153439-40-8 | 2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$15.00	$10.00
10mg	98%	in stock	$18.00	$12.00
50mg	98%	in stock	$22.00	$15.00
1g	98%	in stock	$42.00	$30.00
5g	98%	in stock	$98.00	$68.00
25g	98%	in stock	$269.00	$188.00
100g	98%	in stock	$812.00	$568.00
250g	98%	in stock	$1,812.00	$1,268.00

Description

• Catalog Number: AD50038
• Chemical Name: 2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid hydrochloride
• CAS Number: 153439-40-8
• Molecular Formula: C32H40ClNO4
• Molecular Weight: 538.1173
• MDL Number: MFCD00865710
• SMILES: OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C.Cl
• NSC Number: 758678

Computed Properties

• Complexity: 678
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 38
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 10
• Undefined Atom Stereocenter Count: 1

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  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20061101

• [Inhibition of histamine-induced wheel after a recommended single dose administration of 10 mg cetirizine, 5 mg desloratadine, 120 i 180 mg fexofenadine, 5 mg levocetirizine and 10 mg loratadine--a randomized, double-blind, placebo controlled trial].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101

• [The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101

• Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs.

  European journal of pharmacology 20061010

• QT interval prolongation and beyond.

  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20061001

• Onset of action of fexofenadine hydrochloride 60 mg/pseudoephedrine hydrochloride 120 mg in subjects aged 12 years with moderate to severe seasonal allergic rhinitis: a pooled analysis of two single-dose, randomized, double-blind, placebo-controlled allergen exposure unit studies.

  Clinical therapeutics 20061001

• Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein.

  British journal of clinical pharmacology 20060901

• Altered oral bioavailability and pharmacokinetics of P-glycoprotein substrates by coadministration of biochanin A.

  Journal of pharmaceutical sciences 20060901

• Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes.

  The Journal of pharmacology and experimental therapeutics 20060801

• Facial thermography is a sensitive tool to determine antihistaminic activity: comparison of levocetirizine and fexofenadine.

  British journal of clinical pharmacology 20060801

• Alteration of fexofenadine disposition in the rat isolated perfused liver following injection of bacterial lipopolysaccharide.

  Clinical and experimental pharmacology & physiology 20060801

• Transporter-mediated intestinal absorption of fexofenadine in rats.

  Drug metabolism and pharmacokinetics 20060801

• A combined neurophysiological and behavioural study into the stimulating effects of fexofenadine on performance.

  Journal of psychopharmacology (Oxford, England) 20060701

• First-pass effects of verapamil on the intestinal absorption and liver disposition of fexofenadine in the porcine model.

  Drug metabolism and disposition: the biological fate of chemicals 20060701

• Stimulating effects of the antihistamine fexofenadine: testing the dopamine transporter hypothesis.

  Psychopharmacology 20060701

• Time-dependent interaction between lopinavir/ritonavir and fexofenadine.

  Journal of clinical pharmacology 20060701

• Allergy medication in Japanese volunteers: treatment effect of single doses on nocturnal sleep architecture and next day residual effects.

  Current medical research and opinion 20060701

• Efficacy and central nervous system impairment of newer-generation prescription antihistamines in seasonal allergic rhinitis.

  Southern medical journal 20060601

• Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid.

  Drug metabolism and disposition: the biological fate of chemicals 20060501

• Effect of P-glycoprotein on intestinal absorption and brain penetration of antiallergic agent bepotastine besilate.

  Drug metabolism and disposition: the biological fate of chemicals 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Once-daily immediate-release fexofenadine and sustained-release pseudoephedrine combination: a new treatment option for allergic rhinitis.

  Expert opinion on pharmacotherapy 20060501

• Effects of itraconazole and diltiazem on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein.

  British journal of clinical pharmacology 20060501

• Pustular exacerbation of psoriasis due to fexofenadine.

  Clinical and experimental dermatology 20060501

• Fexofenadine in horses: pharmacokinetics, pharmacodynamics and effect of ivermectin pretreatment.

  Journal of veterinary pharmacology and therapeutics 20060401

• Effect of pretreatment with fexofenadine on the safety of immunotherapy in patients with allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060401

• The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates.

  Clinical pharmacology and therapeutics 20060301

• Efficacy of fexofenadine in the prophylactic control of cat allergen-induced allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060201

• Effect of erythromycin on the absorption of fexofenadine in the jejunum, ileum and colon determined using local intubation in healthy volunteers.

  International journal of clinical pharmacology and therapeutics 20060201

• Fexofenadine, an H1-receptor antagonist, partially but rapidly inhibits the itch of contact dermatitis induced by diphenylcyclopropenone in patients with alopecia areata.

  The Journal of dermatology 20060201

• Differential effects of fexofenadine on arachidonic acid metabolism in cultured human monocytes.

  Pharmacology 20060101

• In vivo pharmacological characterisation of bilastine, a potent and selective histamine H1 receptor antagonist.

  Drugs in R&D 20060101

• Efficacy of desloratadine, 5 mg, compared with fexofenadine, 180 mg, in patients with symptomatic seasonal allergic rhinitis.

  Allergy and asthma proceedings 20060101

• Saliva secretion in patients with allergic rhinitis.

  International archives of allergy and immunology 20060101

• Marketing of a new non-sedating antihistamine (fexofenadine) puts an additional burden on healthcare system resources in Israel.

  The European journal of general practice 20060101

• Simultaneous quantification of fexofenadine and pseudoephedrine in human plasma by liquid chromatography/tandem mass spectrometry with electrospray ionization: method development, validation and application to a clinical study.

  Rapid communications in mass spectrometry : RCM 20060101

• New evidence of H1-receptor independent COX-2 inhibition by fexofenadine HCl in vitro.

  Pharmacology 20060101

• The effect of fexofenadine on pruritus in a mouse model (HR-ADf) of atopic dermatitis.

  The Journal of international medical research 20060101

• Selecting the optimal oral antihistamine for patients with allergic rhinitis.

  Drugs 20060101

• [Treatment of allergic rhinitis associated with hypothyroidism].

  Vestnik otorinolaringologii 20060101

• The methanol disolvate and the dihydrate of fexofenadine, an antihistamine drug.

  Acta crystallographica. Section C, Crystal structure communications 20051201

• The efficacy and safety of 30 mg fexofenadine HCl bid in pediatric patients with allergic rhinitis.

  Asian Pacific journal of allergy and immunology 20051201

• Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans.

  Drug metabolism and disposition: the biological fate of chemicals 20051001

• Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis.

  Pharmacology 20051001

• Effects of fexofenadine and hydroxyzine on brake reaction time during car-driving with cellular phone use.

  Human psychopharmacology 20051001

• Transport of anti-allergic drugs across the passage cultured human nasal epithelial cell monolayer.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20051001

• Treatment of ear pain in pilots in flight.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20051001

• The various effects of four H1-antagonists on serum substance P levels in patients with atopic dermatitis.

  The Journal of dermatology 20051001

• [Wheat anaphylaxis enhanced by administration of acetylsalicylic acid or by exercise].

  Arerugi = [Allergy] 20051001

• Suppression of the histamine-induced wheal and flare response by fexofenadine HCl 60 mg twice daily, loratadine 10 mg once daily and placebo in healthy Japanese volunteers.

  Current medical research and opinion 20050901

• Addition of fexofenadine to inhaled corticosteroid therapy to reduce inflammatory biomarkers in atopic asthma.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050901

• Determination of fexofenadine in tablets by capillary electrophoresis in free solution and in solution with cyclodextrins as analyte carriers.

  Drug development and industrial pharmacy 20050901

• Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050901

• Development and validation of dissolution tests for fexofenadine hydrochloride capsules and coated tablets.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20050811

• Management of seasonal allergic rhinitis: comparative efficacy of the newer-generation prescription antihistamines.

  Journal of the American Academy of Nurse Practitioners 20050801

• Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism.

  Clinical pharmacology and therapeutics 20050801

• The advantages of the Ussing chamber in drug absorption studies.

  Journal of biomolecular screening 20050801

• Assessing the therapeutic benefits of antihistamines for the treatment of chronic idiopathic urticaria--a requirement for well-designed comparative clinical studies.

  The Journal of dermatological treatment 20050801

• P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion.

  Drug metabolism and disposition: the biological fate of chemicals 20050701

• Levocetirizine has a longer duration of action on improving total nasal symptoms score than fexofenadine after single administration.

  British journal of clinical pharmacology 20050701

• Once-daily fexofenadine treatment for chronic idiopathic urticaria: a multicenter, randomized, double-blind, placebo-controlled study.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050601

• Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1).

  British journal of clinical pharmacology 20050501

• Single-dose and steady-state bioequivalence of fexofenadine and pseudoephedrine combination tablets compared with individual formulations in healthy adults.

  Current medical research and opinion 20050501

• Preferential downmodulation of certain chemokines by fexofenadine in human keratinocytes.

  Journal of dermatological science 20050401

• The efficacy of short-term administration of 3 antihistamines vs placebo under natural exposure to Japanese cedar pollen.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050401

• H1 receptor-mediated vasodilatation contributes to postexercise hypotension.

  The Journal of physiology 20050301

• CYP3A and P-glycoprotein activity induction with St. John's Wort in healthy volunteers from 6 ethnic populations.

  Journal of clinical pharmacology 20050301

• Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides.

  Clinical pharmacology and therapeutics 20050301

• Effect of fruit juices on the oral bioavailability of fexofenadine in rats.

  Journal of pharmaceutical sciences 20050201

• Fexofenadine improves the quality of life and work productivity in Japanese patients with seasonal allergic rhinitis during the peak cedar pollinosis season.

  International archives of allergy and immunology 20050201

• Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination.

  Journal of clinical pharmacology 20050101

• Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics.

  Clinical pharmacology and therapeutics 20050101

• Minimal important difference (MID) of the Dermatology Life Quality Index (DLQI): results from patients with chronic idiopathic urticaria.

  Health and quality of life outcomes 20050101

• Comparative effects of fexofenadine and montelukast on allergen-induced wheal and flare.

  Allergy and asthma proceedings 20050101

• Capillary electrophoresis method for fexofenadine hydrochloride in capsules.

  Journal of AOAC International 20050101

• Comparative efficacy of cetirizine and fexofenadine for seasonal allergic rhinitis, 5-12 hours postdose, in the environmental exposure unit.

  Allergy and asthma proceedings 20050101

• The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils.

  Allergy and asthma proceedings 20050101

• The utility of mixed-effects covariate analysis in rapid selection of doses in pediatric subjects: a case study with fexofenadine hydrochloride.

  Biopharmaceutics & drug disposition 20041201

• Similar rapid onset of action and magnitude of effect of fexofenadine and cetirizine as assessed by inhibition of histamine-induced wheal-and-flare reaction.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20041201

• Suppressive activity of fexofenadine hydrochloride on metalloproteinase production from nasal fibroblasts in vitro.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20041201

• Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine.

  Bioorganic & medicinal chemistry letters 20041101

• A variant 2677A allele of the MDR1 gene affects fexofenadine disposition.

  Clinical pharmacology and therapeutics 20041101

• Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance.

  Clinical and experimental dermatology 20040901

• Venom immunotherapy: adverse reactions and treatment failure.

  Current opinion in allergy and clinical immunology 20040801

• Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography.

  Journal of clinical pharmacology 20040801

• Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans.

  Fundamental & clinical pharmacology 20040801

• Validation of the Dermatology Life Quality Index as an outcome measure for urticaria-related quality of life.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20040801

• Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadine.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20040801

• A novel membrane sensor for histamine H1-receptor antagonist 'fexofenadine'.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20040801

• Transport characteristics of fexofenadine in the Caco-2 cell model.

  Pharmaceutical research 20040801

• Determination of fexofenadine in human plasma using 96-well solid phase extraction and HPLC with tandem mass spectrometric detection.

  Journal of pharmaceutical and biomedical analysis 20040629

• Liquid chromatographic determination of fexofenadine in human plasma with fluorescence detection.

  Journal of pharmaceutical and biomedical analysis 20040629

• Effects of single or combined histamine H1-receptor and leukotriene CysLT1-receptor antagonism on nasal adenosine monophosphate challenge in persistent allergic rhinitis.

  British journal of clinical pharmacology 20040601

• Safety and efficacy of oral fexofenadine in children with seasonal allergic rhinitis--a pooled analysis of three studies.

  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20040601

• Fexofenadine does not affect omeprazole pharmacokinetics: both are putative P-glycoprotein substrates.

  Basic & clinical pharmacology & toxicology 20040501

• Comparative efficacy of wheal-and-flare suppression among various non-sedating antihistamines and the pharmacologic insights to their efficacy.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20040501

• Repeated dosing effects of mediator antagonists in inhaled corticosteroid-treated atopic asthmatic patients.

  Chest 20040401

• A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040401

• Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040401

• Lack of association between fexofenadine and rhabdomyolysis.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040401

• Mizolastine and fexofenadine modulate cytokine pattern after nasal allergen challenge.

  European annals of allergy and clinical immunology 20040401

• Suppressive activity of fexofenadine hydrochloride on thymus- and activation-regulated chemokine production from human peripheral blood leukocytes in response to antigenic stimulation in vitro.

  International archives of allergy and immunology 20040301

• The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis.

  International immunopharmacology 20040301

• The effects of butterbur on the histamine and allergen cutaneous response.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20040201

• Assessing patient satisfaction with desloratadine after conversion from loratadine, fexofenadine, or cetirizine.

  Managed care interface 20040201

• Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research.

  Current medical research and opinion 20040101

• Comparative efficacy of cetirizine and fexofenadine in the treatment of chronic idiopathic urticaria.

  The Journal of dermatological treatment 20040101

• Comparison of the combinations of fexofenadine-pseudoephedrine and loratadine-montelukast in the treatment of seasonal allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20040101

• Randomized double-blind comparison of cetirizine and fexofenadine after pollen challenge in the Environmental Exposure Unit: duration of effect in subjects with seasonal allergic rhinitis.

  Allergy and asthma proceedings 20040101

• Onset of action for the relief of allergic rhinitis symptoms with second-generation antihistamines.

  Allergy and asthma proceedings 20040101

• Suppressive activity of fexofenadine hydrochloride on the production of eosinophil chemoattractants from human nasal fibroblasts in vitro.

  Arzneimittel-Forschung 20040101

• Development and validation of a liquid chromatographic method for fexofenadine hydrochloride in capsules.

  Journal of AOAC International 20040101

• Fexofenadine HCl 60 mg/ pseudoephedrine HCl 120 mg has a 60-minute onset of action in the treatment of seasonal allergic rhinitis symptoms, as assessed in an allergen exposure unit.

  Allergy and asthma proceedings 20040101

• [Serum sICAM-1 in patients suffering from allergic rhinitis treated with fexofenadine or fluticasone].

  Pneumonologia i alergologia polska 20040101

• Comparative study of acute effects of single doses of fexofenadine, olopatadine, d-chlorpheniramine and placebo on psychomotor function in healthy volunteers.

  Human psychopharmacology 20031201

• Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine.

  Clinical pharmacology and therapeutics 20031101

• A study comparing the inhibitory effects of single and repeated oral doses of ebastine and fexofenadine against histamine-induced skin reactivity.

  International archives of allergy and immunology 20031101

• Effect of the second-generation antihistamine, fexofenadine, on cough reflex sensitivity and pulmonary function.

  British journal of clinical pharmacology 20031101

• Mite-antigen induced immediate reactions in atopic dermatitis are inhibited by daily administration of fexofenadine.

  The Journal of dermatology 20031101

• Efficacy and safety profile of fexofenadine HCl: a unique therapeutic option in H1-receptor antagonist treatment.

  The Journal of allergy and clinical immunology 20031001

• Effects of fexofenadine and other antihistamines on components of the allergic response: adhesion molecules.

  The Journal of allergy and clinical immunology 20031001

• Effects of fexofenadine on T-cell function in a murine model of allergen-induced airway inflammation and hyperresponsiveness.

  The Journal of allergy and clinical immunology 20031001

• Is 3-mm less drowsiness important?

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20031001

• Fexofenadine hydrochloride, 180 mg, exhibits equivalent efficacy to cetirizine, 10 mg, with less drowsiness in patients with moderate-to-severe seasonal allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20031001

• Omalizumab, an anti-IgE antibody, in the treatment of adults and adolescents with perennial allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030801

• The effects of fexofenadine on reaction time, decision-making, and driver behavior.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030801

• Randomized, double-masked comparison of olopatadine ophthalmic solution, mometasone furoate monohydrate nasal spray, and fexofenadine hydrochloride tablets using the conjunctival and nasal allergen challenge models.

  Clinical therapeutics 20030801

• Herbal supplements and skin testing: the lack of effect of commonly used herbal supplements on histamine skin prick testing.

  Allergy 20030601

• Supplementation of fexofenadine therapy with nedocromil sodium 2% ophthalmic solution to treat ocular symptoms of seasonal allergic conjunctivitis.

  Clinical & experimental ophthalmology 20030601

• H1-antihistaminic activity of cetirizine and fexofenadine in allergic children.

  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20030601

• Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study.

  The British journal of dermatology 20030601

• Relative potency of fexofenadine HCl 180 mg, loratadine 10 mg, and placebo using a skin test model of wheal-and-flare suppression.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030601

• [Clinical aspects of anti-inflammatory action of antihistamines].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030601

• Effects of fexofenadine, diphenhydramine, and placebo on performance of the test of variables of attention (TOVA).

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030501

• A single-center, randomized, double-blind, placebo-controlled, crossover investigation of the effects of fexofenadine hydrochloride 180 mg alone and with alcohol, with hydroxyzine hydrochloride 50 mg as a positive internal control, on aspects of cognitive and psychomotor function related to driving a car.

  Clinical therapeutics 20030501

• Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis.

  The Journal of allergy and clinical immunology 20030401

• The effects of acute doses of fexofenadine, promethazine, and placebo on cognitive and psychomotor function in healthy Japanese volunteers.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030401

• [H1 histamine antagonists].

  Revue medicale de Bruxelles 20030401

• Decongestant effects of antihistamines: a class effect?

  The Journal of allergy and clinical immunology 20030301

• Solar urticaria induced by infrared radiation.

  Clinical and experimental dermatology 20030301

• Effect of fexofenadine hydrochloride on cedar pollinosis.

  Auris, nasus, larynx 20030201

• Failure of cetirizine and fexofenadine to prevent motion sickness.

  The Annals of pharmacotherapy 20030201

• The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique.

  British journal of clinical pharmacology 20030201

• Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma.

  The Journal of allergy and clinical immunology 20030201

• The effects of single-dose fexofenadine, diphenhydramine, and placebo on cognitive performance in flight personnel.

  Aviation, space, and environmental medicine 20030201

• Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects.

  Clinical pharmacology and therapeutics 20030101

• Internal standard signal suppression by co-eluting analyte in isotope dilution LC-ESI-MS.

  The Analyst 20030101

• [Effect of fexofenadine--selective antagonist of histamine receptor (H1) on histamine-induced bronchoconstriction].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030101

• Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine.

  BMC family practice 20030101

• Roles of histamine in regulation of arousal and cognition: functional neuroimaging of histamine H1 receptors in human brain.

  Life sciences 20021220

• Inhibitory effects of oral prednisolone and fexofenadine on skin responses by prick tests with histamine and compound 48/80.

  Journal of dermatological science 20021201

• Facial swelling and eosinophilia in a 44-year-old woman.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021201

• Effects of fexofenadine on the early response to nasal allergen challenge.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021201

• Effect of fexofenadine, a mast cell blocker, in infertile men with significantly increased testicular mast cells.

  Asian journal of andrology 20021201

• The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia.

  British journal of pharmacology 20021101

• Fexofenadine transport in Caco-2 cells: inhibition with verapamil and ritonavir.

  Journal of clinical pharmacology 20021101

• Clinical pharmacology of H1-antihistamines in the skin.

  The Journal of allergy and clinical immunology 20021101

• Effects of fexofenadine and desloratadine on subjective and objective measures of nasal congestion in seasonal allergic rhinitis.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20021001

• Review of fexofenadine in the treatment of chronic idiopathic urticaria.

  International journal of dermatology 20021001

• The use of handheld computers in clinical trials.

  Controlled clinical trials 20021001

• Simultaneous determination of fexofenadine and its related compounds by HPLC.

  Journal of pharmaceutical and biomedical analysis 20020720

• Chronic urticaria and angioedema.

  The New England journal of medicine 20020718

• Role of lung inflammatory mediators as a cause of exercise-induced arterial hypoxemia in young athletes.

  Journal of applied physiology (Bethesda, Md. : 1985) 20020701

• Fexofenadine modulates T-cell function, preventing allergen-induced airway inflammation and hyperresponsiveness.

  The Journal of allergy and clinical immunology 20020701

• Onset of action, efficacy, and safety of fexofenadine 60 mg/pseudoephedrine 120 mg versus placebo in the Atlanta allergen exposure unit.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020701

• Comparison of the efficacy of combined fluticasone propionate and olopatadine versus combined fluticasone propionate and fexofenadine for the treatment of allergic rhinoconjunctivitis induced by conjunctival allergen challenge.

  Clinical therapeutics 20020701

• In vivo anti-inflammatory effects of fexofenadine in chronic idiopathic urticaria.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20020701

• Pharmacological rescue of human K(+) channel long-QT2 mutations: human ether-a-go-go-related gene rescue without block.

  Circulation 20020618

• Are herbal products dietary supplements or drugs? An important question for public safety.

  Clinical pharmacology and therapeutics 20020601

• Effect of St John's wort on the pharmacokinetics of fexofenadine.

  Clinical pharmacology and therapeutics 20020601

• MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine.

  British journal of clinical pharmacology 20020501

• Evaluation of cytokines in nasal secretions after nasal antigen challenge: lack of influence of antihistamines.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020501

• [Hay fever and asthma. Many of your patients have both].

  MMW Fortschritte der Medizin 20020425

• [Chronic idiopathic urticaria: effectiveness of fexofenadine. A double-blind, placebo controlled study with 21 patients].

  Praxis 20020410

• A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020201

• Are antihistamines useful in managing asthma?

  Current opinion in allergy and clinical immunology 20020201

• Determination of fexofenadine in human plasma and urine by liquid chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020125

• Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin.

  Drug metabolism and disposition: the biological fate of chemicals 20020101

• Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.

  Clinical pharmacology and therapeutics 20020101

• Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine.

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