1477-19-6 | Benzarone

Packsize	Purity	Availability	Price	Discounted Price
1g	>98.0%(GC)	in stock	$39.00	$27.00
5g	95%	in stock	$162.00	$114.00
10g	97%	in stock	$233.00	$163.00

Description

• Catalog Number: AA66048
• Chemical Name: Benzarone
• CAS Number: 1477-19-6
• Molecular Formula: C17H14O3
• Molecular Weight: 266.2913
• MDL Number: MFCD00867417
• SMILES: CCc1oc2c(c1C(=O)c1ccc(cc1)O)cccc2
• NSC Number: 82134

Computed Properties

• Complexity: 346
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 4.3

Literature

• Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

  Chemical research in toxicology 20170515

• Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.

  Toxicological sciences : an official journal of the Society of Toxicology 20120601

• The EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by benzbromarone.

  PloS one 20120101

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• [Drug-induced hepatic injury, the challenge for cause investigation].

  Rinsho byori. The Japanese journal of clinical pathology 20111201

• Developing potent human uric acid transporter 1 (hURAT1) inhibitors.

  Journal of medicinal chemistry 20110428

• Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.

  Nephrology (Carlton, Vic.) 20110201

• Current concepts of mechanisms in drug-induced hepatotoxicity.

  Current medicinal chemistry 20090801

• Mechanisms of benzarone and benzbromarone-induced hepatic toxicity.

  Hepatology (Baltimore, Md.) 20050401

• Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.

  Liver 19950201

• Subfulminant hepatitis requiring liver transplantation after benzarone administration.

  Journal of hepatology 19940601

• [Drug-induced hepatitis due to benzarone (Fragivix): apropos of a clinical case report].

  Acta gastro-enterologica Belgica 19900101