154992-24-2 | Ru 58841

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$16.00	$11.00
10mg	98%	in stock	$20.00	$14.00
50mg	98%	in stock	$26.00	$18.00
100mg	98%	in stock	$36.00	$25.00
1g	98%	in stock	$74.00	$52.00
5g	98%	in stock	$187.00	$131.00
25g	98%	in stock	$597.00	$418.00

Description

• Catalog Number: AA76937
• Chemical Name: Ru 58841
• CAS Number: 154992-24-2
• Molecular Formula: C17H18F3N3O3
• Molecular Weight: 369.3383
• MDL Number: MFCD00925776
• SMILES: OCCCCN1C(=O)N(C(=O)C1(C)C)c1ccc(c(c1)C(F)(F)F)C#N

Computed Properties

• Complexity: 611
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 2.1

Literature

• Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.

  Bioorganic & medicinal chemistry letters 20100101

• Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production.

  Bioorganic & medicinal chemistry letters 20090415

• 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production.

  Bioorganic & medicinal chemistry letters 20090301

• Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications.

  Journal of medicinal chemistry 20081113

• Novel vesicular and particulate drug delivery systems for topical treatment of acne.

  Expert opinion on drug delivery 20080601

• (1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.

  Bioorganic & medicinal chemistry letters 20071101

• Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production.

  Bioorganic & medicinal chemistry letters 20071015

• Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production.

  Bioorganic & medicinal chemistry letters 20071015

• Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: particle characterisation and skin uptake.

  Pharmaceutical research 20070501

• Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain.

  Journal of medicinal chemistry 20050224

• Synthesis and structure-activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands.

  Bioorganic & medicinal chemistry letters 20041101

• Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands.

  Bioorganic & medicinal chemistry letters 20010423