1341200-45-0 | 2-​[[5-​Chloro-​2-​[[4-​[(4-​methyl-​1-​piperazinyl)​methyl]​phenyl]​amino]​-​4-​pyrimidinyl]​amino]​-​N,​N-​dimethylbenzenesulfo​namide

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$43.00	$30.00
2mg	95%	in stock	$68.00	$47.00
25mg	95%	in stock	$242.00	$169.00
100mg	95%	in stock	$560.00	$392.00
250mg	95%	in stock	$1,070.00	$749.00

Description

• Catalog Number: AE35993
• Chemical Name: 2-​[[5-​Chloro-​2-​[[4-​[(4-​methyl-​1-​piperazinyl)​methyl]​phenyl]​amino]​-​4-​pyrimidinyl]​amino]​-​N,​N-​dimethylbenzenesulfo​namide
• CAS Number: 1341200-45-0
• Molecular Formula: C24H30ClN7O2S
• Molecular Weight: 516.0587
• MDL Number: MFCD28502172
• SMILES: CN1CCN(CC1)Cc1ccc(cc1)Nc1ncc(c(n1)Nc1ccccc1S(=O)(=O)N(C)C)Cl

Computed Properties

• Complexity: 752
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 8
• XLogP3: 3.9

Literature

• Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20150501

• Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors.

  ACS medicinal chemistry letters 20111208

• Chemistry of tobacco constituents. Oxidation of alpha-ionone and the acid-catalyzed rearrangement of 5-keto-alpha-ionone.

  Journal of agricultural and food chemistry 19760101