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Interplay between lysosomal, mitochondrial and death receptor pathways during manganese-induced apoptosis in glial cells.
Archives of toxicology 20170901
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Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation.
Oncotarget 20161108
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GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death.
Cancer letters 20130201
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Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20120815
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Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process.
Cell death and differentiation 20120801
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Autophagic-lysosomal dysregulation downstream of cathepsin B inactivation in human skin fibroblasts exposed to UVA.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20120101
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Pepstatin A alters host cell autophagic machinery and leads to a decrease in influenza A virus production.
Journal of cellular physiology 20111201
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An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001
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Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity.
The Journal of biological chemistry 20110930
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Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B.
American journal of physiology. Cell physiology 20110501
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Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion.
Breast cancer research : BCR 20110101
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Doxorubicin-induced cell death requires cathepsin B in HeLa cells.
Biochemical pharmacology 20101115
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
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A role for the lysosomal protease cathepsin B in zebrafish follicular apoptosis.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20100601
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Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.
PLoS neglected tropical diseases 20100601
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Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells.
International journal of cancer 20100515
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Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells.
Biological chemistry 20100501
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Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition.
Cellular microbiology 20100201
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Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke.
Brain research 20100122
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Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts.
Photochemistry and photobiology 20100101
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Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.
Virology 20091125
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Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice.
Chinese medical journal 20091020
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Specific cathepsin B inhibitor is cell-permeable and activates presentation of TTC in primary human dendritic cells.
Immunology letters 20090427
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Role of cathepsin B-mediated apoptosis in fulminant hepatic failure in mice.
World journal of gastroenterology 20090314
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Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75.
Molecular cancer 20090101
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IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts.
Journal of cellular physiology 20081101
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Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat.
Neuroscience letters 20080919
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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Nature immunology 20080801
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Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 20080701
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Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.
The Journal of biological chemistry 20080321
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Fluid shear-induced activation and cleavage of CD18 during pseudopod retraction by human neutrophils.
Journal of cellular physiology 20080201
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Calcium signaling leads to mitochondrial depolarization in impact-induced chondrocyte death in equine articular cartilage explants.
Arthritis and rheumatism 20070701
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Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology 20070601
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Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells.
Blood 20070401
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Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease.
Biological chemistry 20070201
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Endogenous expression and endocytosis of tartrate-resistant acid phosphatase (TRACP) by osteoblast-like cells.
Bone 20050601
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Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown.
Cell death and differentiation 20041201
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Inhibitors of cysteine cathepsin and calpain do not prevent ultraviolet-B-induced apoptosis in human keratinocytes and HeLa cells.
Archives of dermatological research 20040701
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Cysteine proteases and cell differentiation: excystment of the ciliated protist Sterkiella histriomuscorum.
Eukaryotic cell 20031201
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Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin.
Cell death and differentiation 20030901
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Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis.
The Journal of biological chemistry 20030606
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Cathepsin B in osteoblasts.
Biochimica et biophysica acta 20030502
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Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity.
American journal of physiology. Gastrointestinal and liver physiology 20020901
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Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells.
The Journal of biological chemistry 20020705
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Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas.
International journal of cancer 20020220
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CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells.
Biological chemistry 20020101
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Treatment with cathepsin L inhibitor potentiates Th2-type immune response in Leishmania major-infected BALB/c mice.
International immunology 20010801
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Inhibition of endosomal insulin-like growth factor-I processing by cysteine proteinase inhibitors blocks receptor-mediated functions.
The Journal of biological chemistry 20010427
