147526-32-7 | Pitavastatin Calcium

Packsize	Purity	Availability	Price	Discounted Price
50mg	98%	in stock	$13.00	$9.00
100mg	98%	in stock	$23.00	$17.00
250mg	98%	in stock	$30.00	$21.00
1g	98%	in stock	$85.00	$60.00
5g	98%	in stock	$294.00	$206.00
25g	98%	in stock	$982.00	$687.00

Description

• Catalog Number: AA65838
• Chemical Name: Pitavastatin Calcium
• CAS Number: 147526-32-7
• Molecular Formula: C50H46CaF2N2O8
• Molecular Weight: 880.9836
• MDL Number: MFCD01937979
• SMILES: O[C@H](C[C@@H](/C=C/c1c(nc2c(c1c1ccc(cc1)F)cccc2)C1CC1)O)CC(=O)[O-].O[C@H](C[C@@H](/C=C/c1c(nc2c(c1c1ccc(cc1)F)cccc2)C1CC1)O)CC(=O)[O-].[Ca+2]

Computed Properties

• Complexity: 626
• Covalently-Bonded Unit Count: 3
• Defined Atom Stereocenter Count: 4
• Defined Bond Stereocenter Count: 2
• Heavy Atom Count: 63
• Hydrogen Bond Acceptor Count: 12
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 14

Literature

• Statins have therapeutic potential for the treatment of Alzheimer's disease, likely via protection of the neurovascular unit in the AD brain.

  Journal of the neurological sciences 20121115

• Pitavastatin decreases tau levels via the inactivation of Rho/ROCK.

  Neurobiology of aging 20121001

• Atorvastatin and pitavastatin enhance lipoprotein lipase production in L6 skeletal muscle cells through activation of adenosine monophosphate-activated protein kinase.

  Metabolism: clinical and experimental 20121001

• Effect of pitavastatin treatment on changes of plaque volume and composition according to the reduction of high-sensitivity C-reactive protein levels.

  Journal of cardiology 20121001

• Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20120901

• Impacts of estimated glomerular filtration rate on coronary atherosclerosis and plaque composition before and during statin therapy in patients with normal to mild renal dysfunction: subanalysis of the TRUTH study.

  Nephrology (Carlton, Vic.) 20120901

• Randomized comparison of pitavastatin and pravastatin treatment on the reduction of urinary albumin in patients with type 2 diabetic nephropathy.

  Diabetes, obesity & metabolism 20120701

• Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects.

  Journal of cardiovascular pharmacology 20120701

• Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer's disease.

  Neurological research 20120701

• [The effect of pitavastatin on blood glucose and its efficacy in diabetic patients with hypercholesterolemia].

  Zhonghua nei ke za zhi 20120701

• [Effect and risk factors of pitavastatin on high sensitivity C-reactive protein in patients with hypercholesterolemia: a multilevel models analysis].

  Zhonghua yi xue za zhi 20120626

• Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages.

  Atherosclerosis 20120601

• Effects of steady-state lopinavir/ritonavir on the pharmacokinetics of pitavastatin in healthy adult volunteers.

  Journal of acquired immune deficiency syndromes (1999) 20120601

• Addressing key questions with statin therapy.

  The Journal of family practice 20120601

• Effects of the SLCO1B1*15 allele on the pharmacokinetics of pitavastatin.

  Xenobiotica; the fate of foreign compounds in biological systems 20120501

• Rationale and design of a study to evaluate effects of pitavastatin on Japanese patients with chronic heart failure: the pitavastatin heart failure study (PEARL study).

  International journal of cardiology 20120419

• [Safety and efficacy of pitavastatin in patients with hypercholesterolemia: a multicenter study].

  Zhonghua yi xue za zhi 20120410

• Meta-analysis of the comparative efficacy and safety of pitavastatin and atorvastatin in patients with dyslipidaemia.

  Journal of clinical pharmacy and therapeutics 20120401

• Pleiotropic effects of pitavastatin.

  British journal of clinical pharmacology 20120401

• The clinical impact of pitavastatin: comparative studies with other statins on LDL-C and HDL-C.

  Expert opinion on pharmacotherapy 20120401

• Pharmacokinetic interaction between pitavastatin and valsartan: a randomized, open-labeled crossover study in healthy male Korean volunteers.

  Clinical therapeutics 20120401

• Pitavastatin: a review of its use in the management of hypercholesterolaemia or mixed dyslipidaemia.

  Drugs 20120305

• Ezetimibe alone or in combination with pitavastatin prevents kidney dysfunction in 5/6 nephrectomized rats fed high-cholesterol.

  Metabolism: clinical and experimental 20120301

• Statin-induced myotoxicity: pharmacokinetic differences among statins and the risk of rhabdomyolysis, with particular reference to pitavastatin.

  Current vascular pharmacology 20120301

• Pitavastatin, a new HMG-CoA reductase inhibitor, induces phototoxicity in human keratinocytes NCTC-2544 through the formation of benzophenanthridine-like photoproducts.

  Archives of toxicology 20120301

• Comparative reactivity of remnant-like lipoprotein particles (RLP) and low-density lipoprotein (LDL) to LDL receptor and VLDL receptor: effect of a high-dose statin on VLDL receptor expression.

  Clinica chimica acta; international journal of clinical chemistry 20120218

• Effect of pitavastatin vs. rosuvastatin on international normalized ratio in healthy volunteers on steady-state warfarin.

  Current medical research and opinion 20120201

• Statin treatment for coronary artery plaque composition based on intravascular ultrasound radiofrequency data analysis.

  American heart journal 20120201

• Impact of statin therapy on plaque characteristics as assessed by serial OCT, grayscale and integrated backscatter-IVUS.

  JACC. Cardiovascular imaging 20120201

• Resolution of inflammation, statins, and plaque regression.

  JACC. Cardiovascular imaging 20120201

• Pitavastatin enhances antiviral efficacy of standard pegylated interferon plus ribavirin in patients with chronic hepatitis C: a prospective randomized pilot study.

  Journal of hepatology 20120101

• Enhancement of antioxidant defense mechanism by pitavastatin and rosuvastatin on obesity-induced oxidative stress in Wistar rats.

  Toxicology mechanisms and methods 20120101

• Effects of pitavastatin on pressure overload-induced heart failure in mice.

  Circulation journal : official journal of the Japanese Circulation Society 20120101

• Qualitative plaque stabilization but not quantitative plaque regression.

  Circulation journal : official journal of the Japanese Circulation Society 20120101

• Reverse vessel remodeling but not coronary plaque regression could predict future cardiovascular events in ACS patients with intensive statin therapy--the extended JAPAN-ACS study.

  Circulation journal : official journal of the Japanese Circulation Society 20120101

• Evaluation of short-term safety and efficacy of HMG-CoA reductase inhibitors in hypercholesterolemic patients with elevated serum alanine transaminase concentrations: PITCH study (PITavastatin versus atorvastatin to evaluate the effect on patients with hypercholesterolemia and mild to moderate hepatic damage).

  Journal of clinical lipidology 20120101

• [Randomized head-to-head comparison of pitavastatin, atorvastatin, and rosuvastatin for safety and efficacy (quantity and quality of LDL): -- the PATROL trial].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20111210

• Long-term safety and efficacy of Pitavastatin in patients with acute myocardial infarction (from the Livalo Acute Myocardial Infarction Study [LAMIS]).

  The American journal of cardiology 20111201

• Clinically evident polyvascular disease and regression of coronary atherosclerosis after intensive statin therapy in patients with acute coronary syndrome: serial intravascular ultrasound from the Japanese assessment of pitavastatin and atorvastatin in acute coronary syndrome (JAPAN-ACS) trial.

  Atherosclerosis 20111201

• Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice: protection by atorvastatin and pitavastatin.

  Neuroscience 20111201

• Comparative long-term efficacy and tolerability of pitavastatin 4 mg and atorvastatin 20-40 mg in patients with type 2 diabetes mellitus and combined (mixed) dyslipidaemia.

  Diabetes, obesity & metabolism 20111101

• Differential effect of statins on diabetic nephropathy in db/db mice.

  International journal of molecular medicine 20111101

• Pitavastatin: an overview.

  Atherosclerosis. Supplements 20111101

• Pitavastatin: novel effects on lipid parameters.

  Atherosclerosis. Supplements 20111101

• Pitavastatin: clinical effects from the LIVES Study.

  Atherosclerosis. Supplements 20111101

• Raising HDL-C can be achieved by both lifestyle changes and pharmacological means. Introduction.

  Atherosclerosis. Supplements 20111101

• [Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-aCS) study].

  Nihon rinsho. Japanese journal of clinical medicine 20111101

• [TOGETHAR Study].

  Nihon rinsho. Japanese journal of clinical medicine 20111101

• Comparison of efficacy of pitavastatin and colestimide in Japanese patients with diabetes mellitus complicated by hyperlipidemia and metabolic syndrome.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20111001

• Comparison of the pharmacokinetics of pitavastatin by formulation and ethnic group: an open-label, single-dose, two-way crossover pharmacokinetic study in healthy Caucasian and Japanese men.

  Clinical drug investigation 20111001

• [Protection from pulmonary apoptosis: a new therapeutic choice for septic acute lung injury].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20111001

• Drug-drug interaction study to assess the effects of multiple-dose pitavastatin on steady-state warfarin in healthy adult volunteers.

  Journal of clinical pharmacology 20110901

• Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders.

  Pharmacological research 20110901

• Statins induce apoptosis and inhibit proliferation in cholangiocarcinoma cells.

  International journal of oncology 20110901

• Long-term efficacy of pitavastatin versus simvastatin.

  Advances in therapy 20110901

• Comparative efficacy of pitavastatin and simvastatin in high-risk patients: a randomized controlled trial.

  Advances in therapy 20110901

• [Prediction of the pharmacokinetic drug-drug interaction of pravastatin and pitavastatin with cyclosporine by a digital liver model based on metabolism and transporter].

  Yao xue xue bao = Acta pharmaceutica Sinica 20110901

• In vivo cardioprotection by pitavastatin from ischemic-reperfusion injury through suppression of IKK/NF-κB and upregulation of pAkt-e-NOS.

  Journal of cardiovascular pharmacology 20110801

• Drug-drug interactions with statins: will pitavastatin overcome the statins' Achilles' heel?

  Current medical research and opinion 20110801

• Pitavastatin calcium: clinical review of a new antihyperlipidemic medication.

  Clinical therapeutics 20110801

• Regulation mechanism of ABCA1 expression by statins in hepatocytes.

  European journal of pharmacology 20110715

• Short-term effect of pitavastatin on the reactive hyperemic index in post-menopausal women with high levels in serum LDL-cholesterol.

  International journal of cardiology 20110715

• Pitavastatin prevents postprandial endothelial dysfunction via reduction of the serum triglyceride level in obese male subjects.

  Heart and vessels 20110701

• Distinct effects of pitavastatin and atorvastatin on lipoprotein subclasses in patients with Type 2 diabetes mellitus.

  Diabetic medicine : a journal of the British Diabetic Association 20110701

• The effect of pitavastatin calcium on endothelial dysfunction induced by hypercholesterolemia.

  Expert opinion on pharmacotherapy 20110701

• Effect of low-dose (1 mg/day) pitavastatin on left ventricular diastolic function and albuminuria in patients with hyperlipidemia.

  The American journal of cardiology 20110601

• Atorvastatin and pitavastatin protect cerebellar Purkinje cells in AD model mice and preserve the cytokines MCP-1 and TNF-α.

  Brain research 20110504

• Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF.

  Laboratory investigation; a journal of technical methods and pathology 20110501

• Lipid peroxidation-induced VEGF expression in the skin of KKAy obese mice.

  Experimental dermatology 20110501

• Efficacy and safety of pitavastatin in Japanese patients with hypercholesterolemia: LIVES study and subanalysis.

  Expert review of cardiovascular therapy 20110501

• Carbon nanotubes linked with pitavastatin: synthesis and characterisation.

  Journal of materials science. Materials in medicine 20110401

• Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats.

  Drug metabolism and disposition: the biological fate of chemicals 20110301

• Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin.

  Journal of hypertension 20110301

• Inhibition of intestinal polyp formation by pitavastatin, a HMG-CoA reductase inhibitor.

  Cancer prevention research (Philadelphia, Pa.) 20110301

• How many 'me-too' drugs is too many?

  JAMA 20110216

• Successful treatment of acute lung injury with pitavastatin in septic mice: potential role of glucocorticoid receptor expression in alveolar macrophages.

  The Journal of pharmacology and experimental therapeutics 20110201

• Nanoparticle-mediated delivery of pitavastatin into lungs ameliorates the development and induces regression of monocrotaline-induced pulmonary artery hypertension.

  Hypertension (Dallas, Tex. : 1979) 20110201

• A crossover study of rosuvastatin and pitavastatin in patients with type 2 diabetes.

  Advances in therapy 20110201

• Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice.

  Brain research 20110131

• Pitavastatin reduces elevated IL-18 levels in Japanese subjects with hypercholesterolemia: sub-analysis of Kansai investigation of statin for hyperlipidemic intervention in metabolism and endocrinology (KISHIMEN).

  Journal of atherosclerosis and thrombosis 20110101

• Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors.

  Xenobiotica; the fate of foreign compounds in biological systems 20110101

• Increase of oxidant-related triglycerides and phosphatidylcholines in serum and small intestinal mucosa during development of intestinal polyp formation in Min mice.

  Cancer science 20110101

• Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients.

  Journal of atherosclerosis and thrombosis 20110101

• Pitavastatin: a new 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor for the treatment of hyperlipidemia.

  Advances in therapy 20110101

• Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1.

  Drug metabolism and pharmacokinetics 20110101

• [Study of MDA-LDL by pioglitazone and pitavastatin in patients with type 2 diabetes].

  Nihon rinsho. Japanese journal of clinical medicine 20110101

• Glucose-lowering effect of colestimide is associated with baseline HbA1c in type 2 diabetic patients with hypercholesterolemia.

  Endocrine journal 20110101

• Are all statins the same? Focus on the efficacy and tolerability of pitavastatin.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20110101

• Randomized head-to-head comparison of pitavastatin, atorvastatin, and rosuvastatin for safety and efficacy (quantity and quality of LDL): the PATROL trial.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• Pitavastatin increases ABCA1 expression by dual mechanisms: SREBP2-driven transcriptional activation and PPARα-dependent protein stabilization but without activating LXR in rat hepatoma McARH7777 cells.

  Journal of pharmacological sciences 20110101

• Strong statins as the major players for dyslipidemia in high-risk patients: are they all the same or not?

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• Place of pitavastatin in the statin armamentarium: promising evidence for a role in diabetes mellitus.

  Drug design, development and therapy 20110101

• Comparison of preventive effect on cardiovascular events with different statins. -The CIRCLE study-.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice.

  BMC cancer 20110101

• Pitavastatin - pharmacological profile from early phase studies.

  Atherosclerosis. Supplements 20101201

• Pitavastatin - results from phase III & IV.

  Atherosclerosis. Supplements 20101201

• Pitavastatin - from clinical trials to clinical practice.

  Atherosclerosis. Supplements 20101201

• Inhibition of the renal renin-angiotensin system and renoprotection by pitavastatin in type1 diabetes.

  Clinical and experimental pharmacology & physiology 20101101

• Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway.

  Arteriosclerosis, thrombosis, and vascular biology 20101101

• [Chiral separation of pitavastatin calcium enantiomers by capillary zone electrophoresis].

  Se pu = Chinese journal of chromatography 20101101

• More intensive lipid lowering is associated with regression of coronary atherosclerosis in diabetic patients with acute coronary syndrome--sub-analysis of JAPAN-ACS study.

  Journal of atherosclerosis and thrombosis 20101027

• [Pitavastatin - the seventh statin].

  Revue medicale suisse 20101006

• Pitavastatin - a novel therapeutic milestone.

  Drugs of today (Barcelona, Spain : 1998) 20101001

• Role of protein kinase C in pitavastatin-induced human paraoxonase I expression in Huh7 cells.

  Metabolism: clinical and experimental 20100901

• Beneficial direct adipotropic actions of pitavastatin in vitro and their manifestations in obese mice.

  Atherosclerosis 20100901

• Stabilization and regression of coronary plaques treated with pitavastatin proven by angioscopy and intravascular ultrasound--the TOGETHAR trial.

  Circulation journal : official journal of the Japanese Circulation Society 20100901

• Correlation between circulating adiponectin levels and coronary plaque regression during aggressive lipid-lowering therapy in patients with acute coronary syndrome: subgroup analysis of JAPAN-ACS study.

  Atherosclerosis 20100901

• Pitavastatin and 4'-hydroxy-3'-methoxyacetophenone (HMAP) reduce cognitive dysfunction in vascular dementia during experimental diabetes.

  Current neurovascular research 20100801

• Nanoparticle-mediated endothelial cell-selective delivery of pitavastatin induces functional collateral arteries (therapeutic arteriogenesis) in a rabbit model of chronic hind limb ischemia.

  Journal of vascular surgery 20100801

• Pitavastatin for the treatment of primary hyperlipidemia and mixed dyslipidemia.

  Expert review of cardiovascular therapy 20100801

• Pitavastatin (Livalo)--the seventh statin.

  The Medical letter on drugs and therapeutics 20100726

• Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo.

  Cardiovascular research 20100715

• Pitavastatin strengthens the barrier integrity in primary cultures of rat brain endothelial cells.

  Cellular and molecular neurobiology 20100701

• Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and low-density lipoprotein on proliferation and migration of keratinocytes.

  The British journal of dermatology 20100701

• Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice.

  Cancer science 20100701

• Effects of pitavastatin (LIVALO tablet) on the estimated glomerular filtration rate (eGFR) in hypercholesterolemic patients with chronic kidney disease. Sub-analysis of the LIVALO Effectiveness and Safety (LIVES) Study.

  Journal of atherosclerosis and thrombosis 20100630

• High density lipoprotein cholesterol and apolipoprotein A-I are persistently elevated during long-term treatment with pitavastatin, a new HMG-CoA reductase inhibitor.

  International journal of cardiology 20100611

• Pitavastatin reduces oxidative stress and attenuates intermittent hypoxia-induced left ventricular remodeling in lean mice.

  Hypertension research : official journal of the Japanese Society of Hypertension 20100601

• Diabetes mellitus is a major negative determinant of coronary plaque regression during statin therapy in patients with acute coronary syndrome--serial intravascular ultrasound observations from the Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome Trial (the JAPAN-ACS Trial).

  Circulation journal : official journal of the Japanese Circulation Society 20100601

• Effects of three strong statins (atorvastatin, pitavastatin, and rosuvastatin) on serum uric acid levels in dyslipidemic patients.

  Nucleosides, nucleotides & nucleic acids 20100601

• Long-term treatment with pitavastatin is effective and well tolerated by patients with primary hypercholesterolemia or combined dyslipidemia.

  Atherosclerosis 20100501

• Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury.

  Hypertension (Dallas, Tex. : 1979) 20100401

• New evidence on pitavastatin: efficacy and safety in clinical studies.

  Expert opinion on pharmacotherapy 20100401

• Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans.

  Lipids 20100401

• Atherosclerosis induced by chronic inhibition of the synthesis of nitric oxide in moderately hypercholesterolaemic rabbits is suppressed by pitavastatin.

  British journal of pharmacology 20100401

• Lack of effect of genetic polymorphisms of SLCO1B1 on the lipid-lowering response to pitavastatin in Chinese patients.

  Acta pharmacologica Sinica 20100301

• Pitavastatin: a new HMG-CoA reductase inhibitor.

  The Annals of pharmacotherapy 20100301

• Comparative efficacy and safety of low-dose pitavastatin versus atorvastatin in patients with hypercholesterolemia.

  The Annals of pharmacotherapy 20100301

• S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.

  Cardiovascular research 20100201

• OATP1B1 388A>G polymorphism and pharmacokinetics of pitavastatin in Chinese healthy volunteers.

  Journal of clinical pharmacy and therapeutics 20100201

• Noninferiority of pitavastatin in intravascular ultrasound findings.

  Journal of the American College of Cardiology 20100119

• Co-administration of ezetimibe enhances proteinuria-lowering effects of pitavastatin in chronic kidney disease patients partly via a cholesterol-independent manner.

  Pharmacological research 20100101

• Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.

  Drug metabolism and disposition: the biological fate of chemicals 20100101

• Pitavastatin, an HMG-CoA reductase inhibitor, ameliorates endothelial function in chronic smokers.

  Circulation journal : official journal of the Japanese Circulation Society 20100101

• New translational research on novel drugs for hepatitis C virus 1b infection by using a replicon system and human induced pluripotent stem cells.

  Hepatology (Baltimore, Md.) 20100101

• An identification of the novel combination therapy for hepatitis C virus 1b infection by using a replicon system and human induced pluripotent stem cells.

  Hepatology (Baltimore, Md.) 20100101

• Pitavastatin: the newest HMG-CoA reductase inhibitor.

  Reviews in cardiovascular medicine 20100101

• New drugs: pitavastatin calcium, vigabatrin, and romidepsin.

  Journal of the American Pharmacists Association : JAPhA 20100101

• Pitavastatin: a new HMG-CoA reductase inhibitor for the treatment of hypercholesterolemia.

  Cardiology in review 20100101

• Pitavastatin further decreases serum high-sensitive C-reactive protein levels in hypertensive patients with hypercholesterolemia treated with angiotensin II, type-1 receptor antagonists.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20100101

• Memory restorative role of statins in experimental dementia: an evidence of their cholesterol dependent and independent actions.

  Pharmacological reports : PR 20100101

• Pitavastatin approved for treatment of primary hypercholesterolemia and combined dyslipidemia.

  Vascular health and risk management 20100101

• Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones.

  Bioorganic & medicinal chemistry 20091201

• A novel method in order to evaluate the efficacies and the safeties of new drugs for hepatocellular carcinoma with loss of transforming growth factor-beta signaling.

  Hepatology (Baltimore, Md.) 20091201

• Photostability of pitavastatin--a novel HMG-CoA reductase inhibitor.

  Journal of pharmaceutical and biomedical analysis 20091101

• Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity.

  Journal of molecular and cellular cardiology 20091101

• Comparison of pitavastatin with simvastatin in primary hypercholesterolaemia or combined dyslipidaemia.

  Current medical research and opinion 20091101

• Effects of pitavastatin on serum lipids and high sensitivity C-reactive protein in type 2 diabetic patients.

  Journal of atherosclerosis and thrombosis 20091001

• Effects of pitavastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on cardio-ankle vascular index in type 2 diabetic patients.

  Journal of atherosclerosis and thrombosis 20091001

• Effects of pitavastatin (LIVALO Tablet) on high density lipoprotein cholesterol (HDL-C) in hypercholesterolemia.

  Journal of atherosclerosis and thrombosis 20091001

• Effects of pitavastatin on monocyte chemoattractant protein-1 in hyperlipidemic patients.

  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20090901

• Early effect of lipid-lowering therapy with pitavastatin on regression of coronary atherosclerotic plaque. Comparison with atorvastatin.

  Circulation journal : official journal of the Japanese Circulation Society 20090801

• Effects of pitavastatin on fasting and postprandial endothelial function and blood rheology in patients with stable coronary artery disease.

  Circulation journal : official journal of the Japanese Circulation Society 20090801

• Pitavastatin fails to lower serum lipid levels or inhibit gastric carcinogenesis in helicobacter pylori-infected rodent models.

  Cancer prevention research (Philadelphia, Pa.) 20090801

• Pitavastatin improves plasma pentraxin 3 and arterial stiffness in atherosclerotic patients with hypercholesterolemia.

  Journal of atherosclerosis and thrombosis 20090801

• Effect of intensive statin therapy on regression of coronary atherosclerosis in patients with acute coronary syndrome: a multicenter randomized trial evaluated by volumetric intravascular ultrasound using pitavastatin versus atorvastatin (JAPAN-ACS [Japan assessment of pitavastatin and atorvastatin in acute coronary syndrome] study).

  Journal of the American College of Cardiology 20090721

• Therapeutic neovascularization by nanotechnology-mediated cell-selective delivery of pitavastatin into the vascular endothelium.

  Arteriosclerosis, thrombosis, and vascular biology 20090601

• Influence of statins on glucose tolerance in patients with type 2 diabetes mellitus: subanalysis of the collaborative study on hypercholesterolemia drug intervention and their benefits for atherosclerosis prevention (CHIBA study).

  Journal of atherosclerosis and thrombosis 20090601

• Stress-induced PAI-1 expression is suppressed by pitavastatin in vivo.

  International journal of hematology 20090501

• Pitavastatin prevents intestinal ischemia/reperfusion-induced bacterial translocation and lung injury in atherosclerotic rats with hypoadiponectinemia.

  Surgery 20090501

• Effects of statins on the pharmacokinetics of midazolam in healthy volunteers.

  Journal of clinical pharmacology 20090501

• Pitavastatin suppresses mitogen activated protein kinase-mediated Erg-1 induction in human vascular smooth muscle cells.

  European journal of pharmacology 20090315

• Induction of autophagic cell death and radiosensitization by the pharmacological inhibition of nuclear factor-kappa B activation in human glioma cell lines.

  Journal of neurosurgery 20090301

• Effects of pitavastatin on cerebral blood flow.

  Clinical therapeutics 20090301

• Pitavastatin induces PON1 expression through p44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells.

  Atherosclerosis 20090201

• Integrated backscatter and intima-media thickness of the thoracic aorta evaluated by transesophageal echocardiography in hypercholesterolemic patients: effect of pitavastatin therapy.

  Ultrasound in medicine & biology 20090201

• Possible involvement of corticotropin-releasing factor receptor signaling on vascular inflammation.

  Peptides 20090201

• Cardioprotective effects of pitavastatin on cardiac performance and remodeling in failing rat hearts.

  American journal of hypertension 20090201

• Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.

  Circulation journal : official journal of the Japanese Circulation Society 20090201

• Treatment with statin on atheroma regression evaluated by intravascular ultrasound with Virtual Histology (TRUTH Study): rationale and design.

  Circulation journal : official journal of the Japanese Circulation Society 20090201

• The effects of pitavastatin, eicosapentaenoic acid and combined therapy on platelet-derived microparticles and adiponectin in hyperlipidemic, diabetic patients.

  Platelets 20090201

• Pitavastatin suppresses formation and progression of cerebral aneurysms through inhibition of the nuclear factor kappaB pathway.

  Neurosurgery 20090201

• Pitavastatin attenuates leukocyte-endothelial interactions induced by ischemia-reperfusion injury in the rat retina.

  Current eye research 20090101

• Estimation of pitavastatin calcium in tablet dosage forms by column liquid chromatography and ultraviolet spectrophotometry.

  Journal of AOAC International 20090101

• Critical appraisal of the role of pitavastatin in treating dyslipidemias and achieving lipid goals.

  Vascular health and risk management 20090101

• Multicenter collaborative randomized parallel group comparative study of pitavastatin and atorvastatin in Japanese hypercholesterolemic patients: collaborative study on hypercholesterolemia drug intervention and their benefits for atherosclerosis prevention (CHIBA study).

  Atherosclerosis 20081201

• Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model.

  Drug metabolism and disposition: the biological fate of chemicals 20081201

• Letter by Ntaios et al regarding article, 'impact of statin therapy on left ventricular function and carotid arterial stiffness in patients with hypercholesterolemia'.

  Circulation journal : official journal of the Japanese Circulation Society 20081201

• Effects of pitavastatin on lipid profiles and high-sensitivity CRP in Japanese subjects with hypercholesterolemia: Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN) investigatars.

  Journal of atherosclerosis and thrombosis 20081201

• Statin suppresses apoptosis in osteoblastic cells: role of transforming growth factor-beta-Smad3 pathway.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20081101

• Influence of pitavastatin on glucose tolerance in patients with type 2 diabetes mellitus.

  Journal of atherosclerosis and thrombosis 20081001

• Comparative pharmacological study of free radical scavenger, nitric oxide synthase inhibitor, nitric oxide synthase activator and cyclooxygenase inhibitor against MPTP neurotoxicity in mice.

  Metabolic brain disease 20080901

• Pitavastatin inhibits intimal hyperplasia in rabbit vein graft.

  The Journal of surgical research 20080801

• Functional consequences of active hepatic uptake on cytochrome P450 inhibition in rat and human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20080801

• Effects of different statins on endothelial nitric oxide synthase and AKT phosphorylation in endothelial cells.

  International journal of cardiology 20080623

• Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression.

  American journal of physiology. Heart and circulatory physiology 20080601

• Solid-phase extraction and liquid chromatography/tandem mass spectrometry assay for the determination of pitavastatin in human plasma and urine for application to Phase I clinical pharmacokinetic studies.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080601

• Effects of statin on small dense low-density lipoprotein cholesterol and remnant-like particle cholesterol in heterozygous familial hypercholesterolemia.

  Journal of atherosclerosis and thrombosis 20080601

• A 52-week, randomized, open-label, parallel-group comparison of the tolerability and effects of pitavastatin and atorvastatin on high-density lipoprotein cholesterol levels and glucose metabolism in Japanese patients with elevated levels of low-density lipoprotein cholesterol and glucose intolerance.

  Clinical therapeutics 20080601

• Combined effects of an 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and angiotensin II receptor antagonist on nitric oxide bioavailability and atherosclerotic change in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits.

  Hypertension research : official journal of the Japanese Society of Hypertension 20080601

• Comparison of effects of pitavastatin and atorvastatin on plasma coenzyme Q10 in heterozygous familial hypercholesterolemia: results from a crossover study.

  Clinical pharmacology and therapeutics 20080501

• Involvement of multiple efflux transporters in hepatic disposition of fexofenadine.

  Molecular pharmacology 20080501

• Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3/IFN-beta pathway in macrophages.

  Arteriosclerosis, thrombosis, and vascular biology 20080501

• Pitavastatin may reduce risk of steroid-induced osteonecrosis in rabbits: a preliminary histological study.

  Clinical orthopaedics and related research 20080501

• The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15.

  Pharmacogenetics and genomics 20080501

• Effect of pitavastatin on type 2 diabetes mellitus nephropathy in KK-Ay/Ta mice.

  Metabolism: clinical and experimental 20080501

• Association between risk of myopathy and cholesterol-lowering effect: a comparison of all statins.

  Life sciences 20080423

• Development and validation of a liquid chromatography-tandem mass spectrometric assay for pitavastatin and its lactone in human plasma and urine.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080401

• Impact of statin therapy on left ventricular function and carotid arterial stiffness in patients with hypercholesterolemia.

  Circulation journal : official journal of the Japanese Circulation Society 20080401

• Pitavastatin improves serum resistin levels in patients with hypercholesterolemia.

  Journal of atherosclerosis and thrombosis 20080401

• Effects of rosuvastatin and pitavastatin on ischemia-induced myocardial stunning in dogs.

  Journal of pharmacological sciences 20080401

• Rapid stabilization of vulnerable carotid plaque within 1 month of pitavastatin treatment in patients with acute coronary syndrome.

  Journal of cardiovascular pharmacology 20080401

• Comparisons of short- and intermediate-term effects of pitavastatin versus atorvastatin on lipid profiles, fibrinolytic parameter, and endothelial function.

  International journal of cardiology 20080328

• Modulation of celecoxib- and streptozotocin-induced experimental dementia of Alzheimer's disease by pitavastatin and donepezil.

  Journal of psychopharmacology (Oxford, England) 20080301

• [Effect of pitavastatin on macrophage cholesterol metabolism].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080301

• Determination of two HMG-CoA reductase inhibitors, pravastatin and pitavastatin, in plasma samples using liquid chromatography-tandem mass spectrometry for pharmaceutical study.

  Biomedical chromatography : BMC 20080201

• Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes.

  Nitric oxide : biology and chemistry 20080201

• Pitavastatin decreases plasma prebeta1-HDL concentration and might promote its disappearance rate in hypercholesterolemic patients.

  Journal of atherosclerosis and thrombosis 20080201

• HMG-CoA reductase inhibition improves anti-aging klotho protein expression and arteriosclerosis in rats with chronic inhibition of nitric oxide synthesis.

  International journal of cardiology 20080111

• Pitavastatin, an HMG-CoA reductase inhibitor, exerts eNOS-independent protective actions against angiotensin II induced cardiovascular remodeling and renal insufficiency.

  Circulation research 20080104

• Correlation between adiponectin and reduction of cell adhesion molecules after pitavastatin treatment in hyperlipidemic patients with type 2 diabetes mellitus.

  Thrombosis research 20080101

• Beneficial effects of pitavastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on cardiac function in ischemic and nonischemic heart failure.

  International heart journal 20080101

• Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats.

  BMC pharmacology 20080101

• Synthesis and HMG CoA reductase inhibition of 4-thiophenyl quinolines as potential hypocholesterolemic agents.

  Bioorganic & medicinal chemistry 20071215

• A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis.

  International journal of cancer 20071115

• SLCO1B1 (OATP1B1, an uptake transporter) and ABCG2 (BCRP, an efflux transporter) variant alleles and pharmacokinetics of pitavastatin in healthy volunteers.

  Clinical pharmacology and therapeutics 20071101

• Impact of lipid-lowering therapy with pitavastatin, a new HMG-CoA reductase inhibitor, on regression of coronary atherosclerotic plaque.

  Circulation journal : official journal of the Japanese Circulation Society 20071101

• Pitavastatin: protection against neuronal retinal damage induced by ischemia-reperfusion injury in rats.

  Current eye research 20071101

• Comparison of the efficacy and tolerability of pitavastatin and atorvastatin: an 8-week, multicenter, randomized, open-label, dose-titration study in Korean patients with hypercholesterolemia.

  Clinical therapeutics 20071101

• [Deadly drug interactions].

  Nihon rinsho. Japanese journal of clinical medicine 20071028

• Pitavastatin: efficacy and safety in intensive lipid lowering.

  Expert opinion on pharmacotherapy 20071001

• Determination of pitavastatin from human plasma using high performance liquid chromatography with fluorescence detection.

  Se pu = Chinese journal of chromatography 20070901

• Renal protective effects of pitavastatin on spontaneously hypercholesterolaemic Imai Rats.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070801

• Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice.

  Kidney international 20070801

• Downregulation of survivin expression and elevation of caspase-3 activity involved in pitavastatin-induced HepG 2 cell apoptosis.

  Oncology reports 20070801

• Anti-adipogenic action of pitavastatin occurs through the coordinate regulation of PPARgamma and Pref-1 expression.

  British journal of pharmacology 20070701

• Effect of pitavastatin on experimental choroidal neovascularization in rats.

  Experimental eye research 20070601

• Pitavastatin inactivates NF-kappaB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells.

  Oncology reports 20070501

• [Effects of NK-104 on apoptosis and caspase-3 activity in hepatocellular carcinoma cells].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070501

• Pitavastatin suppresses acute and chronic rejection in murine cardiac allografts.

  Transplantation 20070427

• Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation.

  Vascular pharmacology 20070401

• Postischemic alterations of BDNF, NGF, HSP 70 and ubiquitin immunoreactivity in the gerbil hippocampus: pharmacological approach.

  Cellular and molecular neurobiology 20070301

• Immunohistochemical study on distribution of NF-kappaB and p53 in gerbil hippocampus after transient cerebral ischemia: effect of pitavastatin.

  Metabolic brain disease 20070301

• Pitavastatin restores vascular dysfunction in insulin-resistant state by inhibiting NAD(P)H oxidase activity and uncoupled endothelial nitric oxide synthase-dependent superoxide production.

  Journal of cardiovascular pharmacology 20070301

• Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins.

  British journal of pharmacology 20070201

• Pitavastatin prevents NMDA-induced retinal ganglion cell death by suppressing leukocyte recruitment.

  Journal of neurochemistry 20070201

• Pitavastatin attenuates the upregulation of tissue factor in restraint-stressed mice.

  Thrombosis research 20070101

• Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats.

  Endocrinology 20070101

• CYP2C76-mediated species difference in drug metabolism: a comparison of pitavastatin metabolism between monkeys and humans.

  Xenobiotica; the fate of foreign compounds in biological systems 20070101

• Determination of pitavastatin in human plasma via HPLC-ESI-MS/MS and subsequent application to a clinical study in healthy Chinese volunteers.

  Clinica chimica acta; international journal of clinical chemistry 20070101

• Short-term effects of pitavastatin on biochemical markers of bone turnover in patients with hypercholesterolemia.

  Internal medicine (Tokyo, Japan) 20070101

• Effects of pitavastatin on adiponectin in patients with hyperlipidemia.

  Pathophysiology of haemostasis and thrombosis 20070101

• Japan assessment of pitavastatin and atorvastatin in acute coronary syndrome (JAPAN-ACS): rationale and design.

  Circulation journal : official journal of the Japanese Circulation Society 20061201

• Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway.

  Clinical and experimental pharmacology & physiology 20061201

• Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-gamma, and aortic stiffness in hypercholesterolemia.

  American journal of physiology. Heart and circulatory physiology 20061101

• Pitavastatin attenuates the PDGF-induced LR11/uPA receptor-mediated migration of smooth muscle cells.

  Biochemical and biophysical research communications 20061006

• A therapeutic dose of the lipophilic statin pitavastatin enhances oxidant-induced apoptosis in human vascular smooth muscle cells.

  Journal of cardiovascular pharmacology 20061001

• Pitavastatin-induced downregulation of CCR2 and CCR5 in monocytes is associated with the arrest of cell-cycle in S phase.

  Atherosclerosis 20060801

• Drug-drug interaction between pitavastatin and various drugs via OATP1B1.

  Drug metabolism and disposition: the biological fate of chemicals 20060701

• Dose-dependent effect of pitavastatin on VEGF and angiogenesis in a mouse model of choroidal neovascularization.

  Investigative ophthalmology & visual science 20060601

• Differential effects of different statins on endothelin-1 gene expression and endothelial NOS phosphorylation in porcine aortic endothelial cells.

  Experimental biology and medicine (Maywood, N.J.) 20060601

• Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure.

  Journal of cardiovascular pharmacology 20060601

• [The pro-angiogenesis effect of Pitavastatin in the Klotho gene-knockout mice].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20060501

• Pitavastatin effect on ATP binding cassette A1-mediated lipid efflux from macrophages: evidence for liver X receptor (LXR)-dependent and LXR-independent mechanisms of activation by cAMP.

  The Journal of pharmacology and experimental therapeutics 20060401

• Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular carcinoma cells.

  Biological & pharmaceutical bulletin 20060401

• Efficacy of a low dose of pitavastatin compared with atorvastatin in primary hyperlipidemia: results of a 12-week, open label study.

  Journal of atherosclerosis and thrombosis 20060401

• The role of pitavastatin-enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes.

  Journal of atherosclerosis and thrombosis 20060401

• [Pitavastatin enhances angiogenesis and perfusion in a murine mode of limb ischemia].

  Zhonghua xin xue guan bing za zhi 20060301

• Endothelial urocortin has potent antioxidative properties and is upregulated by inflammatory cytokines and pitavastatin.

  Journal of vascular research 20060101

• Statins and osteoporosis: new role for old drugs.

  The Journal of pharmacy and pharmacology 20060101

• Effect of pitavastatin on urinary liver-type fatty-acid-binding protein in patients with nondiabetic mild chronic kidney disease.

  American journal of nephrology 20060101

• Efficacy of pitavastatin, a new HMG-CoA reductase inhibitor, on lipid and glucose metabolism in patients with type 2 diabetes.

  Diabetes care 20051201

• Biphasic effect of HMG-CoA reductase inhibitor, pitavastatin, on vascular endothelial cells and angiogenesis.

  Circulation journal : official journal of the Japanese Circulation Society 20051201

• Alterations of interneurons of the gerbil hippocampus after transient cerebral ischemia: effect of pitavastatin.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20051101

• Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin.

  British journal of clinical pharmacology 20051101

• Effect of pitavastatin on urinary liver-type fatty acid-binding protein levels in patients with early diabetic nephropathy.

  Diabetes care 20051101

• Pitavastatin inhibits cardiac hypertrophy in a rat model of progressive renal injury.

  Journal of cardiovascular pharmacology 20051001

• Effect of OATP1B1 (SLCO1B1) variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers.

  Clinical pharmacology and therapeutics 20051001

• Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase.

  The Journal of pharmacy and pharmacology 20051001

• Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin.

  Molecular pharmacology 20050901

• Statin attenuates high glucose-induced and angiotensin II-induced MAP kinase activity through inhibition of NAD(P)H oxidase activity in cultured mesangial cells.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20050901

• Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement.

  Free radical biology & medicine 20050815

• Enhanced oxidative stress in neutrophils from hyperlipidemic guinea pig.

  Atherosclerosis 20050701

• A randomized, open-label study to evaluate the efficacy and safety of pitavastatin compared with simvastatin in Korean patients with hypercholesterolemia.

  Clinical therapeutics 20050701

• Inhibitory effect of pitavastatin (NK-104) on the C-reactive-protein-induced interleukin-8 production in human aortic endothelial cells.

  Clinical science (London, England : 1979) 20050601

• C-reactive protein and statins: IL-8 as a molecular link?

  Clinical science (London, England : 1979) 20050601

• Pitavastatin at low dose activates endothelial nitric oxide synthase through PI3K-AKT pathway in endothelial cells.

  Life sciences 20050325

• Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress.

  Stroke 20050301

• Pharmacokinetics of pitavastatin in subjects with Child-Pugh A and B cirrhosis.

  British journal of clinical pharmacology 20050301

• Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism.

  Arteriosclerosis, thrombosis, and vascular biology 20050201

• A literature search on pharmacokinetic drug interactions of statins and analysis of how such interactions are reflected in package inserts in Japan.

  Journal of clinical pharmacy and therapeutics 20050201

• Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene.

  Metabolism: clinical and experimental 20050201

• Pitavastatin.

  International journal of clinical practice 20050201

• Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins.

  Journal of atherosclerosis and thrombosis 20050101

• Pitavastatin enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes.

  Journal of atherosclerosis and thrombosis 20050101

• Pitavastatin prevents bacterial translocation after nonpulsatile/low-pressure blood flow in early atherosclerotic rat: inhibition of small intestine inducible nitric oxide synthase.

  European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20050101

• Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier.

  The Journal of pharmacology and experimental therapeutics 20041201

• Functional interplay between the macrophage scavenger receptor class B type I and pitavastatin (NK-104).

  Circulation 20041130

• Effect of pitavastatin on apolipoprotein A-I production in HepG2 cell.

  Biochemical and biophysical research communications 20041112

• HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells.

  Cardiovascular research 20041101

• Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells.

  Circulation journal : official journal of the Japanese Circulation Society 20041101

• Contribution of vascular NAD(P)H oxidase to endothelial dysfunction in heart failure and the therapeutic effects of HMG-CoA reductase inhibitor.

  Circulation journal : official journal of the Japanese Circulation Society 20041101

• Optimal windows of statin use for immediate infarct limitation: 5'-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase.

  Circulation 20041012

• Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans.

  The Journal of pharmacology and experimental therapeutics 20041001

• A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits.

  Atherosclerosis 20041001

• Statins as a possible distribution modulator of bone marrow-derived smooth muscle cells in plaques?

  Atherosclerosis 20041001

• Protective effect of pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, on ischemia-induced neuronal damage.

  Neurological research 20040901

• Effect of pitavastatin against expression of S100beta protein in the gerbil hippocampus after transient cerebral ischaemia.

  Acta physiologica Scandinavica 20040901

• Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, reduces hippocampal damage after transient cerebral ischemia in gerbils.

  Journal of neural transmission (Vienna, Austria : 1996) 20040901

• Pitavastatin increases ABCA1-mediated lipid efflux from Fu5AH rat hepatoma cells.

  Biochemical and biophysical research communications 20040827

• Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.

  Arteriosclerosis, thrombosis, and vascular biology 20040801

• MCP-1-induced enhancement of THP-1 adhesion to vascular endothelium was modulated by HMG-CoA reductase inhibitor through RhoA GTPase-, but not ERK1/2-dependent pathway.

  Life sciences 20040730

• Inhibitory efficacy of pitavastatin on the early inflammatory response and neointimal thickening in a porcine coronary after stenting.

  Atherosclerosis 20040601

• Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis.

  Hypertension (Dallas, Tex. : 1979) 20040601

• Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, blocks vascular smooth muscle cell populated-collagen lattice contraction.

  Journal of cardiovascular pharmacology 20040601

• Pitavastatin enhances the anti-fibrogenesis effects of candesartan, an angiotensin II receptor blocker, on CCl4-induced liver fibrosis in rats.

  Journal of UOEH 20040601

• [Pharmacological and pharmacokinetic features and clinical effects of pitavastatin (Livalo Tablet)].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040501

• Anti-lipid deposition effect of HMG-CoA reductase inhibitor, pitavastatin, in a rat model of hypertension and hypercholesterolemia.

  Life sciences 20040312

• The novel HMG-CoA reductase inhibitor, Pitavastatin, induces a protective action in vascular endothelial cells through the production of nitric oxide (NO).

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040301

• Pitavastatin downregulates expression of the macrophage type B scavenger receptor, CD36.

  Circulation 20040217

• Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions.

  Biochemical and biophysical research communications 20040206

• High glucose-induced upregulation of osteopontin is mediated via Rho/Rho kinase pathway in cultured rat aortic smooth muscle cells.

  Arteriosclerosis, thrombosis, and vascular biology 20040201

• Effect of gemfibrozil on the metabolism of pitavastatin--determining the best animal model for human CYP and UGT activities.

  Drug metabolism and drug interactions 20040101

• Metabolic stability and uptake by human hepatocytes of pitavastatin, a new inhibitor of HMG-CoA reductase.

  Arzneimittel-Forschung 20040101

• Pitavastatin alters the expression of thrombotic and fibrinolytic proteins in human vascular cells.

  Journal of cellular biochemistry 20030901

• Pitavastatin inhibits upregulation of intermediate conductance calcium-activated potassium channels and coronary arteriolar remodeling induced by long-term blockade of nitric oxide synthesis.

  Pharmacology 20030801

• Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: similarities and difference in the metabolism of pitavastatin in monkeys and humans.

  Xenobiotica; the fate of foreign compounds in biological systems 20030701

• Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice.

  Lipids 20030501

• Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family.

  Arteriosclerosis, thrombosis, and vascular biology 20030301

• Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization.

  Xenobiotica; the fate of foreign compounds in biological systems 20030101

• Pitavastatin inhibits vascular smooth muscle cell proliferation by inactivating extracellular signal-regulated kinases 1/2.

  Journal of atherosclerosis and thrombosis 20030101

• Interaction between several medicines and statins.

  Arzneimittel-Forschung 20030101

• Triglyceride-lowering effect of pitavastatin in a guinea pig model of postprandial lipemia.

  Arzneimittel-Forschung 20030101

• Plaque-stabilizing effect of pitavastatin in Watanabe heritable hyperlipidemic (WHHL) rabbits.

  Journal of atherosclerosis and thrombosis 20030101

• Effect of pitavastatin on sterol and bile acid excretion in guinea pigs.

  Arzneimittel-Forschung 20030101

• Pitavastatin: efficacy and safety profiles of a novel synthetic HMG-CoA reductase inhibitor.

  Cardiovascular drug reviews 20030101

• Interaction between fibrates and statins--metabolic interactions with gemfibrozil.

  Drug metabolism and drug interactions 20030101

• Pitavastatin Nissan/Kowa Yakuhin/Novartis/Sankyo.

  Current opinion in investigational drugs (London, England : 2000) 20020901

• Pharmacology of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), including rosuvastatin and pitavastatin.

  Journal of clinical pharmacology 20020801

• Long-term treatment with pitavastatin (NK-104), a new HMG-CoA reductase inhibitor, of patients with heterozygous familial hypercholesterolemia.

  Atherosclerosis 20020701

• A randomized, double-blind trial comparing the efficacy and safety of pitavastatin versus pravastatin in patients with primary hypercholesterolemia.

  Atherosclerosis 20020601

• Triglyceride-lowering effect of pitavastatin [corrected] in a rat model of postprandial lipemia.

  European journal of pharmacology 20020524

• Novel statins: pharmacological and clinical results.

  Cardiovascular drugs and therapy 20020501

• Inhibition of migration and proliferation of rat vascular smooth muscle cells by a new HMG-CoA reductase inhibitor, pitavastatin.

  Hypertension research : official journal of the Japanese Society of Hypertension 20020301

• Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.

  Biochemical and biophysical research communications 20020111

• Pitavastatin. Itavastatin, Nisvastatin, Nk 104, Nks 104, P 872441.

  Drugs in R&D 20020101

• Clinical efficacy of pitavastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in patients with hyperlipidemia. Dose-finding study using the double-blind, three-group parallel comparison.

  Arzneimittel-Forschung 20020101

• The effect of statins on mRNA levels of genes related to inflammation, coagulation, and vascular constriction in HUVEC. Human umbilical vein endothelial cells.

  Journal of atherosclerosis and thrombosis 20020101

• Metabolic fate of pitavastatin (NK-104), a new inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase. Effects on drug-metabolizing systems in rats and humans.

  Arzneimittel-Forschung 20020101

• [Lipid-lowering drugs].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20011201

• Synthesis and biological evaluations of quinoline-based HMG-CoA reductase inhibitors.

  Bioorganic & medicinal chemistry 20011001

• Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts.

  Biochemical and biophysical research communications 20010921

• Simultaneous determination of taxol and its metabolites in microsomal samples by a simple thin-layer chromatography radioactivity assay--inhibitory effect of NK-104, a new inhibitor of HMG-CoA reductase.

  Journal of chromatography. B, Biomedical sciences and applications 20010605

• Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I.

  The Journal of clinical investigation 20010601

• NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells.

  British journal of pharmacology 20010501

• [New statins under clinical development: nisvastatin and rosuvastatin].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• Hypolipidemic effect of NK-104 and other 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in guinea pigs.

  Arzneimittel-Forschung 20010101

• Cholesterol-lowering effect of NK-104, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in guinea pig model of hyperlipidemia.

  Arzneimittel-Forschung 20010101