152121-30-7 | 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$20.00	$14.00
10mg	98%	in stock	$38.00	$27.00
25mg	98%	in stock	$55.00	$39.00
50mg	98%	in stock	$66.00	$47.00
100mg	98%	in stock	$80.00	$56.00

Description

• Catalog Number: AD71347
• Chemical Name: 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
• CAS Number: 152121-30-7
• Molecular Formula: C20H14FN3O
• Molecular Weight: 331.3431
• MDL Number: MFCD00941964
• SMILES: Oc1ccc(cc1)C1N=C(C(=N1)c1ccc(cc1)F)c1ccncc1

Computed Properties

• Complexity: 415
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 3.7

Literature

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• Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism.

  Cellular signalling 20080401

• Differential p38 mitogen-activated protein kinase-controlled hypophosphorylation of the retinoblastoma protein induced by nitric oxide in neuroblastoma cells.

  Free radical biology & medicine 20080201

• Prolactin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: involvement of p-38 MAP kinase, STAT3 and NF-kappaB.

  Cytokine 20080201

• Localization of phosphorylated alphaB-crystallin to heart mitochondria during ischemia-reperfusion.

  American journal of physiology. Heart and circulatory physiology 20080101

• Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells.

  Journal of cardiovascular pharmacology 20080101

• The NF-kappaB inhibitor curcumin blocks sepsis-induced muscle proteolysis.

  Mediators of inflammation 20080101

• Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity.

  PloS one 20080101

• Straw blood cell count, growth, inhibition and comparison to apoptotic bodies.

  BMC cell biology 20080101

• COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells.

  Biochimica et biophysica acta 20080101

• Effect of bortezomib on human neuroblastoma: analysis of molecular mechanisms involved in cytotoxicity.

  Molecular cancer 20080101

• Albumin induces interleukin-6 release from primary human proximal tubule epithelial cells.

  Journal of nephrology 20080101

• Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells.

  BMC cancer 20080101

• The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells.

  Cancer research 20071201

• p38 MAPK inhibition in nucleus pulposus cells: a potential target for treating intervertebral disc degeneration.

  Spine 20071201

• Creatine enhances differentiation of myogenic C2C12 cells by activating both p38 and Akt/PKB pathways.

  American journal of physiology. Cell physiology 20071001

• Inhibition of p38MAP kinase suppresses fibrogenic reaction in conjunctiva in mice.

  Molecular vision 20070918

• Manganese chloride stimulates rat microglia to release hydrogen peroxide.

  Toxicology letters 20070910

• Characterization of the effects of cyclooxygenase-2 inhibition in the regulation of apoptosis in human small and non-small cell lung cancer cell lines.

  Annals of surgical oncology 20070901

• The role of p38 mitogen-activated kinase (MAPK) in the mechanism regulating cyclooxygenase gene expression in equine leukocytes.

  Veterinary immunology and immunopathology 20070815

• Sodium nitroprusside activates p38 mitogen activated protein kinase through a cGMP/PKG independent mechanism.

  Life sciences 20070802

• Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite.

  Journal of cellular physiology 20070801

• Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization.

  American journal of physiology. Heart and circulatory physiology 20070801

• Involvement of p38 MAPK in hypotonic stress-induced stimulation of beta- and gamma-ENaC expression in renal epithelium.

  Biochemical and biophysical research communications 20070706

• Evidences for a role of p38 MAP kinase in the stimulation of alkaline phosphatase and matrix mineralization induced by parathyroid hormone in osteoblastic cells.

  Bone 20070701

• Inhibition of p38 mitogen-activated protein kinase-induced apoptosis in cultured mature oligodendrocytes using SB202190 and SB203580.

  Neurochemistry international 20070701

• p38 MAP kinase pathway and stromelysin regulation in trabecular meshwork cells.

  Investigative ophthalmology & visual science 20070701

• Heart HIF-1alpha and MAP kinases during hypoxia: are they associated in vivo?

  Experimental biology and medicine (Maywood, N.J.) 20070701

• Topical p38 MAPK inhibition reduces bacterial growth in an in vivo burn wound model.

  Surgery 20070701

• Calcium induces increases in peroxisome proliferator-activated receptor gamma coactivator-1alpha and mitochondrial biogenesis by a pathway leading to p38 mitogen-activated protein kinase activation.

  The Journal of biological chemistry 20070629

• Activation of p38/MEF2C pathway by all-trans retinoic acid in cardiac myoblasts.

  Life sciences 20070620

• Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity.

  The Journal of biological chemistry 20070525

• Vitamin A potentiates CpG-mediated memory B-cell proliferation and differentiation: involvement of early activation of p38MAPK.

  Blood 20070501

• Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis.

  Toxicological sciences : an official journal of the Society of Toxicology 20070501

• Abrogation of TGFbeta signaling induces apoptosis through the modulation of MAP kinase pathways in breast cancer cells.

  Experimental cell research 20070501

• Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways.

  Cornea 20070501

• p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells.

  Experimental & molecular medicine 20070430

• Activation of MAPK in fibroblasts by Treponema denticola major outer sheath protein.

  Biochemical and biophysical research communications 20070427

• Regulation of lipopolysaccharide-induced increases in neutrophil glucose uptake.

  American journal of physiology. Lung cellular and molecular physiology 20070401

• p38 mitogen-activated protein kinase mediates adenosine-induced alterations in myocardial glucose utilization via 5'-AMP-activated protein kinase.

  American journal of physiology. Heart and circulatory physiology 20070401

• Cross-talk between Smad and p38 MAPK signalling in transforming growth factor beta signal transduction in human glioblastoma cells.

  Biochemical and biophysical research communications 20070323

• Contributions of reactive oxygen species and mitogen-activated protein kinase signaling in arsenite-stimulated hemeoxygenase-1 production.

  Toxicology and applied pharmacology 20070115

• n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism.

  Molecular psychiatry 20070101

• Lack of endothelial nitric oxide synthase-derived nitric oxide formation favors hypertrophy in adult ventricular cardiomyocytes.

  Hypertension (Dallas, Tex. : 1979) 20070101

• Signal-dependent control of autophagy and cell death in colorectal cancer cell: the role of the p38 pathway.

  Autophagy 20070101

• Differentiation-inducing potency of the seco-steroid JK-1624F2-2 can be increased by combination with an antioxidant and a p38MAPK inhibitor which upregulates the JNK pathway.

  The Journal of steroid biochemistry and molecular biology 20070101

• Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy.

  Molecular cancer 20070101

• Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes.

  Cancer letters 20061208

• Species and response dependent differences in the effects of MAPK inhibitors on P2X(7) receptor function.

  British journal of pharmacology 20061201

• The cell adhesion molecule neuroplastin-65 inhibits hippocampal long-term potentiation via a mitogen-activated protein kinase p38-dependent reduction in surface expression of GluR1-containing glutamate receptors.

  Journal of neurochemistry 20061101

• Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma.

  Molecular pharmacology 20061101

• Intracellular delivery of the p38 mitogen-activated protein kinase inhibitor SB202190 [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole] in renal tubular cells: a novel strategy to treat renal fibrosis.

  The Journal of pharmacology and experimental therapeutics 20061001

• Bifunctional modulating effects of an indigo dimer (bisindigotin) to CYP1A1 induction in H4IIE cells.

  Toxicology 20060921

• Mitogen-activated protein kinase (MAPK) signalling pathways in HepG2 cells infected with a virulent strain of Klebsiella pneumoniae.

  Cellular microbiology 20060901

• Activation of p38 MAPK is involved in endothelin-1-stimulated COX-2 expression in cultured Feline esophageal smooth muscle cells.

  Molecules and cells 20060831

• Differential regulation of CC chemokine receptors by 9-cis retinoic acid in the human mast cell line, HMC-1.

  Life sciences 20060822

• atRA-induced apoptosis of mouse embryonic palate mesenchymal cells involves activation of MAPK pathway.

  Toxicology and applied pharmacology 20060815

• Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

  The Journal of experimental medicine 20060807

• Substance P induces expression of the corticotropin-releasing factor receptor 1 by activation of the neurokinin-1 receptor.

  Brain research 20060802

• Mitogen- and stress-activated protein kinase 1 is activated in lesional psoriatic epidermis and regulates the expression of pro-inflammatory cytokines.

  The Journal of investigative dermatology 20060801

• Involvement of ERK1/2 and p38 in Mg2+ accumulation in liver cells.

  Molecular and cellular biochemistry 20060801

• Topical p38MAPK inhibition reduces dermal inflammation and epithelial apoptosis in burn wounds.

  Shock (Augusta, Ga.) 20060801

• Enzyme fragment complementation binding assay for p38alpha mitogen-activated protein kinase to study the binding kinetics of enzyme inhibitors.

  Assay and drug development technologies 20060801

• Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells.

  International journal of molecular medicine 20060701

• Streptococcus pneumoniae induced p38 MAPK- and NF-kappaB-dependent COX-2 expression in human lung epithelium.

  American journal of physiology. Lung cellular and molecular physiology 20060601

• Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling.

  The Journal of pharmacology and experimental therapeutics 20060601

• Interleukin-6 decreases senescence and increases telomerase activity in malignant human cholangiocytes.

  Life sciences 20060418

• JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells.

  Experimental eye research 20060401

• Dual roles for the phosphatase PPM1D in regulating progesterone receptor function.

  The Journal of biological chemistry 20060317

• Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase.

  Journal of medicinal chemistry 20060309

• Mechanisms of Chlamydophila pneumoniae-mediated GM-CSF release in human bronchial epithelial cells.

  American journal of respiratory cell and molecular biology 20060301

• Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells.

  British journal of pharmacology 20060301

• Inhibition of apolipoprotein AI gene expression by tumor necrosis factor alpha: roles for MEK/ERK and JNK signaling.

  Biochemistry 20060221

• A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis.

  Oncogene 20060202

• NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 mitogen-activated protein kinase signaling.

  Stem cells (Dayton, Ohio) 20060201

• CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27.

  Experimental dermatology 20060201

• Mitogen-activated protein kinase is involved in the progesterone-mediated induction of baboon glycodelin.

  Endocrine 20060201

• NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation.

  Biochemical and biophysical research communications 20060106

• Inhibition of NF-kappaB renders human juvenile costal chondrocyte cell lines sensitive to TNF-alpha-mediated cell death.

  Rheumatology international 20060101

• Oncostatin M-induced activation of stress-activated MAP kinases depends on tyrosine 861 in the OSM receptor and requires Jak1 but not Src kinases.

  Cellular signalling 20060101

• Angiotensin II-induced negative inotropy in rat ventricular myocytes: role of reactive oxygen species and p38 MAPK.

  American journal of physiology. Heart and circulatory physiology 20060101

• Nitric oxide-donating aspirin inhibits colon cancer cell growth via mitogen-activated protein kinase activation.

  The Journal of pharmacology and experimental therapeutics 20060101

• Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons.

  Toxicological sciences : an official journal of the Society of Toxicology 20060101

• Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells.

  Journal of immunology (Baltimore, Md. : 1950) 20060101

• Inhibition of mitogen-activated protein kinase signalling by Bacillus anthracis lethal toxin causes destabilization of interleukin-8 mRNA.

  Cellular microbiology 20060101

• Caveolin-1 is associated with VCAM-1 dependent adhesion of gastric cancer cells to endothelial cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

• Delivery of the p38 MAPkinase inhibitor SB202190 to angiogenic endothelial cells: development of novel RGD-equipped and PEGylated drug-albumin conjugates using platinum(II)-based drug linker technology.

  Bioconjugate chemistry 20060101

• Cytokine interactions in mesenchymal stem cells from cord blood.

  Cytokine 20051221

• Epidermal growth factor stimulation of trophoblast differentiation requires MAPK11/14 (p38 MAP kinase) activation.

  Biology of reproduction 20051201

• The role of p38 MAP kinase and c-Jun N-terminal protein kinase signaling in the differentiation and apoptosis of immortalized neural stem cells.

  Mutation research 20051111

• Bioanalysis and pharmacokinetics of the p38 MAPkinase inhibitor SB202190 in rats.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051105

• No correlation between the p38 MAPK pathway and the contractile dysfunction in diabetic cardiomyocytes: hyperglycaemia-induced signalling and contractile function.

  Pflugers Archiv : European journal of physiology 20051101

• Late-gestation rat myometrial cells express multiple isoforms of phospholipase A2 that mediate PCB 50-induced release of arachidonic acid with coincident prostaglandin production.

  Toxicological sciences : an official journal of the Society of Toxicology 20051101

• Inhibition of low density lipoprotein receptor expression by long-term exposure to phorbol ester via p38 mitogen-activated protein kinase pathway.

  Journal of cellular biochemistry 20051101

• IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathway.

  American journal of physiology. Cell physiology 20051001

• HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.

  Journal of leukocyte biology 20051001

• Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia.

  British journal of pharmacology 20051001

• Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis.

  Molecular and cellular biochemistry 20051001

• The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3.

  The Journal of biological chemistry 20050930

• Anisomycin induces COX-2 mRNA expression through p38(MAPK) and CREB independent of small GTPases in intestinal epithelial cells.

  Biochimica et biophysica acta 20050930

• An immunosorbent, nonradioactive p38 MAP kinase assay comparable to standard radioactive liquid-phase assays.

  Analytical biochemistry 20050901

• Interleukin-4 and interleukin-13 enhance CCL26 production in a human keratinocyte cell line, HaCaT cells.

  Clinical and experimental immunology 20050901

• Peptidoglycan of Staphylococcus aureus induces enhanced levels of matrix metalloproteinase-9 in human blood originating from neutrophils.

  Shock (Augusta, Ga.) 20050901

• Response of non-small cell lung cancer cells to the inhibitors of phosphatidylinositol 3-kinase/Akt- and MAPK kinase 4/c-Jun NH2-terminal kinase pathways: an effective therapeutic strategy for lung cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050815

• DNFB activates MAPKs and upregulates CD40 in skin-derived dendritic cells.

  Journal of dermatological science 20050801

• 4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy.

  American journal of respiratory cell and molecular biology 20050801

• Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells.

  Laboratory investigation; a journal of technical methods and pathology 20050701

• Effect of wound type on Smad 2 and 4 translocation.

  Investigative ophthalmology & visual science 20050701

• Cross-interactions of two p38 mitogen-activated protein (MAP) kinase inhibitors and two cholecystokinin (CCK) receptor antagonists with the CCK1 receptor and p38 MAP kinase.

  The Journal of biological chemistry 20050603

• Annexin-1 peptide Anx-1(2-26) protects adult rat cardiac myocytes from cellular injury induced by simulated ischaemia.

  British journal of pharmacology 20050601

• Thyroid hormone induces cardiac myocyte hypertrophy in a thyroid hormone receptor alpha1-specific manner that requires TAK1 and p38 mitogen-activated protein kinase.

  Molecular endocrinology (Baltimore, Md.) 20050601

• p38 MAP-kinase in cultured adult rat ventricular cardiomyocytes: expression and involvement in hypertrophic signalling.

  European journal of heart failure 20050601

• Kinetic studies of small molecule interactions with protein kinases using biosensor technology.

  Analytical biochemistry 20050515

• The role of p38 in the regulation of Na+-Ca2+ exchanger expression in adult cardiomyocytes.

  Journal of molecular and cellular cardiology 20050501

• The Epstein-Barr virus oncoprotein latent membrane protein 1 induces expression of the chemokine IP-10: importance of mRNA half-life regulation.

  International journal of cancer 20050420

• p38MAPK-Dependent sensitivity of Ewing's sarcoma family of tumors to fenretinide-induced cell death.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050415

• Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.

  The Journal of biological chemistry 20050408

• Significance of cyclooxygenase-2 induced via p38 mitogen-activated protein kinase in mechanical stimulus-induced peritoneal adhesion in mice.

  The Journal of pharmacology and experimental therapeutics 20050401

• Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin.

  American journal of physiology. Endocrinology and metabolism 20050401

• Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells.

  Molecular and cellular biology 20050401

• Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling.

  The Journal of biological chemistry 20050325

• Differential phosphorylation of p38 induced by apoptotic and anti-apoptotic stimuli in murine hepatocytes.

  World journal of gastroenterology 20050307

• Angiotensin II-induced Akt activation through the epidermal growth factor receptor in vascular smooth muscle cells is mediated by phospholipid metabolites derived by activation of phospholipase D.

  The Journal of pharmacology and experimental therapeutics 20050301

• alpha1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C-, phosphatidylinositol-3 kinase-, and atypical protein kinase C-dependent pathway.

  Endocrinology 20050201

• Inhibition of p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase decreases UVB-induced activator protein-1 and cyclooxygenase-2 in a SKH-1 hairless mouse model.

  Molecular cancer research : MCR 20050201

• Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites.

  Chemico-biological interactions 20050115

• Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.

  The Journal of biological chemistry 20050114

• Cocaine induces apoptosis in fetal rat myocardial cells through the p38 mitogen-activated protein kinase and mitochondrial/cytochrome c pathways.

  The Journal of pharmacology and experimental therapeutics 20050101

• Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}.

  Diabetes 20050101

• Egr-1 negatively regulates expression of the sodium-calcium exchanger-1 in cardiomyocytes in vitro and in vivo.

  Cardiovascular research 20050101

• Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production.

  Arthritis research & therapy 20050101

• Activation of p38 mitogen-activated protein kinase is necessary for gemcitabine-induced cytotoxicity in human pancreatic cancer cells.

  Anticancer research 20050101

• The HIV protease inhibitor ritonavir synergizes with butyrate for induction of apoptotic cell death and mediates expression of heme oxygenase-1 in DLD-1 colon carcinoma cells.

  British journal of pharmacology 20041201

• Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells.

  Investigative ophthalmology & visual science 20041201

• Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase.

  Molecular and cellular biochemistry 20041201

• Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols.

  The Journal of biological chemistry 20041105

• Roles of mitogen activated protein kinases and EGF receptor in arsenite-stimulated matrix metalloproteinase-9 production.

  Toxicology and applied pharmacology 20041101

• Homologous adaptation to oxidative stress induced by the photosensitized Pd-bacteriochlorophyll derivative (WST11) in cultured endothelial cells.

  The Journal of biological chemistry 20041029

• Ultraviolet A-induced modulation of Bcl-XL by p38 MAPK in human keratinocytes: post-transcriptional regulation through the 3'-untranslated region.

  The Journal of biological chemistry 20041008

• p38 and Src-ERK1/2 pathways regulate crystalline silica-induced chemokine release in pulmonary epithelial cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20041001

• Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression.

  Gastroenterology 20041001

• Mitogen-activated protein kinase regulates neurofilament axonal transport.

  Journal of cell science 20040915

• Combined action of extracellular signal-regulated kinase and p38 kinase rescues Molt4 T cells from nitric oxide-induced apoptotic and necrotic cell death.

  Free radical biology & medicine 20040815

• Gastrodia elata prevents rat pheochromocytoma cells from serum-deprived apoptosis: the role of the MAPK family.

  Life sciences 20040813

• Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen-specific.

  British journal of pharmacology 20040801

• p38 Mitogen-activated protein kinase mediates synergistic induction of inducible nitric-oxide synthase by lipopolysaccharide and interferon-gamma through signal transducer and activator of transcription 1 Ser727 phosphorylation in murine aortic endothelial cells.

  Molecular pharmacology 20040801

• Antiproliferative effects of Src inhibition on medullary thyroid cancer.

  The Journal of clinical endocrinology and metabolism 20040701

• Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini.

  Biochemical and biophysical research communications 20040618

• Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility.

  The Journal of biological chemistry 20040604

• Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes.

  Toxicological sciences : an official journal of the Society of Toxicology 20040601

• Mechanism of heme oxygenase-1 gene induction by quercetin in rat aortic smooth muscle cells.

  Pharmacology 20040601

• Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells.

  Molecular carcinogenesis 20040601

• Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells.

  The Journal of biological chemistry 20040507

• MAPK signaling pathways modulate IL-1beta expression in human keratinocytes.

  Archives of biochemistry and biophysics 20040401

• Inhibition of p38 mitogen-activated protein kinase enhances adrenergic-stimulated arylalkylamine N-acetyltransferase activity in rat pinealocytes.

  Endocrinology 20040301

• Mitogen-activated protein kinase and caspase signaling pathways are required for P2X7 receptor (P2X7R)-induced pore formation in human THP-1 cells.

  The Journal of pharmacology and experimental therapeutics 20040301

• Signaling pathways regulating interleukin-13-stimulated chemokine release from airway smooth muscle.

  American journal of respiratory and critical care medicine 20040301

• Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium.

  Cellular signalling 20040301

• PI 3-kinase and MAP kinase regulate bradykinin induced prostaglandin E(2) release in human pulmonary artery by modulating COX-2 activity.

  FEBS letters 20040227

• Regulation of blood-testis barrier dynamics: an in vivo study.

  Journal of cell science 20040215

• DEP-induced fra-1 expression correlates with a distinct activation of AP-1-dependent gene transcription in the lung.

  American journal of physiology. Lung cellular and molecular physiology 20040201

• Multiple signaling pathways are involved in the regulation of IGF-I receptor inhibition of PTEN-enhanced apoptosis.

  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20040201

• p38 Mitogen-activated protein kinase inhibitor protects the epidermis against the acute damaging effects of ultraviolet irradiation by blocking apoptosis and inflammatory responses.

  The Journal of investigative dermatology 20040201

• Suppression by p38 MAP kinase inhibitors (pyridinyl imidazole compounds) of Ah receptor target gene activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the possible mechanism.

  The Journal of biological chemistry 20040130

• Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423.

  Biochemical pharmacology 20040115

• Retinoblastoma protein and CCAAT/enhancer-binding protein beta are required for 1,25-dihydroxyvitamin D3-induced monocytic differentiation of HL60 cells.

  Cancer research 20040101

• Role of p38 mitogen-activated protein kinase and caspases in UV-B-induced apoptosis of murine peritoneal macrophages.

  Photochemistry and photobiology 20040101

• Involvement of ERK1/2 and p38 MAP kinase in doxorubicin-induced uPA expression in human RC-K8 lymphoma and NCI-H69 small cell lung carcinoma cells.

  Oncology 20040101

• Modulation of histamine-induced Ca2+ release by protein kinase C. Effects on cytosolic and mitochondrial [Ca2+] peaks.

  The Journal of biological chemistry 20031212

• Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells.

  Circulation research 20031212

• Microglial activation state and lysophospholipid acid receptor expression.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20031201

• N-nitrosocarbofuran induces apoptosis in mouse brain microvascular endothelial cells (bEnd.3).

  Journal of pharmacological sciences 20031201

• Cross-talk between the pathways leading to the induction of apoptosis and the secretion of tumor necrosis factor-alpha in ricin-treated RAW 264.7 cells.

  Journal of biochemistry 20031201

• Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival.

  Circulation research 20031128

• Mitogen activated protein kinases selectively regulate palytoxin-stimulated gene expression in mouse keratinocytes.

  Toxicology and applied pharmacology 20031101

• Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines.

  Journal of molecular and cellular cardiology 20031101

• A requirement for calcium-independent phospholipase A2 in thrombin-induced arachidonic acid release and growth in vascular smooth muscle cells.

  The Journal of biological chemistry 20031031

• Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia.

  Cardiovascular research 20031001

• Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor.

  Oncogene 20030911

• IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation.

  American journal of physiology. Lung cellular and molecular physiology 20030901

• Endotoxin-tolerance to the cytotoxicity toward a macrophage-like cell line, J774.1, induced by lipopolysaccharide and cycloheximide: role of p38 MAPK in induction of the cytotoxicity.

  Biological & pharmaceutical bulletin 20030901

• Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell.

  International journal of cancer 20030810

• p38 Mitogen-activated protein kinase regulation of JB6 Cl41 cell transformation promoted by epidermal growth factor.

  The Journal of biological chemistry 20030718

• Mechanical stress-induced apoptosis of endplate chondrocytes in organ-cultured mouse intervertebral discs: an ex vivo study.

  Spine 20030715

• Mucin biosynthesis: epidermal growth factor downregulates core 2 enzymes in a human airway adenocarcinoma cell line.

  American journal of respiratory cell and molecular biology 20030701

• Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells.

  Molecular carcinogenesis 20030701

• The role of JNK and p38 MAPK activities in UVA-induced signaling pathways leading to AP-1 activation and c-Fos expression.

  Neoplasia (New York, N.Y.) 20030701

• The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair.

  The Journal of biological chemistry 20030606

• Endothelial activation by angiotensin II through NFkappaB and p38 pathways: Involvement of NFkappaB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin.

  Journal of cellular physiology 20030601

• Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription.

  The Journal of biological chemistry 20030516

• Involvement of S6 kinase and p38 mitogen activated protein kinase pathways in strain-induced alignment and proliferation of bovine aortic smooth muscle cells.

  Journal of cellular physiology 20030501

• High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells.

  Diabetes 20030501

• The role of phosphatidylinositol 3'-kinase and its downstream signals in erbB-2-mediated transformation.

  Molecular cancer research : MCR 20030501

• MAP kinase kinase 6-p38 MAP kinase signaling cascade regulates cyclooxygenase-2 expression in cardiac myocytes in vitro and in vivo.

  Circulation research 20030418

• Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts.

  The Journal of biological chemistry 20030411

• Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha.

  The Biochemical journal 20030401

• MAPK signal transduction pathway mediates agrin effects on neurite elongation in cultured hippocampal neurons.

  Journal of neurobiology 20030401

• TGF-beta3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study.

  Endocrinology 20030401

• Modulation of vascular smooth muscle cell alignment by cyclic strain is dependent on reactive oxygen species and P38 mitogen-activated protein kinase.

  Journal of vascular surgery 20030301

• p38MAPK induces cell surface alpha4 integrin downregulation to facilitate erbB-2-mediated invasion.

  Neoplasia (New York, N.Y.) 20030301

• [The role of p38 MAPK pathway in ischemia-reperfusion injury of isolated liver].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20030301

• Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite.

  The Journal of biological chemistry 20030227

• Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells.

  European journal of pharmacology 20030221

• Bone morphogenetic protein signaling in articular chondrocyte differentiation.

  Biochemical and biophysical research communications 20030207

• Effects of inhibition of myocardial extracellular-responsive kinase and P38 mitogen-activated protein kinase on mechanical function of rat hearts after prolonged hypothermic ischemia.

  Transplantation 20030127

• Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells.

  The Journal of pharmacology and experimental therapeutics 20030101

• Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells.

  Gastroenterology 20030101

• Rho and p38 MAP kinase signaling pathways mediate LPA-stimulated hepatic myofibroblast migration.

  Journal of biomedical science 20030101

• Interfering with TGFbeta-induced Smad3 nuclear accumulation differentially affects TGFbeta-dependent gene expression.

  Molecular cancer 20030101

• Ligand-independent tyrosine kinase signalling in RTH 149 trout hepatoma cells: comparison among heavy metals and pro-oxidants.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20030101

• Keratinocyte outgrowth from human skin explant cultures is dependent upon p38 signaling.

  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20030101

• Distinct roles of p42/p44(ERK) and p38 MAPK in oxidant-induced AP-1 activation and cardiomyocyte hypertrophy.

  Cardiovascular toxicology 20030101

• A novel regulatory mechanism of the mitochondrial Ca2+ uniporter revealed by the p38 mitogen-activated protein kinase inhibitor SB202190.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021201

• p38 Signaling-mediated hypoxia-inducible factor 1alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells.

  The Journal of biological chemistry 20021122

• P38 mitogen-activated protein kinase inhibitor SB203580 has a bi-directional effect on iNOS expression and NO production.

  European journal of pharmacology 20021115

• In vivo role of p38 mitogen-activated protein kinase in mediating the anti-inflammatory effects of CpG oligodeoxynucleotide in murine asthma.

  Journal of immunology (Baltimore, Md. : 1950) 20021115

• CTLA-4-Ig regulates tryptophan catabolism in vivo.

  Nature immunology 20021101

• Role of bioavailable iron in coal dust-induced activation of activator protein-1 and nuclear factor of activated T cells: difference between Pennsylvania and Utah coal dusts.

  American journal of respiratory cell and molecular biology 20021101

• HIV-1 gp120-induced tubular epithelial cell apoptosis is mediated through p38-MAPK phosphorylation.

  Molecular medicine (Cambridge, Mass.) 20021101

• Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator.

  The Journal of biological chemistry 20021025

• The role of p38 in UVA-induced cyclooxygenase-2 expression in the human keratinocyte cell line, HaCaT.

  Oncogene 20021010

• Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity.

  The Journal of biological chemistry 20021004

• Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition.

  Science (New York, N.Y.) 20020920

• The role of mitogen-activated protein kinases in eotaxin-induced cytokine production from bronchial epithelial cells.

  American journal of respiratory cell and molecular biology 20020901

• Caspase inhibitors induce a switch from apoptotic to proinflammatory signaling in CD95-stimulated T lymphocytes.

  European journal of immunology 20020901

• Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function.

  Biochemical pharmacology 20020901

• Transforming growth factor-beta1 causes transcriptional activation of CD34 and preserves haematopoietic stem/progenitor cell activity.

  British journal of haematology 20020801

• Enhancement of oxidative stress-induced apoptosis by Hsp105alpha in mouse embryonal F9 cells.

  European journal of biochemistry 20020801

• Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils.

  The Journal of biological chemistry 20020719

• Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation.

  The Journal of biological chemistry 20020705

• Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication.

  International journal for parasitology 20020701

• Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity.

  Diabetes 20020701

• The role of p38 map kinase in tumor necrosis factor-induced redistribution of vascular endothelial cadherin and increased endothelial permeability.

  Shock (Augusta, Ga.) 20020701

• The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide.

  Carcinogenesis 20020701

• Activation and translocation of p38 mitogen-activated protein kinase after stimulation of monocytes with contact sensitizers.

  The Journal of investigative dermatology 20020701

• p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons.

  The Journal of biological chemistry 20020621

• Peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1 recruitment regulates PPAR subtype specificity.

  The Journal of biological chemistry 20020510

• Intracellular calcium mobilization induces period genes via MAP kinase pathways in NIH3T3 cells.

  FEBS letters 20020410

• Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C.

  The Journal of biological chemistry 20020405

• A proteasome inhibitor confers cardioprotection.

  Cardiovascular research 20020401

• The oxidized lipid and lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response element-binding protein activation. Mediation of angiotensin II effects.

  The Journal of biological chemistry 20020322

• Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.

  The Journal of biological chemistry 20020315

• ERK and p38 MAP kinase are involved in arachidonic acid release induced by H(2)O(2) and PDGF in mesangial cells.

  American journal of physiology. Renal physiology 20020301

• Glucocorticoids induced the production and gene expression of IL-1alpha through AP-1 and partially NF-kappaB activation in murine epidermal cells.

  Journal of medical and dental sciences 20020301

• Distinct role of p38 and c-Jun N-terminal kinases in IL-10-dependent and IL-10-independent regulation of the costimulatory molecule B7.2 in lipopolysaccharide-stimulated human monocytic cells.

  Journal of immunology (Baltimore, Md. : 1950) 20020215

• IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase dependent pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20020215

• The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation.

  Bone 20020101

• Transforming growth factor-beta1 transcriptionally activates CD34 and prevents induced differentiation of TF-1 cells in the absence of any cell-cycle effects.

  Leukemia 20020101

• Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases.

  Anticancer research 20020101

• Activation of p38 mitogen-activated protein kinase during normal mitosis in the developing retina.

  Neuroscience 20020101

• The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway.

  The Journal of biological chemistry 20011214

• Differential regulation of diverse physiological responses to VEGF in pulmonary endothelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20011201

• TNF-alpha and interleukin 1 activate gastrin gene expression via MAPK- and PKC-dependent mechanisms.

  American journal of physiology. Gastrointestinal and liver physiology 20011201

• Proliferative and morphological effects of endothelins in Schwann cells: roles of p38 mitogen-activated protein kinase and Ca(2+)-independent phospholipase A2.

  Journal of neurochemistry 20011201

• p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response.

  The Journal of biological chemistry 20011130

• Possible involvement of p38 mitogen-activated protein kinase in decidual function in parturition.

  Biochemical and biophysical research communications 20011116

• TNF-alpha enhances intracellular glucocorticoid availability.

  FEBS letters 20011102

• Transcription activator protein 1 (AP-1) mediates NO-induced apoptosis of adult cardiomyocytes.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101

• Effects of homocysteine on murine splenic B lymphocyte proliferation and its signal transduction mechanism.

  Cardiovascular research 20011101

• A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101

• Quercetin abrogates taxol-mediated signaling by inhibiting multiple kinases.

  Experimental cell research 20011015

• Regulation and distribution of MAdCAM-1 in endothelial cells in vitro.

  American journal of physiology. Cell physiology 20011001

• The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription.

  Biological chemistry 20011001

• Inhibition of the ERK pathway prevents HIVgp120-induced REM sleep increase.

  Brain research 20010914

• Keratinocyte growth factor activates p38 MAPK to induce stress fibre formation in human prostate DU145 cells.

  Oncogene 20010830

• Inhibitors of mitogen-activated protein kinases differentially regulate eosinophil-activating cytokine release from human airway smooth muscle.

  American journal of respiratory and critical care medicine 20010815

• Role of p38 MAP kinase in diperoxovanadate-induced phospholipase D activation in endothelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20010801

• Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinase.

  Journal of immunology (Baltimore, Md. : 1950) 20010801

• Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats.

  Gastroenterology 20010801

• Evidence for two mechanisms of amino acid osmolyte release from hippocampal slices.

  Pflugers Archiv : European journal of physiology 20010801

• The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells.

  The Journal of biological chemistry 20010727

• beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase.

  The Journal of biological chemistry 20010720

• Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation.

  The Journal of biological chemistry 20010706

• Effects of the beta-amyloid and carboxyl-terminal fragment of Alzheimer's amyloid precursor protein on the production of the tumor necrosis factor-alpha and matrix metalloproteinase-9 by human monocytic THP-1.

  The Journal of biological chemistry 20010629

• Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.

  The Journal of biological chemistry 20010615

• The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.

  Diabetes 20010601

• Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010601

• The involvement of p38 MAPK in transforming growth factor beta1-induced apoptosis in murine hepatocytes.

  Cell research 20010601

• Robust expression of TNF-alpha, IL-1beta, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virus.

  Journal of neurovirology 20010601

• Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinases.

  The Journal of biological chemistry 20010511

• Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium.

  The Journal of biological chemistry 20010511

• p38 MAP kinase negatively regulates cyclin D1 expression in airway smooth muscle cells.

  American journal of physiology. Lung cellular and molecular physiology 20010501

• Fluoride-induced apoptosis in epithelial lung cells involves activation of MAP kinases p38 and possibly JNK.

  Toxicological sciences : an official journal of the Society of Toxicology 20010501

• Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer.

  The Journal of surgical research 20010501

• Lysophosphatidylcholine induces early growth response factor-1 expression and activates the core promoter of PDGF-A chain in vascular endothelial cells.

  Arteriosclerosis, thrombosis, and vascular biology 20010501

• The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages.

  The Journal of biological chemistry 20010427

• Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis.

  The Journal of biological chemistry 20010413

• Signaling pathways activated by alpha1-adrenergic receptor subtypes in PC12 cells.

  Life sciences 20010406

• Signal transduction pathways involved in soluble fractalkine-induced monocytic cell adhesion.

  Blood 20010401

• Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats.

  Journal of hypertension 20010301

• Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase.

  Cancer research 20010215

• Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid.

  The Journal of biological chemistry 20010209

• Expression of macrophage asialoglycoprotein-binding protein is induced through MAPK classical pathway.

  Biochemical and biophysical research communications 20010209

• Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons.

  Brain research 20010209

• Protection from MPTP-induced neurotoxicity in differentiating mouse N2a neuroblastoma cells.

  Journal of neurochemistry 20010201

• Inhibition of p38 MAPK alpha/beta reduces ischemic injury and does not block protective effects of preconditioning.

  American journal of physiology. Heart and circulatory physiology 20010201

• Overexpression of 12-lipoxygenase causes cardiac fibroblast cell growth.

  Circulation research 20010119

• Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells.

  Free radical biology & medicine 20010115

• Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation.

  The Journal of biological chemistry 20010112

• Integrin and FAK-mediated MAPK activation is required for cyclic strain mitogenic effects in Caco-2 cells.

  American journal of physiology. Gastrointestinal and liver physiology 20010101

• Early growth response factor-1 mediates insulin-inducible vascular endothelial cell proliferation and regrowth after injury.

  Journal of cellular biochemistry 20010101

• The role of p38 MAP kinase in hydrogen peroxide mediated endothelial solute permeability.

  Endothelium : journal of endothelial cell research 20010101

• Specificity and mechanism of action of some commonly used protein kinase inhibitors.

  The Biochemical journal 20001001

• Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity.

  Carcinogenesis 20000801

• Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases.

  Proceedings of the National Academy of Sciences of the United States of America 20000411

• Cocaine and apoptosis in myocardial cells.

  The Anatomical record 19991215

• Inhibitory effect of 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H - imidazole on HCMV DNA replication and permissive infection.

  Antiviral research 19990401

• p38 mitogen-activated protein kinase expression and activation in smooth muscle.

  The American journal of physiology 19980801