137778-20-2 | 5-Bromo-6-methylpicolinic acid

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$8.00	$5.00
250mg	97%	in stock	$13.00	$9.00
1g	97%	in stock	$23.00	$17.00
5g	97%	in stock	$62.00	$43.00
10g	97%	in stock	$115.00	$80.00
25g	97%	in stock	$245.00	$171.00

Description

• Catalog Number: AA51418
• Chemical Name: 5-Bromo-6-methylpicolinic acid
• CAS Number: 137778-20-2
• Molecular Formula: C7H6BrNO2
• Molecular Weight: 216.032
• MDL Number: MFCD13181588
• SMILES: OC(=O)c1ccc(c(n1)C)Br

Upstream Synthesis Route

To synthesize 5-Bromo-6-methylpicolinic acid, start with 6-methylpyridine-3-carboxaldehyde as the starting material. Perform a bromination reaction on the 5-position of the pyridine ring using N-bromosuccinimide (NBS) in the presence of a radical initiator like AIBN (azobisisobutyronitrile) under appropriate solvent conditions to obtain 5-bromo-6-methylpyridine-3-carboxaldehyde.

Next, perform an oxidation reaction to convert the aldehyde group to a carboxylic acid. This can be achieved by using an oxidizing agent such as potassium permanganate (KMnO_4) in a neutral or slightly alkaline medium. This step transforms the aldehyde group into the corresponding carboxylic acid, yielding 5-bromo-6-methylpicolinic acid. Conditions like temperature and reaction time should be carefully controlled to ensure the selective oxidation of the aldehyde without over-oxidation of the methyl group on the pyridine ring.

Ensure purification through recrystallization or chromatography to achieve the desired purity of 5-Bromo-6-methylpicolinic acid.