14675-48-0 | (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-methyl-9H-purin-9-yl)tetrahydrofuran-3,4-diol

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$355.00	$248.00
1g	98%	in stock	$867.00	$607.00
5g	98%	in stock	$4,131.00	$2,892.00

Description

• Catalog Number: AD70505
• Chemical Name: (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-methyl-9H-purin-9-yl)tetrahydrofuran-3,4-diol
• CAS Number: 14675-48-0
• Molecular Formula: C11H14N4O4
• Molecular Weight: 266.2533
• MDL Number: MFCD00056009
• SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2C

Computed Properties

• Complexity: 334
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 19
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: -0.3

Literature

• Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides.

  European journal of medicinal chemistry 20120101

• Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses.

  Journal of medicinal chemistry 20101125

• Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation.

  Nature chemical biology 20100501

• Regioselective metalation of 6-methylpurines: synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer.

  Nucleosides, nucleotides & nucleic acids 20090501

• Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: synthesis and evaluation of 6-substituted purine l-ribonucleosides.

  Bioorganic & medicinal chemistry letters 20061015

• An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines.

  The Journal of organic chemistry 20030711

• Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents.

  Journal of medicinal chemistry 19931001