1436-43-7 | 2-Quinolinecarbonitrile

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$18.00	$12.00
250mg	97%	in stock	$22.00	$15.00
1g	97%	in stock	$32.00	$22.00
5g	97%	in stock	$50.00	$35.00
10g	97%	in stock	$95.00	$67.00
25g	97%	in stock	$234.00	$164.00

Description

• Catalog Number: AB78778
• Chemical Name: 2-Quinolinecarbonitrile
• CAS Number: 1436-43-7
• Molecular Formula: C10H6N2
• Molecular Weight: 154.168
• MDL Number: MFCD00134341
• SMILES: N#Cc1ccc2c(n1)cccc2

Computed Properties

• Complexity: 203
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 1.6

Literature

• Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein.

  Journal of medicinal chemistry 20120209

• Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis.

  Molecular pharmacology 20111001

• 2-Cyano-quinolin-1-ium hydrogen sulfate.

  Acta crystallographica. Section E, Structure reports online 20101101

• 2-Cyano-quinolin-1-ium nitrate.

  Acta crystallographica. Section E, Structure reports online 20101101

• Quinoline-2-carbonitrile-fumaric acid (1/0.5).

  Acta crystallographica. Section E, Structure reports online 20100901

• Quinoline-2-carbonitrile.

  Acta crystallographica. Section E, Structure reports online 20100901

• 3D-QSAR study of c-Src kinase inhibitors based on docking.

  Journal of molecular modeling 20100201

• Preparation of heteroaryloxetanes and heteroarylazetidines by use of a Minisci reaction.

  The Journal of organic chemistry 20090821

• Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways.

  Purinergic signalling 20090301

• Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.

  Bioorganic & medicinal chemistry letters 20090101

• Enzyme kinetics and binding studies on inhibitors of MEK protein kinase.

  Biochemistry 20080429

• 3D-QSAR studies on c-Src kinase inhibitors and docking analyses of a potent dual kinase inhibitor of c-Src and c-Abl kinases.

  Bioorganic & medicinal chemistry 20050801

• Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase.

  Molecular cancer therapeutics 20040601

• Cleavage of carbon-carbon bonds in aromatic nitriles using nickel(0).

  Journal of the American Chemical Society 20020814