145202-66-0 | Rizatriptan Benzoate

Packsize	Purity	Availability	Price	Discounted Price
5mg	≥98%	in stock	$42.00	$29.00
10mg	≥98%	in stock	$79.00	$55.00
25mg	98%(HPLC)powder	in stock	$139.00	$97.00
50mg	>98.0%(T)(HPLC)	in stock	$176.00	$123.00
1g	97%	in stock	$249.00	$174.00

Description

• Catalog Number: AI36238
• Chemical Name: Rizatriptan Benzoate
• CAS Number: 145202-66-0
• Molecular Formula: C22H25N5O2
• Molecular Weight: 391.4662
• MDL Number: MFCD00866224
• SMILES: OC(=O)c1ccccc1.CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C
• NSC Number: 758919

Computed Properties

• Complexity: 412
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6

Literature

• Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

  Chemical research in toxicology 20150518

• Development and evaluation of tamarind seed xyloglucan-based mucoadhesive buccal films of rizatriptan benzoate.

  Carbohydrate polymers 20130116

• Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT(1B/D) agonist.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20121031

• Rizatriptan in migraineurs with unilateral cranial autonomic symptoms: a double-blind trial.

  The journal of headache and pain 20120701

• Efficacy and tolerability of rizatriptan in pediatric migraineurs: results from a randomized, double-blind, placebo-controlled trial using a novel adaptive enrichment design.

  Cephalalgia : an international journal of headache 20120701

• Implication of free cholesterol in LC-MS response enhancement.

  Bioanalysis 20120601

• Pharmacokinetics and tolerability of rizatriptan in pediatric migraineurs in a randomized study.

  Headache 20120401

• Rizatriptan for treatment of acute migraine in patients taking topiramate for migraine prophylaxis.

  Headache 20120101

• Sumatriptan (intranasal route of administration) for acute migraine attacks in adults.

  The Cochrane database of systematic reviews 20120101

• Efficacy of frovatriptan in the acute treatment of menstrually related migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, comparative study versus rizatriptan.

  The journal of headache and pain 20111201

• An approach for rapid development of nasal delivery of analgesics--identification of relevant features, in vitro screening and in vivo verification.

  International journal of pharmaceutics 20111125

• Types of colitis based on histology.

  Disease-a-month : DM 20110901

• Evolution of paediatric off-label use after new significant medicines become available for adults: a study on triptans in Finnish children 1994-2007.

  British journal of clinical pharmacology 20110601

• Efficacy and tolerability of rizatriptan for the treatment of acute migraine in sumatriptan non-responders.

  Cephalalgia : an international journal of headache 20110501

• Rizatriptan is effective for headache in a patient with meningeal carcinomatosis.

  Journal of pain and symptom management 20110501

• A double-blind, randomized, multicenter, Italian study of frovatriptan versus rizatriptan for the acute treatment of migraine.

  The journal of headache and pain 20110401

• Total migraine freedom, a potential primary endpoint to assess acute treatment in migraine: comparison to the current FDA requirement using the complete rizatriptan study database.

  Headache 20110301

• Rizatriptan reduces vestibular-induced motion sickness in migraineurs.

  The journal of headache and pain 20110201

• Nociceptive behaviors were induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats and reduced by morphine and rizatriptan benzoate.

  Brain research 20110112

• The Fos expression in rat brain following electrical stimulation of dura mater surrounding the superior sagittal sinus changed with the pre-treatment of rizatriptan benzoate.

  Brain research 20110107

• Long-term tolerability of telcagepant for acute treatment of migraine in a randomized trial.

  Headache 20110101

• Efficacy of parecoxib, sumatriptan, and rizatriptan in the treatment of acute migraine attacks.

  Clinical neuropharmacology 20110101

• Brain apparent water diffusion coefficient magnetic resonance image during a prolonged visual aura.

  Headache 20100601

• Arterial spin-labeled MRI study of migraine attacks treated with rizatriptan.

  The journal of headache and pain 20100601

• Efficacy and tolerability of rizatriptan 10 mg compared with sumatriptan 100 mg: an evidence-based analysis.

  Expert review of neurotherapeutics 20100401

• A study of triggers of migraine in India.

  Pain medicine (Malden, Mass.) 20100101

• Elevated saliva calcitonin gene-related peptide levels during acute migraine predict therapeutic response to rizatriptan.

  Headache 20091001

• Rizatriptan induced acute on top of chronic ischemic colitis.

  The American journal of gastroenterology 20091001

• A comparison of migraine patients with and without allodynic symptoms.

  The Clinical journal of pain 20091001

• Age effects on placebo response rates in clinical trials of acute agents for migraine: pooled analysis of rizatriptan trials in adults.

  Cephalalgia : an international journal of headache 20090701

• Migraine treatment with rizatriptan and almotriptan: a crossover study.

  Headache 20090501

• Rizatriptan 10-mg ODT for early treatment of migraine and impact of migraine education on treatment response.

  Headache 20090501

• [Utilizing the strength(s) of rizatriptan 10 mg: cost effective against migraine attacks].

  MMW Fortschritte der Medizin 20090326

• Impact of recent prior opioid use on rizatriptan efficacy. A post hoc pooled analysis.

  Headache 20090301

• 10 years of rizatriptan.

  Headache 20090201

• Ten years of rizatriptan: from development to clinical science and future directions.

  Headache 20090201

• Acute migraine treatment with rizatriptan in real world settings - focusing on treatment strategy, effectiveness, and behavior.

  Headache 20090201

• Identification, isolation and characterization of process-related impurities in Rizatriptan benzoate.

  Journal of pharmaceutical and biomedical analysis 20090115

• Identification of aquaporin 4 inhibitors using in vitro and in silico methods.

  Bioorganic & medicinal chemistry 20090101

• Alcohol and cluster headaches.

  Headache 20090101

• A pilot study of rizatriptan and visually-induced motion sickness in migraineurs.

  International journal of medical sciences 20090101

• Expanding access to triptans: assessment of clinical outcome.

  Headache 20090101

• Elastic liposomal formulation for sustained delivery of antimigraine drug: in vitro characterization and biological evaluation.

  Drug development and industrial pharmacy 20081001

• A randomized double-blind study comparing rizatriptan, dexamethasone, and the combination of both in the acute treatment of menstrually related migraine.

  Headache 20081001

• Rizatriptan efficacy in ICHD-II pure menstrual migraine and menstrually related migraine.

  Headache 20080901

• Effects of rizatriptan on the contingent negative variation in healthy women.

  Cephalalgia : an international journal of headache 20080901

• Efficacy and tolerability of coadministration of rizatriptan and acetaminophen vs rizatriptan or acetaminophen alone for acute migraine treatment.

  Headache 20080601

• Acute treatment and prevention of menstrually related migraine headache: evidence-based review.

  Neurology 20080422

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  Ugeskrift for laeger 20080317

• Traditional acupuncture in migraine: a controlled, randomized study.

  Headache 20080301

• Elimination of migraine-associated nausea in patients treated with rizatriptan orally disintegrating tablet (ODT): a randomized, double-blind, placebo-controlled study.

  Headache 20080301

• Efficacy of rizatriptan for menstrual migraine in an early intervention model: a prospective subgroup analysis of the rizatriptan TAME (Treat A Migraine Early) studies.

  Headache 20080201

• Acute treatment of paediatric migraine: a meta-analysis of efficacy.

  Journal of paediatrics and child health 20080101

• Symptoms of cutaneous sensitivity pre-treatment and post-treatment: results from the rizatriptan TAME studies.

  Cephalalgia : an international journal of headache 20070901

• Times to pain relief and pain freedom with rizatriptan 10 mg and other oral triptans.

  International journal of clinical practice 20070701

• Uptake and biodistribution of rizatriptan to blood and brain following different routes of administration in rats.

  International journal of pharmaceutics 20070607

• Association study between clinical response to rizatriptan and some candidate genes.

  The journal of headache and pain 20070601

• Rizatriptan vs. ibuprofen in migraine: a randomised placebo-controlled trial.

  The journal of headache and pain 20070601

• Glutamate levels in cerebrospinal fluid and triptans overuse in chronic migraine.

  Headache 20070601

• [Bonus-malus regulations in the framework of the AVWG guideline-suitable migraine therapy are possible].

  MMW Fortschritte der Medizin 20070521

• Rizatriptan for the acute treatment of ICHD-II proposed menstrual migraine: two prospective, randomized, placebo-controlled, double-blind studies.

  Cephalalgia : an international journal of headache 20070501

• Investigation of low levels of plasma valproic acid concentration following simultaneous administration of sodium valproate and rizatriptan benzoate.

  The Journal of pharmacy and pharmacology 20070301

• Comment on eletriptan in migraine patients reporting unsatisfactory response to rizatriptan.

  Headache 20070301

• Patient preference in migraine therapy. A randomized, open-label, crossover clinical trial of acute treatment of migraine with oral almotriptan and rizatriptan.

  Journal of neurology 20070201

• Simultaneous determination of amiloride and hydrochlorothiazide in human plasma by liquid chromatography/tandem mass spectrometry with positive/negative ion-switching electrospray ionisation.

  Rapid communications in mass spectrometry : RCM 20070101

• Influence of an e-mail with a drug information attachment on sales of prescribed drugs: a randomized controlled study.

  BMC clinical pharmacology 20070101

• Development and validation of a selective and robust LC-MS/MS method for high-throughput quantifying rizatriptan in small plasma samples: application to a clinical pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061205

• A pharmacoeconomic evaluation of oral triptans in the treatment of migraine in Italy.

  Minerva medica 20061201

• Transient ischemic attack after rizatriptan administration in a liver transplant recipient: a case report.

  Transplantation proceedings 20061101

• Increasing the effect of triptans in migraine.

  Lancet (London, England) 20061014

• A randomized trial of rizatriptan in migraine attacks in children.

  Neurology 20061010

• Comparative sensitivity of stopwatch methodology and conventional pain assessment measures for detecting early response to triptans in migraine: results of a randomized, open-label pilot study.

  Clinical therapeutics 20060801

• Rizatriptan vs. rizatriptan plus trimebutine for the acute treatment of migraine: a double-blind, randomized, cross-over, placebo-controlled study.

  Cephalalgia : an international journal of headache 20060701

• Development and validation of a specific stability indicating high performance liquid chromatographic method for rizatriptan benzoate.

  Journal of pharmaceutical and biomedical analysis 20060616

• Efficacy of Rizatriptan 10 mg administered early in a migraine attack.

  Headache 20060601

• Time to pain freedom and onset of pain relief with rizatriptan 10 mg and prescription usual-care oral medications in the acute treatment of migraine headaches: a multicenter, prospective, open-label, two-attack, crossover study.

  Clinical therapeutics 20060601

• [Triptanes in the treatment of migraine. A review based on three Cochrane reviews].

  Ugeskrift for laeger 20060508

• Assessment of clinical, service, and cost outcomes of a conversion program of sumatriptan to rizatriptan ODT in primary care patients with migraine headaches.

  Journal of managed care pharmacy : JMCP 20060401

• Preference for rizatriptan 10-mg wafer vs. eletriptan 40-mg tablet for acute treatment of migraine.

  Cephalalgia : an international journal of headache 20060301

• Clinical-biochemical correlates of migraine attacks in rizatriptan responders and non-responders.

  Cephalalgia : an international journal of headache 20060301

• Company reference estimates for productivity loss due to migraine and productivity gains using rizatriptan 10 mg in Germany.

  International journal of clinical practice 20060301

• Pharmacokinetic profile of rizatriptan 10-mg tablet and 10-mg orally disintegrating tablet administered with or without water in healthy subjects: an open-label, randomized, single-dose, 3-period crossover study.

  Journal of clinical pharmacology 20060201

• Effects of 5-HT1B/1D receptor agonist rizatriptan on cerebral blood flow and blood volume in normal circulation.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20060101

• Determination of rizatriptan in human plasma by liquid chromatographic-eletrospray tandem mass spectrometry: application to a pharmacokinetic study.

  Biomedical chromatography : BMC 20060101

• Prevention of motion sickness with rizatriptan: a double-blind, placebo-controlled pilot study.

  Medical science monitor : international medical journal of experimental and clinical research 20060101

• [Medical treatment of migraine attacks in the child].

  Revue de l'infirmiere 20060101

• Renal infarction during the use of rizatriptan and zolmitriptan: two case reports.

  Clinical toxicology (Philadelphia, Pa.) 20060101

• Eletriptan in migraine patients reporting unsatisfactory response to rizatriptan.

  Headache 20060101

• Evaluation of disintegrating time of rapidly disintegrating tablets by a paddle method.

  Pharmaceutical development and technology 20060101

• Clinical efficacy of rizatriptan for patients with migraine: efficacy of drug therapy for migraine accompanied by tension headache-like symptoms, focusing on neck stiffness.

  The journal of headache and pain 20051201

• Rizatriptan 10-mg wafer versus usual nontriptan therapy for migraine: analysis of return to function and patient preference.

  Headache 20051001

• Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect.

  Clinical science (London, England : 1979) 20050901

• Exposure to rizatriptan during pregnancy: post-marketing experience up to 30 June 2004.

  Cephalalgia : an international journal of headache 20050901

• Rizatriptan in migraine.

  Expert review of neurotherapeutics 20050901

• Multiple attack study on the available triptans in Italy versus placebo.

  European journal of neurology 20050701

• Triptans for migraine therapy: a comparison based on number needed to treat and doses needed to treat.

  Journal of managed care pharmacy : JMCP 20050601

• The treatment of pediatric migraine.

  Pediatric annals 20050601

• Triptans induce vasoconstriction of human arteries and veins from the thoracic wall.

  Journal of cardiovascular pharmacology 20050501

• Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors.

  Pain 20050501

• Rizatriptan does not change cerebral blood flow velocity during migraine attacks.

  Brain research bulletin 20050430

• Correlation between lipophilicity and triptan outcomes.

  Headache 20050101

• Intranasal absorption of rizatriptan--in vivo pharmacokinetics and bioavailability study in humans.

  Die Pharmazie 20050101

• Cost-effectiveness analysis of rizatriptan and sumatriptan versus Cafergot in the acute treatment of migraine.

  CNS drugs 20050101

• Effects on productivity and quality of life of rizatriptan for acute migraine: a workplace study.

  Headache 20050101

• Evaluation of the bioequivalence and pharmacokinetics of two formulations of rizatriptan after single oral administration in healthy volunteers.

  Arzneimittel-Forschung 20050101

• An economic evaluation of rizatriptan in the treatment of migraine.

  PharmacoEconomics 20050101

• Rizatriptan: a pharmacoeconomic review of its use in the acute treatment of migraine.

  PharmacoEconomics 20050101

• [Migraine].

  Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20041201

• The impact of a worksite migraine intervention program on work productivity, productivity costs, and non-workplace impairment among Spanish postal service employees from an employer perspective.

  Current medical research and opinion 20041101

• Rizatriptan 5 mg for the acute treatment of migraine in adolescents: results from a double-blind, single-attack study and two open-label, multiple-attack studies.

  Headache 20041001

• Migraine treatment with rizatriptan and non-triptan usual care medications: a pharmacy-based study.

  Headache 20041001

• Evaluating triptan usage: a rebuttal.

  Headache 20041001

• TRIPSTAR: prioritizing oral triptan treatment attributes in migraine management.

  Acta neurologica Scandinavica 20040901

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  No to shinkei = Brain and nerve 20040901

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  No to shinkei = Brain and nerve 20040901

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  Lakartidningen 20040819

• Meta-analysis of oral triptans.

  Cephalalgia : an international journal of headache 20040801

• Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery.

  Naunyn-Schmiedeberg's archives of pharmacology 20040701

• Comparison of rizatriptan 5 mg and 10 mg tablets and sumatriptan 25 mg and 50 mg tablets.

  Cephalalgia : an international journal of headache 20040701

• Liquid chromatographic method for the determination of rizatriptan in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040605

• Migraine headache.

  Clinical evidence 20040601

• Fast onset medications through thermally generated aerosols.

  The Journal of pharmacology and experimental therapeutics 20040501

• [Rizatriptan (Maxalt), a new entity of triptan for migraine: pharmacology and therapeutic relevance].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040401

• A review of rizatriptan, a quick and consistent 5-HT1B/1D agonist for the acute treatment of migraine.

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• Evaluating triptan usage.

  Headache 20040201

• Naratriptan for the treatment of acute migraine: meta-analysis of randomised controlled trials.

  Pharmacoepidemiology and drug safety 20040201

• Neuronal expression and regulation of CGRP promoter activity following viral gene transfer into cultured trigeminal ganglia neurons.

  Brain research 20040130

• CNS effects of sumatriptan and rizatriptan.

  Cephalalgia : an international journal of headache 20040101

• Defeating migraine pain with triptans: a race against the development of cutaneous allodynia.

  Annals of neurology 20040101

• Productivity cost benefit to employers of treating migraine with rizatriptan: a specific worksite analysis and model.

  Journal of occupational and environmental medicine 20040101

• Early treatment of migraine with rizatriptan: a placebo-controlled study.

  Headache 20040101

• Rizatriptan versus rizatriptan plus rofecoxib versus rizatriptan plus tolfenamic acid in the acute treatment of migraine.

  BMC neurology 20040101

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  Krankenpflege Journal 20040101

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  Krankenpflege Journal 20040101

• Migraine headache.

  Clinical evidence 20031201

• [It impairs quality of life and work time. Migraine therapy should not be left to the patients!].

  MMW Fortschritte der Medizin 20031127

• An in vitro interethnic comparison of monoamine oxidase activities between Japanese and Caucasian livers using rizatriptan, a serotonin receptor 1B/1D agonist, as a model drug.

  British journal of clinical pharmacology 20031101

• Triptans for treatment of acute pediatric migraine: a systematic literature review.

  Pediatric neurology 20031101

• Patient-reported benefits of rizatriptan compared with usual non-triptan therapy for migraine in a primary care setting.

  International journal of clinical practice 20031101

• Cost-effectiveness of almotriptan and rizatriptan in the treatment of acute migraine.

  Clinical therapeutics 20031101

• Investigation of the effects of naratriptan, rizatriptan, and sumatriptan on jugular venous oxygen saturation in anesthetized pigs: implications for their mechanism of acute antimigraine action.

  The Journal of pharmacology and experimental therapeutics 20031001

• Rizatriptan RPD for severe migraine in the emergency department--a multicenter study.

  The Journal of emergency medicine 20031001

• Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein.

  Drug metabolism and disposition: the biological fate of chemicals 20030701

• Migraine treatment patterns and patient satisfaction with prior therapy: a substudy of a multicenter trial of rizatriptan effectiveness.

  Clinical therapeutics 20030701

• [Highly selective beginning. Associated symptoms and side effects in retrospect].

  MMW Fortschritte der Medizin 20030526

• Real-world experiences in migraine therapy with rizatriptan.

  Headache 20030301

• [New therapeutic recommendations for severe migraine. High beginning dosage rather than slow dosage increase].

  MMW Fortschritte der Medizin 20030130

• Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine.

  European neurology 20030101

• Almotriptan versus rizatriptan in patients with migraine in Spain.

  Headache 20030101

• Newer formulations of the triptans: advances in migraine management.

  Drugs 20030101

• Meta-analysis of oral triptan therapy for migraine: number needed to treat and relative cost to achieve relief within 2 hours.

  Journal of managed care pharmacy : JMCP 20030101

• Endothelium-dependent relaxant responses to selective 5-HT(1B/1D) receptor agonists in the isolated middle cerebral artery of the rat.

  Journal of vascular research 20030101

• [Suppressing effect of the serotonin 5HT1B/D receptor agonist rizatriptan on calcitonin gene-related peptide (CGRP) concentration in migraine attacks].

  Neurologia i neurochirurgia polska 20030101

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  Neurologia (Barcelona, Spain) 20021201

• [New onset headache. Which patients should be sent for CT imaging?].

  MMW Fortschritte der Medizin 20021024

• Sum of Pain Intensity Differences (SPID) in migraine trials. A comment based on four rizatriptan trials.

  Cephalalgia : an international journal of headache 20021001

• Determinants of migraine-specific quality of life.

  Cephalalgia : an international journal of headache 20021001

• Further evaluation of rizatriptan in menstrual migraine: retrospective analysis of long-term data.

  Headache 20021001

• Comparison of rizatriptan and other triptans on stringent measures of efficacy.

  Neurology 20020910

• Comparison of rizatriptan and other triptans on stringent measures of efficacy.

  Neurology 20020910

• Rizatriptan 5mg is not efficacious for migraine in adolescents.

  Headache 20020901

• The effect of rizatriptan, ergotamine, and their combination on human peripheral arteries: a double-blind, placebo-controlled, crossover study in normal subjects.

  British journal of clinical pharmacology 20020701

• Mechanisms of action of the 5-HT1B/1D receptor agonists.

  Archives of neurology 20020701

• [New meta-analysis of triptanes. Concrete help, so the choice doesn't become overwhelming].

  MMW Fortschritte der Medizin 20020506

• [Good ruler for assessing effectiveness. Pain free with only one tablet].

  MMW Fortschritte der Medizin 20020506

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  MMW Fortschritte der Medizin 20020506

• CNS effects of sumatriptan and rizatriptan in healthy female volunteers.

  Cephalalgia : an international journal of headache 20020501

• Rizatriptan combined with rofecoxib vs. rizatriptan for the acute treatment of migraine: an open label pilot study.

  Cephalalgia : an international journal of headache 20020501

• Comparison of triptan tablet consumption per attack: a prospective study of migraineurs in Spain.

  Headache 20020201

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  Ideggyogyaszati szemle 20020120

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  Headache 20020101

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  Headache 20020101

• Rizatriptan: an update of its use in the management of migraine.

  Drugs 20020101

• Spotlight on rizatriptan in migraine.

  CNS drugs 20020101

• Restoring migraine sufferers' ability to function normally: a comparison of rizatriptan and other triptans in randomized trials.

  European neurology 20020101

• [Therapy of an acute migraine attack. Uniform patient vote for rizatriptan].

  MMW Fortschritte der Medizin 20011122

• Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials.

  Lancet (London, England) 20011117

• Clinical features of withdrawal headache following overuse of triptans and other headache drugs.

  Neurology 20011113

• Cluster headache without autonomic symptoms?

  Cephalalgia : an international journal of headache 20011101

• Evidence-based migraine therapy.

  Cephalalgia : an international journal of headache 20011101

• Comparison of rizatriptan and other triptans on stringent measures of efficacy.

  Neurology 20011023

• Pharmacokinetics of rizatriptan in healthy elderly subjects.

  International journal of clinical pharmacology and therapeutics 20011001

• Patient satisfaction with rizatriptan versus other triptans: direct head-to-head comparisons.

  International journal of clinical practice 20011001

• Migraine MLT-down: an unusual presentation of migraine in patients with aspartame-triggered headaches.

  Headache 20011001

• Triptans are all different.

  Archives of neurology 20010901

• What matters is not the differences between triptans, but the differences between patients.

  Archives of neurology 20010901

• Preference comparison of rizatriptan ODT 10-mg and sumatriptan 50-mg tablet in migraine.

  Headache 20010901

• Effect of rizatriptan and other triptans on the nausea symptom of migraine: a post hoc analysis.

  Headache 20010901

• A comparison of visual analog scale and categorical ratings of headache pain in a randomized controlled clinical trial with migraine patients.

  Pain 20010801

• The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs.

  British journal of pharmacology 20010801

• Establishing a standard of speed for assessing the efficacy of the serotonin(1B/1D) agonists (triptans).

  Archives of neurology 20010701

• Influence of beta-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HT1B/1D agonist: differential effects of propranolol, nadolol and metoprolol.

  British journal of clinical pharmacology 20010701

• Effect of rizatriptan in the spectrum of headache.

  Headache 20010601

• Migraine treatment outcomes with rizatriptan in triptan-naive patients: a naturalistic study.

  Clinical therapeutics 20010601

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  MedGenMed : Medscape general medicine 20010601

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  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20010410

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  Headache 20010301

• Meta-analysis of rizatriptan efficacy in randomized controlled clinical trials.

  Cephalalgia : an international journal of headache 20010301

• Acute treatment of migraine and the role of triptans.

  Current neurology and neuroscience reports 20010301

• Rizatriptan wafer--sublingual vs. placebo at the onset of acute migraine.

  Cephalalgia : an international journal of headache 20010201

• New abortive agents for the treatment of migraine.

  Advances in internal medicine 20010101

• Comparison of preference for rizatriptan 10-mg wafer versus sumatriptan 50-mg tablet in migraine.

  European neurology 20010101

• Rizatriptan for acute migraine.

  The Cochrane database of systematic reviews 20010101

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  Headache 20010101

• Rizatriptan: pharmacological differences from sumatriptan and clinical results.

  Current medical research and opinion 20010101

• Comparative aspects of triptans in treating migraine.

  Clinical cornerstone 20010101

• A double-blind, placebo-controlled evaluation of the effect of oral doses of rizatriptan 10 mg on oral contraceptive pharmacokinetics in healthy female volunteers.

  Journal of clinical pharmacology 20000301

• Profiles of 5-HT 1B/1D agonists in acute migraine with special reference to second generation agents.

  Acta neurologica Belgica 19990601

• Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors.

  European journal of pharmacology 19990305

• Coronary side-effect potential of current and prospective antimigraine drugs.

  Circulation 19980707

• Pharmacological analysis of the haemodynamic effects of 5-HT1B/D receptor agonists in the normotensive rat.

  British journal of pharmacology 19980101

• Oral rizatriptan versus oral sumatriptan: a direct comparative study in the acute treatment of migraine. Rizatriptan 030 Study Group.

  Headache 19980101