142-64-3 | Piperazine Dihydrochloride

Packsize	Purity	Availability	Price	Discounted Price
5g	95%	in stock	$26.00	$18.00
25g	>98.0%(N)	in stock	$36.00	$25.00
100g	95%	in stock	$106.00	$75.00
500g	>98.0%(N)	in stock	$174.00	$122.00

Description

• Catalog Number: AB46886
• Chemical Name: Piperazine Dihydrochloride
• CAS Number: 142-64-3
• Molecular Formula: C4H12Cl2N2
• Molecular Weight: 159.0575
• MDL Number: MFCD00012754
• SMILES: N1CCNCC1.Cl.Cl

Computed Properties

• Complexity: 26.5
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 4

Literature

• Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1.

  Journal of medicinal chemistry 20161013

• Structure-dependent inhibition of the human α1β2γ2 GABAA receptor by piperazine derivatives: A novel mode of action.

  Neurotoxicology 20151201

• Design, synthesis and antitubercular evaluation of novel series of N-[4-(piperazin-1-yl)phenyl]cinnamamide derivatives.

  European journal of medicinal chemistry 20140321

• Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom.

  Bioorganic & medicinal chemistry 20130901

• Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.

  Journal of medicinal chemistry 20130328

• Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.

  Chemistry & biology 20130321

• Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues.

  Bioorganic & medicinal chemistry letters 20121201

• Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors.

  Bioorganic & medicinal chemistry letters 20121201

• Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.

  Drug metabolism and disposition: the biological fate of chemicals 20121101

• Spectroscopic study of degradation products of ciprofloxacin, norfloxacin and lomefloxacin formed in ozonated wastewater.

  Water research 20121015

• Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent.

  Bioorganic & medicinal chemistry letters 20121015

• Synthesis and anti-inflammatory effects of new piperazine and ethanolamine derivatives of H(1)-antihistaminic drugs.

  Mini reviews in medicinal chemistry 20121001

• Improved solvent formulations for efficient CO₂ absorption and low-temperature desorption.

  ChemSusChem 20120901

• Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.

  European journal of medicinal chemistry 20120901

• Reaction of homopiperazine with endogenous formaldehyde: a carbon hydrogen addition metabolite/product identified in rat urine and blood.

  Drug metabolism and disposition: the biological fate of chemicals 20120801

• Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.

  Journal of medicinal chemistry 20120726

• Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors.

  Bioorganic & medicinal chemistry letters 20120715

• Synthesis of novel imbricatolic acid analogues via insertion of N-substituted piperazine at C-15/C-19 positions, displaying glucose uptake stimulation in L6 skeletal muscle cells.

  Bioorganic & medicinal chemistry letters 20120715

• Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors.

  Bioorganic & medicinal chemistry letters 20120715

• Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with α₁-adrenoceptor antagonistic properties.

  Bioorganic & medicinal chemistry 20120715

• Structural characterization of a novel degradant of the antifungal agent posaconazole.

  Journal of pharmaceutical and biomedical analysis 20120701

• Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties.

  Bioorganic & medicinal chemistry letters 20120701

• Metabolism of a G protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct.

  Drug metabolism and disposition: the biological fate of chemicals 20120601

• Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors.

  Bioorganic & medicinal chemistry letters 20120601

• A Dieckmann cyclization route to piperazine-2,5-diones.

  The Journal of organic chemistry 20120601

• Pharmacological characterization of the Haemonchus contortus GABA-gated chloride channel, Hco-UNC-49: modulation by macrocyclic lactone anthelmintics and a receptor for piperazine.

  Veterinary parasitology 20120430

• Synthesis and cytotoxic evaluation of some new phthalazinylpiperazine derivatives.

  Archiv der Pharmazie 20120401

• Analysis of volatile bases by high performance liquid chromatography with aerosol-based detection.

  Journal of chromatography. A 20120316

• Gastroprotective activity and mechanism of novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl)piperazin-1-iumphenolate complex on ethanol-induced gastric ulceration.

  Chemico-biological interactions 20120125

• The discovery of potent antagonists of NPBWR1 (GPR7).

  Bioorganic & medicinal chemistry letters 20120115

• Prevalence of efflux-mediated ciprofloxacin and levofloxacin resistance in recent clinical isolates of Pseudomonas aeruginosa and its reversal by the efflux pump inhibitors 1-(1-naphthylmethyl)-piperazine and phenylalanine-arginine-β-naphthylamide.

  International journal of antimicrobial agents 20120101

• Cyclosulfamide-based derivatives as inhibitors of noroviruses.

  European journal of medicinal chemistry 20120101

• New N-methylpiperazinyl derivatives of bicyclic antiprotozoal compounds.

  European journal of medicinal chemistry 20120101

• Synthesis, 5-hydroxytryptamine1A receptor affinity and docking studies of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives.

  Chemical & pharmaceutical bulletin 20120101

• Synthesis of macrolones with central piperazine ring in the linker and its influence on antibacterial activity.

  Bioorganic & medicinal chemistry 20111201

• Identification of a new sildenafil analogue in a health supplement.

  Journal of pharmaceutical and biomedical analysis 20111101

• Combined 3D-QSAR, molecular docking, and molecular dynamics study on piperazinyl-glutamate-pyridines/pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation.

  Journal of chemical information and modeling 20111024

• Preparation, spectral and biological investigation of formaldehyde-based ligand containing piperazine moiety and its various polymer metal complexes.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111015

• Expedient entry to the piperazinohydroisoquinoline ring system using a sequential Ugi/Pictet-Spengler/reductive methylation reaction protocol.

  Chemical communications (Cambridge, England) 20111014

• NSC126188, a piperazine alkyl derivative, induces apoptosis via upregulation of RhoB in HeLa cells.

  Investigational new drugs 20111001

• Discovery of inhibitors of plasminogen activator inhibitor-1: structure-activity study of 5-nitro-2-phenoxybenzoic acid derivatives.

  Bioorganic & medicinal chemistry letters 20111001

• Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors.

  Organic & biomolecular chemistry 20110907

• Intestinal nematode infections in Romania: an epidemiological study and brief review of literature.

  Vector borne and zoonotic diseases (Larchmont, N.Y.) 20110801

• Biosynthetic chlorination of the piperazate residue in kutzneride biosynthesis by KthP.

  Biochemistry 20110712

• Design, synthesis and biological activity evaluation of arylpiperazine derivatives for the treatment of neuropathic pain.

  Molecules (Basel, Switzerland) 20110707

• Discriminating octahedral transition metal ions: highly selective tripodal tris-(2,2'-bipyridine) functionalized piperazine cyclophane receptor for Cu2+ ions.

  Dalton transactions (Cambridge, England : 2003) 20110607

• Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator.

  European journal of pharmacology 20110601

• Modelling of serotonin reuptake inhibitory and histamine H₃antagonistic activity of piperazine and diazepane amides: QSAR rationales for co-optimization of the activity profiles.

  SAR and QSAR in environmental research 20110601

• SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides: potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.

  Bioorganic & medicinal chemistry letters 20110515

• Synthesis of homoveratric acid-imprinted polymers and their evaluation as selective separation materials.

  Molecules (Basel, Switzerland) 20110505

• Discovery of PF-00217830: aryl piperazine napthyridinones as D2 partial agonists for schizophrenia and bipolar disorder.

  Bioorganic & medicinal chemistry letters 20110501

• Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging.

  Bioorganic & medicinal chemistry 20110501

• Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.

  Bioorganic & medicinal chemistry letters 20110415

• Chemical absorption of carbon dioxide with asymmetrically heated polytetrafluoroethylene membranes.

  Journal of environmental management 20110401

• Statistically disordered short hydrogen bonds in (pipzH2)(cdoH)2 and a comparison with (pipzH2)(cdo)·H2O (pipz is piperazine and cdoH2 is chelidonic acid).

  Acta crystallographica. Section C, Crystal structure communications 20110401

• Modeling CO2 mass transfer in amine mixtures: PZ-AMP and PZ-MDEA.

  Environmental science & technology 20110315

• Crystallographic characterisation of Ti(IV) piperazine complexes and their exploitation for the ring opening polymerisation of rac-lactide.

  Dalton transactions (Cambridge, England : 2003) 20110307

• II. SAR studies of pyridyl-piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists.

  Bioorganic & medicinal chemistry letters 20110301

• Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.

  Bioorganic & medicinal chemistry 20110301

• 9-Piperazine substituted perylene-3,4-dicarboximide as a fluorescent probe in ratiometric analysis.

  Chemical communications (Cambridge, England) 20110227

• Molecular modeling study and synthesis of quinazolinone-arylpiperazine derivatives as α1-adrenoreceptor antagonists.

  European journal of medicinal chemistry 20110201

• The effects of the 4-(4-Methylpiperazine)phenyl group on nucleosides and oligonucleotides: cellular delivery, detection, and stability.

  Chemistry, an Asian journal 20110201

• Studies of tricyclic piperazine/piperidine furnished molecules as novel integrin αvβ3/αIIbβ3 dual antagonists using 3D-QSAR and molecular docking.

  Journal of molecular graphics & modelling 20110201

• NMR spectroscopy and surface tension measurements applied to the study of self-association of casopitant mesylate, a novel NK1 antagonist.

  Journal of pharmaceutical and biomedical analysis 20110105

• Conformational analysis of piperazine and piperidine analogs of GBR 12909: stochastic approach to evaluating the effects of force fields and solvent.

  Journal of molecular modeling 20110101

• β-Elemene piperazine derivatives induce apoptosis in human leukemia cells through downregulation of c-FLIP and generation of ROS.

  PloS one 20110101

• Engineered multifunctional nanotools for biological applications.

  Methods in molecular biology (Clifton, N.J.) 20110101

• 4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.

  Bioorganic & medicinal chemistry letters 20101215

• Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors.

  Bioorganic & medicinal chemistry letters 20101001

• Patterning of pH sensitive fluorescent bipyridazine derivatives.

  Journal of nanoscience and nanotechnology 20101001

• Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands.

  Bioorganic & medicinal chemistry letters 20100915

• Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor.

  Bioorganic & medicinal chemistry letters 20100915

• Validation of an LC-MS method for the detection and quantification of BZP and TFMPP and their hydroxylated metabolites in human plasma and its application to the pharmacokinetic study of TFMPP in humans.

  Journal of forensic sciences 20100901

• Bicyclic sigma receptor ligands by stereoselective Dieckmann analogous cyclization of piperazinebutyrate.

  Organic & biomolecular chemistry 20100821

• Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.

  Bioorganic & medicinal chemistry letters 20100801

• Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol.

  Bioorganic & medicinal chemistry 20100801

• Effects of shape, porosity, and operating parameters on carbon dioxide recovery in polytetrafluoroethylene membranes.

  Journal of hazardous materials 20100715

• Synthesis and cytotoxic activity of a new potential DNA bisintercalator: 1,4-Bis{3-[N-(4-chlorobenzo[g]phthalazin-1-yl)aminopropyl]}piperazine.

  Bioorganic & medicinal chemistry 20100715

• Synthesis of bile acid derivatives and in vitro cytotoxic activity with pro-apoptotic process on multiple myeloma (KMS-11), glioblastoma multiforme (GBM), and colonic carcinoma (HCT-116) human cell lines.

  European journal of medicinal chemistry 20100701

• Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity.

  Bioorganic & medicinal chemistry letters 20100701

• New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation.

  Journal of enzyme inhibition and medicinal chemistry 20100601

• Three new dioxopiperazine metabolites from a marine-derived fungus Aspergillus fumigatus Fres.

  Natural product research 20100601

• Design of new potent and selective secretory phospholipase A(2) inhibitors. 6-Synthesis, structure-activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivatives.

  Bioorganic & medicinal chemistry 20100515

• Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.

  Bioorganic & medicinal chemistry letters 20100501

• Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds.

  Bioorganic & medicinal chemistry letters 20100501

• A flow-based synthesis of imatinib: the API of Gleevec.

  Chemical communications (Cambridge, England) 20100414

• Responsive, di-metallic lanthanide complexes of a piperazine-bridged bis-macrocyclic ligand: modulation of visible luminescence and proton relaxivity.

  Dalton transactions (Cambridge, England : 2003) 20100414

• Piperazine bridged resorcinarene cages.

  Organic letters 20100402

• Surgical diagnosis and management of intestinal obstruction due to Ascaris lumbricoides.

  Surgical infections 20100401

• New discrete and polymeric supramolecular architectures derived from dinuclear Co(II), Ni(II) and Cu(II) complexes of aryl-linked bis-beta-diketonato ligands and nitrogen bases: synthetic, structural and high pressure studies.

  Dalton transactions (Cambridge, England : 2003) 20100321

• Evaluation of alkanolamine solutions for carbon dioxide removal in cross-flow rotating packed beds.

  Journal of hazardous materials 20100315

• Kinetics of removal of carbon dioxide by aqueous solutions of N,N-diethylethanolamine and piperazine.

  Environmental science & technology 20100315

• A comparative study of the efficacy of piperazine and Carica papaya for the control of helminth parasites in village chickens in Zambia.

  Tropical animal health and production 20100301

• Molecular modeling studies on the human neuropeptide S receptor and its antagonists.

  ChemMedChem 20100301

• Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.

  Bioorganic & medicinal chemistry letters 20100301

• Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands.

  European journal of medicinal chemistry 20100201

• Design and synthesis of piperazine-indole p38 alpha MAP kinase inhibitors with improved pharmacokinetic profiles.

  Bioorganic & medicinal chemistry letters 20100201

• Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.

  Journal of medicinal chemistry 20100128

• Novel organic proteasome inhibitors identified by virtual and in vitro screening.

  Journal of medicinal chemistry 20100114

• Theoretical and experimental studies of the isomeric protonation in solution for a prototype aliphatic ring containing two nitrogens.

  The journal of physical chemistry. B 20100114

• Complete experimental and theoretical proton and carbon nuclear magnetic resonance spectral assignments, molecular structure and conformational study of 1-cyclohexylpiperazine and 1-(4-pyridyl)piperazine.

  Magnetic resonance in chemistry : MRC 20100101

• Antiplasmodial activity of piperazine sulfonamides.

  Bioorganic & medicinal chemistry letters 20100101

• Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits.

  Journal of medicinal chemistry 20091210

• Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain.

  Journal of medicinal chemistry 20091210

• Synthesis and pharmacological evaluation of SNC80 analogues with a bridged piperazine ring.

  ChemMedChem 20091201

• The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists.

  ChemMedChem 20091201

• [Summary of the ICOH 2009 Conference - Cape Town, South Africa].

  Harefuah 20091201

• Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice.

  The international journal of neuropsychopharmacology 20091101

• Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.

  Journal of molecular biology 20090904

• Quantitative structure activity relationship studies of piperazinyl phenylalanine derivatives as VLA-4/VCAM-1 inhibitors.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20090901

• Solvatochromic fluorescence of piperazine-modified bipyridazines for an organic solvent-sensitive film.

  Langmuir : the ACS journal of surfaces and colloids 20090818

• LYG-202, a new flavonoid with a piperazine substitution, shows antitumor effects in vivo and in vitro.

  Biochemical and biophysical research communications 20090807

• Expedite protocol for construction of chiral regioselectively N-protected monosubstituted piperazine, 1,4-diazepane, and 1,4-diazocane building blocks.

  The Journal of organic chemistry 20090807

• Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones.

  European journal of medicinal chemistry 20090801

• Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.

  Bioorganic & medicinal chemistry 20090801

• 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents.

  Bioorganic & medicinal chemistry 20090801

• 'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.

  Bioorganic & medicinal chemistry 20090715

• Retention of ionisable compounds on high-performance liquid chromatography XIX. pH variation in mobile phases containing formic acid, piperazine and tris as buffering systems and methanol as organic modifier.

  Journal of chromatography. A 20090710

• Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities.

  European journal of medicinal chemistry 20090701

• Interaction of organotin with piperazine derived self-assembled cylindrical bisdithiocarbamates: spectral and thermal investigations.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090701

• Synthesis of proline-based diketopiperazine scaffolds.

  The Journal of organic chemistry 20090605

• Influence of fluorocarbon flat-membrane hydrophobicity on carbon dioxide recovery.

  Chemosphere 20090601

• Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor.

  Bioorganic & medicinal chemistry 20090601

• Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.

  Chemistry & biology 20090424

• Non-imidazole histamine H3 ligands, part IV: SAR of 1-[2-thiazol-5-yl-(2-aminoethyl)]-4-n-propylpiperazine derivatives.

  European journal of medicinal chemistry 20090401

• Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, part 1.

  European journal of medicinal chemistry 20090401

• Ghrelin receptor modulators and their therapeutic potential.

  Future medicinal chemistry 20090401

• Retention of ionisable compounds on high-performance liquid chromatography XVIII: pH variation in mobile phases containing formic acid, piperazine, tris, boric acid or carbonate as buffering systems and acetonitrile as organic modifier.

  Journal of chromatography. A 20090320

• Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists.

  Bioorganic & medicinal chemistry letters 20090315

• Discovery of novel non-peptidic beta-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists.

  Bioorganic & medicinal chemistry letters 20090301

• 1,4-Diazepanes derived from (S)-serine--homopiperazines with improved sigma(1) (sigma) receptor affinity and selectivity.

  European journal of medicinal chemistry 20090201

• The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones.

  European journal of medicinal chemistry 20090201

• Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors.

  Bioorganic & medicinal chemistry letters 20090201

• Pleuromutilin derivatives having a purine ring. Part 3: synthesis and antibacterial activity of novel compounds possessing a piperazine ring spacer.

  Bioorganic & medicinal chemistry letters 20090101

• Direct zincation of functionalized aromatics and heterocycles by using a magnesium base in the presence of ZnCl2.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20090101

• An alternative convenient synthesis of piperidazine-3-carboxylic acid derivatives.

  Chemical & pharmaceutical bulletin 20090101

• Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors.

  Bioorganic & medicinal chemistry letters 20081215

• An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds.

  The Journal of organic chemistry 20081107

• Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities.

  Organic & biomolecular chemistry 20081107

• 6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors.

  Bioorganic & medicinal chemistry letters 20081015

• Synthesis and characterization of new piperazine-type inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I).

  Biochemistry 20081007

• 2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.

  Bioorganic & medicinal chemistry letters 20080901

• [Effects of piperazine ferulate on connective tissue growth factor and extracellular matrix in TGF-beta1 induced mesangial cells].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080901

• [Effects of piperazine ferulate on TGF-beta1-induced renal interstitial fibroblast activation].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080901

• 2,6-Diazaspiro[3.3]heptanes: synthesis and application in Pd-catalyzed aryl amination reactions.

  Organic letters 20080821

• Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.

  Journal of medicinal chemistry 20080814

• Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D2 and 5-HT1A receptors.

  European journal of medicinal chemistry 20080801

• Model-based analysis for kinetic complexation study of Pizda and Cu(II).

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080801

• Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists.

  Bioorganic & medicinal chemistry letters 20080715

• Use of N-methylpiperazine for the preparation of piperazine-based unsymmetrical bis-ureas as anti-HIV agents.

  ChemMedChem 20080701

• 2-phenyl-4-piperazinylbenzimidazoles: orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor.

  Bioorganic & medicinal chemistry 20080701

• Two-dimensional QSAR studies on arylpiperazines as high-affinity 5-HT(1A) receptor ligands.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20080701

• Practical synthesis of a vanilloid receptor-1 antagonist.

  The Journal of organic chemistry 20080502

• Internal pH indicators for biomolecular NMR.

  Journal of biomolecular NMR 20080501

• Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines.

  Bioorganic & medicinal chemistry 20080415

• Practical experiences with the synthesis of [11C]CH3I through gas phase iodination reaction using a TRACERlabFXC synthesis module.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20080401

• Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands.

  Bioorganic & medicinal chemistry 20080401

• Crystal structure and vibrational spectra of piperazinium bis(4-hydroxybenzenesulphonate) molecular-ionic crystal.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080201

• Isostructural materials achieved by using structurally equivalent donors and acceptors in halogen-bonded cocrystals.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• Molecular Pacman: folding, inclusion, and X-ray structures of tri- and tetraamino piperazine cyclophanes.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• Piperazine protects the rat heart against sudden cardiac death from barium chloride-induced ventricular fibrillation.

  American journal of therapeutics 20080101

• Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor.

  Bioorganic & medicinal chemistry letters 20071215

• Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug.

  International journal of antimicrobial agents 20071201

• Discovery of 5-HT6 receptor ligands based on virtual HTS.

  Bioorganic & medicinal chemistry letters 20071115

• Atrazine removal by covalent bonding to piperazine functionalized PolyHIPEs.

  The Science of the total environment 20071101

• [Study of new blended chemical absorbents to absorb CO2].

  Huan jing ke xue= Huanjing kexue 20071101

• Synthesis of bridged piperazines with sigma receptor affinity.

  European journal of medicinal chemistry 20071001

• Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position.

  Bioorganic & medicinal chemistry letters 20070901

• Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling.

  Bioorganic & medicinal chemistry letters 20070701

• DNA interactions of new cytotoxic tetrafunctional dinuclear platinum complex trans,trans-[{PtCl2(NH3)}2(piperazine)].

  Biochemical pharmacology 20070615

• Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization.

  Bioorganic & medicinal chemistry letters 20070515

• Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines.

  Bioorganic & medicinal chemistry 20070515

• [(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors.

  Bioorganic & medicinal chemistry letters 20070501

• Legal piperazine-containing party pills--a new trend in substance misuse.

  Drug and alcohol review 20070501

• Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.

  Bioorganic & medicinal chemistry letters 20070301

• Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs.

  Journal of pharmaceutical and biomedical analysis 20070219

• Analysis of structures with saturated hydrogen bonding.

  Acta crystallographica. Section B, Structural science 20070201

• Evaluation of methods for the determination of water in substances with unknown chemical and thermal behaviour.

  Journal of pharmaceutical and biomedical analysis 20070117

• Adsorption of Acid Red 73 on copper dithiocarbamate precipitate-type solid wastes.

  Chemosphere 20070101

• A case of poly-parasitism involving a trematode and four different nematodes in a migrant from Bihar.

  Indian journal of medical microbiology 20070101

• Parallel solution-phase synthesis of 4H-benzo[1,4]thiazin-3-one and 1,1-dioxo-1,4-dihydro-2H-1lambda6-benzo[1,4]thiazin-3-one derivatives from 1,5-difluoro-2,4-dinitrobenzene.

  Journal of combinatorial chemistry 20070101

• Inhibitors of unactivated p38 MAP kinase.

  Bioorganic & medicinal chemistry letters 20061201

• Estrogen receptor alpha regulates insulin sensitivity through IRS-1 tyrosine phosphorylation in mature 3T3-L1 adipocytes.

  Endocrine journal 20061201

• Two new dioxopiperazine derivatives, arestrictins A and B, isolated from Aspergillus restrictus and Aspergillus penicilloides.

  Chemical & pharmaceutical bulletin 20061201

• In vitro anthelmintic activity of Melia azedarach naturalized in Argentina.

  Phytotherapy research : PTR 20061101

• Effect of piperazine (diethylenediamine) on the moulting, proteome expression and pyrophosphatase activity of Ascaris suum lung-stage larvae.

  Acta tropica 20061001

• Quantitative structure-activity relationship study of new potent and selective antagonists at the 5-HT(1A) and adrenergic alpha(1d) receptors: Derivatives of spiroethyl phenyl(substituted)piperazine.

  Journal of enzyme inhibition and medicinal chemistry 20061001

• Propionylpiperazines as human melanocortin-4 receptor ligands.

  Bioorganic & medicinal chemistry letters 20060915

• Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor.

  Bioorganic & medicinal chemistry letters 20060901

• Asymmetric synthesis of 1-(2- and 3-haloalkyl)azetidin-2-ones as precursors for novel piperazine, morpholine, and 1,4-diazepane annulated beta-lactams.

  The Journal of organic chemistry 20060901

• Comparative study on the regeneration of flue-gas desulfurizing agents by using conventional electrodialysis (ED) and bipolar membrane electrodialysis (BMED).

  Environmental science & technology 20060901

• Structure-activity studies on the protection of Trimetazidine derivatives modified with nitroxides and their precursors from myocardial ischemia-reperfusion injury.

  Bioorganic & medicinal chemistry 20060815

• Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors.

  Bioorganic & medicinal chemistry letters 20060815

• Straightforward access to pyrazines, piperazinones, and quinoxalines by reactions of 1,2-diaza-1,3-butadienes with 1,2-diamines under solution, solvent-free, or solid-phase conditions.

  The Journal of organic chemistry 20060804

• The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells.

  Cell calcium 20060701

• In vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice.

  Antimicrobial agents and chemotherapy 20060701

• Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 1. Synthesis and SAR of alpha,alpha-dimethylglycine sulfonamides.

  Journal of medicinal chemistry 20060615

• Axial coordination changes the morphology of porphyrin assemblies in an organogel system.

  Organic & biomolecular chemistry 20060521

• Singular value decomposition of torsional angles of analogs of the dopamine reuptake inhibitor GBR 12909.

  Journal of computational chemistry 20060415

• Determination of piperazine in pharmaceutical drug substances using capillary electrophoresis with indirect UV detection.

  Journal of chromatography. A 20060331

• Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials.

  Bioorganic & medicinal chemistry letters 20060315

• Role of excited state intramolecular charge transfer in the photophysical properties of norfloxacin and its derivatives.

  The journal of physical chemistry. A 20060302

• Enhanced FTase activity achieved via piperazine interaction with catalytic zinc.

  Bioorganic & medicinal chemistry letters 20060215

• Coordination frameworks constructed from bipyridyl piperazine and MCl2 (M = Co, Ni, Zn): structural characterization and optical properties.

  Dalton transactions (Cambridge, England : 2003) 20060214

• In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors.

  Bioorganic & medicinal chemistry letters 20060201

• DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer.

  Bioorganic & medicinal chemistry 20060115

• Clinically useful vanilloid receptor TRPV1 antagonists: just around the corner (or too early to tell)?

  Progress in medicinal chemistry 20060101

• New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20060101

• Synthesis of some n-substituted derivatives of 1-(1h-pyrrole-1 -ylmethyl)- 10-oxa-4-azatricyclo [5.2.1.0(2,6)]dec-8-ene-3,5-dione with an expected anxiolytic activity.

  Acta poloniae pharmaceutica 20060101

• Researching the toxicity of party pills.

  Nursing New Zealand (Wellington, N.Z. : 1995) 20051201

• Privileged structure based ligands for melanocortin receptors--substituted benzylic piperazine derivatives.

  Bioorganic & medicinal chemistry letters 20051115

• Benzyl ether structure-activity relationships in a series of ketopiperazine-based renin inhibitors.

  Bioorganic & medicinal chemistry letters 20051101

• Chiral separation and CD characterisation of enantiomeric cyclotriphosphazene derivatives.

  Chirality 20051001

• A facile synthesis of novel herbicidal 1-phenyl-piperazine-2,6-diones.

  Molecules (Basel, Switzerland) 20050930

• Design, synthesis, and biological testing of thiosalicylamides as a novel class of calcium channel blockers.

  Bioorganic & medicinal chemistry 20050701

• Effect of heterocyclic based organoclays on the properties of polyimide-clay nanocomposites.

  Journal of nanoscience and nanotechnology 20050701

• Reciprocal mutations in TM2/TM3 in a D2 dopamine receptor background confirms the importance of this microdomain as a selective determinant of para-halogenated 1,4-disubstituted aromatic piperazines.

  Archiv der Pharmazie 20050601

• Novel fluoroquinolones: design, synthesis, and in vivo activity in mice against Mycobacterium tuberculosis H37Rv.

  Bioorganic & medicinal chemistry letters 20050401

• Water soluble cationic trans-platinum complexes which induce programmed cell death in the protozoan parasite Leishmania infantum.

  Journal of inorganic biochemistry 20050301

• Simultaneous separation of different types of amphetamine and piperazine designer drugs by capillary electrophoresis with a chiral selector.

  Journal of forensic sciences 20050301

• Cyp2D6 catalyzes 5-hydroxylation of 1-(2-pyrimidinyl)-piperazine, an active metabolite of several psychoactive drugs, in human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20050201

• NMR study on (+/-)-1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine dihydrochloride salt.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050201

• IR, MS studies on (+/-)-1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine dihydrochloride salt.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050201

• Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines.

  Bioorganic & medicinal chemistry letters 20050201

• Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.

  Bioorganic & medicinal chemistry letters 20050117

• Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.

  Bioorganic & medicinal chemistry 20050103

• Characterization of inward-rectifier K+ channel inhibition by antiarrhythmic piperazine.

  Biochemistry 20041214

• The histamine H4 receptor and potential therapeutic uses for H4 ligands.

  Mini reviews in medicinal chemistry 20041101

• Effects of 'Legal X' piperazine analogs on dopamine and serotonin release in rat brain.

  Annals of the New York Academy of Sciences 20041001

• Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.

  Journal of medicinal chemistry 20040909

• Anti-angiogenic and anti-tumor apoptotic activities of SJ-8002, a new piperazine derivative.

  International journal of oncology 20040801

• Effect of temperature on the chromatographic retention of ionizable compounds. I. Methanol-water mobile phases.

  Journal of chromatography. A 20040709

• A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.

  The Journal of biological chemistry 20040618

• Chiral, nonracemic (piperazin-2-yl)methanol derivatives with sigma-receptor affinity.

  Bioorganic & medicinal chemistry 20040615

• Infection with pinworms (Syphacia obvelata) does not affect the plasma corticosterone concentration in male, nonpregnant female, and pregnant female rats.

  Contemporary topics in laboratory animal science 20040501

• [Ion-exchange chromatographic behavior and characterization of Staphylococcus aureus in exponential phase].

  Se pu = Chinese journal of chromatography 20040501

• New designer drug 1-(3,4-methylenedioxybenzyl) piperazine (MDBP): studies on its metabolism and toxicological detection in rat urine using gas chromatography/mass spectrometry.

  Journal of mass spectrometry : JMS 20040301

• The influence of the boat-to-chair conversion on the demetallation of the nickel(II) complex of an open-chain tetramine containing a piperazine fragment.

  Dalton transactions (Cambridge, England : 2003) 20040221

• Electrospray mass spectrometry of a series of mixed nitrido 99gTc- heterocomplexes conjugated with bioactive molecules.

  European journal of mass spectrometry (Chichester, England) 20040101

• Direct activation by dopamine of recombinant human 5-HT1A receptors: comparison with human 5-HT2C and 5-HT3 receptors.

  Synapse (New York, N.Y.) 20031215

• Array synthesis of novel lipodepsipeptide.

  Bioorganic & medicinal chemistry letters 20031201

• Massive gastrointestinal bleeding in infants with ascariasis.

  Journal of pediatric surgery 20031101

• Formation of p-cresol:piperazine complex in solution monitored by spin-lattice relaxation times and pulsed field gradient NMR diffusion measurements.

  Journal of magnetic resonance (San Diego, Calif. : 1997) 20031001

• An action plan to prevent and combat threadworm infection.

  Nursing times 20031001

• Influence of pH on electrophoretic behavior of phenothiazines and determination of pKa values by capillary zone electrophoresis.

  Electrophoresis 20030901

• Synthesis and in vitro antibacterial evaluation of N-[5-(5-nitro-2-thienyl)-1,3,4-thiadiazole-2-yl] piperazinyl quinolones.

  European journal of medicinal chemistry 20030901

• [Antithrombotic effects of morpholine and piperazine ring derivatives and their molecular mechanism].

  Yao xue xue bao = Acta pharmaceutica Sinica 20030901

• Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety.

  Behavioural brain research 20030318

• Ligand effects on the binding of cis- and trans-[PtCl(2)Am(1)Am(2)] to proteins.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030101

• Structure-activity relationship studies: M2 and CCR5 receptor antagonists.

  Current topics in medicinal chemistry 20030101

• The formation of paracetamol (acetaminophen) adducts with hydrogen-bond acceptors.

  Acta crystallographica. Section B, Structural science 20021201

• A modified synthesis of iodoazidoaryl prazosin.

  The Journal of organic chemistry 20021115

• Unusual cerebellar ataxia: 'worm wobble' revisited.

  Archives of disease in childhood 20021001

• Natural abundance nitrogen-15 nuclear magnetic resonance spectral studies on selected donors.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20021001

• Synthesis and structure-activity relationships of neuromuscular blocking agents.

  Current medicinal chemistry 20020801

• A novel series of hybrid compounds derived by combining 2-aminotetralin and piperazine fragments: binding activity at D2 and D3 receptors.

  Bioorganic & medicinal chemistry letters 20020225

• Functional group interactions of a 5-HT3R antagonist.

  BMC biochemistry 20020101

• Biliary ascariasis.

  Indian journal of pediatrics 20011201

• Intracellular signaling pathway of FGF-2-modulated corneal endothelial cell migration during wound healing in vitro.

  Experimental eye research 20011101

• Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors.

  Bioorganic & medicinal chemistry letters 20010903

• Significance of ligand tails for interaction with the minor groove of B-DNA.

  Biophysical journal 20010901

• Chemistry of the diazeniumdiolates. 2. Kinetics and mechanism of dissociation to nitric oxide in aqueous solution.

  Journal of the American Chemical Society 20010613