144-83-2 | 4-amino-N-(pyridin-2-yl)benzene-1-sulfonamide

Packsize	Purity	Availability	Price	Discounted Price
1mg	98+%	in stock	$6.00	$4.00
5g	98+%	in stock	$10.00	$7.00
25g	98+%	in stock	$12.00	$9.00

Description

• Catalog Number: AD71755
• Chemical Name: 4-amino-N-(pyridin-2-yl)benzene-1-sulfonamide
• CAS Number: 144-83-2
• Molecular Formula: C11H11N3O2S
• Molecular Weight: 249.2889
• MDL Number: MFCD00038036
• SMILES: Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1

Computed Properties

• Complexity: 331
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3

Literature

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  Ryumachi. [Rheumatism] 20030601

• Effect of food on gastrointestinal transit of liquids in cynomolgus monkeys.

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  Journal of clinical pharmacy and therapeutics 20021201

• Idiosyncratic NSAID drug induced oxidative stress.

  Chemico-biological interactions 20021110

• The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production.

  Experimental and molecular pathology 20021001

• Dissociated ROS production and ceramide generation in sulfasalazine-induced cell death in Raw 264.7 cells.

  Journal of leukocyte biology 20021001

• N-acetyltransferase 2 genotype-related sulfapyridine acetylation and its adverse events.

  Biological & pharmaceutical bulletin 20020801

• N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitis.

  The American journal of gastroenterology 20020701

• Regulation of human B cell function by sulfasalazine and its metabolites.

  International immunopharmacology 20020401

• Successful treatment of postoperative pyoderma gangrenosum with cyclosporin.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20020301

• Comparative absorption of 5-aminosalicylic acid (5-ASA) after administration of a 5-ASA enema and salazosulfapyridine (SASP) after an SASP suppository in Japanese volunteers.

  Biological & pharmaceutical bulletin 20020201

• Comparative tolerability of therapies for ulcerative colitis.

  Drug safety 20020101

• Role of mesalazine in acute and long-term treatment of ulcerative colitis and its complications.

  Scandinavian journal of gastroenterology. Supplement 20020101

• Bioavailability factors of isoniazid in fast and slow acetylators, healthy volunteers.

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• Quantitative determination of sulfonamide in meat by liquid chromatography-electrospray-mass spectrometry.

  Talanta 20011224

• Kinetic phenotypic diagnosis of N-acetylation polymorphism in patients based on ratio of urinary metabolites of salicylazosulfapyridine.

  International journal of pharmaceutics 20011023

• Review article: balsalazide therapy in ulcerative colitis.

  Alimentary pharmacology & therapeutics 20011001

• Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug.

  Leukemia 20011001

• Maturation of human dendritic cells as sulfasalazine target.

  Croatian medical journal 20010801

• Sulphasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, interleukin-12 production and major histocompatibility complex II expression.

  Immunology 20010801

• Small bowel motility and colonic transit are altered in dogs with moderate renal failure.

  American journal of physiology. Regulatory, integrative and comparative physiology 20010701

• Study of the behaviour, digestive efficiency and gut transit times of crib-biting horses.

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• Dapsone and sulfapyridine.

  Dermatologic clinics 20010101

• Is it Crohn's disease? A severe systemic granulomatous reaction to sulfasalazine in patient with rheumatoid arthritis.

  BMC gastroenterology 20010101

• Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine.

  Immunopharmacology and immunotoxicology 20000501

• Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts.

  The Journal of rheumatology 20000301

• [A case of drug induced urolithiasis composed of acetyl sulphapyridine associated with ulcerative colitis].

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• Effects of BX661A, a new therapeutic agent for ulcerative colitis, on reactive oxygen species in comparison with salazosulfapyridine and its metabolite sulfapyridine.

  Arzneimittel-Forschung 19981001

• Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.

  The Journal of clinical investigation 19980301

• Sulphasalazine in the treatment of rheumatoid arthritis.

  British journal of rheumatology 19970301

• Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.

  Annals of tropical medicine and parasitology 19961201

• Identification of a class of sulfonamides highly active against dihydropteroate synthase form Toxoplasma gondii, Pneumocystis carinii, and Mycobacterium avium.

  Antimicrobial agents and chemotherapy 19960301

• Inhibitory effects of sulfasalazine and its metabolites on histamine release and TNF-alpha production by mast cells.

  Journal of immunology (Baltimore, Md. : 1950) 19960101

• Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs.

  Antimicrobial agents and chemotherapy 19950801

• Modulation of cytokine release from human monocytes by drugs used in the therapy of inflammatory bowel diseases.

  European journal of gastroenterology & hepatology 19950801

• 5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells.

  The Journal of pharmacology and experimental therapeutics 19950101

• Bilateral acetylsulfapyridine nephrolithiasis associated with chronic sulfasalazine therapy.

  The Journal of urology 19940601

• Dapsone suppresses integrin-mediated neutrophil adherence function.

  The Journal of investigative dermatology 19920201

• Interaction of sulfonamide and sulfone compounds with Toxoplasma gondii dihydropteroate synthase.

  The Journal of clinical investigation 19900201

• Inhibition of stress-induced gastric ulcers by sulphasalazine and its constituents (sulphapyridine and 5-aminosalicylic acid) in rats.

  Pharmacology 19900101

• Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products.

  European journal of pharmacology 19891010

• Drugs as allergens: detection and combining site specificities of IgE antibodies to sulfamethoxazole.

  Molecular immunology 19881201

• Dapsone-induced peripheral neuropathy.

  International journal of dermatology 19860601

• Dapsone-induced motor polyneuropathy. A complication of prolonged treatment of subcorneal pustular dermatosis.

  Archives of dermatology 19760801