140674-76-6 | Benzoic acid, 4-​[[(2,​5-​dihydroxyphenyl)​methyl]​amino]​-​, methyl ester

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$48.00	$34.00
5mg	98%	in stock	$150.00	$105.00
10mg	98%	in stock	$274.00	$192.00

Description

• Catalog Number: AA62892
• Chemical Name: Benzoic acid, 4-​[[(2,​5-​dihydroxyphenyl)​methyl]​amino]​-​, methyl ester
• CAS Number: 140674-76-6
• Molecular Formula: C15H15NO4
• Molecular Weight: 273.2839
• MDL Number: MFCD01074970
• SMILES: COC(=O)c1ccc(cc1)NCc1cc(O)ccc1O
• NSC Number: 654705

Computed Properties

• Complexity: 315
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 5
• XLogP3: 2.5

Literature

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Metabolic alterations in K562 cells exposed to taxol and tyrphostin AG957: 1H NMR and biochemical studies.

  Cell biology international 20051101

• The tyrosine kinase inhibitors imatinib and AG957 reverse multidrug resistance in a chronic myelogenous leukemia cell line.

  Leukemia research 20050701

• Synthesis, 11C labeling and biological properties of derivatives of the tyrphostin AG957.

  Nuclear medicine and biology 20050501

• Synthesis, structure-activity relationship, and p210(bcr-abl) protein tyrosine kinase activity of novel AG 957 analogs.

  Bioorganic & medicinal chemistry 20050301

• Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells.

  Blood 20031215

• Inhibition of fast sodium current in rabbit ventricular myocytes by protein tyrosine kinase inhibitors.

  Pflugers Archiv : European journal of physiology 20030701

• Regulation of transient outward current in human atrial myocytes by protein tyrosine kinase pathway.

  Journal of cardiovascular electrophysiology 20020901

• Abnormal growth factor modulation of beta1-integrin-mediated adhesion in chronic myelogenous leukaemia haematopoietic progenitors.

  British journal of haematology 20011201

• Comparison of effects of the tyrosine kinase inhibitors AG957, AG490, and STI571 on BCR-ABL--expressing cells, demonstrating synergy between AG490 and STI571.

  Blood 20010401

• BCR-ABL down-regulates the DNA repair protein DNA-PKcs.

  Blood 20010401