14907-98-3 | Brusatol

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$37.00	$26.00
5mg	98%	in stock	$92.00	$65.00

Description

• Catalog Number: AB53317
• Chemical Name: Brusatol
• CAS Number: 14907-98-3
• Molecular Formula: C26H32O11
• Molecular Weight: 520.5257
• MDL Number: MFCD01746220
• SMILES: COC(=O)[C@@]12OC[C@]34[C@H]2[C@@H](OC(=O)C=C(C)C)C(=O)O[C@@H]4C[C@@H]2[C@]([C@H]3[C@H]([C@@H]1O)O)(C)CC(=O)C(=C2C)O

Computed Properties

• Complexity: 1150
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 10
• Heavy Atom Count: 37
• Hydrogen Bond Acceptor Count: 11
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 5
• XLogP3: 0.9

Literature

• T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180401

• Gypenosides protect retinal pigment epithelium cells from oxidative stress.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180201

• Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells.

  Toxicology and applied pharmacology 20161101

• One new pregnane glycoside from the seeds of cultivated Brucea javanica.

  Archives of pharmacal research 20110801

• Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism.

  Proceedings of the National Academy of Sciences of the United States of America 20110125

• Brusatol-mediated induction of leukemic cell differentiation and G(1) arrest is associated with down-regulation of c-myc.

  Leukemia 20021101

• Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture.

  Journal of natural products 20011201