148016-81-3 | Doripenem

Packsize	Purity	Availability	Price	Discounted Price
5mg	95%	in stock	$47.00	$33.00
10mg	95%	in stock	$79.00	$55.00
25mg	95%	in stock	$185.00	$130.00
50mg	95	in stock	$327.00	$229.00
100mg	95	in stock	$478.00	$335.00

Description

• Catalog Number: AD19474
• Chemical Name: Doripenem
• CAS Number: 148016-81-3
• Molecular Formula: C15H24N4O6S2
• Molecular Weight: 420.5043
• MDL Number: MFCD02092739
• SMILES: C[C@H]([C@H]1C(=O)N2[C@@H]1[C@@H](C)C(=C2C(=O)O)S[C@@H]1CN[C@@H](C1)CNS(=O)(=O)N)O

Computed Properties

• Complexity: 780
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 6
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 5
• Rotatable Bond Count: 7
• XLogP3: -3.4

Literature

• Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

  Chemical research in toxicology 20150518

• Pharmacokinetics of single-dose doripenem in adults with cystic fibrosis.

  Journal of clinical pharmacology 20121101

• Pharmacodynamics of doripenem in critically ill patients with ventilator-associated Gram-negative bacilli pneumonia.

  International journal of antimicrobial agents 20121101

• Two cases of peritonsillar abscess complicated by von Willebrand disease.

  Auris, nasus, larynx 20121001

• Pharmacokinetics and monte carlo simulations of doripenem in patients with febrile neutropenia.

  The Annals of pharmacotherapy 20121001

• Doripenem: excess mortality.

  Prescrire international 20120901

• [Septic shock following flexible transurethral lithotripsy showing favourable response after multidisciplinary treatment mainly composed of recombinant thrombomodulin : a case report].

  Hinyokika kiyo. Acta urologica Japonica 20120901

• In vitro antimicrobial activity of 'last-resort' antibiotics against unusual nonfermenting Gram-negative bacilli clinical isolates.

  Microbial drug resistance (Larchmont, N.Y.) 20120801

• Pharmacokinetics of doripenem in CSF of patients with non-inflamed meninges.

  The Journal of antimicrobial chemotherapy 20120701

• Antimicrobial susceptibility patterns of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii against carbapenems, colistin, and tigecycline.

  Saudi medical journal 20120701

• What's behind the failure of emerging antibiotics in the critically ill? Understanding the impact of altered pharmacokinetics and augmented renal clearance.

  International journal of antimicrobial agents 20120601

• Current epidemiology and growing resistance of gram-negative pathogens.

  The Korean journal of internal medicine 20120601

• Synergy of fosfomycin with carbapenems, colistin, netilmicin, and tigecycline against multidrug-resistant Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa clinical isolates.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20120501

• Penetration of doripenem in human brain: an observational microdialysis study in patients with acute brain injury.

  International journal of antimicrobial agents 20120401

• Comparative in vitro activity of carbapenems against major Gram-negative pathogens: results of Asia-Pacific surveillance from the COMPACT II study.

  International journal of antimicrobial agents 20120401

• Pseudomonas aeruginosa is not just in the intensive care unit any more: implications for empirical therapy.

  Critical care medicine 20120401

• Essentials for selecting antimicrobial therapy for intra-abdominal infections.

  Drugs 20120401

• Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin.

  Expert review of anti-infective therapy 20120401

• Efficacy of doripenem against Escherichia coli and Klebsiella pneumoniae in experimental meningitis.

  The Journal of antimicrobial chemotherapy 20120301

• Evaluation of doripenem in an experimental model of resistant Pseudomonas aeruginosa pneumonia.

  The Journal of antimicrobial chemotherapy 20120301

• Predicting doripenem susceptibility based on meropenem and imipenem interpretation for Pseudomonas aeruginosa.

  Diagnostic microbiology and infectious disease 20120301

• Comparative Activity of Carbapenem Testing (COMPACT) study in Germany.

  International journal of antimicrobial agents 20120301

• Carbapenem-resistant Pseudomonas aeruginosa pneumonia with intermediate minimum inhibitory concentrations to doripenem: combination therapy with high-dose, 4-h infusion of doripenem plus fosfomycin versus intravenous colistin plus fosfomycin.

  International journal of antimicrobial agents 20120301

• Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic-pharmacodynamic evaluation.

  Journal of chemotherapy (Florence, Italy) 20120201

• [Sensitivity surveillance of Pseudomonas aeruginosa isolates for several antibacterial agents in Gifu and Aichi prefecture (2008)].

  The Japanese journal of antibiotics 20120201

• [Antimicrobial susceptibilityof clinical isolates of aerobic gram-negative bacteria in 2008].

  The Japanese journal of antibiotics 20120201

• ESBLs: A Clear and Present Danger?

  Critical care research and practice 20120101

• Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation.

  European journal of clinical pharmacology 20120101

• Carbapenem stewardship: does ertapenem affect Pseudomonas susceptibility to other carbapenems? A review of the evidence.

  International journal of antimicrobial agents 20120101

• Clostridia in premature neonates' gut: incidence, antibiotic susceptibility, and perinatal determinants influencing colonization.

  PloS one 20120101

• Comparative activity of carbapenem testing (the COMPACT study) in Turkey.

  BMC infectious diseases 20120101

• CTX-M Enzymes: Origin and Diffusion.

  Frontiers in microbiology 20120101

• A comparative analysis of meropenem and doripenem in febrile patients with hematologic malignancies: a single-center retrospective study.

  Japanese journal of infectious diseases 20120101

• Correlation between the consumption of meropenem or doripenem and meropenem susceptibility of Pseudomonas aeruginosa in a university hospital in Japan.

  Biological & pharmaceutical bulletin 20120101

• A case of Lemierre's syndrome in association with liver abscess without any other metastatic lesions.

  Internal medicine (Tokyo, Japan) 20120101

• Doripenem vs meropenem against Pseudomonas and Acinetobacter.

  Indian journal of medical microbiology 20120101

• Doripenem dosing recommendations for critically ill patients receiving continuous renal replacement therapy.

  ISRN pharmacology 20120101

• Evaluation of doripenem utilization and susceptibilities at a large urban hospital.

  International journal of clinical pharmacy 20111201

• In vitro activity studies of doripenem and two other carbapenems tested against Pseudomonas aeruginosa and other non-fermentative bacilli.

  Journal of chemotherapy (Florence, Italy) 20111201

• [Surveillance of antimicrobial activity of Pseudomonas aeruginosa isolated in the Kinki district].

  The Japanese journal of antibiotics 20111201

• In vitro antibacterial activities of doripenem, imipenem, and meropenem against recent Streptococcus pneumoniae isolates.

  Diagnostic microbiology and infectious disease 20111101

• Validation of doripenem dosing in patients with end-stage renal disease receiving hemodialysis.

  The Annals of pharmacotherapy 20111101

• Continuous-infusion antipseudomonal Beta-lactam therapy in patients with cystic fibrosis.

  P & T : a peer-reviewed journal for formulary management 20111101

• Bacteremia caused by Brevundimonas species at a tertiary care hospital in Taiwan, 2000-2010.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20111001

• Longitudinal survey of carbapenem resistance and resistance mechanisms in Enterobacteriaceae and non-fermenters from the USA in 2007-09.

  The Journal of antimicrobial chemotherapy 20111001

• Pseudomonas aeruginosa carbapenem resistance mechanisms in Spain: impact on the activity of imipenem, meropenem and doripenem.

  The Journal of antimicrobial chemotherapy 20110901

• Pharmacodynamic evaluation of i.v. antimicrobials against Pseudomonas aeruginosa samples collected from U.S. hospitals.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110901

• Bacteraemia caused by Weissella confusa at a university hospital in Taiwan, 1997-2007.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20110801

• The laboratory diagnosis of Pseudomonas aeruginosa that produce metallo-β-lactamases in a Dutch tertiary care centre.

  Scandinavian journal of infectious diseases 20110801

• Update on resistance of Bacteroides fragilis group and related species with special attention to carbapenems 2006-2009.

  Anaerobe 20110801

• Consensus review of the epidemiology and appropriate antimicrobial therapy of complicated urinary tract infections in Asia-Pacific region.

  The Journal of infection 20110801

• The Retrospective Cohort of Extended-Infusion Piperacillin-Tazobactam (RECEIPT) study: a multicenter study.

  Pharmacotherapy 20110801

• [In vitro combination effects of doripenem with aminoglycoside or ciprofloxacin against Pseudomonas aeruginosa].

  The Japanese journal of antibiotics 20110801

• Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime.

  The Medical clinics of North America 20110701

• In vivo efficacy of doripenem (DRPM) against Pseudomonas aeruginosa in murine chronic respiratory tract infection model.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110601

• Phenotypic and genotypic screening and clonal analysis of carbapenem-resistant Klebsiella pneumoniae at a single hospital.

  Microbial drug resistance (Larchmont, N.Y.) 20110601

• Comparative in vitro susceptibility of Burkholderia pseudomallei to doripenem, ertapenem, tigecycline and moxifloxacin.

  International journal of antimicrobial agents 20110601

• Removal of doripenem during hemodialysis and the optimum dosing regimen for patients undergoing hemodialysis.

  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20110601

• Diagnosis and management of community-acquired pneumonia in adults.

  American family physician 20110601

• Comparative activity of carbapenem testing: the COMPACT study.

  The Journal of antimicrobial chemotherapy 20110501

• Simultaneous determination of eight β-lactam antibiotics in human serum by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110501

• A liquid chromatography assay for a quantification of doripenem, ertapenem, imipenem, meropenem concentrations in human plasma: application to a clinical pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110501

• Bacteremia caused by Laribacter hongkongensis misidentified as Acinetobacter lwoffii: report of the first case in Korea.

  Journal of Korean medical science 20110501

• [Activity of doripenem against anaerobic bacteria].

  Pathologie-biologie 20110401

• In vitro antibacterial activity of doripenem against clinical isolates from French teaching hospitals: proposition of zone diameter breakpoints.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20110401

• Fluoroquinolone use is not associated with the change in imipenem susceptibility of Pseudomonas aeruginosa in 25 hospitals.

  Advances in therapy 20110401

• Epileptogenic potential of carbapenem agents: mechanism of action, seizure rates, and clinical considerations.

  Pharmacotherapy 20110401

• Gastrointestinal selective capacity of doripenem, meropenem, and imipenem for carbapenem-resistant gram-negative bacilli in treated patients with pneumonia.

  Infection control and hospital epidemiology 20110401

• Efficacy of combination use of Beta-lactamase inhibitor with penicillin and fluoroquinolones for antibiotic prophylaxis in transrectal prostate biopsy.

  Korean journal of urology 20110401

• [Comparative evaluation of in vitro activities of carbapenems against gram-negative pathogens: Turkish data of COMPACT study].

  Mikrobiyoloji bulteni 20110401

• Structures of the class D carbapenemase OXA-24 from Acinetobacter baumannii in complex with doripenem.

  Journal of molecular biology 20110304

• Antimicrobial activity of doripenem and other carbapenems against gram-negative pathogens from Korea.

  Microbial drug resistance (Larchmont, N.Y.) 20110301

• Pharmacodynamic profiling of intravenous antibiotics against prevalent Gram-negative organisms across the globe: the PASSPORT Program-Asia-Pacific Region.

  International journal of antimicrobial agents 20110301

• Antimicrobial susceptibility of 15,644 pathogens from Canadian hospitals: results of the CANWARD 2007-2009 study.

  Diagnostic microbiology and infectious disease 20110301

• Pretracheal abscess following two weeks of endotracheal intubation.

  The Yale journal of biology and medicine 20110301

• Stability of doripenem, imipenem and meropenem at elevated room temperatures.

  International journal of antimicrobial agents 20110201

• Potential interaction between valproic acid and doripenem.

  Current drug safety 20110201

• Determination of doripenem and related substances in medicinal product using capillary electrophoresis.

  Journal of separation science 20110201

• [Validity of using imipenem as a representative carbapenems and levofloxacin as a representative fluoroquinolones in antibiotics susceptibility test for enterobacteriaceae].

  The Japanese journal of antibiotics 20110201

• Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms.

  Journal of molecular biology 20110107

• Clostridium sphenoides bloodstream infection in man.

  Emerging infectious diseases 20110101

• WSES consensus conference: Guidelines for first-line management of intra-abdominal infections.

  World journal of emergency surgery : WJES 20110101

• Antimicrobial resistance surveillance in the AFHSC-GEIS network.

  BMC public health 20110101

• [Antibiotic susceptibility to parental antibiotics and penicillin-binding-protein genotype in Haemophilus influenzae isolated from children with invasive infection].

  Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20110101

• Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong.

  PloS one 20110101

• New treatment options against gram-negative organisms.

  Critical care (London, England) 20110101

• Antimicrobial treatment of 'complicated' intra-abdominal infections and the new IDSA guidelines ? a commentary and an alternative European approach according to clinical definitions.

  European journal of medical research 20110101

• Impact of a Multimodal Antimicrobial Stewardship Program on Pseudomonas aeruginosa Susceptibility and Antimicrobial Use in the Intensive Care Unit Setting.

  Critical care research and practice 20110101

• Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis.

  Infection and drug resistance 20110101

• Does prolonged β-lactam infusions improve clinical outcomes compared to intermittent infusions? A meta-analysis and systematic review of randomized, controlled trials.

  BMC infectious diseases 20110101

• Effect of hemopurification rate on doripenem pharmacokinetics in critically ill patients receiving high-flow continuous hemodiafiltration.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110101

• Molecular basis of NDM-1, a new antibiotic resistance determinant.

  PloS one 20110101

• Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo-β-lactamase.

  PloS one 20110101

• Meropenem vs standard of care for treatment of late onset sepsis in children of less than 90 days of age: study protocol for a randomised controlled trial.

  Trials 20110101

• [Review of the effectiveness of an empirical antibiotic therapy in suspected ventilator-associated pneumonia].

  Anestezjologia intensywna terapia 20110101

• Diuretics induced uremia and nonrecovery of renal function in a patient with acute renal failure caused by sepsis.

  Indian journal of pharmacology 20110101

• Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases.

  Case reports in medicine 20110101

• Effective antibiotics in combination against extreme drug-resistant Pseudomonas aeruginosa with decreased susceptibility to polymyxin B.

  PloS one 20110101

• Surveillance of broad-spectrum antibiotic prescription in Singaporean hospitals: a 5-year longitudinal study.

  PloS one 20110101

• [Antimicrobial sensitive of Morganella morganii].

  Medycyna doswiadczalna i mikrobiologia 20110101

• [Susceptibility to antibiotics of Enterobacter spp. rods isolated from urine].

  Medycyna doswiadczalna i mikrobiologia 20110101

• Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study.

  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101

• Assessing the pharmacodynamic profile of intravenous antibiotics against prevalent Gram-negative organisms collected in Colombia.

  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101

• A novel combination regimen for the treatment of refractory bacteremia due to multidrug-resistant Pseudomonas aeruginosa in a liver transplant recipient.

  Transplant infectious disease : an official journal of the Transplantation Society 20101201

• In vitro activity of doripenem and other carbapenems against contemporary Gram-negative pathogens isolated from hospitalised patients in the Asia-Pacific region: results of the COMPACT Asia-Pacific Study.

  International journal of antimicrobial agents 20101201

• Use of high-dose 4-hour infusion of doripenem, in combination with fosfomycin, for treatment of carbapenem-resistant Pseudomonas aeruginosa pneumonia.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20101201

• Doripenem: a new carbapenem antibiotic.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20101201

• Safety and efficacy of intravenous doripenem for the treatment of complicated urinary tract infections and pyelonephritis.

  Journal of chemotherapy (Florence, Italy) 20101201

• Efficacy of doripenem in the treatment of Pseudomonas aeruginosa experimental pneumonia versus imipenem and meropenem.

  The Journal of antimicrobial chemotherapy 20101101

• Nosocomial infections: new therapeutic alternatives.

  Expert review of anti-infective therapy 20101101

• The UV-derivative spectrophotometry for the determination of doripenem in the presence of its degradation products.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20101001

• Cost-effectiveness model of empiric doripenem compared with imipenem-cilastatin in ventilator-associated pneumonia.

  Surgical infections 20101001

• Antimicrobial activity of doripenem against bacterial isolates from humans and animals.

  The Journal of antibiotics 20101001

• Stability of doripenem in polyvinyl chloride bags and elastomeric pumps.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100915

• Activity of doripenem against extended-spectrum beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa isolates.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20100901

• Newer antibacterial agents and their potential role in cystic fibrosis pulmonary exacerbation management.

  The Journal of antimicrobial chemotherapy 20100901

• [Comparative activity of doripenem, meropenem, and imipenem in recent clinical isolates obtained during the COMPACT-Spain epidemiological surveillance study].

  Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20100901

• [Available carbapenems: Properties and differences].

  Enfermedades infecciosas y microbiologia clinica 20100901

• [Role of new carbapenems in nosocomial intraabdominal infection].

  Enfermedades infecciosas y microbiologia clinica 20100901

• Clostridium difficile bacteremia, Taiwan.

  Emerging infectious diseases 20100801

• The pharmacokinetics and pharmacodynamics of the carbapanemes: focus on doripenem.

  Journal of chemotherapy (Florence, Italy) 20100801

• Proposed disc zone breakpoints for doripenem for use with the BSAC disc susceptibility testing method.

  The Journal of antimicrobial chemotherapy 20100701

• Activity of doripenem with and without levofloxacin, amikacin, and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii.

  Diagnostic microbiology and infectious disease 20100601

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20100601

• Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.

  Biochemistry 20100504

• Pharmacokinetic/pharmacodynamic modeling and simulation to determine effective dosage regimens for doripenem.

  Journal of pharmaceutical sciences 20100501

• Stability of meropenem and doripenem solutions for administration by continuous infusion.

  The Journal of antimicrobial chemotherapy 20100501

• Penetration of doripenem into prostatic tissue following intravenous administration in prostatectomy patients.

  International journal of antimicrobial agents 20100501

• Potential of doripenem for the treatment of infections with multidrug-resistant Pseudomonas spp.

  International journal of antimicrobial agents 20100501

• In vitro activities of doripenem and other carbapenems against clinically important bacteria isolated in intensive care units: nationwide data from the SMART Programme.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20100401

• Treatment of Acinetobacter infections.

  Expert opinion on pharmacotherapy 20100401

• Predictability of doripenem susceptibility in Acinetobacter baumannii isolates based on other carbapenem susceptibilities and bla OXA gene status.

  Pharmacotherapy 20100401

• Pharmacodynamic modeling of intravenous antibiotics against gram-negative bacteria collected in the United States.

  Clinical therapeutics 20100401

• [Update on antimicrobial chemotherapy].

  Medecine et maladies infectieuses 20100301

• Economic assessment of doripenem versus imipenem in the treatment of ventilator-associated pneumonia.

  Journal of medical economics 20100301

• Enhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2.

  Biochemistry 20100209

• Doripenem: an early look at a carbapenem not yet approved for pediatrics.

  The Pediatric infectious disease journal 20100201

• Economic evaluation of doripenem for the treatment of nosocomial pneumonia in the US: discrete event simulation.

  Current medical research and opinion 20100101

• Doripenem pharmacokinetics in critically ill patients receiving continuous hemodiafiltration (CHDF).

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100101

• Lessons learned from the anaerobe survey: historical perspective and review of the most recent data (2005-2007).

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100101

• Infected foot ulcers in male and female diabetic patients: a clinico-bioinformative study.

  Annals of clinical microbiology and antimicrobials 20100101

• Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion.

  BMC genomics 20100101

• Novel treatment approach to combat an infection with Acinetobacter.

  Proceedings (Baylor University. Medical Center) 20100101

• A focus on intra-abdominal infections.

  World journal of emergency surgery : WJES 20100101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20100101

• Medical resource utilization among patients with ventilator-associated pneumonia: pooled analysis of randomized studies of doripenem versus comparators.

  Critical care (London, England) 20100101

• Pharmacokinetic-pharmacodynamic profiling of four antimicrobials against gram-negative bacteria collected from Shenyang, China.

  BMC infectious diseases 20100101

• Bench-to-bedside review: The role of beta-lactamases in antibiotic-resistant Gram-negative infections.

  Critical care (London, England) 20100101

• Current status of carbapenem antibiotics.

  Current topics in medicinal chemistry 20100101

• [Nonfermentative gram-negative bacteria: isolation rates and antibiotic sensitivity].

  Anesteziologiia i reanimatologiia 20100101

• Imipenem resistance of Pseudomonas in pneumonia: a systematic literature review.

  BMC pulmonary medicine 20100101

• Molecular and therapeutic potential and toxicity of valproic acid.

  Journal of biomedicine & biotechnology 20100101

• Multidrug resistant acinetobacter.

  Journal of global infectious diseases 20100101

• Interaction of CTX-M-15 enzyme with cefotaxime: a molecular modelling and docking study.

  Bioinformation 20100101

• [PCR-RAPD typing of carbapenem-resistant Pseudomonas aeruginosa strains].

  Medycyna doswiadczalna i mikrobiologia 20100101

• Multiresistant bacteria and current therapy - the economical side of the story.

  European journal of medical research 20100101

• [In vitro activity of doripenem and other carbapenems against Pseudomonas aeruginosa].

  Revista Argentina de microbiologia 20100101

• Comparison of the in vitro activity of meropenem and doripenem against Pseudomonas aeruginosa and multidrug-resistant Enterobacteriaceae.

  Acta clinica Belgica 20100101

• Current strategies for the prevention and management of central line-associated bloodstream infections.

  Infection and drug resistance 20100101

• The 1.4 A crystal structure of the class D beta-lactamase OXA-1 complexed with doripenem.

  Biochemistry 20091222

• Correlation between meropenem and doripenem use density and the incidence of carbapenem-resistant Pseudomonas aeruginosa.

  International journal of antimicrobial agents 20091201

• Susceptibility of Pseudomonas aeruginosa clinical isolates in Japan to doripenem and other antipseudomonal agents.

  International journal of antimicrobial agents 20091201

• Meta-analysis of doripenem vs comparators in patients with pseudomonas infections enrolled in four phase III efficacy and safety clinical trials.

  Current medical research and opinion 20091201

• [Doripenem: need for a new carbapenem].

  Medecine et maladies infectieuses 20091201

• Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime.

  Infectious disease clinics of North America 20091201

• [A case of pulmonary infection caused by Pseudomonas aeruginosa with anorexia nervosa].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20091201

• Doripenem versus bacteria: an emerging battleground.

  Journal of chemotherapy (Florence, Italy) 20091101

• The role of sulfamide derivatives in medicinal chemistry: a patent review (2006-2008).

  Expert opinion on therapeutic patents 20091001

• [New antibiotics: small or big advances?].

  Der Internist 20091001

• Multidrug-resistant Gram-negative infections: what are the treatment options?

  Drugs 20091001

• The changing face of antibiotic therapy.

  British journal of hospital medicine (London, England : 2005) 20091001

• BSAC standardized disc susceptibility testing method (version 8).

  The Journal of antimicrobial chemotherapy 20090901

• Doripenem: a new carbapenem in the treatment of nosocomial infection.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090815

• In vitro activity of doripenem.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090815

• Efficacy of intravenous infusion of doripenem.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090815

• Safety of intravenous infusion of doripenem.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090815

• Clinical and economic consequences of ventilator-associated pneumonia.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090815

• Antimicrobial resistance among and therapeutic options against gram-negative pathogens.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090815

• Impact of dissimilar susceptibility breakpoints for doripenem on susceptibility and carbapenem discordance for Pseudomonas aeruginosa.

  Diagnostic microbiology and infectious disease 20090801

• Doripenem-induced intertriginous drug eruption as a mild form of AGEP.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20090801

• Update on the treatment of Pseudomonas aeruginosa pneumonia.

  The Journal of antimicrobial chemotherapy 20090801

• Doripenem.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090715

• An analysis of current pharmaceutical industry practices for making clinical trial results publicly accessible.

  Contemporary clinical trials 20090701

• Comparative in vitro activities of nemonoxacin, doripenem, tigecycline and 16 other antimicrobials against Nocardia brasiliensis, Nocardia asteroides and unusual Nocardia species.

  The Journal of antimicrobial chemotherapy 20090701

• Pharmacokinetics, safety, and tolerability of doripenem after 0.5-, 1-, and 4-hour infusions in healthy volunteers.

  Journal of clinical pharmacology 20090701

• Lost in translation: differences in antimicrobial indication approval policies between the United States and Europe.

  Clinical therapeutics 20090701

• Successful treatment with doripenem and tobramycin of ventriculitis due to imipenem- and meropenem-resistant Pseudomonas aeruginosa.

  The Journal of antimicrobial chemotherapy 20090601

• Doripenem: position in clinical practice.

  Expert review of anti-infective therapy 20090601

• [Analysis on the sensitivity to beta-lactam antibiotics of respiratory-infectious isolates on the second survey on the sensitivity of isolates conducted by the Japanese Society of Chemotherapy in 2007--concerning the aspect of PK/PD break points].

  The Japanese journal of antibiotics 20090601

• Doripenem activity tested against a global collection of Enterobacteriaceae, including isolates resistant to other extended-spectrum agents.

  Diagnostic microbiology and infectious disease 20090401

• Activity of a novel carbapenem, doripenem, against anaerobic pathogens.

  Diagnostic microbiology and infectious disease 20090401

• Antimicrobial activities of doripenem and other carbapenems against Pseudomonas aeruginosa, other nonfermentative bacilli, and Aeromonas spp.

  Diagnostic microbiology and infectious disease 20090401

• Pharmacokinetic-pharmacodynamic modeling to support doripenem dose regimen optimization for critically ill patients.

  Diagnostic microbiology and infectious disease 20090401

• In vitro potency of doripenem tested against an international collection of rarely isolated bacterial pathogens.

  Diagnostic microbiology and infectious disease 20090401

• Antimicrobial activity of doripenem tested against prevalent Gram-positive pathogens: results from a global surveillance study (2003-2007).

  Diagnostic microbiology and infectious disease 20090401

• Doripenem: antimicrobial profile and clinical potential.

  Diagnostic microbiology and infectious disease 20090401

• Pharmacokinetic-pharmacodynamic target attainment analysis of doripenem in infected patients.

  International journal of antimicrobial agents 20090301

• Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA.

  The Journal of antimicrobial chemotherapy 20090301

• In vitro activity of doripenem against Acinetobacter baumannii clinical isolates.

  International journal of antimicrobial agents 20090201

• New antibiotics for healthcare-associated pneumonia.

  Seminars in respiratory and critical care medicine 20090201

• Monte Carlo simulation for evaluation of the efficacy of carbapenems and new quinolones against ESBL-producing Escherichia coli.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20090201

• Doripenem: a new addition to the carbapenem class of antimicrobials.

  Recent patents on anti-infective drug discovery 20090101

• Management of severe abdominal infections.

  Recent patents on anti-infective drug discovery 20090101

• Current status of newer carbapenems.

  Current medicinal chemistry 20090101

• Doripenem monohydrate, a broad-spectrum carbapenem antibiotic.

  Clinical therapeutics 20090101

• Current treatment of pseudomonal infections in the elderly.

  Drugs & aging 20090101

• The use of carbapenems in the treatment of serious infections.

  Journal of intensive care medicine 20090101

• Overview of seizure-inducing potential of doripenem.

  Drug safety 20090101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20090101

• Characteristics of doripenem: a new broad-spectrum antibiotic.

  Drug design, development and therapy 20090101

• New antibiotics: optimal use in current clinical practice.

  International journal of antimicrobial agents 20090101

• [Activity of doripenem against Pseudomonas spp. and Acinetobacter spp. rods].

  Medycyna doswiadczalna i mikrobiologia 20090101

• New antibiotics for antibiotic-resistant bacteria.

  F1000 biology reports 20090101

• Recent changes in the epidemiology and management of extended-spectrum β-lactamase-producing Enterobacteriaceae.

  F1000 medicine reports 20090101

• Management of infections due to KPC-producing Klebsiella pneumoniae.

  F1000 medicine reports 20090101

• Doripenem in hospital infections: a focus on nosocomial pneumonia, complicated intra-abdominal infections, and complicated urinary tract infections.

  Infection and drug resistance 20090101

• What's new and not so new on the antimicrobial horizon?

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20081201

• New developments in carbapenems.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20081201

• Gateways to clinical trials. December 2008.

  Methods and findings in experimental and clinical pharmacology 20081201

• Effects of treatment with antimicrobial agents on the human colonic microflora.

  Therapeutics and clinical risk management 20081201

• Pharmacodynamic assessment of doripenem in peritoneal fluid against Gram-negative organisms: use of population pharmacokinetic modeling and Monte Carlo simulation.

  Diagnostic microbiology and infectious disease 20081101

• New antibiotic agents for bloodstream infections.

  International journal of antimicrobial agents 20081101

• Non-susceptibility trends among Enterobacteriaceae from bacteraemias in the UK and Ireland, 2001-06.

  The Journal of antimicrobial chemotherapy 20081101

• Current status of newer antiinfectives.

  Recent patents on anti-infective drug discovery 20081101

• Stability of doripenem in vitro in representative infusion solutions and infusion bags.

  Clinical therapeutics 20081101

• Lucasti et al in the May 2008 issue of Clinical Therapeutics.

  Clinical therapeutics 20081001

• Pharmacokinetic-pharmacodynamic modeling and simulation for bactericidal effect in an in vitro dynamic model.

  Journal of pharmaceutical sciences 20080901

• Development of breakpoints of carbapenems for intraabdominal infections based on pharmacokinetics and pharmacodynamics in peritoneal fluid.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080801

• Efficacy and safety of doripenem versus piperacillin/tazobactam in nosocomial pneumonia: a randomized, open-label, multicenter study.

  Current medical research and opinion 20080701

• Compatibility of doripenem with other drugs during simulated Y-site administration.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080701

• New drugs08, part 2.

  Nursing 20080701

• Doripenem (Doribax): the newest addition to the carbapenems.

  Proceedings (Baylor University. Medical Center) 20080701

• Doripenem: a new carbapenem.

  South Dakota medicine : the journal of the South Dakota State Medical Association 20080701

• Susceptibility of clinical isolates of Pseudomonas aeruginosa in the Northern Kyushu district of Japan to carbapenem antibiotics, determined by an integrated concentration method: evaluation of the method based on Monte Carlo simulation.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080601

• Quantification of doripenem in human plasma and peritoneal fluid by high-performance liquid chromatography with ultraviolet detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080501

• Doripenem: an expected arrival in the treatment of infections caused by multidrug-resistant Gram-negative pathogens.

  Expert opinion on investigational drugs 20080501

• Doripenem (doribax)--a new parenteral carbapenem.

  Obstetrics and gynecology 20080501

• Efficacy and tolerability of IV doripenem versus meropenem in adults with complicated intra-abdominal infection: a phase III, prospective, multicenter, randomized, double-blind, noninferiority study.

  Clinical therapeutics 20080501

• Pharmacokinetic-pharmacodynamic modeling and simulation for in vivo bactericidal effect in murine infection model.

  Journal of pharmaceutical sciences 20080401

• Current therapies for pseudomonas aeruginosa.

  Critical care clinics 20080401

• Efficacy and safety of intravenous infusion of doripenem versus imipenem in ventilator-associated pneumonia: a multicenter, randomized study.

  Critical care medicine 20080401

• 'The truth, if it exists, is in the details'.

  Critical care medicine 20080401

• Hospital resource utilization with doripenem versus imipenem in the treatment of ventilator-associated pneumonia.

  Clinical therapeutics 20080401

• [Clinical examination of doripenem for infectious diseases in gynecological and associated fields].

  The Japanese journal of antibiotics 20080401

• Activity of doripenem and comparator beta-lactams against US clinical isolates of Streptococcus pneumoniae with defined mutations in the penicillin-binding domains of pbp1a, pbp2b and pbp2x.

  The Journal of antimicrobial chemotherapy 20080301

• The role of carbapenems in the treatment of severe nosocomial respiratory tract infections.

  Expert opinion on pharmacotherapy 20080301

• Doripenem (doribax), a new carbapenem antibacterial agent.

  P & T : a peer-reviewed journal for formulary management 20080301

• Multidrug-resistant Gram-negative bacterial infections: the emerging threat and potential novel treatment options.

  Current opinion in investigational drugs (London, England : 2000) 20080201

• [In-vitro activity of panipenem against clinical isolates in 2006].

  The Japanese journal of antibiotics 20080201

• Doripenem (Doribax)--a new parenteral carbapenem.

  The Medical letter on drugs and therapeutics 20080128

• Carbapenems: a potent class of antibiotics.

  Expert opinion on pharmacotherapy 20080101

• New drugs: doripenem, raltegravir, and ixabepilone.

  Journal of the American Pharmacists Association : JAPhA 20080101

• Pharmacodynamic optimization of beta-lactams in the patient care setting.

  Critical care (London, England) 20080101

• An overview of harms associated with beta-lactam antimicrobials: where do the carbapenems fit in?

  Critical care (London, England) 20080101

• Doripenem: a review of its use in the treatment of bacterial infections.

  Drugs 20080101

• Clinical review: balancing the therapeutic, safety, and economic issues underlying effective antipseudomonal carbapenem use.

  Critical care (London, England) 20080101

• Peritoneal penetration of doripenem after intravenous administration in abdominal-surgery patients.

  The Journal of antimicrobial chemotherapy 20071201

• Selection of a surrogate beta-lactam testing agent for initial susceptibility testing of doripenem, a new carbapenem.

  Diagnostic microbiology and infectious disease 20071201

• [Antimicrobial activity of meropenem against main bacterial species isolated from patient blood in 2006].

  The Japanese journal of antibiotics 20071201

• [Analysis on the effective dosage regimens for meropenem, biapenem and doripenem against P. aeruginosa infection based on pharmacokinetics and pharmacodynamics theory].

  The Japanese journal of antibiotics 20071201

• Carbapenems in the USA: focus on doripenem.

  Expert review of anti-infective therapy 20071001

• Doripenem: A new carbapenem antibiotic a review of comparative antimicrobial and bactericidal activities.

  Therapeutics and clinical risk management 20071001

• [Strategies for management of difficult to treat Gram-negative infections: focus on Pseudomonas aeruginosa].

  Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20070901

• Empiric treatment options in the management of complicated intra-abdominal infections.

  Cleveland Clinic journal of medicine 20070801

• Development of an HPLC method for the determination of doripenem in human and mouse serum.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615

• Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20070601

• Biochemical characterisation of the CTX-M-14 beta-lactamase.

  International journal of antimicrobial agents 20070201

• Investigational treatments for postoperative surgical site infections.

  Expert opinion on investigational drugs 20070201

• Comparative review of the carbapenems.

  Drugs 20070101

• Occurrence of PER-1 producing clinical isolates of Pseudomonas aeruginosa in Japan and their susceptibility to doripenem.

  The Journal of antibiotics 20061201

• Clinical experience with recently approved antibiotics.

  Current opinion in pharmacology 20061001

• Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter baumannii and Pseudomonas aeruginosa.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060901

• Delayed resistance selection for doripenem when passaging Pseudomonas aeruginosa isolates with doripenem plus an aminoglycoside.

  Diagnostic microbiology and infectious disease 20060701

• [New antibiotics for the therapy of respiratory tract infections].

  Pneumologie (Stuttgart, Germany) 20060701

• Doripenem.

  Drugs of today (Barcelona, Spain : 1998) 20060601

• Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibiotics.

  Toxicology 20060501

• Potency of carbapenems for the prevention of carbapenem-resistant mutants of Pseudomonas aeruginosa: the high potency of a new carbapenem doripenem.

  The Journal of antibiotics 20060401

• Pharmacokinetics and tissue penetration of a new carbapenem, doripenem, intravenously administered to laboratory animals.

  In vivo (Athens, Greece) 20060101

• Antimicrobial activity of doripenem (S-4661): a global surveillance report (2003).

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20051201

• [A new carbapenem antibiotic for injection: characteristics of doripenem].

  The Japanese journal of antibiotics 20051201

• Study of the synergism between carbapenems and vancomycin or teicoplanin against MRSA, focusing on S-4661, a carbapenem newly developed in Japan.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20051001

• Acquisitions not a cure for anti-infectives.

  Nature reviews. Drug discovery 20050901

• Comparative in vitro antimicrobial activity of a new carbapenem, doripenem: tentative disc diffusion criteria and quality control.

  The Journal of antimicrobial chemotherapy 20050601

• Comparative activity of doripenem and three other carbapenems tested against Gram-negative bacilli with various beta-lactamase resistance mechanisms.

  Diagnostic microbiology and infectious disease 20050501

• Antibacterial Drug Discovery and Development Summit - Tenth Annual SRI Summit.

  IDrugs : the investigational drugs journal 20050501

• Mechanism of the drug interaction between valproic acid and carbapenem antibiotics in monkeys and rats.

  Drug metabolism and disposition: the biological fate of chemicals 20041201

• Activities of doripenem (S-4661) against drug-resistant clinical pathogens.

  Antimicrobial agents and chemotherapy 20040801

• Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations.

  The Journal of antimicrobial chemotherapy 20040701

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20031201

• Antimicrobial-induced release of endotoxin from Pseudomonas aeruginosa: comparison of in vitro and animal models.

  The Journal of antimicrobial chemotherapy 20030201

• Doripenem: S 4661.

  Drugs in R&D 20030101

• In vitro antibacterial activity of S-4661, a new parenteral carbapenem, against urological pathogens isolated from patients with complicated urinary tract infections.

  Journal of chemotherapy (Florence, Italy) 20020401