15318-45-3 | 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$25.00	$18.00
5g	97%	in stock	$50.00	$35.00
25g	97%	in stock	$122.00	$86.00
100g	97%	in stock	$403.00	$282.00

Description

• Catalog Number: AI37159
• Chemical Name: 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide
• CAS Number: 15318-45-3
• Molecular Formula: C12H15Cl2NO5S
• Molecular Weight: 356.2222
• MDL Number: MFCD00467983
• SMILES: OC[C@H]([C@@H](c1ccc(cc1)S(=O)(=O)C)O)NC(=O)C(Cl)Cl
• NSC Number: 758396

Computed Properties

• Complexity: 443
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 6
• XLogP3: -0.3

Literature

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  Veterinary microbiology 20121109

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• 4-(Methyl-sulfon-yl)benzaldehyde.

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  Molecular microbiology 20091101

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  The Journal of antimicrobial chemotherapy 20081101

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  American journal of veterinary research 20080801

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  Emerging infectious diseases 20080801

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• Donovanosis treated with thiamphenicol.

  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20070801

• Acute toxicity of oxytetracycline and florfenicol to the microalgae Tetraselmis chuii and to the crustacean Artemia parthenogenetica.

  Ecotoxicology and environmental safety 20070701

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• Treating experimentally induced vibriosis (Listonella anguillarum) in cod, Gadus morhua L., with florfenicol.

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  Experimental hematology 20061101

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• Simultaneous determination of florfenicol and florfenicol amine in fish, shrimp, and swine muscle by gas chromatography with a microcell electron capture detector.

  Journal of AOAC International 20060101

• Comparative evaluation between capillary electrophoresis and high-performance liquid chromatography for the analysis of florfenicol in plasma.

  Journal of pharmaceutical and biomedical analysis 20051004

• Molecular basis of florfenicol-induced increase in adherence of Staphylococcus aureus strain Newman.

  The Journal of antimicrobial chemotherapy 20050801

• Fusobacterium nucleatum apoptosis-inducing outer membrane protein.

  Journal of dental research 20050801

• A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503.

  Molecular microbiology 20050801

• Pharmacokinetics of florfenicol in the red pacu (Piaractus brachypomus) after single dose intramuscular administration.

  Journal of veterinary pharmacology and therapeutics 20050601

• Plasmid-borne florfenicol resistance in Pasteurella multocida.

  The Journal of antimicrobial chemotherapy 20050501

• Evaluation of the antimicrobial activity of florfenicol against bacteria isolated from bovine and porcine respiratory disease.

  Veterinary microbiology 20050320

• Molecular evaluation of antibiotic susceptibility of Tropheryma whipplei in axenic medium.

  The Journal of antimicrobial chemotherapy 20050201

• Effects of some antibiotics on glutathione reductase activities from human erythrocytes in vitro and from rat erythrocytes in vivo.

  Journal of enzyme inhibition and medicinal chemistry 20050201

• [Analysis of chloramphenicol, thiamphenicol and florfenicol in chicken by high performance liquid chromatography with electrospray ionization mass spectrometry].

  Se pu = Chinese journal of chromatography 20050101

• Resistance pattern and assessment of phenicol agents' minimum inhibitory concentration in multiple drug resistant Chryseobacterium isolates from fish and aquatic habitats.

  Journal of applied microbiology 20050101

• Efficacy of tulathromycin in the treatment and prevention of natural outbreaks of bovine respiratory disease in European cattle.

  Veterinary therapeutics : research in applied veterinary medicine 20050101

• Efficacy of tulathromycin compared with tilmicosin and florfenicol for the control of respiratory disease in cattle at high risk of developing bovine respiratory disease.

  Veterinary therapeutics : research in applied veterinary medicine 20050101

• Comparative efficacy of tulathromycin, tilmicosin, and florfenicol in the treatment of bovine respiratory disease in stocker cattle.

  Veterinary therapeutics : research in applied veterinary medicine 20050101

• Comparative efficacy of tulathromycin versus florfenicol and tilmicosin against undifferentiated bovine respiratory disease in feedlot cattle.

  Veterinary therapeutics : research in applied veterinary medicine 20050101

• Evaluation of the therapeutic activity of tulathromycin against swine respiratory disease on farms in Europe.

  Veterinary therapeutics : research in applied veterinary medicine 20050101

• Assessing the effect of a single dose florfenicol treatment in feedlot cattle on the antimicrobial resistance patterns in faecal Escherichia coli.

  Veterinary research 20050101

• Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa.

  Microbiology and immunology 20050101

• Determination of florfenicol in fish feed by liquid chromatography.

  Journal of AOAC International 20050101

• Optimization and validation of a micellar electrokinetic chromatographic method for the analysis of florfenicol.

  Journal of pharmaceutical and biomedical analysis 20041115

• Molecular basis of bacterial resistance to chloramphenicol and florfenicol.

  FEMS microbiology reviews 20041101

• Influence of thiamphenicol on the primary functions of human polymorphonuclear leucocytes against Streptococcus pyogenes.

  International journal of antimicrobial agents 20041001

• Pharmacokinetics of florfenicol in North American elk (Cervus elaphus).

  Journal of veterinary pharmacology and therapeutics 20041001

• In vitro activity of thiamphenicol, erythromycin and fluoroquinolones against Legionella pneumophila.

  Journal of chemotherapy (Florence, Italy) 20041001

• Monitoring of florfenicol susceptibility among bovine and porcine respiratory tract pathogens collected in Germany during the years 2002 and 2003.

  The Journal of antimicrobial chemotherapy 20040801

• Intravenous and subcutaneous pharmacokinetics of florfenicol in sheep.

  Journal of veterinary pharmacology and therapeutics 20040801

• Effects of subinhibitory concentrations of florfenicol on morphology, growth, and viability of Staphylococcus aureus.

  Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20040801

• The effect of testosterone propionate supplement on testicular toxicity with thiamphenicol in male Sprague-Dawley rats.

  The Journal of toxicological sciences 20040801

• Pharmacokinetics and bioavailability of florfenicol following intravenous, intramuscular and oral administrations in rabbits.

  Veterinary research communications 20040801

• Characterization of florfenicol resistance among calf pathogenic Escherichia coli.

  FEMS microbiology letters 20040715

• Subinhibitory concentrations of florfenicol enhance the adherence of florfenicol-susceptible and florfenicol-resistant Staphylococcus aureus.

  The Journal of antimicrobial chemotherapy 20040701

• [Construction of SW480 cell model identifying Shigella virulent genes].

  Yi chuan = Hereditas 20040701

• Use of florfenicol in non-human primates.

  Journal of medical primatology 20040601

• Bioavailability and pharmacokinetics of florfenicol in healthy sheep.

  Journal of veterinary pharmacology and therapeutics 20040601

• Rickettsia felis, Bartonella henselae, and B. clarridgeiae, New Zealand.

  Emerging infectious diseases 20040501

• Plasmid-mediated florfenicol and ceftriaxone resistance encoded by the floR and bla(CMY-2) genes in Salmonella enterica serovars Typhimurium and Newport isolated in the United States.

  FEMS microbiology letters 20040415

• Gonorrhoea surveillance system in France: 1986-2000.

  Sexually transmitted diseases 20040401

• Molecular analysis of florfenicol-resistant Escherichia coli isolates from pigs.

  The Journal of antimicrobial chemotherapy 20040101

• [Role of thiamphenicol in the treatment of community-acquired lung infections].

  Medecine tropicale : revue du Corps de sante colonial 20040101

• In vitro effects of some antibiotics on glutathione reductase from sheep liver.

  Journal of enzyme inhibition and medicinal chemistry 20031201

• In vitro evaluation of the susceptibility of Edwardsiella ictaluri, etiological agent of enteric septicemia in channel catfish, Ictalurus punctatus (Rafinesque), to florfenicol.

  Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20031101

• Serogroup A Neisseria meningitidis outside meningitis belt in southwest Cameroon.

  Emerging infectious diseases 20031001

• Bioavailability and pharmacokinetics of florfenicol in broiler chickens.

  Journal of veterinary pharmacology and therapeutics 20031001

• Pharmacokinetics of florfenicol in cod Gadus morhua and in vitro antibacterial activity against Vibrio anguillarum.

  Diseases of aquatic organisms 20030924

• Mobile genes coding for efflux-mediated antimicrobial resistance in Gram-positive and Gram-negative bacteria.

  International journal of antimicrobial agents 20030901

• Comparative plasma pharmacokinetics and tolerance of florfenicol following intramuscular and intravenous administration to camels, sheep and goats.

  Veterinary research communications 20030901

• Rickettsia felis in the United Kingdom.

  Emerging infectious diseases 20030801

• Effect of oral enrofloxacin and florfenicol on pigs experimentally infected with Actinobacillus pleuropneumoniae serotype 1.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20030601

• Florfenicol resistance in Salmonella enterica serovar Newport mediated by a plasmid related to R55 from Klebsiella pneumoniae.

  The Journal of antimicrobial chemotherapy 20030401

• Pharmacokinetics of florfenicol in loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular injections.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030301

• Antimicrobial susceptibilities of Neisseria gonorrhoeae strains isolated in Java, Indonesia.

  Sexually transmitted diseases 20030101

• Stability of florfenicol in drinking water.

  Journal of AOAC International 20030101

• Simultaneous determination of residues of chloramphenicol, thiamphenicol, florfenicol, and florfenicol amine in farmed aquatic species by liquid chromatography/mass spectrometry.

  Journal of AOAC International 20030101

• Determination of florfenicol amine in channel catfish muscle by liquid chromatography.

  Journal of AOAC International 20030101

• Safety of Aquaflor (florfenicol, 50% type A medicated article), administered in feed to channel catfish, Ictalurus punctatus.

  Toxicologic pathology 20030101

• Chloramphenicol and florfenicol susceptibility of fish-pathogenic bacteria isolated in France: comparison of minimum inhibitory concentration, using recommended provisory standards for fish bacteria.

  Journal of applied microbiology 20030101

• Haemotoxicity of thiamphenicol in the BALB/c mouse and Wistar Hanover rat.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021201

• A comparative kinetic study of thiamphenicol in pre-ruminant lambs and calves.

  Research in veterinary science 20021201

• Pharmacokinetics of thiamphenicol in pigs.

  Journal of veterinary pharmacology and therapeutics 20021201

• An evaluation of the relative efficacy of a new formulation of oxytetracycline for the treatment of undifferentiated fever in feedlot calves in western Canada.

  The Canadian veterinary journal = La revue veterinaire canadienne 20021201

• In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy.

  Journal of chemotherapy (Florence, Italy) 20021201

• Liquid chromatographic determination of florfenicol in the plasma of multiple species of fish.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021115

• Pharmacokinetics of florfenicol in healthy and Escherichia coli-infected broiler chickens.

  Research in veterinary science 20021001

• Relationship of vitamin E supplementation and antimicrobial treatment with acute-phase protein responses in cattle affected by naturally acquired respiratory tract disease.

  American journal of veterinary research 20020801

• An open, comparative pilot study of thiamphenicol glycinate hydrochloride vs clarithromycin in the treatment of acute lower respiratory tract infections due to Chlamydia pneumoniae.

  Journal of chemotherapy (Florence, Italy) 20020601

• Recent clinical evidence of the efficacy and safety of thiamphenicol glycinate acetylcysteinate and thiamphenicol glycinate.

  Journal of chemotherapy (Florence, Italy) 20020601

• Salmonella enterica serotype Typhimurium DT104 isolated from humans, United States, 1985, 1990, and 1995.

  Emerging infectious diseases 20020401

• The effects of certain antibiotics on biogas production in the anaerobic digestion of pig waste slurry.

  Bioresource technology 20020401

• Effects of vaccination prior to transit and administration of florfenicol at time of arrival in a feedlot on the health of transported calves and detection of Mannheimia haemolytica in nasal secretions.

  American journal of veterinary research 20020201

• Residue depletion of thiamphenicol in the sea-bass.

  Journal of veterinary pharmacology and therapeutics 20020201

• Clinical efficacy of florfenicol in the treatment of calf respiratory tract infections.

  The Veterinary quarterly 20020201

• Molecular analysis of chromosomally florfenicol-resistant Escherichia coli isolates from France and Germany.

  The Journal of antimicrobial chemotherapy 20020101

• Comparative in vitro activity of 16 antimicrobial agents against Actinobacillus pleuropneumoniae.

  Veterinary research communications 20020101

• Pyrrole analogues of chloramphenicol. III. Synthesis and antibacterial activity of DL-threo-1-(1-methylsulfonylpyrrole-3-yl)-2-dichloroacetamidopropane-1,3-diol.

  Acta poloniae pharmaceutica 20020101

• Tissue pharmacokinetics of florfenicol in pigs experimentally infected with Actinobacillus pleuropneumoniae.

  European journal of drug metabolism and pharmacokinetics 20020101

• Evaluation of certain veterinary drug residues in food.

  World Health Organization technical report series 20020101

• Effects of florfenicol injection on the meat characteristics of the cervical muscles in cattle.

  American journal of veterinary research 20020101

• An optimized system for studies of EPO-dependent murine pro-erythroblast development.

  Experimental hematology 20011101

• Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.

  Immunopharmacology and immunotoxicology 20011101

• Antimicrobial susceptibilities of Neisseria gonorrhoeae in Kigali, Rwanda, and trends of resistance between 1986 and 2000.

  Sexually transmitted diseases 20010901

• Pharmacodisposition of thiamphenicol in rabbits.

  DTW. Deutsche tierarztliche Wochenschrift 20010901

• Antimicrobial susceptibility of Pasteurella multocida isolated from cattle and pigs.

  Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20010901

• ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.

  Journal of medicinal chemistry 20010719

• Serum soluble transferrin receptor concentration is an accurate estimate of the mass of tissue receptors.

  Experimental hematology 20010601

• Allometric analysis of thiamphenicol disposition among seven mammalian species.

  Journal of veterinary pharmacology and therapeutics 20010601

• Chronotoxicology of florfenicol.

  Chronobiology international 20010501

• Inhibition of mitochondrial protein synthesis promotes autonomous regulation of mtDNA expression and generation of a new mitochondrial RNA species.

  FEBS letters 20010413

• Disposition kinetics of florfenicol in goats by using two analytical methods.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20010401

• Antimicrobial susceptibilities and plasmid patterns of Neisseria gonorrhoeae in Bénin.

  International journal of STD & AIDS 20010201

• Molecular features determining lymphocyte reactivity in allergic contact dermatitis to chloramphenicol and azidamphenicol.

  Allergy 20010101

• Antimicrobial activity of thiamphenicol-glycinate-acetylcysteinate and other drugs against Chlamydia pneumoniae.

  Arzneimittel-Forschung 20010101

• A simple classification method for residual antibiotics using E. coli cells transformed by the calcium chloride method and drug resistance plasmid DNA.

  Microbios 20010101

• Comparative in vitro activity of thiamphenicol-glycinate and thiamphenicol-glycinate-acetylcysteinate and other antimicrobials against respiratory pathogens.

  Arzneimittel-Forschung 20010101

• An assessment of chloramphenicol and thiamphenicol in the induction of aplastic anaemia in the BALB/c mouse.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20001001

• Toxic etiology of aplastic anemia. The Cooperative Study Group for Aplastic and Refractory Anemias.

  Sexually transmitted diseases 19840101

• Aplastic anemia due to chemicals and drugs: a study of 108 patients.

  Sexually transmitted diseases 19840101

• [Hematotoxicity of thiamphenicol. Report of two cases of acute erythroblastopenia (author's transl)].

  La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 19811201

• [A new case of optic neuritis induced by chloramphenicol in a child].

  Bulletin des societes d'ophtalmologie de France 19770101

• [Blood damage due to chloramphenicol and thiamphenicol].

  Schweizerische medizinische Wochenschrift 19750823

• [Hematologic toxicity of thiamphenicol. Analysis of a case of irreversible total medullary aplasia and general review of the problem].

  Sangre 19720101