1337531-36-8 | Gsk2606414

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$23.00	$16.00
5mg	98%	in stock	$48.00	$33.00
100mg	98%	in stock	$288.00	$201.00
250mg	98%	in stock	$513.00	$359.00

Description

• Catalog Number: AE35690
• Chemical Name: Gsk2606414
• CAS Number: 1337531-36-8
• Molecular Formula: C24H20F3N5O
• Molecular Weight: 451.4437
• MDL Number: MFCD25976926
• SMILES: O=C(N1CCc2c1ccc(c2)c1cn(c2c1c(N)ncn2)C)Cc1cccc(c1)C(F)(F)F

Computed Properties

• Complexity: 721
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 33
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 3.8

Literature

• Niclosamide induced cell apoptosis via upregulation of ATF3 and activation of PERK in Hepatocellular carcinoma cells.

  BMC gastroenterology 20160101

• Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development.

  ACS medicinal chemistry letters 20131010

• Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice.

  Science translational medicine 20131009

• Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).

  Journal of medicinal chemistry 20120823