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Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes.
Toxicology and applied pharmacology 20151201
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A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
The Biochemical journal 20130415
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Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model.
Breast cancer research and treatment 20120701
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Small molecule screening identifies targetable zebrafish pigmentation pathways.
Pigment cell & melanoma research 20120301
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Uridine adenosine tetraphosphate (Up4A) is a strong inductor of smooth muscle cell migration via activation of the P2Y2 receptor and cross-communication to the PDGF receptor.
Biochemical and biophysical research communications 20120120
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HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers.
Cancer research 20111101
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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Nature biotechnology 20111101
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Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves the antiangiogenic efficacy for advanced stage mouse corneal neovascularization.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20111001
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PDGF-β receptor and PKC have no effect on angiotensin II-induced JAK2 and STAT1 phosphorylation in vascular smooth muscle cells under high glucose condition.
Journal of receptor and signal transduction research 20111001
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
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Protein kinase C-delta transactivates platelet-derived growth factor receptor-alpha in mechanical strain-induced collagenase 3 (matrix metalloproteinase-13) expression by osteoblast-like cells.
The Journal of biological chemistry 20090918
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FGF2 is crucial for the development of bovine luteal endothelial networks in vitro.
Reproduction (Cambridge, England) 20090901
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VEGF/KDR loop is a target of AG1296 in acute myeloid leukaemia showing FLT3-internal tandem duplications.
British journal of haematology 20090601
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Bovine lactoferrin stimulates human corneal epithelial alkali wound healing in vitro.
Investigative ophthalmology & visual science 20090401
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Stem cell factor and interleukin-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells.
Blood 20090319
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BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.
Blood 20090305
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Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells.
Journal of cellular physiology 20090201
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Growth factors involved in aqueous humour-induced lens cell proliferation.
Growth factors (Chur, Switzerland) 20090201
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Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting platelet-derived growth factor signaling.
Journal of pharmacological sciences 20080801
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Inhibiting the platelet derived growth factor receptor increases signs of retinoic acid syndrome in myeloid differentiated HL-60 cells.
FEBS letters 20080723
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Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment.
Leukemia 20080701
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Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumors.
Molecular cancer research : MCR 20080701
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Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation.
The Journal of pharmacology and experimental therapeutics 20080101
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Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts.
Journal of bone and mineral metabolism 20080101
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FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells.
Leukemia 20071201
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Platelet-derived growth factor receptor regulates myeloid and monocytic differentiation of HL-60 cells.
Cancer research 20070815
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Hepatic stellate cell protrusions couple platelet-derived growth factor-BB to chemotaxis.
Hepatology (Baltimore, Md.) 20070601
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Platelet-derived growth factors and receptors in the rat corpus luteum: localization and identification of an effect on luteogenesis.
Biology of reproduction 20070301
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Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells.
Molecular vision 20070101
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Synergistic effect of arsenic trioxide and flt3 inhibition on cells with flt3 internal tandem duplication.
International journal of hematology 20061001
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Increase of C-type natriuretic peptide expression by serum and platelet-derived growth factor-BB in human aortic smooth muscle cells is dependent on protein kinase C activation.
Endocrinology 20060901
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P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1.
Cellular signalling 20060801
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Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis.
The New England journal of medicine 20060622
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Fibroblast growth factor 2 and transforming growth factor beta1 synergism in human bronchial smooth muscle cell proliferation.
American journal of respiratory cell and molecular biology 20060601
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The role of PDGF receptor inhibitors and PI3-kinase signaling in the pathogenesis of corneal neovascularization.
Investigative ophthalmology & visual science 20060501
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Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301
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Tyrphostin-A47 inhibitable tyrosine phosphorylation of flagellar proteins is associated with distinct alteration of motility pattern in hamster spermatozoa.
Molecular reproduction and development 20060201
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The role of platelet-derived growth factor receptor in eotaxin signaling of eosinophils.
International archives of allergy and immunology 20060101
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Independent role of phosphoinositol-3-kinase (PI3K) and casein kinase II (CK-2) in EGFR and Her-2-mediated constitutive NF-kappaB activation in prostate cancer cells.
The Prostate 20051201
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The FLT3 internal tandem duplication mutation prevents apoptosis in interleukin-3-deprived BaF3 cells due to protein kinase A and ribosomal S6 kinase 1-mediated BAD phosphorylation at serine 112.
Cancer research 20050815
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Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells.
FEBS letters 20050718
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Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening.
Journal of medicinal chemistry 20050505
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Inhibitors of tyrosine kinase inhibit the production of urokinase plasminogen activator in human prostatic cancer cells.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20050501
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Platelet-derived growth factor-BB-induced human smooth muscle cell proliferation depends on basic FGF release and FGFR-1 activation.
Circulation research 20050204
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Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor.
Journal of molecular biology 20050128
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Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis.
Blood 20050101
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Signal transduction of c-Kit receptor tyrosine kinase in CHRF myeloid leukemia cells.
Journal of cancer research and clinical oncology 20041201
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Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 1. Comparison with conventional ELISA.
Journal of medicinal chemistry 20041007
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Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells.
Circulation research 20040430
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Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.
Blood 20040315
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Experimental systems for studying the role of G-protein-coupled receptors in receptor tyrosine kinase signal transduction.
Methods in enzymology 20040101
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Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration.
Developmental cell 20031001
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Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B.
American journal of physiology. Renal physiology 20030801
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Lysophosphatidic acid induces alpha1B-adrenergic receptor phosphorylation through G beta gamma, phosphoinositide 3-kinase, protein kinase C and epidermal growth factor receptor transactivation.
Biochimica et biophysica acta 20030721
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Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor.
Blood 20030715
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Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells.
Oncogene 20030417
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P2Y receptor-mediated stimulation of Müller glial cell DNA synthesis: dependence on EGF and PDGF receptor transactivation.
Investigative ophthalmology & visual science 20030301
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PDGF and FGF2 regulate oligodendrocyte progenitor responses to demyelination.
Journal of neurobiology 20030215
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Platelet-derived growth factor up-regulates the expression of transcription factors NF-E2, GATA-1 and c-Fos in megakaryocytic cell lines.
Cytokine 20030121
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Platelet-derived growth factor receptor kinase inhibitor AG1295 and inhibition of experimental proliferative vitreoretinopathy.
Japanese journal of ophthalmology 20030101
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Constitutive activation of c-kit by the juxtamembrane but not the catalytic domain mutations is inhibited selectively by tyrosine kinase inhibitors STI571 and AG1296.
International journal of hematology 20021201
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Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src.
The Journal of biological chemistry 20021122
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Inhibition of aortic allograft vasculopathy by local delivery of platelet-derived growth factor receptor tyrosine-kinase blocker AG-1295.
Transplantation 20021115
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Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021101
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Study of the drug release mechanism from tyrphostin AG-1295-loaded nanospheres by in situ and external sink methods.
Journal of controlled release : official journal of the Controlled Release Society 20021030
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Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor.
Leukemia 20021001
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Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001
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Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein Shc in endothelial cells.
Circulation research 20020712
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Inhibition of platelet-derived growth factor actions in the embryonic testis influences normal cord development and morphology.
Biology of reproduction 20020301
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Formulation and delivery mode affect disposition and activity of tyrphostin-loaded nanoparticles in the rat carotid model.
Arteriosclerosis, thrombosis, and vascular biology 20010901
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A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations.
Blood 20010801
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Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.
The Journal of biological chemistry 20010727
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Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor.
Leukemia 20010701
-
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 20010213
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Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation.
Cancer research 19941201
