15291-75-5 | Ginkgolide a

Packsize	Purity	Availability	Price	Discounted Price
5mg	≥98%	in stock	$42.00	$29.00
10mg	≥98%	in stock	$74.00	$52.00
25mg	99%(HPLC)powder	in stock	$154.00	$108.00
50mg	≥98%	in stock	$197.00	$138.00
100mg	99%(HPLC)powder	in stock	$360.00	$252.00
1000mg	98% by HPLC	in stock	$3,185.00	$2,230.00

Description

• Catalog Number: AB50253
• Chemical Name: Ginkgolide a
• CAS Number: 15291-75-5
• Molecular Formula: C20H24O9
• Molecular Weight: 408.3992
• MDL Number: MFCD07437829
• SMILES: O=C1OC2C(C1C)(O)C13C4(C2)C(OC3=O)CC(C24C(O1)OC(=O)C2O)C(C)(C)C
• NSC Number: 603665

Computed Properties

• Complexity: 893
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• Undefined Atom Stereocenter Count: 10
• XLogP3: 0.6

Literature

• Effects of ginkgolide A on okadaic acid-induced tau hyperphosphorylation and the PI3K-Akt signaling pathway in N2a cells.

  Planta medica 20120801

• Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.

  Magnetic resonance in chemistry : MRC 20120801

• Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides.

  The Journal of pharmacology and experimental therapeutics 20101201

• Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans.

  Phytotherapy research : PTR 20100301

• Chemical constituents of the bark of Machilus wangchiana and their biological activities.

  Journal of natural products 20091201

• Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20080501

• [Optimized preparation of ginkgolides A and B long-circulating solid lipid nanoparticles by central composite design and response surface method].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080501

• Spectroscopic investigation of Ginkgo biloba terpene trilactones and their interaction with amyloid peptide Abeta(25-35).

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080401

• Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080315

• Induction of cyp3a in primary cultures of human hepatocytes by ginkgolides a and B.

  Clinical and experimental pharmacology & physiology 20070701

• Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence.

  Cancer letters 20070618

• Interference by leptin with Helicobacter pylori lipopolysaccharide-induced cytosolic phospholipase A2 activation in gastric mucosal cells.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070301

• Single-laboratory validation for the determination of terpene lactones in Ginkgo biloba dietary supplement crude materials and finished products by high-performance liquid chromatography with evaporative light-scattering detection.

  Journal of AOAC International 20070101

• Validation of capillary gas chromatographic method for determination of bilobalide and ginkgolides A, B, C in Ginkgo biloba dry and liquid extracts.

  Acta poloniae pharmaceutica 20070101

• Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes.

  Toxicology and applied pharmacology 20061201

• Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis.

  IUBMB life 20060401

• LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts Correlation with pharmacological activity.

  Journal of pharmaceutical and biomedical analysis 20060224

• Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20060201

• [Quantitative determination of ginkgolides by liquid chromatography-electrospray mass spectrometry].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051201

• Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts.

  Phytochemistry 20041101

• A method for extraction and quantification of Ginkgo terpene trilactones.

  Analytical chemistry 20040801

• Microglial calcium responses to platelet-activating factor are inhibited by analogue CAS 99103-16-9 and dihydropyridine PCA 4248 but not by ginkgolide A.

  Basic & clinical pharmacology & toxicology 20040801

• Effect of ginkgolides on beta-amyloid-suppressed acetylocholine release from rat hippocampal slices.

  Phytotherapy research : PTR 20040701

• Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors.

  European journal of pharmacology 20040628

• Determination of ginkgolide A, B, and bilobalide in biloba L. extracts by microdialysis-HPLC.

  Analytical and bioanalytical chemistry 20040601

• Determination of specific receptor sites for platelet activating factor in bovine neutrophils.

  American journal of veterinary research 20040501

• A new geranylgeranyl diphosphate synthase gene from Ginkgo biloba, which intermediates the biosynthesis of the key precursor for ginkgolides.

  DNA sequence : the journal of DNA sequencing and mapping 20040401

• Platelet-activating factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase-dependent constitutive nitric-oxide synthase activation.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301

• Platelet-activating factor mediates Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis.

  IUBMB life 20040101

• An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice.

  Journal of natural products 20031001

• Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: antagonizing effect of ginkgolides and bilobalide.

  Molecular and cellular biochemistry 20030101