13670-99-0 | 2',6'-Difluoroacetophenone

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$10.00	$7.00
5g	97%	in stock	$22.00	$15.00
10g	97%	in stock	$25.00	$17.00
25g	97%	in stock	$43.00	$31.00

Description

• Catalog Number: AA49363
• Chemical Name: 2',6'-Difluoroacetophenone
• CAS Number: 13670-99-0
• Molecular Formula: C8H6F2O
• Molecular Weight: 156.1294
• MDL Number: MFCD00000328
• SMILES: CC(=O)c1c(F)cccc1F

Computed Properties

• Complexity: 148
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• XLogP3: 1.8

Upstream Synthesis Route

2,6-Difluoroacetophenone is a versatile compound widely used in chemical synthesis for its unique properties and diverse applications. This compound serves as a crucial building block in the preparation of various pharmaceuticals, agrochemicals, and advanced materials. Due to its electron-withdrawing difluoromethyl group, 2,6-Difluoroacetophenone exhibits enhanced reactivity and selectivity in many organic reactions.In organic synthesis, 2,6-Difluoroacetophenone is commonly employed in the preparation of fluorinated compounds, which are important in medicinal chemistry and materials science. The fluoroacetophenone moiety can undergo various transformations, including halogenation, nucleophilic addition, and metal-catalyzed cross-coupling reactions, making it a valuable precursor for the introduction of fluorine atoms into organic molecules. Moreover, the use of 2,6-Difluoroacetophenone in chemical reactions can lead to the formation of chiral centers, enabling the synthesis of enantiomerically pure compounds with potential biological activity. Its reactivity and versatility make it an indispensable tool for the construction of complex organic molecules with fluorinated motifs, which are often desired for their improved properties and bioactivity.Overall, the application of 2,6-Difluoroacetophenone in chemical synthesis is pivotal for the development of novel compounds with important pharmaceutical, agricultural, and materials science applications. Its unique properties and synthetic utility make it a valuable component in the toolkit of organic chemists striving to create innovative molecules with enhanced reactivity and functionality.

Literature

• 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues.

  Bioorganic & medicinal chemistry letters 20030721