-
Naringin enhances endothelial progenitor cell (EPC) proliferation and tube formation capacity through the CXCL12/CXCR4/PI3K/Akt signaling pathway.
Chemico-biological interactions 20180425
-
Inhibitory effects of 3,3'-diindolylmethane on epithelial-mesenchymal transition induced by endocrine disrupting chemicals in cellular and xenograft mouse models of breast cancer.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171101
-
A Novel CXCR4 Antagonist CX549 Induces Neuroprotection in Stroke Brain.
Cell transplantation 20170401
-
Resveratrol suppresses vascular endothelial growth factor secretion via inhibition of CXC-chemokine receptor 4 expression in ARPE-19 cells.
Molecular medicine reports 20150701
-
Expression and regulation of stromal cell-derived factor-1 (SDF1) and chemokine CXC motif receptor 4 (CXCR4) in equine and bovine preovulatory follicles.
Molecular and cellular endocrinology 20140625
-
Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity.
Toxicology 20131215
-
Plerixafor plus G-CSF in combination with chemotherapy for stem cell mobilization in a pediatric patient with Ewing's sarcoma.
Journal of clinical apheresis 20121101
-
Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20121101
-
Efficacy and safety of hematopoietic stem cell remobilization with plerixafor+G-CSF in adult patients with germ cell tumors.
Bone marrow transplantation 20121001
-
Inhibition of stromal CXCR4 impairs development of lung metastases.
Cancer immunology, immunotherapy : CII 20121001
-
Plerixafor plus granulocyte colony-stimulating factor versus placebo plus granulocyte colony-stimulating factor for mobilization of CD34(+) hematopoietic stem cells in patients with multiple myeloma and low peripheral blood CD34(+) cell count: results of a subset analysis of a randomized trial.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20121001
-
Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML.
Blood 20120927
-
Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells.
Journal of medicinal chemistry 20120913
-
Plerixafor, a CXCR4 antagonist, mitigates skin radiation-induced injury in mice.
Radiation research 20120901
-
Vinorelbine inhibits angiogenesis and 95D migration via reducing hypoxic fibroblast stromal cell-derived factor 1 secretion.
Experimental biology and medicine (Maywood, N.J.) 20120901
-
Preemptive dosing of plerixafor given to poor stem cell mobilizers on day 5 of G-CSF administration.
Bone marrow transplantation 20120801
-
European data on stem cell mobilization with plerixafor in non-Hodgkin's lymphoma, Hodgkin's lymphoma and multiple myeloma patients. A subgroup analysis of the European Consortium of stem cell mobilization.
Bone marrow transplantation 20120801
-
Plerixafor in AL amyloidosis: improved graft composition and faster lymphocyte recovery after auto-SCT in patient with end-stage renal-disease.
Bone marrow transplantation 20120801
-
Systematic review of randomized controlled trials of hematopoietic stem cell mobilization strategies for autologous transplantation for hematologic malignancies.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20120801
-
Blood graft lymphocyte subsets after plerixafor injection in non-Hodgkin's lymphoma patients mobilizing poorly with chemotherapy plus granulocyte-colony-stimulating factor.
Transfusion 20120801
-
Progenitor cell mobilizing treatments prevent experimental transplant arteriosclerosis.
The Journal of surgical research 20120801
-
Who should be really considered as a poor mobilizer in the plerixafor era?
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 20120801
-
Blood graft composition after plerixafor injection in patients with NHL.
European journal of haematology 20120801
-
Plerixafor use in patients with previous mobilization failure: A multicenter experience.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 20120801
-
CXCR4 inhibition with AMD3100 sensitizes prostate cancer to docetaxel chemotherapy.
Neoplasia (New York, N.Y.) 20120801
-
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 20120726
-
Higher BMI is not a barrier to stem cell mobilization with standard doses of plerixafor and G-CSF.
Bone marrow transplantation 20120701
-
High white blood cell concentration in the peripheral blood stem cell product can induce seizures during infusion of autologous peripheral blood stem cells.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20120701
-
Kinetics of blood CD34(+) cells after chemotherapy plus G-CSF in poor mobilizers: implications for pre-emptive plerixafor use.
Annals of hematology 20120701
-
Retrospective comparison of filgrastim plus plerixafor to other regimens for remobilization after primary mobilization failure: clinical and economic outcomes.
American journal of hematology 20120701
-
Plerixafor as first- and second-line strategies for autologous stem cell mobilization in patients with non-Hodgkin's lymphoma or multiple myeloma.
Pharmacotherapy 20120701
-
CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling.
British journal of cancer 20120626
-
Pharmacophore-based small molecule CXCR4 ligands.
Bioorganic & medicinal chemistry letters 20120615
-
Exposure to ambient air fine particulate matter prevents VEGF-induced mobilization of endothelial progenitor cells from the bone marrow.
Environmental health perspectives 20120601
-
Pre-emptive plerixafor injection increases blood neutrophil, lymphocyte and monocyte counts in addition to CD34+ counts in patients with non-Hodgkin lymphoma mobilizing poorly with chemotherapy plus G-CSF: potential implications for apheresis and graft composition.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 20120601
-
Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib.
Leukemia 20120501
-
α-Tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation-induced gastrointestinal injury in mice.
Experimental hematology 20120501
-
Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists.
European journal of medicinal chemistry 20120501
-
A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia.
Blood 20120426
-
A risk-based approach to optimize autologous hematopoietic stem cell (HSC) collection with the use of plerixafor.
Bone marrow transplantation 20120401
-
Preemptive use of plerixafor in difficult-to-mobilize patients: an emerging concept.
Transfusion 20120401
-
AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments.
Haematologica 20120401
-
Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells.
Haematologica 20120401
-
The use of plerixafor in hematopoietic progenitor cell collection in pediatric patients: a single center experience.
Cytotherapy 20120401
-
Expression of chemokine CXCL12 and its receptor CXCR4 in folliculostellate (FS) cells of the rat anterior pituitary gland: the CXCL12/CXCR4 axis induces interconnection of FS cells.
Endocrinology 20120401
-
[Anti-angiogenesis effect of AMD3100 in oxygen-induced retinopathy mice].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20120401
-
S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release.
Blood 20120315
-
Plerixafor plus granulocyte-colony stimulating factor for autologous hematopoietic stem cell mobilization in patients with metastatic neuroblastoma.
Pediatric blood & cancer 20120301
-
Priming of hematopoietic progenitor cells by plerixafor and filgrastim in children with previous failure of mobilization with chemotherapy and/or cytokine treatment.
Journal of pediatric hematology/oncology 20120301
-
Discovery of novel stem cell mobilizers that target the CXCR4 receptor.
ChemMedChem 20120206
-
Plerixafor added to chemotherapy plus G-CSF is safe and allows adequate PBSC collection in predicted poor mobilizer patients with multiple myeloma or lymphoma.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20120201
-
Plerixafor and Filgrastim XM02 (Tevagastrim) as a first line peripheral blood stem cell mobilisation strategy in patients with multiple myeloma and lymphoma candidated to autologous bone marrow transplantation.
European journal of haematology 20120201
-
Plerixafor for autologous peripheral blood stem cell mobilization in patients previously treated with fludarabine or lenalidomide.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20120201
-
Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice.
Blood 20120119
-
PBSCs Sphingoling along S1P/S1P1 axis.
Blood 20120119
-
Plerixafor for PBSC mobilisation in myeloma patients with advanced renal failure: safety and efficacy data in a series of 21 patients from Europe and the USA.
Bone marrow transplantation 20120101
-
Efficacy and cost-benefit analysis of risk-adaptive use of plerixafor for autologous hematopoietic progenitor cell mobilization.
Transfusion 20120101
-
Enhancement of the anti-tumor activity of therapeutic monoclonal antibodies by CXCR4 antagonists.
Leukemia & lymphoma 20120101
-
Hematopoietic stem cell mobilization for gene therapy of adult patients with severe β-thalassemia: results of clinical trials using G-CSF or plerixafor in splenectomized and nonsplenectomized subjects.
Molecular therapy : the journal of the American Society of Gene Therapy 20120101
-
In vivo imaging of ligand receptor binding with Gaussia luciferase complementation.
Nature medicine 20120101
-
Optimizing stem cell collection through CXCR4 antagonists.
Frontiers in bioscience (Scholar edition) 20120101
-
The effective use of plerixafor as a real-time rescue strategy for patients poorly mobilizing autologous CD34(+) cells.
Journal of clinical apheresis 20120101
-
CXCR4 expression in prostate cancer progenitor cells.
PloS one 20120101
-
Economic evaluation of plerixafor for stem cell mobilization.
The American journal of managed care 20120101
-
Successful mobilization using a combination of plerixafor and G-CSF in pediatric patients who failed previous chemomobilization with G-CSF alone and possible complications of the treatment.
Journal of hematology & oncology 20120101
-
Efficacy and adverse effects of the antiviral compound plerixafor in feline immunodeficiency virus-infected cats.
Journal of veterinary internal medicine 20120101
-
Initial assessment of the role of CXC chemokine receptor 4 after polytrauma.
Molecular medicine (Cambridge, Mass.) 20120101
-
Hematopoietic stem cell mobilization: a clinical protocol.
Methods in molecular biology (Clifton, N.J.) 20120101
-
[Hematopoietic stem cells mobilization: state of the art in 2011 and perspectives].
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine 20111201
-
Evaluation of a fluorescent derivative of AMD3100 and its interaction with the CXCR4 chemokine receptor.
Chembiochem : a European journal of chemical biology 20111125
-
The CXCR4 antagonist plerixafor is a potential therapy for myelokathexis, WHIM syndrome.
Blood 20111103
-
The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome.
Blood 20111103
-
AMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome.
Journal of cellular and molecular medicine 20111001
-
Effectiveness and cost analysis of 'just-in-time' salvage plerixafor administration in autologous transplant patients with poor stem cell mobilization kinetics.
Transfusion 20111001
-
The effect of gp120 on morphine's antinociceptive and neurophysiological actions.
Brain, behavior, and immunity 20111001
-
Plerixafor to rescue failing chemotherapy-based stem cell mobilization: it's not too late.
Leukemia & lymphoma 20110901
-
Novel strategies for blood stem cell mobilization: special focus on plerixafor.
Expert opinion on biological therapy 20110901
-
Plerixafor: a review of its use in stem-cell mobilization in patients with lymphoma or multiple myeloma.
Drugs 20110820
-
Astrocytes and pericytes cooperatively maintain a capillary-like structure composed of endothelial cells on gel matrix.
Brain research 20110811
-
Plerixafor with and without chemotherapy in poor mobilizers: results from the German compassionate use program.
Bone marrow transplantation 20110801
-
Successful mobilization with plerixafor and autologous hematopoietic SCT in a patient with refractory Hodgkin's lymphoma and Gaucher disease.
Bone marrow transplantation 20110801
-
Plerixafor is effective and safe for stem cell mobilization in heavily pretreated germ cell tumor patients.
Bone marrow transplantation 20110801
-
Transplanted CD34(+) cell dose is associated with long-term platelet count recovery following autologous peripheral blood stem cell transplant in patients with non-Hodgkin lymphoma or multiple myeloma.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20110801
-
Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist.
Leukemia 20110801
-
Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells.
Leukemia 20110801
-
[New molecular targets and new clinical practices for hematopoietic stem cell mobilization].
Bulletin du cancer 20110801
-
[Development of novel agents for multiple myeloma; now and the future].
[Rinsho ketsueki] The Japanese journal of clinical hematology 20110801
-
Plerixafor 'just in time' for stem cell mobilization in a normal donor.
Bone marrow transplantation 20110701
-
Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice.
Arteriosclerosis, thrombosis, and vascular biology 20110701
-
Accelerated lymphocyte reconstitution and long-term recovery after transplantation of lentiviral-transduced rhesus CD34+ cells mobilized by G-CSF and plerixafor.
Experimental hematology 20110701
-
In and out of the niche: perspectives in mobilization of hematopoietic stem cells.
Experimental hematology 20110701
-
Identification of prognostic factors for plerixafor-based hematopoietic stem cell mobilization.
American journal of hematology 20110701
-
Plerixafor and G-CSF for PBSC mobilization in patients with lymphoma who failed previous attempts with G-CSF and chemotherapy: a REL (Rete Ematologica Lombarda) experience.
Leukemia research 20110601
-
Haematopoietic stem cell mobilization with plerixafor and G-CSF in patients with multiple myeloma transplanted with autologous stem cells.
European journal of haematology 20110601
-
Clinical and genetic features of Warts, Hypogammaglobulinemia, Infections and Myelokathexis (WHIM) syndrome.
Current molecular medicine 20110601
-
Late afternoon dosing of plerixafor for stem cell mobilization: a practical solution.
Clinical lymphoma, myeloma & leukemia 20110601
-
[Some research progress of CXCR4 antagonist AMD3100].
Zhongguo shi yan xue ye xue za zhi 20110601
-
Successful mobilization of PBSCs in a healthy volunteer donor by addition of plerixafor after failure of mobilization with G-CSF alone.
Bone marrow transplantation 20110501
-
Cost and clinical analysis of autologous hematopoietic stem cell mobilization with G-CSF and plerixafor compared to G-CSF and cyclophosphamide.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20110501
-
Plerixafor and granulocyte-colony-stimulating factor (G-CSF) in patients with lymphoma and multiple myeloma previously failing mobilization with G-CSF with or without chemotherapy for autologous hematopoietic stem cell mobilization: the Austrian experience on a named patient program.
Transfusion 20110501
-
Hematopoietic stem cell mobilization with the reversible CXCR4 receptor inhibitor plerixafor (AMD3100)-Polish compassionate use experience.
Annals of hematology 20110501
-
Importance of blood graft characteristics in auto-SCT: implications for optimizing mobilization regimens.
Bone marrow transplantation 20110501
-
Tanshinone IIA increases recruitment of bone marrow mesenchymal stem cells to infarct region via up-regulating stromal cell-derived factor-1/CXC chemokine receptor 4 axis in a myocardial ischemia model.
Phytomedicine : international journal of phytotherapy and phytopharmacology 20110415
-
CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Clinical cancer research : an official journal of the American Association for Cancer Research 20110415
-
Growth factor and patient-adapted use of plerixafor is superior to CY and growth factor for autologous hematopoietic stem cells mobilization.
Bone marrow transplantation 20110401
-
Characterization of hematopoietic stem cell subsets from patients with multiple myeloma after mobilization with plerixafor.
Cytotherapy 20110401
-
Efficacy of pre-emptively used plerixafor in patients mobilizing poorly after chemomobilization: a single centre experience.
European journal of haematology 20110401
-
A pilot study evaluating the safety and CD34+ cell mobilizing activity of escalating doses of plerixafor in healthy volunteers.
British journal of haematology 20110401
-
Potential of CXCR4 antagonists for the treatment of metastatic lung cancer.
Expert review of anticancer therapy 20110401
-
Plerixafor (Mozobil) for stem cell mobilization in patients with multiple myeloma previously treated with lenalidomide.
Bone marrow transplantation 20110301
-
The addition of plerixafor is safe and allows adequate PBSC collection in multiple myeloma and lymphoma patients poor mobilizers after chemotherapy and G-CSF.
Bone marrow transplantation 20110301
-
CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth.
Experimental hematology 20110301
-
The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma.
The Journal of pathology 20110301
-
Addition of plerixafor to a chemotherapy plus G-CSF mobilization in hard-to-mobilize patients.
Bone marrow transplantation 20110201
-
Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases.
European journal of cancer (Oxford, England : 1990) 20110201
-
Importance of receptor flexibility in binding of cyclam compounds to the chemokine receptor CXCR4.
Journal of chemical information and modeling 20110124
-
Plerixafor plus granulocyte CSF can mobilize hematopoietic stem cells from multiple myeloma and lymphoma patients failing previous mobilization attempts: EU compassionate use data.
Bone marrow transplantation 20110101
-
Development and validation of a decision-making algorithm to guide the use of plerixafor for autologous hematopoietic stem cell mobilization.
Bone marrow transplantation 20110101
-
The feasibility of plerixafor as a second-line stem cell mobilizing agent in children.
Journal of pediatric hematology/oncology 20110101
-
Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1.
Journal of immunology (Baltimore, Md. : 1950) 20110101
-
The role of plerixafor in optimizing peripheral blood stem cell mobilization for autologous stem cell transplantation.
Leukemia 20110101
-
Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats.
Respiratory research 20110101
-
Plerixafor in poor stem cell mobilizers: the Belgian Compassionate Use Program.
Acta clinica Belgica 20110101
-
Stem cells in acute liver failure.
Advances in surgery 20110101
-
Successful mobilization of peripheral blood stem cells in children with cancer using plerixafor (Mozobil) and granulocyte-colony stimulating factor.
Drug design, development and therapy 20110101
-
Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis.
PloS one 20110101
-
CXCR4 antagonist AMD3100 modulates claudin expression and intestinal barrier function in experimental colitis.
PloS one 20110101
-
Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity.
Journal of medicinal chemistry 20101223
-
CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche.
Cancer research 20101215
-
Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists.
Blood 20101209
-
The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains.
The Journal of biological chemistry 20101203
-
Mobilization strategies in hard-to-mobilize patients with lymphoid malignancies.
European journal of haematology 20101201
-
Recent advances on the use of the CXCR4 antagonist plerixafor (AMD3100, Mozobilâ„¢) and potential of other CXCR4 antagonists as stem cell mobilizers.
Pharmacology & therapeutics 20101201
-
Plerixafor dosing and administration in a patient with dialysis-dependent renal failure.
The Annals of pharmacotherapy 20101201
-
Can every patient be mobilized?
Best practice & research. Clinical haematology 20101201
-
CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy.
British journal of cancer 20101101
-
Chronic AMD3100 antagonism of SDF-1alpha-CXCR4 exacerbates cardiac dysfunction and remodeling after myocardial infarction.
Journal of molecular and cellular cardiology 20101001
-
Phosphodiesterase-5 inhibitor tadalafil acts on endothelial progenitor cells by CXCR4 signalling.
Current drug delivery 20101001
-
Stem cell mobilization is life saving in an animal model of acute liver failure.
Annals of surgery 20101001
-
Profound blockage of CXCR4 signaling at multiple points using the synergy between plerixafor, mirtazapine, and clotrimazole as a new glioblastoma treatment adjunct.
Turkish neurosurgery 20101001
-
Novel monocyclam derivatives as HIV entry inhibitors: Design, synthesis, anti-HIV evaluation, and their interaction with the CXCR4 co-receptor.
ChemMedChem 20100802
-
Plerixafor and pegylated filgrastim: a case of safe and effective hematopoietic stem cell mobilization.
Bone marrow transplantation 20100801
-
Decreased circulating progenitor cell number and failed mechanisms of stromal cell-derived factor-1alpha mediated bone marrow mobilization impair diabetic tissue repair.
Diabetes 20100801
-
Repeated phlebotomy augments angiogenesis to improve blood flow in murine ischemic legs.
American journal of physiology. Heart and circulatory physiology 20100801
-
Plerixafor. Only for certain patients when G-CSF stem cell mobilisation fails.
Prescrire international 20100801
-
Evaluation of CXCR4 inhibition in the prevention and intervention model of laser-induced choroidal neovascularization.
Investigative ophthalmology & visual science 20100701
-
Update on clinical experience with AMD3100, an SDF-1/CXCL12-CXCR4 inhibitor, in mobilization of hematopoietic stem and progenitor cells.
Current opinion in hematology 20100701
-
Plerixafor given before the third leukapheresis to rescue an unsuccessful stem cell mobilization with CY and G-CSF.
Bone marrow transplantation 20100601
-
Safe and effective use of plerixafor plus G-CSF in dialysis-dependent renal failure.
American journal of hematology 20100601
-
CXCR4, a potential predictive marker for docetaxel sensitivity in gastric cancer.
Anticancer research 20100601
-
HIV-1 tropism.
Protein & cell 20100601
-
Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography.
Cancer research 20100515
-
Plerixafor (Mozobil) alone to mobilize hematopoietic stem cells from multiple myeloma patients for autologous transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20100501
-
Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex.
Leukemia 20100501
-
Plerixafor: a peripheral blood stem cell mobilizer.
Pharmacotherapy 20100501
-
Plerixafor: A chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation after high-dose chemotherapy for non-Hodgkin's lymphoma or multiple myeloma.
Clinical therapeutics 20100501
-
Plerixafor (Mozobil).
The Medical letter on drugs and therapeutics 20100405
-
Molecular Medicine - CHI's 17th International Tri-Conference: Mastering Medicinal Chemistry - CHI's Seventh Annual Conference.
IDrugs : the investigational drugs journal 20100401
-
Expression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis.
American journal of physiology. Renal physiology 20100301
-
Mobilization of peripheral blood stem cells for autologous transplant in non-Hodgkin's lymphoma and multiple myeloma patients by plerixafor and G-CSF and detection of tumor cell mobilization by PCR in multiple myeloma patients.
Bone marrow transplantation 20100201
-
SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus.
Neuropharmacology 20100201
-
Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists.
Inorganic chemistry 20100201
-
New Drugs2010, PART 1.
Nursing 20100201
-
Safety and preliminary efficacy of plerixafor (Mozobil) in combination with chemotherapy and G-CSF: an open-label, multicenter, exploratory trial in patients with multiple myeloma and non-Hodgkin's lymphoma undergoing stem cell mobilization.
Bone marrow transplantation 20100101
-
A pharmacokinetic study of plerixafor in subjects with varying degrees of renal impairment.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20100101
-
Plerixafor for stem cell mobilization in patients with non-Hodgkin's lymphoma and multiple myeloma.
The Annals of pharmacotherapy 20100101
-
Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.
International journal of radiation biology 20100101
-
CXCR4 in clinical hematology.
Current topics in microbiology and immunology 20100101
-
Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4.
BMC cancer 20100101
-
FDA review summary: Mozobil in combination with granulocyte colony-stimulating factor to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation.
Oncology 20100101
-
Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model.
PloS one 20100101
-
Plerixafor mobilization leads to a lower ratio of CD34+ cells to total nucleated cells which results in greater storage costs.
Journal of clinical apheresis 20100101
-
Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk.
Molecular cancer 20100101
-
Plerixafor enables successful hematopoietic stem cell collection in an extensively pretreated patient with testicular cancer.
Acta haematologica 20100101
-
Successful stem-cell mobilization and transplantation using plerixafor in a patient with a germ cell tumor.
Hematology/oncology and stem cell therapy 20100101
-
Booster of plerixafor can be successfully used in addition to chemotherapy-based regimen to rescue stem cell mobilization failure.
Annals of transplantation 20100101
-
Glycosaminoglycans and syndecan-4 are involved in SDF-1/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells.
Biochimica et biophysica acta 20091201
-
Successful stem cell remobilization using plerixafor (mozobil) plus granulocyte colony-stimulating factor in patients with non-hodgkin lymphoma: results from the plerixafor NHL phase 3 study rescue protocol.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20091201
-
Mobilization of hematopoietic stem cells into the peripheral blood.
Expert review of hematology 20091201
-
[Stem cell harvesting after plerixafor treatment].
Ugeskrift for laeger 20091116
-
[Mobilisation of haematopoietic stem cells with plerixafor--secondary publication].
Ugeskrift for laeger 20091102
-
International myeloma working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for multiple myeloma and the role of plerixafor (AMD 3100).
Leukemia 20091001
-
Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib.
Leukemia & lymphoma 20091001
-
Phase III prospective randomized double-blind placebo-controlled trial of plerixafor plus granulocyte colony-stimulating factor compared with placebo plus granulocyte colony-stimulating factor for autologous stem-cell mobilization and transplantation for patients with non-Hodgkin's lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091001
-
Inhibition of stromal cell-derived factor-1/CXCR4 axis for the cure of BCR-ABL positive chronic myeloid leukemia.
Leukemia & lymphoma 20091001
-
Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression signatures.
Blood 20090917
-
Extracellular calcium increases CXCR4 expression on bone marrow-derived cells and enhances pro-angiogenesis therapy.
Journal of cellular and molecular medicine 20090901
-
Advances in mobilization for the optimization of autologous stem cell transplantation.
Leukemia & lymphoma 20090901
-
Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures.
Neuroscience 20090818
-
BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells.
Blood 20090813
-
Bis-14-membered ring diketal diamines: synthesis and evaluation of their anti-HIV and anti-tumoral activities.
European journal of medicinal chemistry 20090801
-
Plerixafor hydrochloride: a novel agent for the mobilization of peripheral blood stem cells.
Drugs of today (Barcelona, Spain : 1998) 20090701
-
Modulation of cocaine-induced activity by intracerebral administration of CXCL12.
Neuroscience 20090616
-
Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.
Blood 20090611
-
Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma.
Blood 20090604
-
Rescue from failed growth factor and/or chemotherapy HSC mobilization with G-CSF and plerixafor (AMD3100): an institutional experience.
Bone marrow transplantation 20090601
-
Impairment of filgrastim-induced stem cell mobilization after prior lenalidomide in patients with multiple myeloma.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20090601
-
New macrocyclic amines showing activity as HIV entry inhibitors against wild type and multi-drug resistant viruses.
Molecules (Basel, Switzerland) 20090522
-
Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting.
Blood 20090507
-
AMD3100 is a CXCR7 ligand with allosteric agonist properties.
Molecular pharmacology 20090501
-
CXCR4 mediates the homing of B cell progenitor acute lymphoblastic leukaemia cells to the bone marrow via activation of p38MAPK.
British journal of haematology 20090501
-
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.
Blood 20090430
-
Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090225
-
Treatment with plerixafor in non-Hodgkin's lymphoma and multiple myeloma patients to increase the number of peripheral blood stem cells when given a mobilizing regimen of G-CSF: implications for the heavily pretreated patient.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20090201
-
Plerixafor.
Nature reviews. Drug discovery 20090201
-
Plerixafor approved for autologous hematopoietic stem-cell transplantation.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090115
-
Differential mobilization of subsets of progenitor cells from the bone marrow.
Cell stem cell 20090109
-
Pharmacokinetics and pharmacodynamics of plerixafor in patients with non-Hodgkin lymphoma and multiple myeloma.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20090101
-
Plerixafor: in patients with non-Hodgkin's lymphoma or multiple myeloma.
Drugs 20090101
-
Recent patents regarding the discovery of small molecule CXCR4 antagonists.
Expert opinion on therapeutic patents 20090101
-
CXCR4 and mobilization of hematopoietic precursors.
Methods in enzymology 20090101
-
A combination of granulocyte-colony-stimulating factor (G-CSF) and plerixafor mobilizes more primitive peripheral blood progenitor cells than G-CSF alone: results of a European phase II study.
Cytotherapy 20090101
-
Targeted antagonism of CXCR4 mobilizes progenitor cells under investigation for cardiovascular disease.
Cytotherapy 20090101
-
Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1.
BMC developmental biology 20090101
-
Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule CXC chemokine receptor 4 inhibitors.
Molecular pharmacology 20081201
-
The discovery of antiviral agents: ten different compounds, ten different stories.
Medicinal research reviews 20081101
-
Plerixafor, a CXCR4 antagonist for the mobilization of hematopoietic stem cells.
Expert opinion on biological therapy 20081101
-
A novel CXCR4 antagonist for hematopoietic stem cell mobilization.
Expert opinion on investigational drugs 20081101
-
A phase II study of plerixafor (AMD3100) plus G-CSF for autologous hematopoietic progenitor cell mobilization in patients with Hodgkin lymphoma.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20081101
-
Discovery of novel non-cyclam polynitrogenated CXCR4 coreceptor inhibitors.
ChemMedChem 20081001
-
Impact of mobilization and remobilization strategies on achieving sufficient stem cell yields for autologous transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20080901
-
Curcumin modulates SDF-1alpha/CXCR4-induced migration of human retinal endothelial cells (HRECs).
Investigative ophthalmology & visual science 20080801
-
SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia.
Blood 20080701
-
Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs.
Antimicrobial agents and chemotherapy 20080601
-
NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activity.
Biochimica et biophysica acta 20080601
-
Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20080423
-
Anti-HIV activity and resistance profile of the CXC chemokine receptor 4 antagonist POL3026.
Molecular pharmacology 20080401
-
Stromal cell-derived factor-1 promotes bone marrow-derived cells differentiation to cardiomyocyte phenotypes in vitro.
Cell proliferation 20080401
-
HIV-1 escape to CCR5 coreceptor antagonism through selection of CXCR4-using variants in vitro.
AIDS (London, England) 20080102
-
Distinct efficacy of HIV-1 entry inhibitors to prevent cell-to-cell transfer of R5 and X4 viruses across a human placental trophoblast barrier in a reconstitution model in vitro.
Retrovirology 20080101
-
Differentiation of two types of mobilized peripheral blood stem cells by microRNA and cDNA expression analysis.
Journal of translational medicine 20080101
-
Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development.
BMC immunology 20080101
-
Effects of AMD3100 on transmigration and survival of acute myelogenous leukemia cells.
Leukemia research 20071101
-
Mobilization of peripheral blood stem cells.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 20071001
-
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor.
The Journal of biological chemistry 20070914
-
Stromal cell-derived factor-1 induces matrix metalloprotease-13 expression in human chondrocytes.
Molecular pharmacology 20070901
-
Migration of endothelial progenitor cells mediated by stromal cell-derived factor-1alpha/CXCR4 via PI3K/Akt/eNOS signal transduction pathway.
Journal of cardiovascular pharmacology 20070901
-
HIV entry inhibitors.
Lancet (London, England) 20070707
-
CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy.
Brain, behavior, and immunity 20070701
-
Modification of post-myocardial infarction granulocyte-colony stimulating factor therapy with myelo-suppressives.
Circulation journal : official journal of the Japanese Circulation Society 20070401
-
Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion.
World journal of gastroenterology 20070314
-
Plerixafor: AMD 3100, AMD3100, JM 3100, SDZ SID 791.
Drugs in R&D 20070101
-
Mobilization of bone marrow-derived progenitors.
Handbook of experimental pharmacology 20070101
-
Small molecule CXCR4 chemokine receptor antagonists: developing drug candidates.
Current medicinal chemistry 20070101
-
CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 20061115
-
Configurationally restricted bismacrocyclic CXCR4 receptor antagonists.
Journal of medicinal chemistry 20061019
-
Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling.
Nature neuroscience 20061001
-
HIV co-receptor inhibitors as novel class of anti-HIV drugs.
Antiviral research 20060901
-
Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4.
Biochemical pharmacology 20060828
-
Axonal transport of human immunodeficiency virus type 1 envelope protein glycoprotein 120 is found in association with neuronal apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20060621
-
AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates.
Blood 20060501
-
Stromal cell-derived factor-1alpha modulation of the excitability of rat substantia nigra dopaminergic neurones: presynaptic mechanisms.
Journal of neurochemistry 20060301
-
The temperature arrested intermediate of virus-cell fusion is a functional step in HIV infection.
Virology journal 20060101
-
The development of an europium-GTP assay to quantitate chemokine antagonist interactions for CXCR4 and CCR5.
Assay and drug development technologies 20051201
-
A CXCR4-dependent chemorepellent signal contributes to the emigration of mature single-positive CD4 cells from the fetal thymus.
Journal of immunology (Baltimore, Md. : 1950) 20051015
-
Regulation of neuronal P53 activity by CXCR 4.
Molecular and cellular neurosciences 20050901
-
Potential clinical applications of the CXCR4 antagonist bicyclam AMD3100.
Mini reviews in medicinal chemistry 20050901
-
Stromal cell-derived factor-1alpha directly modulates voltage-dependent currents of the action potential in mammalian neuronal cells.
Journal of neurochemistry 20050501
-
The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050420
-
Innovative strategies for PBPC mobilization.
Cytotherapy 20050101
-
Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis.
Arthritis research & therapy 20050101
-
Profile of resistance of human immunodeficiency virus to mannose-specific plant lectins.
Journal of virology 20041001
-
Cyclam complexes and their applications in medicine.
Chemical Society reviews 20040510
-
Mechanism of feline immunodeficiency virus envelope glycoprotein-mediated fusion.
Virology 20040410
-
Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor.
The Journal of biological chemistry 20040123
-
New bicyclam-GalCer analogue conjugates: synthesis and in vitro anti-HIV activity.
Bioorganic & medicinal chemistry letters 20040119
-
The chemokine receptor CXCR4 and not the N-methyl-D-aspartate receptor mediates gp120 neurotoxicity in cerebellar granule cells.
Journal of neuroscience research 20040101
-
AMD3100 conjugates as components of targeted nonviral gene delivery systems: synthesis and in vitro transfection efficiency of CXCR4-expressing cells.
Bioconjugate chemistry 20040101
-
Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists.
Retrovirology 20040101
-
Resistance to HIV-1 entry inhibitors.
Current drug targets. Infectious disorders 20031201
-
Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists.
The Journal of biological chemistry 20031121
-
Direct synthesis of 1,1'-[1,4-phenylenebis(methylene)]-bis- 1,4,8,11-tetraazacyclotetradecane octahydrochloride (AMD 3100) without the use of protecting groups.
The Journal of organic chemistry 20030808
-
Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry.
FEBS letters 20030710
-
Brain-derived neurotrophic factor inhibits human immunodeficiency virus-1/gp120-mediated cerebellar granule cell death by preventing gp120 internalization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030702
-
The CCR5 and CXCR4 coreceptors are both used by human immunodeficiency virus type 1 primary isolates from subtype C.
Journal of virology 20030401
-
Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof.
Journal of virological methods 20030301
-
Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor.
Biochemistry 20030128
-
Evaluation of SDF-1/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20030101
-
Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer.
Cancer research 20021015
-
Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.
FEBS letters 20020911
-
Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor.
Journal of the American Chemical Society 20020807
-
A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists.
The Journal of biological chemistry 20020705
-
Non-peptidic chemokine receptors antagonists as emerging anti-HIV agents.
Journal of enzyme inhibition and medicinal chemistry 20020401
-
AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 20011015
-
Hamao Umezawa Memorial Award Lecture: 'An Odyssey in the Viral Chemotherapy Field'.
International journal of antimicrobial agents 20011001
-
Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5.
The Journal of biological chemistry 20010914
-
Pharmacological evidence for complex and multiple site interaction of CXCR4 with SDF-1alpha: implications for development of selective CXCR4 antagonists.
Immunology letters 20010801
-
Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.
Molecular pharmacology 20010701
-
HIV fusion and its inhibition.
Antiviral research 20010501
-
Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor.
The Journal of biological chemistry 20010427
-
Increase of R5 HIV-1 infection and CCR5 expression in T cells treated with high concentrations of CXCR4 antagonists and SDF-1.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20010301
-
Strong in vitro synergy between the fusion inhibitor T-20 and the CXCR4 blocker AMD-3100.
Journal of acquired immune deficiency syndromes (1999) 20001001
-
Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists.
Molecular pharmacology 20000501
-
Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection.
AIDS research and human retroviruses 20000501
-
The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis.
Antimicrobial agents and chemotherapy 20000101
-
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4.
Journal of medicinal chemistry 19990923
-
T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure.
Journal of virology 19990201
-
New bicyclam-AZT conjugates: design, synthesis, anti-HIV evaluation, and their interaction with CXCR-4 coreceptor.
Journal of medicinal chemistry 19990128
-
A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.
Biochemical and biophysical research communications 19981230
-
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.
Nature medicine 19980101
-
Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4.
The Journal of experimental medicine 19971020
-
Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4.
Antiviral research 19970801
-
The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding.
Antiviral research 19960301
-
Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1.
Antiviral research 19960301
-
The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication.
Journal of virology 19960201
-
Quantitative structural activity relationship study of bis-tetraazacyclic compounds. A novel series of HIV-1 and HIV-2 inhibitors.
Journal of medicinal chemistry 19950915
-
Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100.
Antimicrobial agents and chemotherapy 19940401