133550-34-2 | AG 555

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$19.00	$13.00
5mg	98%	in stock	$33.00	$23.00
10mg	98%	in stock	$48.00	$33.00
25mg	98%	in stock	$76.00	$53.00
50mg	98%	in stock	$110.00	$77.00
100mg	98%	in stock	$175.00	$122.00
250mg	98%	in stock	$279.00	$195.00

Description

• Catalog Number: AD73623
• Chemical Name: AG 555
• CAS Number: 133550-34-2
• Molecular Formula: C19H18N2O3
• Molecular Weight: 322.3578
• MDL Number: MFCD00209865
• SMILES: N#CC(=Cc1ccc(c(c1)O)O)C(=O)NCCCc1ccccc1

Computed Properties

• Complexity: 488
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 6
• XLogP3: 3.2

Literature

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20081015

• S-adenosylmethionine-dependent protein methylation in mammalian cytosol via tyrphostin modification by catechol-O-methyltransferase.

  The Journal of biological chemistry 20071019

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• MITF-M plays an essential role in transcriptional activation and signal transduction in Xiphophorus melanoma.

  Gene 20031127

• Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors.

  Journal of medicinal chemistry 20031023

• Tyrphostin AG 555 inhibits bovine papillomavirus transcription by changing the ratio between E2 transactivator/repressor function.

  The Journal of biological chemistry 20030926

• Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition.

  Developmental cell 20020901

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.

  Biochemistry 19951121

• Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.

  Journal of medicinal chemistry 19910601