150322-43-3 | 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4H,5H,6H,7H-thieno[3,2-c]pyridin-2-yl acetate

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$11.00	$8.00
250mg	98%	in stock	$26.00	$18.00
1g	98%	in stock	$58.00	$41.00
5g	98%	in stock	$203.00	$142.00
10g	98%	in stock	$386.00	$270.00
25g	98%	in stock	$758.00	$531.00

Description

• Catalog Number: AA75638
• Chemical Name: 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4H,5H,6H,7H-thieno[3,2-c]pyridin-2-yl acetate
• CAS Number: 150322-43-3
• Molecular Formula: C20H20FNO3S
• Molecular Weight: 373.44110319999993
• MDL Number: MFCD09954140
• SMILES: CC(=O)Oc1sc2c(c1)CN(CC2)C(c1ccccc1F)C(=O)C1CC1

Computed Properties

• Complexity: 555
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Undefined Atom Stereocenter Count: 1
• XLogP3: 3.6

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  Giornale italiano di cardiologia (2006) 20101201

• Platelet inhibition and cancer promotion.

  Archives of internal medicine 20101122

• Prasugrel and cancer.

  Archives of internal medicine 20101122

• Identification, evaluation and treatment of prasugrel low-response after coronary stent implantation--a preliminary study.

  Thrombosis research 20101101

• A new era for antiplatelet therapy in patients with acute coronary syndrome.

  The American journal of the medical sciences 20101101

• A comparison of the metabolism of clopidogrel and prasugrel.

  Expert opinion on drug metabolism & toxicology 20101101

• Ticagrelor and prasugrel: two novel, most-promising antiplatelet agents.

  Recent patents on cardiovascular drug discovery 20101101

• Price, pragmatism and ∇prasugrel.

  Drug and therapeutics bulletin 20101101

• Clinical impact of enhanced inhibition of P2Y12-mediated platelet aggregation in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention.

  Hospital practice (1995) 20101101

• [Medication of the month. Prasugrel (Efient): potent thienopyridine antiplatelet agent].

  Revue medicale de Liege 20101101

• Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.

  Lancet (London, England) 20101016

• Response to antiplatelet treatment: from genes to outcome.

  Lancet (London, England) 20101016

• State of the art of new P2Y12 antagonists.

  Internal and emergency medicine 20101001

• Diabetes and the platelet: toward new therapeutic paradigms for diabetic atherothrombosis.

  Atherosclerosis 20101001

• Prasugrel as antiplatelet therapy in patients with acute coronary syndromes or undergoing percutaneous coronary intervention.

  Critical care nurse 20101001

• Impact of genetic polymorphisms and drug-drug interactions on clopidogrel and prasugrel response variability.

  Current drug metabolism 20101001

• Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in patients with acute coronary syndromes: results of the SWAP (SWitching Anti Platelet) study.

  Journal of the American College of Cardiology 20100921

• New antithrombotic agents--insights from clinical trials.

  Nature reviews. Cardiology 20100901

• Prasugrel versus clopidogrel in Asian patients with acute coronary syndromes: design and rationale of a multi-dose, pharmacodynamic, phase 3 clinical trial.

  Current medical research and opinion 20100901

• Controversies in oral antiplatelet therapy in patients undergoing aortocoronary bypass surgery.

  The Annals of thoracic surgery 20100901

• Prasugrel for the treatment of acute coronary syndromes with percutaneous coronary intervention: NICE technology appraisal guidance.

  Heart (British Cardiac Society) 20100901

• Letter by Serebruany regarding article, 'Cost-effectiveness of prasugrel versus clopidogrel in patients with acute coronary syndromes and planned percutaneous coronary intervention: results from the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis in Myocardial Infarction TRITON-TIMI 38'.

  Circulation 20100824

• Prasugrel vs. clopidogrel for cytochrome P450 2C19-genotyped subgroups: integration of the TRITON-TIMI 38 trial data.

  Journal of thrombosis and haemostasis : JTH 20100801

• [Platelet inhibition with prasugrel].

  Deutsche medizinische Wochenschrift (1946) 20100801

• Pharmacologic therapy for non ST-segment elevation acute coronary syndromes: focus on antithrombotic therapy.

  Cardiovascular drugs and therapy 20100801

• Angiographic and clinical outcomes among patients with acute coronary syndromes presenting with isolated anterior ST-segment depression: a TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis In Myocardial Infarction 38) substudy.

  JACC. Cardiovascular interventions 20100801

• Prasugrel.

  Circulation 20100727

• Formation and fate of a sulfenic acid intermediate in the metabolic activation of the antithrombotic prodrug prasugrel.

  Chemical research in toxicology 20100719

• Mortality in the TRITON trial: update from the FDA prasugrel action package.

  The American journal of cardiology 20100715

• The role of antiplatelet therapy in the secondary prevention of coronary artery disease.

  Current opinion in cardiology 20100701

• A comparison of the VerifyNow P2Y12 point-of-care device and light transmission aggregometry to monitor platelet function with prasugrel and clopidogrel: an integrated analysis.

  Journal of cardiovascular pharmacology 20100701

• Antiplatelet therapy in percutaneous coronary intervention: recent advances in oral antiplatelet agents.

  Current opinion in cardiology 20100701

• Acute coronary syndrome in the patient with diabetes: is the management different?

  Current cardiology reports 20100701

• What goes into a major acute coronary syndrome trial and what will future trials look like?

  Current cardiology reports 20100701

• Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial.

  American heart journal 20100701

• [Novel agents in antiplatelet therapy].

  Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20100701

• Prasugrel and cancer: an uncertain association or a credible risk that meaningfully alters the benefit-risk balance.

  Archives of internal medicine 20100628

• Prasugrel as a potential cancer promoter: review of the unpublished data.

  Archives of internal medicine 20100628

• What is the risk of intensifying platelet inhibition beyond clopidogrel? A systematic review and a critical appraisal of the role of prasugrel.

  QJM : monthly journal of the Association of Physicians 20100601

• Preventing serious sequelae after an acute coronary syndrome: the consequences of thrombosis versus bleeding with antiplatelet therapy.

  Journal of cardiovascular pharmacology 20100601

• Biotransformation of prasugrel, a novel thienopyridine antiplatelet agent, to the pharmacologically active metabolite.

  Drug metabolism and disposition: the biological fate of chemicals 20100601

• Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact.

  Nature reviews. Drug discovery 20100601

• The year in interventional cardiology.

  Journal of the American College of Cardiology 20100518

• Advances in antiplatelet treatment for acute coronary syndromes.

  Heart (British Cardiac Society) 20100501

• Mortality in the TRITON trial: update from the FDA prasugrel action package.

  The American journal of cardiology 20100501

• Implementing genotype-guided antithrombotic therapy.

  Future cardiology 20100501

• Prasugrel for the treatment of acute coronary artery syndromes with percutaneous coronary intervention.

  Health technology assessment (Winchester, England) 20100501

• A potent alternative to clopidogrel emerges. Prasugrel appears to lower heart attack risk for patients with acute coronary syndrome.

  Heart advisor 20100501

• Antiplatelet therapy prasugrel: a novel platelet ADP P2Y12 receptor antagonist.

  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20100401

• [Interview with Prof. Franz-Joseph Krozingen: Interventional cardiology on the success course].

  MMW Fortschritte der Medizin 20100401

• Diabetes and acute coronary syndrome.

  Minerva medica 20100401

• Dosing strategies for antiplatelet therapy in percutaneous coronary intervention.

  Hospital practice (1995) 20100401

• A time for growth.

  The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20100401

• Thienopyridine antiplatelet agents: focus on prasugrel.

  The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20100401

• Role of ticagrelor in clopidogrel nonresponders: resistance is futile?

  Circulation 20100316

• Prasugrel, Māori, and personalised medicine in New Zealand.

  The New Zealand medical journal 20100305

• Management of antiplatelet therapy during acute percutaneous coronary intervention: new strategies and therapeutics.

  Annals of the Academy of Medicine, Singapore 20100301

• The pharmacokinetics and pharmacodynamics of prasugrel in healthy Chinese, Japanese, and Korean subjects compared with healthy Caucasian subjects.

  European journal of clinical pharmacology 20100201

• Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans.

  Journal of clinical pharmacology 20100201

• The TRITON versus PLATO trials: differences beyond platelet inhibition.

  Thrombosis and haemostasis 20100201

• Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases.

  British journal of pharmacology 20100201

• Lack of outcome benefit and clopidogrel 'resistance.' The TRITON trial challenge.

  Thrombosis and haemostasis 20100201

• Pharmacodynamics and pharmacokinetics of single doses of prasugrel 30 mg and clopidogrel 300 mg in healthy Chinese and white volunteers: an open-label trial.

  Clinical therapeutics 20100201

• [Extent of platelet aggregation inhibition and clinical events: new evidence with prasugrel].

  Giornale italiano di cardiologia (2006) 20100201

• Ticagrelor in ACS: redefining a new standard of care?

  Lancet (London, England) 20100123

• Cost-effectiveness of prasugrel versus clopidogrel in patients with acute coronary syndromes and planned percutaneous coronary intervention: results from the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with Prasugrel-Thrombolysis in Myocardial Infarction TRITON-TIMI 38.

  Circulation 20100105

• Emerging P2Y12 receptor antagonists: role in coronary artery disease.

  Current vascular pharmacology 20100101

• Interpreting the TRITON results in light of the event adjudication process.

  Cardiology 20100101

• Prasugrel compared with high-dose clopidogrel in acute coronary syndrome. The randomised, double-blind ACAPULCO study.

  Thrombosis and haemostasis 20100101

• Reducing cardiac ischemic events in patients with ACS: prasugrel versus clopidogrel. Commentary.

  Postgraduate medicine 20100101

• Platelet inhibitors: update on clopidogrel (Plavix) and the recently approved prasugrel (Effient).

  General dentistry 20100101

• Trial watch. DAPT study.

  Harvard heart letter : from Harvard Medical School 20100101

• Delays of event adjudication in the TRITON trial.

  Cardiology 20100101

• Prasugrel, a new platelet inhibitor.

  The Mount Sinai journal of medicine, New York 20100101

• Prasugrel: a novel platelet ADP P2Y(12) receptor antagonist.

  Methods in molecular biology (Clifton, N.J.) 20100101

• [Antiplatelet therapy in coronary heart disease. Some problems and achivements].

  Kardiologiia 20100101

• [Comparison of effects of prasugrel and clopidogrel in patients with acute coronary syndrome, subjected to percutaneous coronary intervention: TRITON-TIMI 38 trial].

  Kardiologiia 20100101

• Prevention of the renarrowing of coronary arteries using drug-eluting stents in the perioperative period: an update.

  Vascular health and risk management 20100101

• Antagonism of P2Y₁₂ reduces physiological thromboxane levels.

  Platelets 20100101

• New antiplatelet agents.

  Acta anaesthesiologica Belgica 20100101

• Antiplatelet therapy in the perioperative period.

  Acta anaesthesiologica Belgica 20100101

• New antiplatelet agents: why they are needed.

  European journal of internal medicine 20091201

• Ticagrelor--a new platelet aggregation inhibitor in patients with acute coronary syndromes. An improvement of other inhibitors?

  Medical science monitor : international medical journal of experimental and clinical research 20091201

• Clopidogrel versus prasugrel: times are changing, but not for everyone.

  Pharmacotherapy 20091201

• Prasugrel: a critical comparison with clopidogrel.

  Pharmacotherapy 20091201

• Prasugrel for acute coronary syndromes: faster, more potent, but higher bleeding risk.

  Cleveland Clinic journal of medicine 20091201

• Clinical trial update II: TRITON-TIMI 38 provides reassurance on concomitant use of proton pump inhibitors and thienopyridines.

  European heart journal 20091201

• Prasugrel: a novel antiplatelet therapy for acute coronary syndromes.

  Recent patents on cardiovascular drug discovery 20091101

• Comparison of ticagrelor and thienopyridine P2Y(12) binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasis.

  Thrombosis research 20091101

• A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel.

  Drug metabolism and disposition: the biological fate of chemicals 20091101

• Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel.

  Xenobiotica; the fate of foreign compounds in biological systems 20091101

• Stent thrombosis: who's guilty?

  European heart journal 20091101

• P2Y12 inhibitors: thienopyridines and direct oral inhibitors.

  Hamostaseologie 20091101

• Dual antiplatelet therapy in coronary artery disease: a case-based approach.

  Cleveland Clinic journal of medicine 20091101

• Prasugrel: Clinical development and therapeutic application.

  Advances in therapy 20091101

• Pharmacokinetics and pharmacodynamics of prasugrel in subjects with moderate liver disease.

  Journal of clinical pharmacy and therapeutics 20091001

• Prasugrel pharmacokinetics and pharmacodynamics in subjects with moderate renal impairment and end-stage renal disease.

  Journal of clinical pharmacy and therapeutics 20091001

• Prasugrel: new drug. After angioplasty and stenting: continue to use aspirin + clopidogrel.

  Prescrire international 20091001

• [Changing times for clopidogrel].

  Medizinische Monatsschrift fur Pharmazeuten 20091001

• Risk of combining PPIs with thienopyridines: fact or fiction?

  Lancet (London, England) 20090919

• Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials.

  Lancet (London, England) 20090919

• Ticagrelor--is there need for a new player in the antiplatelet-therapy field?

  The New England journal of medicine 20090910

• Challenges in oral antiplatelet therapy: ST-segment elevation myocardial infarction.

  The American journal of cardiology 20090907

• Prasugrel (Effient) vs. clopidogrel (Plavix).

  The Medical letter on drugs and therapeutics 20090907

• Prasugrel in clinical practice.

  The New England journal of medicine 20090903

• Weighing benefits and risks--the FDA's review of prasugrel.

  The New England journal of medicine 20090903

• [New thrombocyte inhibitor. Fewer ischemic complications in acute coronary syndrome].

  MMW Fortschritte der Medizin 20090903

• Pharmacokinetics and pharmacodynamics of prasugrel, a thienopyridine P2Y12 inhibitor.

  Pharmacotherapy 20090901

• Effect of prasugrel versus clopidogrel on outcomes among patients with acute coronary syndrome undergoing percutaneous coronary intervention without stent implantation: a TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet inhibitioN with prasugrel (TRITON)-Thrombolysis in Myocardial Infarction (TIMI) 38 substudy.

  American heart journal 20090901

• Prasugrel: a review of its use in patients with acute coronary syndromes undergoing percutaneous coronary intervention.

  Drugs 20090820

• Cardiovascular disease gets personal.

  Nature 20090820

• The efficacy and safety of prasugrel with and without a glycoprotein IIb/IIIa inhibitor in patients with acute coronary syndromes undergoing percutaneous intervention: a TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis In Myocardial Infarction 38) analysis.

  Journal of the American College of Cardiology 20090818

• The Italian Horizon Scanning Project.

  European journal of clinical pharmacology 20090801

• Aggressive chronic platelet inhibition with prasugrel and increased cancer risks: revising oral antiplatelet regimens?

  Fundamental & clinical pharmacology 20090801

• Effect of rifampin on the pharmacokinetics and pharmacodynamics of prasugrel in healthy male subjects.

  Current medical research and opinion 20090801

• Population pharmacokinetic analyses to evaluate the influence of intrinsic and extrinsic factors on exposure of prasugrel active metabolite in TRITON-TIMI 38.

  Journal of clinical pharmacology 20090801

• Prediction of prasugrel active metabolite concentrations from 2 downstream inactive metabolite concentrations using multilinear regression analysis.

  Journal of clinical pharmacology 20090801

• P2Y(12) inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use.

  European heart journal 20090801

• Inhibition of platelet aggregation with prasugrel and clopidogrel: an integrated analysis in 846 subjects.

  Platelets 20090801

• Test before you stop.

  Archives of surgery (Chicago, Ill. : 1960) 20090801

• Prasugrel, new platelet inhibitor, subject of formulary debates.

  Managed care (Langhorne, Pa.) 20090801

• Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease.

  European heart journal 20090701

• Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial.

  European heart journal 20090701

• New P2Y12 blockers.

  Journal of thrombosis and haemostasis : JTH 20090701

• Letter by Rosenstein and Parra regarding article, 'Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel: Thrombolysis in Myocardial Infarction 38'.

  Circulation 20090630

• Effects of prasugrel, a novel P2Y(12) inhibitor, in rat models of cerebral and peripheral artery occlusive diseases.

  European journal of pharmacology 20090610

• Effect of the novel thienopyridine prasugrel compared with clopidogrel on spontaneous and procedural myocardial infarction in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis in Myocardial Infarction 38: an application of the classification system from the universal definition of myocardial infarction.

  Circulation 20090602

• Can we override clopidogrel resistance?

  Circulation 20090602

• Management of patients with high gastrointestinal risk on antiplatelet therapy.

  Gastroenterology clinics of North America 20090601

• Prasugrel.

  Nature reviews. Drug discovery 20090601

• Future of oral antiplatelet therapy: four challenged hypotheses.

  Thrombosis and haemostasis 20090601

• Review of prasugrel for the secondary prevention of atherothrombosis.

  Journal of managed care pharmacy : JMCP 20090601

• Pharmacy benefit spending poised to increase for antithrombotic drug therapy -- prasugrel versus clopidogrel.

  Journal of managed care pharmacy : JMCP 20090601

• Diabetes and acute coronary syndromes.

  Best practice & research. Clinical endocrinology & metabolism 20090601

• Prasugrel STEMI subgroup analysis.

  Lancet (London, England) 20090530

• Prasugrel STEMI subgroup analysis.

  Lancet (London, England) 20090530

• Prasugrel STEMI subgroup analysis.

  Lancet (London, England) 20090530

• Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes.

  Circulation 20090519

• Bedside evaluation of thienopyridine antiplatelet therapy.

  Circulation 20090519

• Platelet inhibition with prasugrel and increased cancer risks: potential causes and implications.

  The American journal of medicine 20090501

• New antiplatelet drugs: beyond aspirin and clopidogrel.

  International journal of clinical practice 20090501

• Critical review of prasugrel for formulary decision makers.

  Journal of managed care pharmacy : JMCP 20090501

• Prasugrel: newest antiplatelet agent and its emerging role in management of acute coronary syndrome and percutaneous coronary intervention.

  Future cardiology 20090501

• Update on oral antiplatelet therapy: principles, problems and promises.

  Future cardiology 20090501

• Novel antiplatelet strategies in acute coronary syndromes.

  Cleveland Clinic journal of medicine 20090401

• Response variability and the role of platelet function testing.

  The Journal of invasive cardiology 20090401

• Adjunctive Pharmacotherapy Part II.

  The Journal of invasive cardiology 20090401

• Prasugrel in acute coronary syndrome patients undergoing percutaneous coronary intervention.

  Expert review of cardiovascular therapy 20090401

• Mechanism-based inhibition of human cytochrome P450 2B6 by ticlopidine, clopidogrel, and the thiolactone metabolite of prasugrel.

  Drug metabolism and disposition: the biological fate of chemicals 20090301

• Facts and controversies of aspirin and clopidogrel therapy.

  American heart journal 20090301

• Assessment of P2Y(12) inhibition with the point-of-care device VerifyNow P2Y12 in patients treated with prasugrel or clopidogrel coadministered with aspirin.

  American heart journal 20090301

• Antiplatelet therapy in percutaneous coronary intervention: integration of prasugrel into clinical practice.

  Critical pathways in cardiology 20090301

• Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs.

  Xenobiotica; the fate of foreign compounds in biological systems 20090301

• Ischaemia versus bleeding: the art of clinical decision-making.

  Lancet (London, England) 20090227

• Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial.

  Lancet (London, England) 20090227

• [American Heart Association conference 2008. The JUPITER trial, the approval of prasugrel, the (aging) heart of obese adolescents].

  Revue medicale suisse 20090225

• Advances in antiplatelet therapy: agents in clinical development.

  The American journal of cardiology 20090202

• Prasugrel for arterial coronary thrombosis.

  Drugs of today (Barcelona, Spain : 1998) 20090201

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  Revue medicale suisse 20090114

• P2Y12 inhibitors in cardiovascular disease: focus on prasugrel.

  The Annals of pharmacotherapy 20090101

• Efficacy and safety of prasugrel compared with clopidogrel in patients with acute coronary syndromes: results of TRITON-TIMI 38 trials.

  Expert review of cardiovascular therapy 20090101

• Another view on prasugrel.

  Thrombosis and haemostasis 20090101

• Prasugrel development - claims and achievements.

  Thrombosis and haemostasis 20090101

• Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability.

  Thrombosis and haemostasis 20090101

• Current problems, new opportunities and future directions of anti-platelet therapy - increasing role of novel antiplatelet agents in cardiovascular diseases.

  Recent patents on cardiovascular drug discovery 20090101

• The potential role of prasugrel in secondary prevention of ischemic events in patients with acute coronary syndromes.

  Postgraduate medicine 20090101

• Novel antiplatelet agents in development: prasugrel, ticagrelor, and cangrelor and beyond.

  American journal of therapeutics 20090101

• Prasugrel for the treatment of patients with acute coronary syndrome.

  Vascular health and risk management 20090101

• Improving outcomes in patients undergoing percutaneous coronary intervention: role of prasugrel.

  Vascular health and risk management 20090101

• The FDA prasugrel review: adjudication of myocardial infarction controversy.

  Cardiology 20090101

• Late prasugrel benefit in STEMI patients?

  American journal of therapeutics 20090101

• Relevance of metabolic activation pathways: the example of clopidogrel and prasugrel.

  Arzneimittel-Forschung 20090101

• [Pharmazie in unserer Zeit 4/2009].

  Pharmazie in unserer Zeit 20090101

• [Prodrug activation as a crucial difference. Prasugrel - a new ADP receptor antagonist].

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• [Technological and biopharmaceutical aspects. Antiplatelet agents for oral administration].

  Pharmazie in unserer Zeit 20090101

• Improving adjunctive pharmacotherapy for primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: beyond the HORIZONS-AMI trial.

  Reviews in cardiovascular medicine 20090101

• Role of prasugrel, a novel P2Y(12) receptor antagonist, in the management of acute coronary syndromes.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101

• Prasugrel: a novel platelet ADP P2Y receptor antagonist.

  Cardiovascular therapeutics 20090101

• Effect of age on the pharmacokinetics and pharmacodynamics of prasugrel during multiple dosing: an open-label, single-sequence, clinical trial.

  Drugs & aging 20090101

• Comparison of prasugrel and clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention.

  Vascular health and risk management 20090101

• Prasugrel hydrochloride, dronedarone, and saxagliptin hydrochloride.

  Journal of the American Pharmacists Association : JAPhA 20090101

• New advances and new questions in cardiovascular therapeutics.

  American journal of therapeutics 20090101

• Update on antiplatelet therapy in acute coronary syndromes: what do new drugs bring into clinical practice?

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101

• Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo.

  Journal of the American College of Cardiology 20081209

• The pursuit of clinically relevant measures of platelet function after antiplatelet drug therapy.

  Journal of the American College of Cardiology 20081209

• Platelet ADP-receptor antagonists for cardiovascular disease: past, present and future.

  Nature clinical practice. Cardiovascular medicine 20081201

• Population pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in aspirin-treated patients with stable coronary artery disease.

  Journal of pharmacokinetics and pharmacodynamics 20081201

• Modulation of clopidogrel pharmacodynamic response.

  Pharmacotherapy 20081201

• Effect of atorvastatin on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in healthy subjects.

  Pharmacotherapy 20081201

• Is prasugrel more effective than clopidogrel in patients with acute coronary syndrome scheduled for PCI?

  American family physician 20081201

• Interaction of the active metabolite of prasugrel, R-138727, with cysteine 97 and cysteine 175 of the human P2Y12 receptor.

  Journal of thrombosis and haemostasis : JTH 20081101

• Intensity of antiplatelet therapy in patients with acute coronary syndromes and percutaneous coronary intervention: the promise of prasugrel?

  Cardiology clinics 20081101

• Prasugrel: a novel platelet ADP P2Y12 receptor antagonist. A review on its mechanism of action and clinical development.

  Expert opinion on pharmacotherapy 20081101

• Future prospects in anti-platelet therapy: a review of potential P2Y12 and thrombin receptor antagonists.

  Recent patents on cardiovascular drug discovery 20081101

• Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38.

  Circulation 20081014

• Acute coronary syndromes and diabetes mellitus: a winning ticket for prasugrel.

  Circulation 20081014

• Reduction in recurrent cardiovascular events with prasugrel compared with clopidogrel in patients with acute coronary syndromes from the TRITON-TIMI 38 trial.

  European heart journal 20081001

• Greater reduction of platelet activation markers and platelet-monocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease.

  Thrombosis and haemostasis 20081001

• Intensive antiplatelet therapy for reduction of ischaemic events.

  Lancet (London, England) 20080816

• Intensive antiplatelet therapy for reduction of ischaemic events.

  Lancet (London, England) 20080816

• Pharmacology of emerging novel platelet inhibitors.

  American heart journal 20080801

• Clinical profile of prasugrel, a novel thienopyridine.

  American heart journal 20080801

• Treatment strategies in non-ST-elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention: an evidence-based review of clinical trial results and treatment guidelines: report on a roundtable discussion.

  Journal of interventional cardiology 20080801

• Effect of ranitidine on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel.

  Current medical research and opinion 20080801

• The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2.

  Drug metabolism and disposition: the biological fate of chemicals 20080701

• The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function.

  Journal of thrombosis and haemostasis : JTH 20080701

• Antiplatelet therapy in acute coronary syndromes.

  Current cardiology reports 20080701

• For better or for worse: the future of antiplatelet therapy.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080601

• Prasugrel: a novel antiplatelet agent.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080601

• Multiple electrode aggregometry and P2Y(12) antagonists.

  Thrombosis and haemostasis 20080601

• Switching directly to prasugrel from clopidogrel results in greater inhibition of platelet aggregation in aspirin-treated subjects.

  Platelets 20080601

• Antiplatelet drugs in cardiological practice: established strategies and new developments.

  Vascular health and risk management 20080601

• Early and late benefits of prasugrel in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a TRITON-TIMI 38 (TRial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet InhibitioN with Prasugrel-Thrombolysis In Myocardial Infarction) analysis.

  Journal of the American College of Cardiology 20080527

• Excess rates of nonfatal myocardial infarction in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel (preventing clinical events or chasing enzymatic ghosts?).

  The American journal of cardiology 20080501

• A perspective on the efficacy and safety of intensive antiplatelet therapy in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-thrombolysis in myocardial infarction 38.

  The American journal of cardiology 20080501

• Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trial.

  Lancet (London, England) 20080419

• Approaching an age of reason with antiplatelet therapy.

  Lancet (London, England) 20080419

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  The Medical journal of Australia 20080407

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