophysica acta 20101201

• [The effect of Janus kinase 2 inhibitor AG490 on renal tubular epithelial-myofibroblast transdifferentiation induced by interleukin-1β].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101201

• [The expression of suppressor of cytokine signaling-1/3 in renal tubular epithelial cells induced by high glucose].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Ethanolamine is a novel STAT-3 dependent cardioprotective agent.

  Basic research in cardiology 20101101

• Leptin-induced cardioprotection involves JAK/STAT signaling that may be linked to the mitochondrial permeability transition pore.

  American journal of physiology. Heart and circulatory physiology 20101001

• Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway.

  Stem cells (Dayton, Ohio) 20101001

• Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice.

  Lupus 20100901

• Estrogen increases, whereas IL-27 and IFN-gamma decrease, splenocyte IL-17 production in WT mice.

  European journal of immunology 20100901

• Blockade of Janus kinase 2 signaling ameliorates mouse liver damage due to ischemia and reperfusion.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20100901

• Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling.

  Molecular and cellular endocrinology 20100830

• JAK2V617F/STAT5 signaling pathway promotes cell proliferation through activation of Pituitary Tumor Transforming Gene 1 expression.

  Biochemical and biophysical research communications 20100806

• Frequent STAT3 activation is associated with Mcl-1 expression in nasal NK-cell lymphoma.

  International journal of laboratory hematology 20100801

• JAK2 inhibition prevents innate immune responses and rescues animals from sepsis.

  Journal of molecular medicine (Berlin, Germany) 20100801

• JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation.

  British journal of haematology 20100801

• Activation of the JAK-STAT pathway by olanzapine is necessary for desensitization of serotonin2A receptor-stimulated phospholipase C signaling in rat frontal cortex but not serotonin2A receptor-stimulated hormone release.

  Journal of psychopharmacology (Oxford, England) 20100701

• Antagonists of growth hormone-releasing hormone inhibit the proliferation of human benign prostatic hyperplasia cells.

  The Prostate 20100701

• [Helicobacter pylori cytotoxin associated protein CagA regulates gastrin gene promoter activity].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20100701

• Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20100601

• Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20100501

• An important role of increase in tetrahydrobiopterin via H2O2-JAK2 signalling pathway in late phase of ischaemic preconditioning.

  Experimental physiology 20100501

• Molecular mechanisms of cellular proliferation in acute myelogenous leukemia by leptin.

  Oncology reports 20100501

• Blockade of Janus kinase-2 signaling ameliorates mouse liver damage due to ischemia and reperfusion.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20100501

• Cinnamaldehyde impairs high glucose-induced hypertrophy in renal interstitial fibroblasts.

  Toxicology and applied pharmacology 20100415

• A receptor-independent, cell-based JAK activation assay for screening for JAK3-specific inhibitors.

  Journal of immunological methods 20100331

• Intermediate Ca2+-sensitive K+ channels are necessary for prolactin-induced proliferation in breast cancer cells.

  The Journal of membrane biology 20100301

• [Inhibitor of tyrosine phosphorylation AG490 inhibits the proliferation of Jurkat T cells].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20100301

• Effects of AG490 on lens epithelial cell death induced by H(2)O(2).

  Japanese journal of ophthalmology 20100301

• STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells.

  Proceedings of the National Academy of Sciences of the United States of America 20100216

• Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin.

  Cancer letters 20100201

• Leptin excites proopiomelanocortin neurons via activation of TRPC channels.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100127

• Angiotensin II activates JAK2/STAT3 pathway and induces interleukin-6 production in cultured rat brainstem astrocytes.

  Regulatory peptides 20100108

• IL-23 induces receptor activator of NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways.

  Immunology letters 20100104

• Aberrant expression of serum amyloid A in head and neck squamous cell carcinoma.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20100101

• The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation.

  The American journal of pathology 20100101

• Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro.

  PloS one 20100101

• Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro.

  Journal of experimental & clinical cancer research : CR 20100101

• Inhibition of the signal transducers and activators of transcription (STAT) 3 signalling pathway by AG490 in laryngeal carcinoma cells.

  The Journal of international medical research 20100101

• Role of Janus kinase-2 in IgE receptor-mediated leukotriene C4 production by mast cells.

  Biochemical and biophysical research communications 20091218

• Synergistic effect of radiation and interleukin-6 on hepatitis B virus reactivation in liver through STAT3 signaling pathway.

  International journal of radiation oncology, biology, physics 20091201

• Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis.

  The Journal of biological chemistry 20091127

• STAT1/2 is involved in the inhibition of cell growth induced by U0126 in HeLa cells.

  Cellular and molecular biology (Noisy-le-Grand, France) 20091115

• Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34+ cells via EpoR-mediated JAK2/STAT5 signaling pathway.

  Journal of ethnopharmacology 20091112

• Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway.

  Cardiovascular research 20091101

• Histamine induces human beta-defensin-3 production in human keratinocytes.

  Journal of dermatological science 20091101

• IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.

  Anticancer research 20091101

• NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells.

  Toxicology and applied pharmacology 20091015

• Stat3 is involved in angiotensin II-induced expression of MMP2 in gastric cancer cells.

  Digestive diseases and sciences 20091001

• Involvement of JAK-STAT signaling/function after cyclophosphamide-induced bladder inflammation in female rats.

  American journal of physiology. Renal physiology 20091001

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma).

  Biology of the cell 20090923

• 17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells.

  Cancer research 20090915

• Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3.

  Cell research 20090901

• Roles of phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase in the regulation of protein kinase C-alpha activation in interferon-gamma-stimulated macrophages.

  Immunology 20090901

• Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.

  Journal of medicinal chemistry 20090827

• Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways.

  Journal of cellular biochemistry 20090801

• Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells.

  American journal of physiology. Cell physiology 20090801

• Serenoa repens induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of STAT 3 signaling.

  Oncology reports 20090801

• The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model.

  Investigative ophthalmology & visual science 20090701

• The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice.

  International immunopharmacology 20090701

• [Role of angiotensin II and JAK2 signal pathway in transdifferentation of renal tubular cells in mice after acute ischemic followed by reperfusion].

  Zhonghua bing li xue za zhi = Chinese journal of pathology 20090701

• Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer.

  British journal of cancer 20090616

• Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, clozapine and MDL 100907.

  The international journal of neuropsychopharmacology 20090601

• Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head and neck carcinoma cell lines.

  International journal of molecular medicine 20090601

• Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090527

• Ozone stress down-regulates the expression of cystic fibrosis transmembrane conductance regulator in human bronchial epithelial cells.

  Chemico-biological interactions 20090515

• The acute lymphoblastic leukemia-associated JAK2 L611S mutant induces tumorigenesis in nude mice.

  The Journal of biological chemistry 20090508

• Orbital fibroblasts from patients with thyroid-associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1.

  Investigative ophthalmology & visual science 20090501

• A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes.

  Biochemical and biophysical research communications 20090501

• STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria.

  Molecular immunology 20090501

• Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: an implication for the pathogenesis of arthritis.

  Arthritis and rheumatism 20090501

• Possible role of JAK-2 in attenuated cardioprotective effect of ischemic preconditioning in hyperhomocysteinemic rat hearts.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090501

• Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients.

  Oncogene 20090409

• IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner.

  Atherosclerosis 20090401

• Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation.

  Journal of molecular endocrinology 20090401

• STAT3 induces muscle stem cell differentiation by interaction with myoD.

  Cytokine 20090401

• Myricetin directly targets JAK1 to inhibit cell transformation.

  Cancer letters 20090308

• Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils.

  The Journal of allergy and clinical immunology 20090301

• Inhibition of Janus kinase 2 and signal transduction and activator of transcription 3 protect against cecal ligation and puncture-induced multiple organ damage and mortality.

  The Journal of trauma 20090301

• Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-kappaB.

  Brain research 20090223

• Inhibition of JAK2 protects renal endothelial and epithelial cells from oxidative stress and cyclosporin A toxicity.

  Kidney international 20090101

• IL-12-dependent activation of ERK1/2 in human T lymphoblasts.

  Immunobiology 20090101

• Effects of a JAK inhibitor, AG490, on proliferation and apoptosis of human nasopharyngeal carcinoma cell line CNE-2Z.

  Ai zheng = Aizheng = Chinese journal of cancer 20090101

• Oxidative stress induces PKR-dependent apoptosis via IFN-gamma activation signaling in Jurkat T cells.

  Biochemical and biophysical research communications 20081219

• Development of a STAT3 reporter prostate cancer cell line for high throughput screening of STAT3 activators and inhibitors.

  Biochemical and biophysical research communications 20081212

• Interferon-sensitive response element (ISRE) is mainly responsible for IFN-alpha-induced upregulation of programmed death-1 (PD-1) in macrophages.

  Biochimica et biophysica acta 20081201

• AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathways.

  Molecules and cells 20081130

• JAK2-STAT3 signaling pathway mediates thrombin-induced proinflammatory actions of microglia in vitro.

  Journal of neuroimmunology 20081115

• Tyrphostin AG-490 inhibited the acute phase of zymosan-induced inflammation.

  International immunopharmacology 20081101

• Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of Stat3 function.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081101

• High-fat diet-induced obesity leads to resistance to leptin-induced cardiomyocyte contractile response.

  Obesity (Silver Spring, Md.) 20081101

• [Neuroprotective effects of combined application of JAK-STAT signal pathway inhibitor and free radical scavenger on focal cerebral ischemia/reperfusion injury in rats].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20081101

• Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3.

  Molecular cancer research : MCR 20081101

• Cloning and characterization of 5'-untranslated region of porcine beta casein gene (CSN2).

  Domestic animal endocrinology 20081001

• Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells.

  European journal of haematology 20081001

• Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons.

  Histochemistry and cell biology 20081001

• Regulating RISK: a role for JAK-STAT signaling in postconditioning?

  American journal of physiology. Heart and circulatory physiology 20081001

• A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490.

  Anti-cancer agents in medicinal chemistry 20081001

• Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion.

  Basic research in cardiology 20080901

• Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20080801

• [Simvastatin attenuated cardiac hypertrophy via inhibiting JAK-STAT pathways].

  Zhonghua xin xue guan bing za zhi 20080801

• Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters.

  Journal of medicinal chemistry 20080724

• Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity.

  Journal of immunology (Baltimore, Md. : 1950) 20080715

• Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning.

  Cardiovascular research 20080701

• Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly.

  Endocrinology 20080701

• The role of eNOS, iNOS, and NF-kappaB in upregulation and activation of cyclooxygenase-2 and infarct size reduction by atorvastatin.

  American journal of physiology. Heart and circulatory physiology 20080701

• Enhanced resistance against systemic Candida albicans infection in mice treated with C. albicans DNA.

  FEMS immunology and medical microbiology 20080701

• Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells.

  Neoplasia (New York, N.Y.) 20080701

• Potential role of JAK2 in cerebral vasospasm after experimental subarachnoid hemorrhage.

  Brain research 20080612

• Amino acid supplementation differentially modulates STAT1 and STAT3 activation in the myocardium exposed to ischemia/reperfusion injury.

  The American journal of cardiology 20080602

• Antiapoptotic properties of erythropoiesis-stimulating proteins in models of cisplatin-induced acute kidney injury.

  American journal of physiology. Renal physiology 20080601

• [Interferon-alpha upregulates thymidine phosphorylase expression via JAK-STAT transcriptional activation and mRNA stabilization in human hepatocellular carcinoma SMMC-7721 cells].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20080601

• Simvastatin prevents cardiac hypertrophy in vitro and in vivo via JAK/STAT pathway.

  Life sciences 20080507

• Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501

• Granulocyte colony-stimulating factor prevents reperfusion injury after heart preservation.

  The Annals of thoracic surgery 20080401

• Possible involvement of prolactin in the synthesis of lactoferrin in bovine mammary epithelial cells.

  Bioscience, biotechnology, and biochemistry 20080401

• Transcriptional activity of the DeltaNp63 promoter is regulated by STAT3.

  The Journal of biological chemistry 20080321

• Mao (Ephedra sinica Stapf) protects against D-galactosamine and lipopolysaccharide-induced hepatic failure.

  Cytokine 20080301

• The tyrphostin B42 inhibits cell proliferation and HER-2 autophosphorylation in cervical carcinoma cell lines.

  Cancer investigation 20080301

• Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells.

  Neoplasia (New York, N.Y.) 20080301

• Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas.

  Blood 20080201

• Orazipone inhibits activation of inflammatory transcription factors nuclear factor-kappa B and signal transducer and activator of transcription 1 and decreases inducible nitric-oxide synthase expression and nitric oxide production in response to inflammatory stimuli.

  The Journal of pharmacology and experimental therapeutics 20080201

• [Effects of Yisui Jiedu Recipe on JAK2-STAT5 signal transduction pathway in bone marrow hematopoietic cells from patients with myelodysplastic syndrome-refractory anemia].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080201

• Prolactin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: involvement of p-38 MAP kinase, STAT3 and NF-kappaB.

  Cytokine 20080201

• Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization.

  The Journal of biological chemistry 20080118

• Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rat.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080101

• Coronary effluent from a preconditioned heart activates the JAK-STAT pathway and induces cardioprotection in a donor heart.

  American journal of physiology. Heart and circulatory physiology 20080101

• Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells.

  The international journal of biochemistry & cell biology 20080101

• [The molecular mechanism of survivin expression in activated human peripheral lymphocytes].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20080101

• [Effect of Janus kinase inhibitor AG490 on invasion and metastasis of human breast cancer cells].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080101

• Postreceptor crosstalk on PI3K/Akt between GH and insulin in non-catch-up growth rats born small for gestational age.

  Hormone research 20080101

• Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery.

  Journal of nephrology 20080101

• Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line.

  Cancer letters 20071218

• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

  Proceedings of the National Academy of Sciences of the United States of America 20071218

• WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells.

  Cancer research 20071201

• Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells.

  Biochemical and biophysical research communications 20071123

• Jak2 dampens the induction by IL-1beta of prostaglandin endoperoxide H synthase 2 expression in human orbital fibroblasts: evidence for divergent influence on the prostaglandin E2 biosynthetic pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20071115

• AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation.

  Cancer letters 20071108

• JAK/STAT pathway mediates retinal ganglion cell survival after acute ocular hypertension but not under normal conditions.

  Experimental eye research 20071101

• S-adenosylmethionine-dependent protein methylation in mammalian cytosol via tyrphostin modification by catechol-O-methyltransferase.

  The Journal of biological chemistry 20071019

• Modulation of mast cell proteinase-activated receptor expression and IL-4 release by IL-12.

  Immunology and cell biology 20071001

• Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis.

  Journal of hepatology 20071001

• Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490.

  Glia 20071001

• Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors.

  American journal of physiology. Heart and circulatory physiology 20070801

• Direct effects of prolactin on adrenal steroid release in male Hatano high-avoidance (HAA) rats may be mediated through Janus kinase 2 (Jak2) activity.

  The Journal of reproduction and development 20070801

• Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation.

  American journal of physiology. Heart and circulatory physiology 20070801

• PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury.

  The European journal of neuroscience 20070801

• Olanzapine increases RGS7 protein expression via stimulation of the Janus tyrosine kinase-signal transducer and activator of transcription signaling cascade.

  The Journal of pharmacology and experimental therapeutics 20070701

• Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway.

  Endocrinology 20070701

• Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells.

  Journal of cardiovascular pharmacology 20070701

• Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation.

  Cancer research 20070601

• Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling.

  Journal of leukocyte biology 20070501

• Raloxifene plus 17beta-estradiol inhibits proliferation of primary cultured vascular smooth muscle cells and human mammary endothelial cells via the janus kinase/signal transducer and activator of transcription3 cascade.

  European journal of pharmacology 20070430

• A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo.

  Oncogene 20070412

• GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals.

  Biogerontology 20070401

• JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization.

  Journal of leukocyte biology 20070401

• Mechanisms of endothelial cell protection by blockade of the JAK2 pathway.

  American journal of physiology. Cell physiology 20070301

• Actions of neuropoietic cytokines and cyclic AMP in regenerative conditioning of rat primary sensory neurons.

  Experimental neurology 20070301

• Growth hormone stimulates osteoprotegerin expression and secretion in human osteoblast-like cells.

  The Journal of endocrinology 20070301

• Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth.

  The Journal of biological chemistry 20070209

• Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells.

  Journal of hepatology 20070101

• Constitutive phosphorylation of Janus kinase 2 in the GL15 glioblastoma derived human cell line.

  Oncology reports 20070101

• Roles of mTOR and STAT3 in autophagy induced by telomere 3' overhang-specific DNA oligonucleotides.

  Autophagy 20070101

• Modulation of protein tyrosine phosphatase 1B by erythropoietin in UT-7 cell line.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• Inhibition of Jak/STAT signaling ameliorates mice experimental nephrotic syndrome.

  American journal of nephrology 20070101

• Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cells.

  Folia biologica 20070101

• Inhibition of Jak2 phosphorylation attenuates pressure overload cardiac hypertrophy.

  Vascular pharmacology 20061201

• Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro.

  Cancer science 20061201

• [Inhibitory effect of AG490 on invasion and metastasis of human pancreatic cancer cells in vitro].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20061201

• Suppression of IL-1beta expression by the Jak 2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells.

  Biochemical pharmacology 20061130

• Direct evidence of astrocytic modulation in the development of rewarding effects induced by drugs of abuse.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20061101

• Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation.

  Acta pharmacologica Sinica 20061101

• Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells.

  Cytokine 20061101

• Role of signal transducer and activator of transcription 3 (STAT3) in stretch injury to bladder smooth muscle cells.

  Cell and tissue research 20061001

• Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.

  Biology of reproduction 20061001

• Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells.

  Cancer research 20061001

• [Effects of a JAK inhibitor, AG490, on proliferation and survivin expression of breast cancer cell line MDA-MB-231].

  Ai zheng = Aizheng = Chinese journal of cancer 20061001

• Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane).

  International journal of cancer 20060915

• Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion.

  American journal of physiology. Cell physiology 20060901

• All-trans retinoic acid stimulates IL-2-mediated proliferation of human T lymphocytes: early induction of cyclin D3.

  Journal of immunology (Baltimore, Md. : 1950) 20060901

• JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia.

  Journal of neurochemistry 20060901

• STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells.

  Kidney international 20060801

• Interferon-gamma enhances superoxide production in human mesangial cells via the JAK-STAT pathway.

  Kidney international 20060801

• Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2 and Janus kinase-2 but not c-Jun NH2-terminal kinase 1/2 signalling pathways.

  Clinical and experimental immunology 20060701

• Janus kinase 2: a critical target in chronic myelogenous leukemia.

  Cancer research 20060701

• STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I.

  Biochemical pharmacology 20060628

• American Association for Cancer Research--97th annual meeting.

  IDrugs : the investigational drugs journal 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Constitutive activation of STAT proteins in the HDLM-2 and L540 Hodgkin lymphoma-derived cell lines supports cell survival.

  Cellular signalling 20060401

• CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2.

  Cellular signalling 20060401

• Specific function of STAT3, SOCS1, and SOCS3 in the regulation of proliferation and survival of classical Hodgkin lymphoma cells.

  International journal of cancer 20060315

• Pancreatitis-associated protein I suppresses NF-kappa B activation through a JAK/STAT-mediated mechanism in epithelial cells.

  Journal of immunology (Baltimore, Md. : 1950) 20060315

• Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer.

  Cancer research 20060315

• Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways.

  Molecular and cellular endocrinology 20060309

• Janus kinase-signal transducer and activator of transcription mediates phosphatidic acid-induced interleukin (IL)-1beta and IL-6 production.

  Molecular pharmacology 20060301

• Simvastatin attenuates hypertrophic responses induced by cardiotrophin-1 via JAK-STAT pathway in cultured cardiomyocytes.

  Molecular and cellular biochemistry 20060301

• Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes.

  Cardiovascular research 20060215

• Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).

  FEBS letters 20060206

• Activation of JAK/STAT signalling in neurons following spinal cord injury in mice.

  Journal of neurochemistry 20060201

• Signal transducer and activator of transcription 6 down-regulates toll-like receptor-4 expression of a monocytic cell line.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060201

• Suppression of IL-6 production and proliferation by blocking STAT3 activation in malignant soft tissue tumor cells.

  Cancer letters 20060118

• The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages.

  Journal of molecular medicine (Berlin, Germany) 20060101

• Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060101

• Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy.

  Molecular cancer therapeutics 20060101

• Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells.

  Retrovirology 20060101

• The tyrosine kinase inhibitor AG490 inhibits growth of cancer cells and activates ERK in LS174T and HT-29 cells.

  Anticancer research 20060101

• Induction of interleukin-8 secretion and activation of ERK1/2, p38 MAPK signaling pathways by thrombin in dermal fibroblasts.

  The international journal of biochemistry & cell biology 20060101

• JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages.

  Mediators of inflammation 20060101

• TRAIL expression up-regulated by interferon-gamma via phosphorylation of STAT1 induces myeloma cell death.

  Anticancer research 20060101

• LIF upregulates expression of NK-1R in NHBE cells.

  Mediators of inflammation 20060101

• Leptin potentiates ADP-induced [Ca(2+)](i) increase via JAK2 and tyrosine kinases in a megakaryoblast cell line.

  Diabetes research and clinical practice 20051201

• STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells.

  The Biochemical journal 20051201

• Prolactin specifically activates signal transducer and activator of transcription 5b in neuroendocrine dopaminergic neurons.

  Endocrinology 20051201

• Divergent action of calcium channel blockers on ATP-binding cassette protein expression.

  Journal of cardiovascular pharmacology 20051201

• Jak2 tyrosine kinase prevents angiotensin II-mediated inositol 1,4,5 trisphosphate receptor degradation.

  Vascular pharmacology 20051101

• Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1.

  Neuron 20051020

• Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia.

  British journal of pharmacology 20051001

• Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells.

  The American journal of pathology 20051001

• Prevention of acute lung allograft rejection in rat by the janus kinase 3 inhibitor, tyrphostin AG490.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20051001

• A VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia.

  The Biochemical journal 20050901

• Aldosterone induces angiotensin converting enzyme gene expression via a JAK2-dependent pathway in rat endothelial cells.

  Endocrinology 20050901

• The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells.

  International journal of oncology 20050901

• Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.

  Brain : a journal of neurology 20050701

• Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2.

  Journal of leukocyte biology 20050701

• Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor.

  The Journal of biological chemistry 20050701

• Combinatorial approach to identification of tyrphostin inhibitors of cytokine signaling.

  Bioorganic & medicinal chemistry 20050701

• Targeting Stat3 in cancer therapy.

  Anti-cancer drugs 20050701

• JAK-STAT signaling pathway in pulmonary arterial smooth muscle cells is activated by hypoxia.

  Cell biology international 20050701

• Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma.

  Oncogene 20050623

• Requirement of multiple signaling pathways for the augmented production of hyaluronan by v-Src.

  Nagoya journal of medical science 20050601

• Interferons upregulate thymidine phosphorylase expression via JAK-STAT-dependent transcriptional activation and mRNA stabilization in human glioblastoma cells.

  Journal of neuro-oncology 20050501

• Inhibitors of tyrosine kinase inhibit the production of urokinase plasminogen activator in human prostatic cancer cells.

  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20050501

• Inflammatory cytokines interleukin-6 and oncostatin m induce plasminogen activator inhibitor-1 in human adipose tissue.

  Circulation 20050419

• IFNgamma and TNFalpha synergistically induce neurite outgrowth on PC12 cells.

  Neuroscience letters 20050411

• JAK and STAT proteins are expressed and activated by IFN-gamma in rat pancreatic acinar cells.

  Journal of cellular physiology 20050401

• Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells.

  Biochemical and biophysical research communications 20050401

• Caffeic acid inhibits vascular smooth muscle cell proliferation induced by angiotensin II in stroke-prone spontaneously hypertensive rats.

  Hypertension research : official journal of the Japanese Society of Hypertension 20050401

• KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway.

  Oncogene 20050317

• Stat5 mediates the IL-7-induced accessibility of a representative D-Distal VH gene.

  Journal of immunology (Baltimore, Md. : 1950) 20050315

• Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells.

  Carcinogenesis 20050301

• Role of the STAT1 pathway in apoptosis induced by fludarabine and JAK kinase inhibitors in B-cell chronic lymphocytic leukemia.

  Leukemia & lymphoma 20050301

• Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216

• Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3.

  Circulation research 20050204

• AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway.

  Journal of neurochemistry 20050201

• [Mechanisms of increased survival rate by administration of AG490 in rats following extensive liver resection].

  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20050201

• Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells.

  Molecular cancer 20050101

• [Influence on the cytokines expression on hepatic tissue by inhibition the signal pathway of inflammatory mediators following extensive hepatectomy in rats].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20050101

• EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes.

  American journal of physiology. Gastrointestinal and liver physiology 20041201

• Angiotensin II stimulates Pax-2 in rat kidney proximal tubular cells: impact on proliferation and apoptosis.

  Kidney international 20041201

• Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201

• Erythropoietin induces cancer cell resistance to ionizing radiation and to cisplatin.

  Molecular cancer therapeutics 20041201

• Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide synthase.

  Blood 20041115

• Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression.

  Journal of immunology (Baltimore, Md. : 1950) 20041115

• STAT3 induces anti-hepatitis C viral activity in liver cells.

  Biochemical and biophysical research communications 20041112

• The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells.

  European journal of immunology 20041101

• Janus kinase 2 signaling in the angiotensin II-dependent activation of StAR expression.

  Endocrine research 20041101

• The androgen receptor co-activator CBP is up-regulated following androgen withdrawal and is highly expressed in advanced prostate cancer.

  The Journal of pathology 20041001

• STAT signaling underlies difference between flagellin-induced and tumor necrosis factor-alpha-induced epithelial gene expression.

  The Journal of biological chemistry 20040820

• Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells.

  The Journal of biological chemistry 20040813

• CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins.

  FEBS letters 20040716

• Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.

  Journal of the American Society of Nephrology : JASN 20040601

• Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction.

  The Biochemical journal 20040515

• Phosphatidylinositol-3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells.

  British journal of haematology 20040501

• FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production.

  Circulation research 20040430

• Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli.

  American journal of physiology. Renal physiology 20040401

• The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase.

  The Journal of pharmacology and experimental therapeutics 20040401

• Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy.

  Molecular cancer therapeutics 20040401

• Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC.

  Life sciences 20040312

• Activation of STAT signaling pathways and induction of suppressors of cytokine signaling (SOCS) proteins in mammalian lens by growth factors.

  Investigative ophthalmology & visual science 20040301

• The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells.

  The Journal of endocrinology 20040301

• Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol.

  The Journal of biological chemistry 20040227

• Interleukin-6 is a positive regulator of tumor necrosis factor alpha-induced adipose-related protein in 3T3-L1 adipocytes.

  FEBS letters 20040227

• IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system.

  Biochemical and biophysical research communications 20040206

• AG490 inhibits G1-S traverse in BALB/c-3T3 cells following either mitogenic stimulation or exogenous expression of E2F-1.

  Molecular cancer therapeutics 20040201

• Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microglia.

  Glia 20040115

• Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines.

  Molecular cancer therapeutics 20040101

• Role of JAK/STAT pathway in IL-6-induced activation of vascular smooth muscle cells.

  American journal of nephrology 20040101

• Janus kinase 2 and calcium are required for angiotensin II-dependent activation of steroidogenic acute regulatory protein transcription in H295R human adrenocortical cells.

  The Journal of biological chemistry 20031226

• Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival.

  British journal of haematology 20031201

• Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways.

  Cardiovascular research 20031101

• Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.

  Science (New York, N.Y.) 20031031

• PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production.

  Biochemical and biophysical research communications 20031024

• Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors.

  Journal of medicinal chemistry 20031023

• Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.

  Journal of immunology (Baltimore, Md. : 1950) 20031001

• Insulin resistance induces hyperleptinemia, cardiac contractile dysfunction but not cardiac leptin resistance in ventricular myocytes.

  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20031001

• A critical role for Stat3 signaling in immune tolerance.

  Immunity 20030901

• Excretory-secretory products secreted by Paragonimus westermani delay the spontaneous cell death of human eosinophils through autocrine production of GM-CSF.

  International archives of allergy and immunology 20030901

• Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma.

  Oncogene 20030821

• Interferon gamma stimulates beta-secretase expression and sAPPbeta production in astrocytes.

  Biochemical and biophysical research communications 20030808

• Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia.

  Blood 20030715

• Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20030715

• Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription.

  The Journal of biological chemistry 20030516

• Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro.

  Hypertension (Dallas, Tex. : 1979) 20030501

• Inhibitors that target protein kinases for the treatment of ovarian carcinoma.

  American journal of obstetrics and gynecology 20030501

• Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells.

  Experimental hematology 20030401

• Cytosolic phospholipase A2 is an effector of Jak/STAT signaling and is involved in platelet-derived growth factor BB-induced growth in vascular smooth muscle cells.

  The Journal of biological chemistry 20030314

• Local insulin-like growth factor-II mediates prolactin-induced mammary gland development.

  Molecular endocrinology (Baltimore, Md.) 20030301

• [Role of Janus kinase/signal transducer and activator of transcription pathway in mediating mRNA expression of high mobility group box1 protein in the liver in septic rats].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20030301

• Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma.

  Blood 20030215

• Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia.

  Blood 20030201

• CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway.

  Blood 20030101

• Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030101

• Analysis of signal transducer and activator of transcription 3 (STAT3) in gastrointestinal stromal tumors.

  Anticancer research 20030101

• Gamma interferon-induced nitric oxide production in mouse CD5+ B1-like cell line and its association with apoptotic cell death.

  Microbiology and immunology 20030101

• Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells.

  Oncogene 20021205

• Inhibition of the Jak/STAT signaling pathway prevents the high glucose-induced increase in tgf-beta and fibronectin synthesis in mesangial cells.

  Diabetes 20021201

• Dual mechanism of signal transducer and activator of transcription 5 activation by the insulin receptor.

  Molecular endocrinology (Baltimore, Md.) 20021201

• Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid.

  The Journal of biological chemistry 20021122

• Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells.

  Oncogene 20021031

• JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells.

  The Journal of biological chemistry 20021025

• Jak2 is involved in c-Myc induction by Bcr-Abl.

  Oncogene 20021017

• Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation.

  American journal of respiratory cell and molecular biology 20020901

• Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone.

  Molecular cancer therapeutics 20020901

• IL-12 plays a significant role in the apoptosis of human T cells in the absence of antigenic stimulation.

  Cytokine 20020807

• Multiple signaling pathways mediate LIF-induced skeletal muscle satellite cell proliferation.

  American journal of physiology. Cell physiology 20020701

• Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127-189 of c-myc.

  Oncogene 20020627

• Leukemia inhibitory factor relaxes arteries through endothelium-dependent mechanism.

  Biochemical and biophysical research communications 20020607

• Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines.

  The Journal of biological chemistry 20020517

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Leukemia inhibitory factor enhances bFGF-induced IL-6 synthesis in osteoblasts: involvement of JAK2/STAT3.

  Cellular signalling 20020401

• IL-6 induces expression of the Fli-1 proto-oncogene via STAT3.

  Biochemical and biophysical research communications 20020322

• Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists.

  European journal of pharmacology 20020308

• Distinct region of the granulocyte colony-stimulating factor receptor mediates proliferative signaling through activation of Janus kinase 2 and p44/42 mitogen-activated protein kinase.

  Cellular signalling 20020301

• STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P.

  Kidney international 20020301

• Acute stimulation of glucose uptake by leptin in l6 muscle cells.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020301

• Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation.

  Journal of immunology (Baltimore, Md. : 1950) 20020215

• Role of mitogen-activated protein kinases and tyrosine kinases on IL-1-Induced NF-kappaB activation and iNOS expression in bovine articular chondrocytes.

  Nitric oxide : biology and chemistry 20020201

• Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression.

  European journal of biochemistry 20020201

• Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway.

  Hypertension (Dallas, Tex. : 1979) 20020101

• Effects of combinations of therapeutic agents on the proliferation of progenitor cells in chronic myeloid leukaemia.

  British journal of haematology 20020101

• [Inhibition of constitutively activated Jak3 and induction of apoptosis in NALM-6 cell line].

  Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20020101

• Neuroprotective effects of leptin in vivo and in vitro.

  Neuroreport 20011221

• Activation of JAK2 by the oxidative stress generated with oxidized low-density lipoprotein.

  Free radical biology & medicine 20011201

• Nuclear factor kappa B is involved in lipopolysaccharide-stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells.

  British journal of pharmacology 20011201

• 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) modulates lactogenic hormone-mediated differentiation and gene expression in HC11 mouse mammary epithelial cells.

  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20011201

• Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20011201

• Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells.

  Oncogene 20011129

• HTLV-1 cell lines differ in constitutively activated signaling pathways that can be altered by cytokine exposure.

  Virology 20011110

• The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome.

  Leukemia 20011101

• PRL-induced ERalpha gene expression is mediated by Janus kinase 2 (Jak2) while signal transducer and activator of transcription 5b (Stat5b) phosphorylation involves Jak2 and a second tyrosine kinase.

  Molecular endocrinology (Baltimore, Md.) 20011101

• Role of STAT3 in ischemic preconditioning.

  Journal of molecular and cellular cardiology 20011101

• Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of STAT6, ERK and p38 MAPK pathways.

  Oncogene 20011011

• Activation of the transcription factor NF-kappaB by the erythropoietin receptor: structural requirements and biological significance.

  Cellular signalling 20010901

• JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures.

  Journal of neuroscience research 20010901

• Constitutive activation of STAT transcription factors in acute myelogenous leukemia.

  European journal of haematology 20010801

• JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion.

  Circulation 20010717

• Hydrogen peroxide is a novel inducer of connective tissue growth factor.

  Biochemical and biophysical research communications 20010622

• IL-6 upregulates its own receptor on some human myeloma cell lines.

  Cytokine 20010621

• Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils.

  Journal of immunology (Baltimore, Md. : 1950) 20010615

• Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells.

  Blood 20010601

• Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation.

  Journal of hypertension 20010601

• TGF beta-induced SMAD2 phosphorylation predicts inhibition of thymidine incorporation in CD34+ cells from healthy donors, but not from patients with AML after MDS.

  Leukemia 20010601

• [The effect of AG490 on NK activity and lymphocyte transformation of PBMC].

  Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20010601

• Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells.

  Oncogene 20010503

• SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity.

  Nature genetics 20010501

• Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells.

  Leukemia 20010501

• Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells.

  Experimental hematology 20010501

• Comparison of effects of the tyrosine kinase inhibitors AG957, AG490, and STI571 on BCR-ABL--expressing cells, demonstrating synergy between AG490 and STI571.

  Blood 20010401

• Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.

  Journal of immunology (Baltimore, Md. : 1950) 20010315

• Characterization of a rat uterine cell line, U(III) cells: prolactin (PRL) expression and endogenous regulation of PRL-dependent genes; estrogen receptor beta, alpha(2)-macroglobulin, and decidual PRL involving the Jak2 and Stat5 pathway.

  Endocrinology 20010301

• Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20010301

• Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway.

  Arteriosclerosis, thrombosis, and vascular biology 20010301

• Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.

  The Journal of clinical investigation 20010201

• LPS induction of I kappa B-alpha degradation and iNOS expression in a skin dendritic cell line is prevented by the janus kinase 2 inhibitor, Tyrphostin b42.

  Nitric oxide : biology and chemistry 20010201

• New dermatological agents for the treatment of psoriasis.

  Journal of medicinal chemistry 20010201

• Role of receptor for advanced glycation end-product (RAGE) and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells.

  Journal of cellular biochemistry 20010101

• Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts.

  Transplantation proceedings 20010101

• Modulation of primary T cell responses and tolerance induction by tyrphostin AG490.

  Transplantation proceedings 20010101

• Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smooth muscle cell proliferation.

  Journal of vascular research 20010101

• IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells.

  BMC cancer 20010101

• Naphthyl ketones: a new class of Janus kinase 3 inhibitors.

  Bioorganic & medicinal chemistry letters 20000320

• Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.

  Biochemistry 19951121

• Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.

  Journal of medicinal chemistry 19910601