139051-78-8 | (2R,4S)-5,7-Dichloro-4-(3-phenylureido)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid

Packsize	Purity	Availability	Price	Discounted Price
10mg		in stock	$979.00	$685.00

Description

• Catalog Number: AD24813
• Chemical Name: (2R,4S)-5,7-Dichloro-4-(3-phenylureido)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid
• CAS Number: 139051-78-8
• Molecular Formula: C17H15Cl2N3O3
• Molecular Weight: 380.2253
• MDL Number: MFCD00672670
• SMILES: O=C(NC1CC(Nc2c1c(Cl)cc(c2)Cl)C(=O)O)Nc1ccccc1

Computed Properties

• Complexity: 502
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 3
• Undefined Atom Stereocenter Count: 2
• XLogP3: 3.5

Literature

• Pharmacological evaluation of a novel assay for detecting glycine transporter 1 inhibitors and their antipsychotic potential.

  Pharmacology, biochemistry, and behavior 20101101

• Disruption of the interaction between myosin VI and SAP97 is associated with a reduction in the number of AMPARs at hippocampal synapses.

  Journal of neurochemistry 20100201

• The contribution of the NMDA receptor glycine site to rhythm generation during fictive swimming in Xenopus laevis tadpoles.

  The European journal of neuroscience 20071101

• Medium supplementation with zinc enables detection of imipramine-induced adaptation in glycine/NMDA receptors labeled with [3H]L-689,560.

  Pharmacological reports : PR 20060101

• Glycine binding site of the synaptic NMDA receptor in subpostremal NTS neurons.

  Journal of neurophysiology 20050701

• In vitro and in vivo antagonistic activities of SM-31900 for the NMDA receptor glycine-binding site.

  Brain research 20020719

• Catalytic enantioselective Reissert-type reaction: development and application to the synthesis of a potent NMDA receptor antagonist (-)-L-689,560 using a solid-supported catalyst.

  Journal of the American Chemical Society 20010718

• Structure-activity relationships of 1,4-dihydro-(1H,4H)-quinoxaline-2,3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists. 1. Heterocyclic substituted 5-alkyl derivatives.

  Journal of medicinal chemistry 20010607

• Increased density of glutamate/N-methyl-D-aspartate receptors in superior temporal cortex in schizophrenia.

  Neuroscience letters 20010518

• 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor.

  Journal of medicinal chemistry 19940513

• 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.

  Journal of medicinal chemistry 19920529