1420-04-8 | 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compound with 2-aminoethanol (1:1)

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$26.00	$18.00
25g	98%	in stock	$34.00	$24.00
50g	95%	in stock	$50.00	$35.00
100g	98%	in stock	$74.00	$52.00
250g	95%	in stock	$92.00	$64.00

Description

• Catalog Number: AI34789
• Chemical Name: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compound with 2-aminoethanol (1:1)
• CAS Number: 1420-04-8
• Molecular Formula: C15H15Cl2N3O5
• Molecular Weight: 388.2027
• MDL Number: MFCD01941566
• SMILES: Clc1ccc(c(c1)C(=O)Nc1ccc(cc1Cl)[N+](=O)[O-])O.NCCO

Computed Properties

• Complexity: 414
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 3

Literature

• Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.

  Nature medicine 20161001

• The anthelmintic niclosamide inhibits colorectal cancer cell lines via modulation of the canonical and noncanonical Wnt signaling pathway.

  The Journal of surgical research 20160601

• Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling.

  The Biochemical journal 20160501

• Niclosamide suppresses RANKL-induced osteoclastogenesis and prevents LPS-induced bone loss.

  Biochemical and biophysical research communications 20160205

• Niclosamide inhibits epithelial-mesenchymal transition and tumor growth in lapatinib-resistant human epidermal growth factor receptor 2-positive breast cancer.

  The international journal of biochemistry & cell biology 20160201

• Niclosamide induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.

  International immunopharmacology 20160201

• Niclosamide induced cell apoptosis via upregulation of ATF3 and activation of PERK in Hepatocellular carcinoma cells.

  BMC gastroenterology 20160101

• Discovery of Small-Molecule Modulators of the Human Y4 Receptor.

  PloS one 20160101

• A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20160101

• Altered Gene Expression in the Schistosome-Transmitting Snail Biomphalaria glabrata following Exposure to Niclosamide, the Active Ingredient in the Widely Used Molluscicide Bayluscide.

  PLoS neglected tropical diseases 20151001

• Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition.

  The Prostate 20150901

• Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes.

  Biochemical and biophysical research communications 20150814

• Controlled delivery of bPEI-niclosamide complexes by PEO nanofibers and evaluation of its anti-neoplastic potentials.

  Colloids and surfaces. B, Biointerfaces 20150701

• Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.

  Neoplasia (New York, N.Y.) 20150701

• WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.

  Oncogene 20150601

• Niclosamide inhibits the proliferation of human osteosarcoma cell lines by inducing apoptosis and cell cycle arrest.

  Oncology reports 20150401

• Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancer.

  Gynecologic oncology 20140701

• Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20140615

• Niclosamide enhances ROS-mediated cell death through c-Jun activation.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20140601

• Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth.

  Fertility and sterility 20140501

• Effect of niclosamide on basal-like breast cancers.

  Molecular cancer therapeutics 20140401

• Antihelminthic niclosamide modulates dendritic cells activation and function.

  Cellular immunology 20140101

• Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer.

  Molecular cancer therapeutics 20131001

• Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells.

  Cellular signalling 20130401

• Drug screening identifies niclosamide as an inhibitor of breast cancer stem-like cells.

  PloS one 20130101

• Growth inhibition of ovarian tumor-initiating cells by niclosamide.

  Molecular cancer therapeutics 20120801

• [Effect of niclosamide spreading oil on killing schistosome cercariae].

  Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20120601

• Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.

  The Journal of biological chemistry 20120518

• Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells.

  Chinese journal of cancer 20120401

• Detection of Taenia solium taeniasis coproantigen is an early indicator of treatment failure for taeniasis.

  Clinical and vaccine immunology : CVI 20120401

• Education and Imaging. Gastrointestinal: An unexpected cause of refractory iron deficiency anemia; Taenia SPP. on capsule endoscopy.

  Journal of gastroenterology and hepatology 20120401

• [Effect of snail control of niclosamide by soil mixing and spraying methods in high dam of terrace].

  Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20120401

• Effects of Bayluscide on Bithynia siamensis goniomphalos, the first intermediate host of the human liver fluke, Opisthorchis viverrini, in laboratory and field trials.

  Parasitology international 20120301

• [Studies on standardization of methods for screening molluscicides in laboratory IV sensitivity of Oncomelania snails from different months to niclosamide].

  Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20120201

• Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress.

  British journal of cancer 20120103

• [Snail control effect of film covering method in fish ponds and ditches].

  Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20111201

• [Determination of niclosamide ethanolamine residue in rice and paddy field by high performance liquid chromatography].

  Se pu = Chinese journal of chromatography 20111101

• [Studies on spray of niclosamide ethanolamine salt. I. development and effect assessment of spray of niclosamide ethanolamine salt].

  Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20111001

• Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death.

  BMB reports 20110801

• [Molluscicidal effect of LDS in mountainous areas of Yunnan Province].

  Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110801

• Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer.

  Journal of the National Cancer Institute 20110706

• Niclosamide: an established antihelminthic drug as a potential therapy against S100A4-mediated metastatic colon tumors.

  Journal of the National Cancer Institute 20110706

• Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.

  Cancer research 20110615

• [Molluscicidal effect of film on ditches in mountainous schistosomiasis endemic regions].

  Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110401

• [Study on preservation of niclosamide in water samples].

  Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110401

• [Surveillance and forecast system of schistosomiasis in Jiangsu Province. IV. Establishment of Schistosoma japonicum cercaria-killing method by spraying niclosamide suspension on water surface].

  Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110201

• [Toxicity of niclosamide with plastic film mulching to fish].

  Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110201

• [Evaluation on molluscicidal effect of suspension concentrate of metaldehyde and niclosamide].

  Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control 20110201

• [Preparation of the compound MCT-01 and its antihymenolepidiasis activity].

  Meditsinskaia parazitologiia i parazitarnye bolezni 20110101

• [The antihymenolepidiasis activity of MCT-31: preparation and study].

  Meditsinskaia parazitologiia i parazitarnye bolezni 20110101

• A strategy for emergency treatment of Schistosoma japonicum-infested water.

  Parasites & vectors 20110101

• Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway.

  PloS one 20110101

• [The preparation of antihymenolepidiasis activity of MCT-44].

  Meditsinskaia parazitologiia i parazitarnye bolezni 20110101

• Comparative toxicity of Euphorbia milii latex and synthetic molluscicides to Biomphalaria glabrata embryos.

  Chemosphere 20100901

• Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.

  American journal of physiology. Gastrointestinal and liver physiology 20100801

• A human case of Hymenolepis diminuta in a child from eastern Sicily.

  The Korean journal of parasitology 20100601

• Human taeniasis in western Romania and its relationship to multicultural food habits and influences.

  Foodborne pathogens and disease 20100501

• Toxicity of a novel suspension concentrate of niclosamide against Biomphalaria glabrata.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20100401

• Human infection with Bertiella studeri (Cestode: Anoplocephalidae) in an Egyptian worker returning back from Saudi Arabia.

  Journal of the Egyptian Society of Parasitology 20100401

• Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species.

  Cancer research 20100315

• Cyanolide A, a glycosidic macrolide with potent Molluscicidal activity from the Papua New Guinea cyanobacterium Lyngbya bouillonii.

  Journal of natural products 20100226

• Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition.

  PloS one 20100101

• The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

  Biochemistry 20091103

• Halogenated pesticide transformation by a laccase-mediator system.

  Chemosphere 20091001

• Neurocysticercosis in the infant of a pregnant mother with a tapeworm.

  The American journal of tropical medicine and hygiene 20090901

• A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.

  Journal of lipid research 20090801

• Diphyllobothrium latum identified by capsule endoscopy--an unusual cause of iron-deficiency anemia.

  Journal of gastrointestinal and liver diseases : JGLD 20090601

• [Molluscicidal effect and toxicity of META-Li on Oncomelania snails in the mountain area].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20090601

• The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells.

  Journal of cellular biochemistry 20090301

• Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

  PloS one 20090101

• Potential of some monoterpenoids and their new N-methyl carbamate derivatives against Schistosomiasis snail vector, Biomphalaria alexandrina.

  Ecotoxicology and environmental safety 20081101

• Efficacy of temperature, and two commonly used molluscicides and fertilizers on Fasciola gigantica eggs.

  Journal of the Egyptian Society of Parasitology 20080801

• [Snail control by using soil pasting mixed with niclosamide].

  Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20080801

• A novel molluscicidal formulation of niclosamide.

  Parasitology research 20080701

• In vitro trypanocidal activity of the anti-helminthic drug niclosamide.

  Experimental parasitology 20080401

• [Human infection due to Bertiella sp (cestode: Anoplocephalidae) in a man originating from Yemen in Algeria].

  Bulletin de la Societe de pathologie exotique (1990) 20080401

• Effect of niclosamide on the tegumental surface of Haplorchis taichui using scanning electron microscopy.

  Journal of helminthology 20071201

• [Study on molluscicidal effect of chlorosalicylicamide].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20071001

• Community acceptability of the use of low-dose niclosamide (Bayluscide), as a molluscicide in the control of human schistosomiasis in Sahelian Cameroon.

  Annals of tropical medicine and parasitology 20070901

• A studies on chemical control of S. mansoni intermediate host.

  Pakistan journal of biological sciences : PJBS 20070801

• Cream formulations protecting against cercarial dermatitis by Trichobilharzia.

  Parasitology research 20070601

• Synthesis of furo-salicylanilides and their heterocyclic derivatives with anticipated molluscicidal activity.

  Archiv der Pharmazie 20060801

• [A study on the effect of Oncomelania hupensis hupensiss killed with niclosamide in China].

  Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 20060801

• [Synergic effects of synthesis arecoline in combination with snail-killing drugs niclosamide].

  Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20060701

• Field trials of low dose Bayluscide on snail hosts of schistosome and selected non-target organisms in sahelian Cameroon.

  Memorias do Instituto Oswaldo Cruz 20060601

• Role of chemotherapy of taeniasis in prevention of neurocysticercosis.

  Parasitology international 20060101

• [Cleaning and molluscicide treatment for schistosomiasis control].

  Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 20060101

• [Case report: taeniasis, is it a cause of psychiatric and neural symptoms?].

  Turkiye parazitolojii dergisi 20060101

• Impact of certain plants and synthetic molluscicides on some fresh water snails and fish.

  Journal of the Egyptian Society of Parasitology 20051201

• Comparison of the aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins.

  International journal of pharmaceutics 20051104

• Taeniasis and cysticercosis in housemaids working in affluent neighborhoods in Lima, Peru.

  The American journal of tropical medicine and hygiene 20050901

• Residues of the lampricides 3-trifluoromethyl-4-nitrophenol and niclosamide in muscle tissue of rainbow trout.

  Journal of agricultural and food chemistry 20050629

• Transport of Schistosoma japonicum cercariae and the feasibility of niclosamide for cercariae control.

  Parasitology international 20050301

• Effect of 4-sulphonato-calix[n]arenes and cyclodextrins on the solubilization of niclosamide, a poorly water soluble anthelmintic.

  The AAPS journal 20050301

• [Treatment of intestinal helminthiasis with albendazole].

  Meditsinskaia parazitologiia i parazitarnye bolezni 20050101

• Metabolism of niclosamide in sediment and water systems.

  Journal of agricultural and food chemistry 20040922

• Human Monieziasis expansa: the first Egyptian parastic zoonosis.

  Journal of the Egyptian Society of Parasitology 20040801

• The Hymenolepis diminuta-golden hamster (Mesocricetus auratus) model for the evaluation of gastrointestinal anticestode activity.

  The Journal of parasitology 20040801

• Case of megaloblastic anemia caused by intestinal taeniasis.

  Annals of hematology 20040701

• Comparison of the physical and chemical stability of niclosamide crystal forms in aqueous versus nonaqueous suspensions.

  Drug development and industrial pharmacy 20040701

• Physical transformation of niclosamide solvates in pharmaceutical suspensions determined by DSC and TG analysis.

  Die Pharmazie 20040701

• Bertiella studeri infection: resistance to niclosamide.

  The Ceylon medical journal 20040601

• Old drugs as lead compounds for a new disease? Binding analysis of SARS coronavirus main proteinase with HIV, psychotic and parasite drugs.

  Bioorganic & medicinal chemistry 20040515

• Purging the worm: management of Taenia solium taeniasis.

  Lancet (London, England) 20040320

• Species identification after treatment for human taeniasis.

  Lancet (London, England) 20040320

• Preparation and physicochemical characterization of 5 niclosamide solvates and 1 hemisolvate.

  AAPS PharmSciTech 20040301

• Influence of moisture on the crystal forms of niclosamide obtained from acetone and ethyl acetate.

  AAPS PharmSciTech 20040301

• Molluscicidal effect of nicotinanilide and its intermediate compounds against a freshwater snail Lymnaea luteola, the vector of animal schistosomiasis.

  Memorias do Instituto Oswaldo Cruz 20040301

• Aqueous photolysis of niclosamide.

  Journal of agricultural and food chemistry 20040225

• Polymeric controlled release formulations of niclosamide for control of Biomphalaria alexandrina, the vector snail of schistosomiasis.

  Macromolecular bioscience 20040220

• Preparation and physicochemical properties of niclosamide anhydrate and two monohydrates.

  International journal of pharmaceutics 20040128

• [Efficacy of the Russian anthelmintic agent trichlorophen].

  Meditsinskaia parazitologiia i parazitarnye bolezni 20040101

• Measures for the prevention and control of Taenia solium taeniosis and cysticercosis.

  Acta tropica 20030601

• The first human infection with Bertiella studeri in Vietnam.

  The Southeast Asian journal of tropical medicine and public health 20030601

• [Preliminary test of the effect of niclosamide-impregnated tissue for the prevention of Schistosoma japonicum infection].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20030101

• Effects of fertilizer and soil components on pesticide photolysis.

  Journal of agricultural and food chemistry 20021204

• Detection of the damage caused to DNA by niclosamide using an electrochemical DNA-biosensor.

  Biosensors & bioelectronics 20021201

• Rapid loss of lampricide from catfish and rainbow trout following routine treatment.

  Journal of agricultural and food chemistry 20021106

• Per oral removal of tapeworm following vomiting after surgery.

  Anesthesia and analgesia 20021001

• The molluscicidal activity of niclosamide (Bayluscide WP70(R)) on Melanoides tuberculata (Thiaridae), a snail associated with habitats of Biomphalaria glabrata (Planorbidae).

  Memorias do Instituto Oswaldo Cruz 20020701

• Effect of soil moisture and sample depth on pesticide photolysis.

  Journal of agricultural and food chemistry 20020424

• Voltammetric determination of niclosamide at a glassy carbon electrode.

  The Analyst 20020101

• [Sensitivity of Oncomelania snail to niclosamide in China].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20020101

• Meckel's diverticulitis due to Taenia saginata: case report.

  East African medical journal 20010201

• [Parasitologic finding in a Saharan girl].

  Enfermedades infecciosas y microbiologia clinica 20010101

• Biochemical and metabolic peculiarities of some parasites availing as targets for therapy.

  Le Journal medical libanais. The Lebanese medical journal 20010101

• [Climbing-upward inhibition of Oncomelania hupensis by niclosamide combination].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20010101