136553-81-6 | BQ-123

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$26.00	$18.00
10mg	98%	in stock	$75.00	$52.00
25mg	98%	in stock	$126.00	$88.00
50mg	98%	in stock	$190.00	$133.00
100mg	98%	in stock	$305.00	$213.00
250mg	98%	in stock	$516.00	$361.00

Description

• Catalog Number: AE33667
• Chemical Name: BQ-123
• CAS Number: 136553-81-6
• Molecular Formula: C31H42N6O7
• Molecular Weight: 610.7011800000002
• MDL Number: MFCD00133204
• SMILES: CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C

Computed Properties

• Complexity: 1110
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 5
• Heavy Atom Count: 44
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 6
• Rotatable Bond Count: 7
• XLogP3: 2.2

Literature

• Induction of endothelium-dependent constriction of mesenteric arteries in endotoxemic hypotensive shock.

  British journal of pharmacology 20160401

• BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.

  Toxicology and applied pharmacology 20150201

• Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy.

  The American journal of pathology 20141101

• Selective ET(A) receptor blockade protects against cisplatin-induced acute renal failure in male rats.

  European journal of pharmacology 20140505

• Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2.

  Biochimica et biophysica acta 20140201

• Interplay between endothelin and erythropoietin in astroglia: the role in protection against hypoxia.

  International journal of molecular sciences 20140201

• Endothelin-1 increases superoxide production in human coronary artery bypass grafts.

  Life sciences 20121015

• The adipokine chemerin augments vascular reactivity to contractile stimuli via activation of the MEK-ERK1/2 pathway.

  Life sciences 20121015

• The influence of ETA and ETB receptor blockers on LPS-induced oxidative stress and NF-κB signaling pathway in heart.

  General physiology and biophysics 20120901

• Cathepsin E induces itch-related response through the production of endothelin-1 in mice.

  European journal of pharmacology 20120705

• Agonist-dependent modulation of arterial endothelinA receptor function.

  British journal of pharmacology 20120701

• Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia.

  Hypertension (Dallas, Tex. : 1979) 20120701

• Blocking endothelin-B receptors rescues retinal ganglion cells from optic nerve injury through suppression of neuroinflammation.

  Investigative ophthalmology & visual science 20120608

• Ouabain stimulates atrial natriuretic peptide secretion via the endothelin-1/ET(B) receptor-mediated pathway in beating rabbit atria.

  Life sciences 20120522

• Elevated endothelin-1 vasoconstrictor tone in prehypertensive adults.

  The Canadian journal of cardiology 20120501

• EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ.

  Naunyn-Schmiedeberg's archives of pharmacology 20120401

• Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart.

  PloS one 20120101

• Fluorescence correlation spectroscopy in drug discovery: study of Alexa532-endothelin 1 binding to the endothelin ETA receptor to describe the pharmacological profile of natural products.

  TheScientificWorldJournal 20120101

• Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral sphingomyelinase.

  Journal of vascular research 20120101

• Pharmacological differences of endothelin receptors-mediated modulation in cultured interstitial cells of Cajal from the murine small and large intestine.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Endothelin-1 in paraventricular nucleus modulates cardiac sympathetic afferent reflex and sympathetic activity in rats.

  PloS one 20120101

• Age-associated alterations in retinal arteriole reactivity to endothelin-1 differ between the sexes.

  Mechanisms of ageing and development 20120101

• ETA and ETB receptors are expressed in vascular adventitial fibroblasts.

  American journal of physiology. Heart and circulatory physiology 20111201

• Endothelin-1 promotes osteosarcoma cell invasion and survival against cisplatin-induced apoptosis.

  Clinical orthopaedics and related research 20111101

• Endothelin-induced changes in blood flow in STZ-diabetic and non-diabetic rats: relation to nitric oxide synthase and cyclooxygenase inhibition.

  The journal of physiological sciences : JPS 20111101

• Low-intensity interval exercise training attenuates coronary vascular dysfunction and preserves Ca²⁺-sensitive K⁺ current in miniature swine with LV hypertrophy.

  American journal of physiology. Heart and circulatory physiology 20111001

• Irregular electrical activation of intrinsic cardiac adrenergic cells increases catecholamine-synthesizing enzymes.

  Biochemical and biophysical research communications 20110930

• Exogenous ghrelin improves blood flow distribution in pulmonary hypertension-assessed using synchrotron radiation microangiography.

  Pflugers Archiv : European journal of physiology 20110901

• Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men.

  Clinical science (London, England : 1979) 20110601

• Tobacco-associated pulmonary vascular dysfunction in smokers: role of the ET-1 pathway.

  American journal of physiology. Lung cellular and molecular physiology 20110601

• Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow.

  Life sciences 20110425

• 20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1.

  American journal of physiology. Heart and circulatory physiology 20110401

• Effect of avosentan (SPP-301) in porcine ciliary arteries.

  Current eye research 20110201

• From a molecular biological viewpoint, does endothelin type A receptor antagonist therapy reduce diabetes-induced testicular damage in rats?

  Urology 20110101

• Endothelin-A receptor antagonists prevent amyloid-β-induced increase in ETA receptor expression, oxidative stress, and cognitive impairment.

  Journal of Alzheimer's disease : JAD 20110101

• Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis.

  Arthritis research & therapy 20110101

• Protective effects of endothelin-A receptor antagonist BQ123 against LPS-induced oxidative stress in lungs.

  Pharmacological reports : PR 20110101

• Glial response to lipopolysaccharide: possible role of endothelins.

  Peptides 20101201

• Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ.

  Clinical and experimental pharmacology & physiology 20101201

• Endothelin receptor antagonist BQ-123 ameliorates myocardial ischemic-reperfusion injury in rats: a hemodynamic, biochemical, histopathological and electron microscopic evidence.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20101101

• Molecular signaling of pruritus induced by endothelin-1 in mice.

  Experimental biology and medicine (Maywood, N.J.) 20101101

• Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats.

  European journal of pharmacology 20101010

• Effects of cardiopulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation.

  Circulation 20100914

• Inhibition of endothelin-1 receptors improves impaired nitric oxide synthase-dependent dilation of cerebral arterioles in type-1 diabetic rats.

  Microcirculation (New York, N.Y. : 1994) 20100801

• Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries.

  Circulation research 20100723

• Endothelin-A receptor antagonism attenuates carcinoma-induced pain through opioids in mice.

  The journal of pain : official journal of the American Pain Society 20100701

• Endothelin-1-induced contractile responses of human coronary arterioles via endothelin-A receptors and PKC-alpha signaling pathways.

  Surgery 20100601

• Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells.

  Molecular neurobiology 20100601

• Activation of endothelin A receptors contributes to impaired responsiveness of renal mechanosensory nerves in congestive heart failure.

  Canadian journal of physiology and pharmacology 20100601

• Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats.

  Canadian journal of physiology and pharmacology 20100601

• Endothelium-derived endothelin-1.

  Pflugers Archiv : European journal of physiology 20100501

• Regulation of glucose uptake by endothelin-1 in human skeletal muscle in vivo and in vitro.

  The Journal of clinical endocrinology and metabolism 20100501

• [The mechanism and pulmonary-protective effects of endothelin-1 receptor antagonist in chronic obstructive pulmonary diseases rat model].

  Zhonghua nei ke za zhi 20100501

• The vasodilatory effect of juxta-arteriolar microinjection of endothelinA receptor inhibitor in healthy and acute branch retinal vein occlusion minipig retinas.

  Investigative ophthalmology & visual science 20100401

• Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats.

  The European respiratory journal 20100401

• Attenuation of Doxorubicin-induced cardiomyopathy by endothelin-converting enzyme-1 ablation through prevention of mitochondrial biogenesis impairment.

  Hypertension (Dallas, Tex. : 1979) 20100301

• Sex differences in endothelin-1-mediated vasoconstrictor tone in middle-aged and older adults.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100201

• Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction.

  Peptides 20100201

• Role of endogenous ET-1 in the regulation of myocardial blood flow in lean and obese humans.

  Obesity (Silver Spring, Md.) 20100101

• Potential of endothelin-1 and vasopressin antagonists for the treatment of congestive heart failure.

  Heart failure reviews 20100101

• Production and binding of endothelin-2 (EDN2) in the rat ovary: endothelin receptor subtype A (EDNRA)-mediated contraction.

  Reproduction, fertility, and development 20100101

• Ablation of transient receptor potential vanilloid 1 abolishes endothelin-induced increases in afferent renal nerve activity: mechanisms and functional significance.

  Hypertension (Dallas, Tex. : 1979) 20091201

• Endothelin-1 induces the expression of C-reactive protein in rat vascular smooth muscle cells.

  Biochemical and biophysical research communications 20091120

• [Cardioprotection of ramipril and BQ-123 against myocardial ischemia/reperfusion injury in vivo in rats].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20091101

• Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin.

  American journal of physiology. Regulatory, integrative and comparative physiology 20090801

• Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats.

  Neuroscience letters 20090703

• Functional and molecular characterization of the endothelin system in retinal arterioles.

  Investigative ophthalmology & visual science 20090701

• Blood pressure-independent reduction in proteinuria and arterial stiffness after acute endothelin-a receptor antagonism in chronic kidney disease.

  Hypertension (Dallas, Tex. : 1979) 20090701

• Angiotensin II-induced increase in myocardial distensibility and its modulation by the endocardial endothelium in the rabbit heart.

  Experimental physiology 20090601

• Improved endothelial function after endothelin receptor blockade in patients with systemic sclerosis.

  Arthritis and rheumatism 20090601

• Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat.

  American journal of physiology. Heart and circulatory physiology 20090501

• Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways.

  Arteriosclerosis, thrombosis, and vascular biology 20090401

• The effect of endothelin-1 on alveolar fluid clearance and pulmonary edema formation in the rat.

  Anesthesia and analgesia 20090101

• Normothermic perfusion of ischaemic porcine kidneys: an evaluation of ex vivo function and endothelin receptor antagonism.

  Journal of nephrology 20090101

• Selective endothelin A-receptor blockade attenuates coronary microvascular dysfunction after coronary stenting in patients with type 2 diabetes.

  Vascular health and risk management 20090101

• Endothelin A receptor antagonist modulates lymphocyte and eosinophil infiltration, hyperreactivity and mucus in murine asthma.

  International immunopharmacology 20081220

• Molecular analysis of cocaine-induced endothelial dysfunction: role of endothelin-1 and nitric oxide.

  Cardiovascular toxicology 20081201

• Regulation of glial inflammatory mediators synthesis: possible role of endothelins.

  Peptides 20081201

• Adenosine 5'-tetraphosphate is a highly potent purinergic endothelium-derived vasoconstrictor.

  Circulation research 20081107

• Endothelium-derived vasoconstriction by purines and pyrimidines.

  Circulation research 20081107

• Role of nitric oxide in regulation of retinal blood flow in response to hyperoxia in cats.

  Investigative ophthalmology & visual science 20081001

• Pharmacological characterization of 3-azabicyclo[3,2,1] octane-1-yl-l-leucyl-d-tryptophanyl-d-4-Cl-phenylalanine: A novel ET(A) receptor-selective antagonist.

  Pulmonary pharmacology & therapeutics 20081001

• The endothelin-converting enzyme-1/endothelin-1 pathway plays a critical role in inflammation-associated premature delivery in a mouse model.

  The American journal of pathology 20081001

• Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1.

  Journal of leukocyte biology 20080901

• Endothelin-1 regulates cardiac L-type calcium channels via NAD(P)H oxidase-derived superoxide.

  The Journal of pharmacology and experimental therapeutics 20080901

• Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes.

  American journal of physiology. Heart and circulatory physiology 20080901

• The role of endothelin pathway in modulation of airway reactivity to methacholine in C57Bl/6 and BALB/c mice.

  European journal of pharmacology 20080820

• ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo.

  American journal of physiology. Renal physiology 20080801

• Antagonism of endothelin-1 inhibits hypoxia-induced apoptosis in cardiomyocytes.

  Canadian journal of physiology and pharmacology 20080801

• Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats.

  British journal of pharmacology 20080701

• Effect of chronic and selective endothelin receptor antagonism on microvascular function in type 2 diabetes.

  American journal of physiology. Heart and circulatory physiology 20080601

• Endothelin receptor blockers protect against ischemia/reperfusion impairment of gastrointestinal motility in rats.

  Pharmacological research 20080601

• Role of endothelin receptors on basal and endothelin-1-stimulated lung myofibroblast proliferation.

  Canadian journal of physiology and pharmacology 20080601

• Central endothelin: effects on vasopressin and the arterial baroreflex in doxorubicin heart failure rats.

  Canadian journal of physiology and pharmacology 20080601

• Potentiation of 2-methoxyestradiol-induced cytotoxicity by blocking endothelin A receptor in prostate cancer cells.

  The Prostate 20080501

• Contractile changes of the clitoral cavernous smooth muscle in female rabbits with experimentally induced overactive bladder.

  The journal of sexual medicine 20080501

• Effects of endothelin receptor type-A and type-B antagonists on prostaglandin F2alpha-induced luteolysis of the sheep corpus luteum.

  Biology of reproduction 20080401

• Interruption of endothelin signaling modifies membrane type 1 matrix metalloproteinase activity during ischemia and reperfusion.

  American journal of physiology. Heart and circulatory physiology 20080201

• Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes.

  American journal of physiology. Lung cellular and molecular physiology 20080201

• Intracellular mechanisms and receptor types for endothelin-1-induced positive and negative inotropy in mouse ventricular myocardium.

  Naunyn-Schmiedeberg's archives of pharmacology 20080201

• Expression of the hyperpolarization-activated current, I(f), in cultured adult rat ventricular cardiomyocytes and its modulation by hypertrophic factors.

  Pharmacological research 20080201

• Effects of endothelin-1 1-31 on cell viabililty and [Ca2+]i in cultured neonatal rat cardiomyocytes.

  Physiological research 20080101

• The endothelin-1 pathway and the development of cardiovascular defects in the haemodynamically challenged chicken embryo.

  Journal of vascular research 20080101

• 19F NMR in vivo spectroscopy reflects the effectiveness of perfusion-enhancing vascular modifiers for improving gemcitabine chemotherapy.

  Magnetic resonance in medicine 20080101

• Endothelin-1 potentiation of coronary artery contraction after ischemia-reperfusion.

  Vascular pharmacology 20080101

• Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation.

  Journal of cardiovascular pharmacology 20071201

• Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and alpha1-adrenoceptor-mediated vasoconstriction in Type 2 diabetes.

  American journal of physiology. Heart and circulatory physiology 20071001

• NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts.

  Cardiovascular research 20070901

• Involvement of inducible nitric oxide synthase in blood flow decrease in vein induced by hen-egg white lysozyme.

  Biological & pharmaceutical bulletin 20070701

• Endothelin-1 and pancreatic islet vasculature: studies in vivo and on isolated, vascularly perfused pancreatic islets.

  American journal of physiology. Endocrinology and metabolism 20070601

• Peripheral endothelin A receptor antagonism attenuates carcinoma-induced pain.

  European journal of pain (London, England) 20070501

• Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.

  British journal of pharmacology 20070501

• Endogenous endothelin in human coronary vascular function: differential contribution of endothelin receptor types A and B.

  Hypertension (Dallas, Tex. : 1979) 20070501

• Sarcoplasmic-endoplasmic reticulum Ca2+-ATPase inhibition prevents endothelin A receptor antagonism in rat aorta.

  American journal of physiology. Heart and circulatory physiology 20070401

• Endothelins mediate neutrophil activation, ProMMP-9 release and endothelial cell detachment.

  Inflammation 20070401

• Mechanisms of direct peritoneal resuscitation-mediated splanchnic hyperperfusion following hemorrhagic shock.

  Shock (Augusta, Ga.) 20070401

• Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.

  Circulation research 20070330

• Endothelin-1 induces functionally active CD40 protein via nuclear factor-kappaB in human vascular smooth muscle cells.

  European journal of medical research 20070326

• Dual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease.

  Diabetes care 20070301

• Endothelin limits insulin action in obese/insulin-resistant humans.

  Diabetes 20070301

• Intraindividual comparison of human radial and internal thoracic arteries in vitro and the effect of preoperative calcium blocker therapy.

  Fundamental & clinical pharmacology 20070201

• Activation of endothelin-a receptors contributes to angiotensin-induced suppression of renal sensory nerve activation.

  Hypertension (Dallas, Tex. : 1979) 20070101

• Endothelin-1-mediated wave-like [Ca2+]i oscillations in intact rabbit inferior vena cava.

  Journal of vascular research 20070101

• Protection from renal ischemia reperfusion injury by an endothelin-A receptor antagonist BQ-123 in relation to nitric oxide production.

  Toxicology 20061207

• Regulation of dHAND protein expression by all-trans retinoic acid through ET-1/ETAR signaling in H9c2 cells.

  Journal of cellular biochemistry 20061001

• Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats.

  American journal of physiology. Heart and circulatory physiology 20061001

• Impaired effect of endothelin-1 on coronary artery stiffness in type 2 diabetes.

  International journal of cardiology 20060920

• Activation of p38 MAPK is involved in endothelin-1-stimulated COX-2 expression in cultured Feline esophageal smooth muscle cells.

  Molecules and cells 20060831

• Ethanol consumption enhances endothelin-1-induced contraction in the isolated rat carotid.

  The Journal of pharmacology and experimental therapeutics 20060801

• Cerebrovascular dysfunction is an attractive target for therapy in heat stroke.

  Clinical and experimental pharmacology & physiology 20060801

• Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs.

  Pain 20060701

• Autocrine effects of endothelin on in vitro proliferation of vascular smooth muscle cells from spontaneously hypertensive and normotensive rats.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20060701

• Enzymatic pathways involved in the generation of endothelin-1(1-31) from exogenous big endothelin-1 in the rabbit aorta.

  British journal of pharmacology 20060601

• Arrhythmogenic action of endothelin-1(1-31) through conversion to endothelin-1(1-21).

  Experimental biology and medicine (Maywood, N.J.) 20060601

• Targeting the endothelin axis in human melanoma: combination of endothelin receptor antagonism and alkylating agents.

  Experimental biology and medicine (Maywood, N.J.) 20060601

• Effect of BQ-123 and nitric oxide inhibition on liver in rats after renal ischemia-reperfusion injury.

  General physiology and biophysics 20060601

• Endothelin-1, an ulcer inducer, promotes gastric ulcer healing via mobilizing gastric myofibroblasts and stimulates production of stroma-derived factors.

  American journal of physiology. Gastrointestinal and liver physiology 20060501

• Effects of antagonists for endothelin ET(A) and ET(B) receptors on coronary endothelial and myocardial function after ischemia-reperfusion in anesthetized goats.

  Vascular pharmacology 20060501

• Endothelin B receptor antagonist increases preproendothelin-1 transcription in bovine aortic endothelial cells and in vivo.

  Journal of cardiovascular pharmacology 20060501

• ETa-receptor blockade, but not ACE inhibition, blunts retinal vessel response during isometric exercise.

  American journal of physiology. Heart and circulatory physiology 20060401

• Increased vascular angiotensin II binding capacity and ET-1 release in young cardiomyopathic hamsters.

  Vascular pharmacology 20060401

• Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes.

  European journal of pharmacology 20060318

• Effect of age on insulin-induced endothelin release and vasoreactivity in hypertriglyceridemic and hypertensive rats.

  Experimental gerontology 20060301

• Enhanced endothelium-dependent vasodilatation by dual endothelin receptor blockade in individuals with insulin resistance.

  Journal of cardiovascular pharmacology 20060301

• Difference in the characteristics of ETA-receptor-stimulated response between rat small pulmonary and renal arteries.

  Journal of cardiovascular pharmacology 20060301

• Selective endothelin a (ETA) receptor antagonist (BQ-123) reduces both myocardial infarct size and oxidant injury.

  Toxicology 20060215

• Pulmonary perfusion during lipopolysaccharide (LPS) induced fetal endotoxemia in the preterm fetal sheep.

  European journal of obstetrics, gynecology, and reproductive biology 20060201

• Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells.

  Molecular pharmacology 20060201

• Leptin regulates cardiomyocyte contractile function through endothelin-1 receptor-NADPH oxidase pathway.

  Hypertension (Dallas, Tex. : 1979) 20060201

• Involvement of endothelium and endothelin-1 in lead-induced smooth muscle cell dysfunction in rats.

  Kidney international 20060201

• Pharmacological properties of endothelin-1 in the rabbit corpus cavernosum.

  In vivo (Athens, Greece) 20060101

• Endothelin(B) receptor blocker inhibits high glucose-induced synthesis of fibronectin in human peritoneal mesothelial cells.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20060101

• Effects of endothelin receptor blockade on hypervasoreactivity in streptozotocin-diabetic rats: vessel-specific involvement of thromboxane A2.

  Canadian journal of physiology and pharmacology 20060101

• Morphine tolerance does not develop in mice treated with endothelin-A receptor antagonists.

  Brain research 20051207

• Endothelin-1 enhances glutamate-induced retinal cell death, possibly through ETA receptors.

  Investigative ophthalmology & visual science 20051201

• Blood pressure responses of endothelin-1 1-31 within the rostral ventrolateral medulla through conversion to endothelin-1 1-21.

  Journal of cardiovascular pharmacology 20051201

• Inhibition of angiotensin II- and endothelin-1-stimulated proliferation by selective MEK inhibitor in cultured rabbit gingival fibroblastsdagger.

  Fundamental & clinical pharmacology 20051201

• Endothelin-1 receptor antagonist BQ123 prevents pulmonary artery hypertension induced by low ambient temperature in broilers.

  Biological & pharmaceutical bulletin 20051201

• Endothelins: pathophysiology and treatment implications in chronic heart failure.

  Current heart failure reports 20051201

• Pathways of glomerular toxicity of cyclosporine-A: an 'in vitro' study.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20051201

• Enhanced response of pig coronary arteries to endothelin-1 after ischemia-reperfusion. Role of endothelin receptors, nitric oxide and prostanoids.

  European journal of pharmacology 20051107

• Effect of chymase on intraocular pressure in rabbits.

  European journal of pharmacology 20051107

• Nociceptive effect of subcutaneously injected interleukin-12 is mediated by endothelin (ET) acting on ETB receptors in rats.

  The Journal of pharmacology and experimental therapeutics 20051101

• Endothelin-1-mediated increase in reactive oxygen species and NADPH Oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20051101

• Functional characterization and expression of endothelin receptors in rat carotid artery: involvement of nitric oxide, a vasodilator prostanoid and the opening of K+ channels in ETB-induced relaxation.

  British journal of pharmacology 20051101

• Glibenclamide reveals role for endothelin in hypoxia-induced vasoconstriction in rat intrapulmonary arteries.

  Journal of cardiovascular pharmacology 20051001

• [Effects of airway epithelium injury on the transdifferentiation of sub-epithelial fibroblasts and its role in the development of airway hyperresponsiveness in asthma].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20051001

• Modulation of the myocardial effects of selective ETB receptor stimulation and its implications for heart failure.

  Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20050901

• Systemic endothelial dysfunction in adults with cyanotic congenital heart disease.

  Circulation 20050823

• Endothelin-1-induced translocation of RhoA is mediated by endothelin ET(A) receptors in rat bronchial smooth muscle.

  European journal of pharmacology 20050711

• Nitric oxide inhibition unmasks ischemic myocardium-derived vasoconstrictor signals activating endothelin type A receptor of coronary microvessels.

  American journal of physiology. Heart and circulatory physiology 20050701

• Endothelin isoforms and the response to myocardial stretch.

  American journal of physiology. Heart and circulatory physiology 20050601

• The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050504

• Gender differences in small intestinal perfusion following trauma hemorrhage: the role of endothelin-1.

  American journal of physiology. Gastrointestinal and liver physiology 20050501

• Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C.

  Cardiovascular research 20050501

• Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension.

  Journal of hypertension 20050501

• Endothelin receptors in lower esophageal sphincter circular smooth muscle.

  Regulatory peptides 20050415

• [H]BQ-123 binding to native endothelin ET(A) receptors in human astrocytoma 1321N1 cells and screening of potential ligands.

  Pharmacology 20050401

• Endothelin 1 versus endothelin 3 in the development of the slow force response to myocardial stretch.

  The Canadian journal of cardiology 20050401

• Cardiovascular effects and lethality of venom from nematocysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rats.

  Toxicon : official journal of the International Society on Toxinology 20050315

• Endothelin mediates superoxide production in angiotensin II-induced hypertension in rats.

  Free radical biology & medicine 20050301

• Endothelin receptor blockade improves endothelial function in atherosclerotic patients on angiotensin converting enzyme inhibition.

  Journal of internal medicine 20050301

• Delphinidin-3-rutinoside relaxes the bovine ciliary smooth muscle through activation of ETB receptor and NO/cGMP pathway.

  Experimental eye research 20050301

• Insulin and endothelin in the acute regulation of adiponectin in vivo in humans.

  Obesity research 20050301

• Chronic endothelin exposure inhibits connexin43 expression in cultured cortical astroglia.

  Journal of neuroscience research 20050201

• Intercellular communication via gap junctions in activated rat hepatic stellate cells.

  Gastroenterology 20050201

• [Changes of activity of the endothelial system in experimental heart failure].

  Kardiologiia 20050101

• Mast cells promote homeostasis by limiting endothelin-1-induced toxicity.

  Nature 20041125

• Mechanisms underlying enhanced contractile response to endothelin-1 in diabetic rat basilar artery.

  Peptides 20041101

• A novel combination of opiates and endothelin antagonists to manage pain without any tolerance development.

  Journal of cardiovascular pharmacology 20041101

• Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.

  Journal of cardiovascular pharmacology 20041101

• The impact of respiratory syncytial virus infection on endothelin receptor function and release in sheep bronchial explants.

  Journal of cardiovascular pharmacology 20041101

• Synergistic stimulation of aldosterone production in human adrenocortical carcinoma NCI-H295R cells by endothelin-1 and angiotensin II.

  Journal of cardiovascular pharmacology 20041101

• Inhibitory actions of endothelin-1 on pain processing.

  Journal of cardiovascular pharmacology 20041101

• Pharmacological characterization of YM598, a selective endothelin-A receptor antagonist.

  Journal of cardiovascular pharmacology 20041101

• The effect of cerivastatin therapy on vascular responses to endothelin antagonists in humans.

  Journal of cardiovascular pharmacology 20041101

• Endothelins induce ETB receptor-mediated mechanical hypernociception in rat hindpaw: roles of cAMP and protein kinase C.

  European journal of pharmacology 20041006

• Endothelin-B-receptor-selective antagonist inhibits endothelin-1 induced potentiation on the vasoconstriction to noradrenaline and angiotensin II.

  Journal of hypertension 20041001

• Endothelin ETB receptor signaling in the median eminence and subfornical organ of the rat brain.

  Neuropeptides 20041001

• Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism.

  Journal of the American Society of Nephrology : JASN 20041001

• Prior antagonism of endothelin-1A receptors alleviates circulatory shock and cerebral ischemia during rat heatstroke.

  Journal of pharmacological sciences 20041001

• Association of endothelin with lung hemorrhage induced by immune complexes in rats.

  Inflammation 20041001

• Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist.

  European journal of pharmacology 20040913

• Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2.

  Molecular pharmacology 20040901

• Endothelin upregulates the expression of vasopressin V2 mRNA in the inner medullary collecting duct of the rat.

  Metabolism: clinical and experimental 20040901

• Endothelin-1-mediated coronary vasoconstriction deteriorates myocardial depression in hearts isolated from lipopolysaccharide-treated rats: interaction with nitric oxide.

  Clinical and experimental pharmacology & physiology 20040901

• [Endothelin-1 and arteriosclerosis].

  Nihon rinsho. Japanese journal of clinical medicine 20040901

• [Prospects for endothelin-related drugs].

  Nihon rinsho. Japanese journal of clinical medicine 20040901

• Endothelin-1-induced responses in isolated mouse vessels: the expression and function of receptor types.

  American journal of physiology. Heart and circulatory physiology 20040801

• Interleukin-18 induces mechanical hypernociception in rats via endothelin acting on ETB receptors in a morphine-sensitive manner.

  The Journal of pharmacology and experimental therapeutics 20040801

• Proliferative response to phenytoin and nifedipine in gingival fibroblasts cultured from humans with gingival fibromatosis.

  Fundamental & clinical pharmacology 20040801

• Obligatory role for endogenous endothelin in mediating the hypertrophic effects of phenylephrine and angiotensin II in neonatal rat ventricular myocytes: evidence for two distinct mechanisms for endothelin regulation.

  The Journal of pharmacology and experimental therapeutics 20040701

• Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide.

  British journal of clinical pharmacology 20040601

• Endothelin-induced constriction of the ductus venosus in fetal sheep: developmental aspects and possible interaction with vasodilatory prostaglandin.

  British journal of pharmacology 20040601

• [Endothelin].

  Nihon rinsho. Japanese journal of clinical medicine 20040601

• Dual effects of endothelin-1 (1-31): induction of mesangial cell migration and facilitation of monocyte recruitment through monocyte chemoattractant protein-1 production by mesangial cells.

  Hypertension research : official journal of the Japanese Society of Hypertension 20040601

• Ventricular nonmyocytes inhibit doxorubicin-induced myocyte apoptosis: involvement of endogenous endothelin-1 as a paracrine factor.

  Endocrinology 20040501

• ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathway in vivo.

  American journal of physiology. Heart and circulatory physiology 20040401

• Regulation of vasopressin secretion by ETA and ETB receptors in compartmentalized rat hypothalamo-neurohypophysial explants.

  American journal of physiology. Endocrinology and metabolism 20040401

• Effects of endothelin-1 on portal-systemic collaterals of common bile duct-ligated cirrhotic rats.

  European journal of clinical investigation 20040401

• Implantation of tumoral XC cells induces chronic, endothelin-dependent, thermal hyperalgesia in mice.

  Cellular and molecular neurobiology 20040401

• Endothelin causes contraction of human esophageal muscularis mucosae through interaction with both ETA and ETB receptors.

  Regulatory peptides 20040315

• Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery.

  European journal of pharmacology 20040223

• Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1.

  European journal of pharmacology 20040213

• The role of endothelin in mediating ischemia/hypoxia-induced atrial natriuretic peptide release.

  Journal of cardiovascular pharmacology 20040201

• Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice.

  British journal of pharmacology 20040201

• Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCA-salt hypertensive rats.

  British journal of pharmacology 20040201

• Inward current oscillation underlying tonic contraction caused via ETA receptors in pig detrusor smooth muscle.

  American journal of physiology. Renal physiology 20040101

• In-vivo interaction of nitric oxide and endothelin.

  Journal of hypertension 20040101

• Profibrotic effects of endothelin-1 via the ETA receptor in cultured human cardiac fibroblasts.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101

• Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels.

  Circulation research 20031212

• Endothelin receptor blockade has an oxygen-saving effect in Dahl salt-sensitive rats with heart failure.

  American journal of physiology. Heart and circulatory physiology 20031001

• Endothelin-A receptors mediate renal hemodynamic effects of exogenous Angiotensin II in humans.

  Hypertension (Dallas, Tex. : 1979) 20031001

• [Involvement of endothelin in the proliferative effect of lysophosphatidic acid on vascular smooth muscle cells in rats].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20031001

• Cerebral angiogenesis and expression of VEGF after subarachnoid hemorrhage (SAH) in rats.

  Brain research 20030815

• Reduction of nitrite production by endothelin-1 in isolated porcine ciliary processes.

  Experimental eye research 20030801

• Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo.

  The American journal of pathology 20030801

• Actions of endothelin and corticotropin releasing factor in the guinea-pig ileum: no evidence for an interaction with capsaicin-sensitive neurons.

  Neuropeptides 20030801

• Endothelin-1 is a potent regulator in vivo in vascular calcification and in vitro in calcification of vascular smooth muscle cells.

  Peptides 20030801

• Dual role of endothelin-1 via ETA and ETB receptors in regulation of cardiac contractile function in mice.

  American journal of physiology. Heart and circulatory physiology 20030701

• Endothelin-1 and vascular tone in subjects with atherogenic risk factors.

  Hypertension (Dallas, Tex. : 1979) 20030701

• Endothelin-1 inhibits TNF alpha-induced iNOS expression in 3T3-F442A adipocytes.

  British journal of pharmacology 20030701

• Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin.

  The Journal of physiology 20030615

• Hemodynamic and proinflammatory actions of endothelin-1 in guinea pig small intestine submucosal microcirculation.

  American journal of physiology. Gastrointestinal and liver physiology 20030601

• Role of endothelin ETA and ETB receptors in the guinea-pig urinary bladder contraction.

  European journal of pharmacology 20030530

• Endothelin ET(A) but not ET(B) receptors mediate contraction of common bile duct.

  Regulatory peptides 20030515

• Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro.

  Hypertension (Dallas, Tex. : 1979) 20030501

• Regulation of human retinal blood flow by endothelin-1.

  Experimental eye research 20030501

• Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors.

  Naunyn-Schmiedeberg's archives of pharmacology 20030501

• Pharmacological characterization of TA-0201, an endothelin receptor antagonist, with recombinant and human prostate endothelin receptors.

  European journal of pharmacology 20030425

• Endothelin receptor antagonists restore morphine analgesia in morphine tolerant rats.

  Peptides 20030401

• Binding of a new bioactive 31-amino-acid endothelin-1 to an endothelin ET(B) or ET(B)-like receptor in porcine lungs.

  European journal of pharmacology 20030328

• Will endothelin receptor antagonists have a role in heart failure?

  The Medical clinics of North America 20030301

• Endothelin-1 stimulated capacitative Ca2+ entry through ET(A) receptors of a rat brain-derived type-1 astrocyte cell line, IA-1g1.

  Cellular signalling 20030201

• Role of endothelin-1 in choroidal blood flow regulation during isometric exercise in healthy humans.

  Investigative ophthalmology & visual science 20030201

• Effect of endothelin-1 (1-31) on the renal resistance vessels.

  The journal of medical investigation : JMI 20030201

• ETA, mixed ETA/ETB receptor antagonists, and protein kinase C inhibitor prevent acute hypoxic pulmonary vasoconstriction: influence of potassium channels.

  Journal of cardiovascular pharmacology 20030101

• Endothelin receptor blockade lowers plasma aldosterone levels via different mechanisms in primary aldosteronism and high-to-normal renin hypertension.

  Cardiovascular research 20030101

• Role of K+ATP channels, endothelin A receptors, and effect of angiotensin II on blood flow in oral tissues.

  Journal of dental research 20030101

• Et-A receptor antagonist BQ123 prevents radiocontrast media-induced renal medullary hypoxia.

  Acta radiologica (Stockholm, Sweden : 1987) 20030101

• Endothelin ET A- and ET B-receptor-mediated inhibition of noradrenaline release from isolated rat stomach.

  Journal of pharmacological sciences 20030101

• Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.

  American journal of physiology. Heart and circulatory physiology 20021201

• Insulin sensitivity and big ET-1 conversion to ET-1 after ETA- or ETB-receptor blockade in humans.

  Journal of applied physiology (Bethesda, Md. : 1985) 20021201

• Endothelin-1-induced vasospasms of spiral modiolar artery are mediated by rho-kinase-induced Ca(2+) sensitization of contractile apparatus and reversed by calcitonin gene-related Peptide.

  Stroke 20021201

• Mechanisms of peripheral microvascular dysfunction in transgenic mice overexpressing the Alzheimer's disease amyloid Abeta protein.

  Journal of Alzheimer's disease : JAD 20021201

• Role of endothelin type B receptor in NO/cGMP signaling pathway in rat median eminence.

  Cellular and molecular neurobiology 20021201

• Mechanism of endothelin-1-induced cytosolic Ca(2+) mobility in cultured H9c2 myocardiac ventricular cells.

  Cellular signalling 20021001

• Endothelin-induced modulation of neuropeptide Y and norepinephrine release from the rat mesenteric bed.

  American journal of physiology. Heart and circulatory physiology 20021001

• Increased activity of endogenous endothelin in patients with type II diabetes mellitus.

  Circulation 20021001

• Different contractile effects of alpha1- and alpha2-adrenergic agonists on horse isolated common digital artery smooth muscle ring preparations in vitro.

  Pharmacological research 20021001

• Potentiation of morphine analgesia by BQ123, an endothelin antagonist.

  Peptides 20021001

• The vascular endothelin system is not overactive in normotensive hemodialysis patients.

  Kidney international 20020901

• Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors.

  European journal of immunology 20020901

• Involvement of endothelin-1 and its receptors in PGF2alpha-induced luteolysis in the rat.

  Molecular reproduction and development 20020901

• Inhibitory activity on binding of specific ligands to the human angiotensin II AT(1) and endothelin 1 ET(A) receptors: bioactive benzo[c]phenanthridine alkaloids from the root of Bocconia frutescens.

  Planta medica 20020901

• Possible mechanism of endothelin-induced Ca2+ mobility in A7r5 cultured vascular smooth muscle cells.

  The Kaohsiung journal of medical sciences 20020901

• Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation.

  Pharmacogenetics 20020801

• Forearm vasoconstriction to endothelin-1 is impaired, but constriction to sarafotoxin 6c and vasodilatation to BQ-123 unaltered, in patients with essential hypertension.

  Clinical science (London, England : 1979) 20020801

• Endothelin-1 (1-31) induces a thiorphan-sensitive release of eicosanoids via ET(B) receptors in the guinea pig perfused lung.

  Clinical science (London, England : 1979) 20020801

• Modulation of ET(B) receptor-induced arginine-vasopressin secretion by N-methyl-D-aspartate (NMDA) and gamma-aminobutyric acid (GABA)-dependent mechanisms in hypothalamo-neurohypophysial explants.

  Clinical science (London, England : 1979) 20020801

• Differential vasoactive response to endothelin receptor antagonists and prostacyclin in patients with severe pulmonary hypertension.

  Clinical science (London, England : 1979) 20020801

• Impact of parainfluenza-3 virus infection on endothelin receptor density and function in guinea pig airways.

  Clinical science (London, England : 1979) 20020801

• Role of endothelin receptors in the hypertensive state of kinin B(2) knockout mice subjected to a high-salt diet.

  Clinical science (London, England : 1979) 20020801

• Reduction of endothelin-1 binding and inhibition of endothelin-1-mediated detrusor contraction by naftidrofuryl.

  Clinical science (London, England : 1979) 20020801

• Altered mitogen-activated protein kinase activation in vascular smooth muscle cells from spontaneously hypertensive rats.

  Clinical and experimental pharmacology & physiology 20020701

• Mental stress induces prolonged endothelial dysfunction via endothelin-A receptors.

  Circulation 20020618

• International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature.

  Pharmacological reviews 20020601

• Action of the endothelin receptor (ETA) antagonist BQ-123 on forearm blood flow in young normotensive subjects.

  Clinical science (London, England : 1979) 20020601

• Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: reversal with endothelin antagonism.

  The Journal of thoracic and cardiovascular surgery 20020601

• Pronatriuretic peptide is a sensitive marker of the endocrine function of teleost heart.

  American journal of physiology. Endocrinology and metabolism 20020401

• Endothelin ETA receptor-subtype specific antagonism does not mitigate the acute systemic or renal effects of exogenous angiotensin II in humans.

  European journal of clinical investigation 20020401

• Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins.

  The Annals of thoracic surgery 20020401

• A novel bioactive 31-amino acid ET-1 peptide stimulates eosinophil recruitment and increases the levels of eotaxin and IL-5.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401

• Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: possible formation of an ETA-ETB receptor heterodimer.

  Cellular and molecular neurobiology 20020401

• Endothelin-A receptors and NO mediate decrease in arterial pressure during recovery from restraint.

  American journal of physiology. Regulatory, integrative and comparative physiology 20020301

• Endothelin-1 inhibits endothelium-dependent vasodilatation in the human forearm: reversal by ETA receptor blockade in patients with atherosclerosis.

  Clinical science (London, England : 1979) 20020301

• Stimulation of catecholamine biosynthesis via the protein kinase C pathway by endothelin-1 in PC12 rat pheochromocytoma cells.

  Biochemical pharmacology 20020301

• Endothelin-3 induces both human and opossum gallbladder contraction mediated mainly by endothelin-B receptor subtype in vitro.

  Journal of gastroenterology and hepatology 20020301

• Endothelial modulation of skeletal muscle blood flow and VO(2) during low- and high-intensity contractions.

  Journal of applied physiology (Bethesda, Md. : 1985) 20020201

• Improved endothelium-dependent vasodilation after blockade of endothelin receptors in patients with essential hypertension.

  Circulation 20020129

• Endothelin in the mechanism of endothelial injury and neutrophil adhesion in the post-ischemic guinea-pig heart.

  European journal of pharmacology 20020102

• Endothelin-1[1-31]: a novel autocrine-paracrine regulator of human adrenal cortex secretion and growth.

  The Journal of clinical endocrinology and metabolism 20020101

• Endothelin-1 activates ET(A) receptors to increase intracellular calcium in model sensory neurons.

  Neuroreport 20011204

• Coronary vasodilation and improvement in endothelial dysfunction with endothelin ET(A) receptor blockade.

  Circulation research 20011123

• Myocardial contractile responsiveness to endothelin-1 in the post-infarction rat model of heart failure: effects of chronic quinapril.

  Journal of molecular and cellular cardiology 20011101

• Rationale and perspective of endothelin-1 antagonism in acute heart failure.

  Journal of cardiovascular pharmacology 20011101

• Autocrine regulation of prolactin secretion by endothelins: a permissive role for estradiol.

  Endocrine 20011101

• Endothelin-1 induces contraction of human and Australian possum gallbladder in vitro.

  Regulatory peptides 20011015

• Endothelin receptor blockade and nitric oxide bioactivity.

  Cardiovascular research 20011001

• [Down-regulation of ETA receptor of vascular smooth muscle cells by 17 beta-estradiol].

  Sheng li xue bao : [Acta physiologica Sinica] 20011001

• Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries.

  Circulation 20010904

• Endothelin-A receptor antagonist inhibits angiotensin II and noradrenaline in man.

  British journal of clinical pharmacology 20010801

• Differential desensitization of Ca2+ mobilization and vasoconstriction by ET(A) receptors in the gerbil spiral modiolar artery.

  The Journal of membrane biology 20010801

• Endothelin mediates some of the renal actions of acutely administered angiotensin II.

  Hypertension (Dallas, Tex. : 1979) 20010701

• Factors involved in the time course of response to acetylcholine in mesenteric arteries from spontaneously hypertensive rats.

  European journal of pharmacology 20010629

• Endothelin-1 mediates prostaglandin F(2alpha)-induced luteal regression in the ewe.

  Biology of reproduction 20010601

• Endothelium-dependent relaxation in response to low concentrations of bradykinin is enhanced by phosphoramidon, bosentan and BQ-123 in bovine coronary arteries in vitro.

  Japanese journal of pharmacology 20010601

• Paradoxically enhanced endothelin-B receptor-mediated vasoconstriction in conscious old monkeys.

  Circulation 20010515

• Functional and biochemical evidence for capsaicin-induced neural endothelin release in isolated working rat heart.

  European journal of pharmacology 20010511

• A novel pharmacological action of ET-1 to prevent the cytotoxicity of doxorubicin in cardiomyocytes.

  American journal of physiology. Regulatory, integrative and comparative physiology 20010501

• Caged and clustered structures of endothelin inhibitor BQ123, cyclo(-D-Trp-D-Asp--Pro-D-Val-Leu-)-Na+, forming five and six coordination bonds between sodium ions and peptides.

  Acta crystallographica. Section D, Biological crystallography 20010501

• The polycationic aminoglycosides modulate the vasoconstrictive effects of endothelin: relevance to cerebral vasospasm.

  British journal of pharmacology 20010501

• Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future?

  Journal of the American College of Cardiology 20010501

• Pulmonary adrenomedullin counteracts deterioration of coronary flow and myocardial performance evoked by pulmonary endothelins in experimental acute respiratory distress syndrome.

  Critical care medicine 20010501

• Endothelin receptors in human and guinea-pig gallbladder muscle.

  Regulatory peptides 20010420

• Intravasal peroxynitrite generation causes dysfunction in the isolated perfused rat lung via endothelin.

  The Journal of pharmacology and experimental therapeutics 20010401

• Endothelin-1 induces vasoconstriction on portal-systemic collaterals of portal hypertensive rats.

  Hepatology (Baltimore, Md.) 20010401

• Effect of the blood substitute diaspirin crosslinked hemoglobin in rat mesenteric and human radial collateral arteries.

  Journal of cardiovascular pharmacology 20010401

• Effects of endothelin-1 and nitric oxide on proliferation of cultured guinea pig bronchial smooth muscle cells.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010401

• Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex.

  International journal of molecular medicine 20010301

• Endothelin receptor blockade inhibits proliferation of Kaposi's sarcoma cells.

  The American journal of pathology 20010301

• Inositolphosphate formation in thoracic and abdominal rat aorta following Gq/11-coupled receptor stimulation.

  Naunyn-Schmiedeberg's archives of pharmacology 20010301

• Augmentation of endothelial function by endothelin antagonism in human saphenous vein conduits.

  Journal of neurosurgery 20010201

• Endothelin antagonism uncovers insulin-mediated vasorelaxation in vitro and in vivo.

  Hypertension (Dallas, Tex. : 1979) 20010201

• Design, syntheses, and structure-activity relationships of indan derivatives as endothelin antagonists; new lead generation of non-peptidic antagonist from peptidic leads.

  Bioorganic & medicinal chemistry 20010201

• Mitogen-activated protein kinase activity regulation role of angiotensin and endothelin systems in vascular smooth muscle cells.

  European journal of pharmacology 20010105

• Endothelin receptor blockade improves endothelial function in human internal mammary arteries.

  Cardiovascular research 20010101

• A N-terminal PTHrP peptide fragment void of a PTH/PTHrP-receptor binding domain activates cardiac ET(A) receptors.

  British journal of pharmacology 20010101

• Contribution of angiotensin II, endothelin 1 and the endothelium to the slow inotropic response to stretch in ferret papillary muscle.

  Pflugers Archiv : European journal of physiology 20010101

• Bone blood flow and vascular reactivity.

  Cells, tissues, organs 20010101

• Allosteric inhibition of endothelin ETA receptors by 3, 5-dibromosalicylic acid.

  Molecular pharmacology 20001201

• Location of alkali metal binding sites in endothelin A selective receptor antagonists, cyclo(D-Trp-D-Asp-Pro-D-Val-Leu) and cyclo(D-Trp-D-Asp-Pro-D-Ile-Leu), from multistep collisionally activated decompositions.

  Journal of mass spectrometry : JMS 20000201

• Angiotensin II receptor blockade unmasks a depressor response to endothelin antagonists in rats.

  Fundamental & clinical pharmacology 20000101

• Suc-[Glu9,Ala11,15]-endothelin-1 (8-21), IRL 1620, identifies two populations of ET(B) receptors in guinea-pig bronchus.

  British journal of pharmacology 19990701

• Novel sodium binding properties of some cyclopentapeptide endothelin A selective receptor antagonists: electrospray and fast-atom-bombardment mass spectrometric studies.

  Biochemical and biophysical research communications 19990127

• Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy.

  Cardiovascular research 19980901

• Role of endothelin in the human craniofacial morphogenesis.

  Journal of craniofacial genetics and developmental biology 19980101

• Endothelin receptor-mediated Ca2+ mobilization and contraction in bovine oviductal arteries: comparison with noradrenaline and potassium.

  General pharmacology 19971001

• Endothelin ETA receptors subtype mediates phosphoinositide hydrolysis in adrenal medulla.

  Archives of physiology and biochemistry 19970901

• Excitatory gastric motor and cardiovascular effects of endothelins in the dorsal vagal complex are mediated through ET(A) receptors.

  The Journal of pharmacology and experimental therapeutics 19970801

• Rediscovering an endothelin antagonist (BQ-123): a self-deconvoluting cyclic pentapeptide library.

  Journal of medicinal chemistry 19960913

• Endothelin-1 stimulates deoxyribonucleic acid synthesis and contraction in testicular peritubular myoid cells.

  Biology of reproduction 19960301

• Endothelin-1 inhibits L-type Ca currents enhanced by isoproterenol in guinea-pig ventricular myocytes.

  Pflugers Archiv : European journal of physiology 19960201

• Endothelin-induced nociception in mice: mediation by ETA and ETB receptors.

  The Journal of pharmacology and experimental therapeutics 19960201

• Role of endothelin in the cardiovascular effects of diaspirin crosslinked and stroma reduced hemoglobin.

  Critical care medicine 19960101

• The effect of endothelin-2 (ET-2) on migration and changes in cytosolic free calcium of neutrophils.

  Naunyn-Schmiedeberg's archives of pharmacology 19960101

• Endothelin acts as a paracrine regulator of stretch-induced atrial natriuretic peptide release.

  The American journal of physiology 19951101

• Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists.

  Journal of medicinal chemistry 19951013

• [Demonstration of a vasopressor role of endogenous endothelin after inhibition of nitric oxide synthesis in rats].

  Archives des maladies du coeur et des vaisseaux 19950801

• ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro.

  British journal of pharmacology 19950501

• Nonpeptide endothelin receptor antagonists: IV. Identification of receptors in rabbit colonic mucosa and smooth muscle and correlation with physiological effects.

  The Journal of pharmacology and experimental therapeutics 19950301

• [3H]BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype.

  European journal of pharmacology 19950214

• In vivo evidence of an endothelin-induced vasopressor tone after inhibition of nitric oxide synthesis in rats.

  Circulation 19950201

• Characterization of endothelin-1-induced vascular effects in the rat heart by using endothelin receptor antagonists.

  European journal of pharmacology 19941212

• Solvent effects on the conformation of cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu-). An NMR spectroscopy and molecular modeling study.

  International journal of peptide and protein research 19940501

• Mutational analysis of human endothelin receptors ETA and ETB identification of regions involved in the selectivity for endothelin 3 or cyclo-(D-Trp-D-Asp-Pro-D-Val-Leu).

  European journal of biochemistry 19940501

• Differential blockade of the renal vasoconstrictor and diuretic responses to endothelin-1 by endothelin antagonist.

  Clinical and experimental pharmacology & physiology 19940401

• Characterization of iris sphincter smooth muscle endothelin receptor subtypes which are coupled to cyclic AMP formation and polyphosphoinositide hydrolysis.

  The Journal of pharmacology and experimental therapeutics 19940301

• [125I]-PD151242: a selective radioligand for human ETA receptors.

  British journal of pharmacology 19940101

• Reversal of subarachnoid hemorrhage-induced vasoconstriction with an endothelin receptor antagonist.

  Neurosurgery 19940101

• A conformational study by 1H NMR of a cyclic pentapeptide antagonist of endothelin.

  Journal of medicinal chemistry 19930903

• Receptor externalization determines sustained contractile responses to endothelin-1 in the rat aorta.

  The American journal of physiology 19930301

• BQ-123, cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu), is a non-competitive antagonist of the actions of endothelin-1 in SK-N-MC human neuroblastoma cells.

  Biochemical and biophysical research communications 19920415

• Solution conformation of a cyclic pentapeptide endothelin antagonist. Comparison of structures obtained from constrained dynamics and conformational search.

  FEBS letters 19920316

• Conformational study of cyclo[D-Trp-D-Asp-Pro-D-Val-Leu], an endothelin-A receptor-selective antagonist.

  FEBS letters 19920113