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1,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism.
Toxicology letters 20170415
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Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450.
Toxicology letters 20160906
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Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism.
Journal of applied toxicology : JAT 20160101
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Genotoxicity of 1-methylpyrene and 1-hydroxymethylpyrene in Chinese hamster V79-derived cells expressing both human CYP2E1 and SULT1A1.
Environmental and molecular mutagenesis 20150501
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Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.
Journal of applied toxicology : JAT 20140801
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Regulation of CYP3A genes by glucocorticoids in human lung cells.
F1000Research 20130101
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Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes.
Toxicology and applied pharmacology 20121101
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Bioactivation of nevirapine to a reactive quinone methide: implications for liver injury.
Chemical research in toxicology 20120820
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Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophen.
Drug metabolism and disposition: the biological fate of chemicals 20120801
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Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: results with model toxicants aflatoxin B1, cyclophosphamide and tamoxifen.
Chemico-biological interactions 20120730
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Metabolic activation and major protein target of a 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonist.
Chemical research in toxicology 20120716
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Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine.
European journal of pharmacology 20120705
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Vestibular toxicity of cis-2-pentenenitrile in the rat.
Toxicology letters 20120620
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[Metabolic detoxification of bakuchiol is mediated by cytochrome P450 enzymes in human liver microsomes].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20120618
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Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors.
Drug metabolism and disposition: the biological fate of chemicals 20120501
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Cytochrome P450 11A1 bioactivation of a kinase inhibitor in rats: use of radioprofiling, modulation of metabolism, and adrenocortical cell lines to evaluate adrenal toxicity.
Chemical research in toxicology 20120319
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Absorption, translocation and metabolism of metamitron in Chenopodium album.
Pest management science 20120201
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Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 20120201
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Determination of metabolic profile of anti-malarial trioxane CDRI 99/411 in rat liver microsomes using HPLC.
Biomedical chromatography : BMC 20120101
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Testosterone-dependent increase in blood pressure is mediated by elevated Cyp4A expression in fructose-fed rats.
Molecular and cellular biochemistry 20120101
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Cytochrome P-450-catalyzed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in H9c2 cardiomyocytes.
Indian journal of pharmacology 20120101
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The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo.
Toxicology 20111218
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Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes.
Biochemical and biophysical research communications 20111216
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Biotransformation of the organochlorine pesticide trans-chlordane by wood-rot fungi.
New biotechnology 20111215
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Degradation of the antibiotics norfloxacin and ciprofloxacin by a white-rot fungus and identification of degradation products.
Bioresource technology 20111201
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Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes.
Toxicology and applied pharmacology 20111201
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Biotransformation enzyme-dependent formation of micronucleus and multinuclei in cell line V79-hCYP2E1-hSULT1A1 by 2-nitropropane and N-nitrosodimethylamine.
Mutation research 20111127
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Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans.
American journal of veterinary research 20111101
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Cross talk between keratinocytes and dendritic cells: impact on the prediction of sensitization.
Toxicological sciences : an official journal of the Society of Toxicology 20111001
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Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices.
Chemico-biological interactions 20110905
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1-Aminobenzotriazole, a known cytochrome P450 inhibitor, is a substrate and inhibitor of N-acetyltransferase.
Drug metabolism and disposition: the biological fate of chemicals 20110901
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Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction.
Journal of biomolecular screening 20110901
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Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 20110801
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The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s.
Drug metabolism and disposition: the biological fate of chemicals 20110801
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Higher throughput human hepatocyte assays for the evaluation of time-dependent inhibition of CYP3A4.
Drug metabolism letters 20110801
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Postmenopausal hypertension: role of 20-HETE.
American journal of physiology. Regulatory, integrative and comparative physiology 20110601
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Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity.
Toxicology and applied pharmacology 20110501
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Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model.
Archives of toxicology 20110401
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Interaction of nitric oxide and the cytochrome P-450 system on blood pressure and renal function in the rat: dependence on sodium intake.
Acta physiologica (Oxford, England) 20110401
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Reductive metabolism of the dinitrobenzamide mustard anticancer prodrug PR-104 in mice.
Cancer chemotherapy and pharmacology 20110301
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Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model.
Journal of clinical biochemistry and nutrition 20110301
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Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening.
Drug metabolism and disposition: the biological fate of chemicals 20110201
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Dual effects of estrogen on vascular smooth muscle cells: receptor-mediated proliferative vs. metabolite-induced pro-senescent actions.
Steroids 20110201
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An oxygenase inhibitor study in Solanum lycopersicum combined with metabolite profiling analysis revealed a potent peroxygenase inactivator.
Journal of experimental botany 20110101
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The effect of cocoa supplementation on hepatic steatosis, reactive oxygen species and LFABP in a rat model of NASH.
Comparative hepatology 20110101
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In vitro hepatic metabolism of cediranib, a potent vascular endothelial growth factor tyrosine kinase inhibitor: interspecies comparison and human enzymology.
Drug metabolism and disposition: the biological fate of chemicals 20101001
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Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution.
Current drug metabolism 20101001
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Removal of diclofenac and mefenamic acid by the white rot fungus Phanerochaete sordida YK-624 and identification of their metabolites after fungal transformation.
Biodegradation 20100901
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Reactive oxygen species and small-conductance calcium-dependent potassium channels are key mediators of inflammation-induced hypotension and shock.
Journal of molecular medicine (Berlin, Germany) 20100901
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Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytes.
Drug metabolism letters 20100801
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Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor.
Xenobiotica; the fate of foreign compounds in biological systems 20100601
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Derivatization of the azole 1-aminobenzotriazole using laccase of Pycnoporus cinnabarinus and Myceliophthora thermophila: influence of methanol on the reaction and biological evaluation of the derivatives.
Biotechnology and applied biochemistry 20100527
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Differential oxidative metabolism and 5-ketoclomazone accumulation are involved in Echinochloa phyllopogon resistance to clomazone.
Plant physiology 20100501
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Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR.
Journal of hazardous materials 20100415
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Biodegradation of the analgesic naproxen by Trametes versicolor and identification of intermediates using HPLC-DAD-MS and NMR.
Bioresource technology 20100401
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3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively.
Chemical research in toxicology 20100315
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Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis.
Environmental and molecular mutagenesis 20100101
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Biotransformation of beta-myrcene to geraniol by a strain of Rhodococcus erythropolis isolated by selective enrichment from hop plants.
Applied microbiology and biotechnology 20100101
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White-rot fungus-mediated degradation of the analgesic ketoprofen and identification of intermediates by HPLC-DAD-MS and NMR.
Chemosphere 20100101
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Investigation of the intestinal permeability and first-pass metabolism of drugs in cynomolgus monkeys using single-pass intestinal perfusion.
Biological & pharmaceutical bulletin 20100101
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20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice.
PloS one 20100101
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Benzyne arylation of oxathiane glycosyl donors.
Beilstein journal of organic chemistry 20100101
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Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice.
Lipids in health and disease 20100101
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Capsaicinoids, chloropicrin and sulfur mustard: possibilities for exposure biomarkers.
Frontiers in pharmacology 20100101
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nature chemical biology 20091001
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Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers.
Drug metabolism and disposition: the biological fate of chemicals 20090801
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Differential action of bradykinin on intrarenal regional perfusion in the rat: waning effect in the cortex and major impact in the medulla.
The Journal of physiology 20090801
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Dechlorination of 1,2,3- and 1,2,4-trichlorobenzene by the white-rot fungus Trametes versicolor.
Journal of hazardous materials 20090730
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Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice.
Archives of toxicology 20090701
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Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1.
Chemico-biological interactions 20090415
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Allylnitrile metabolism by CYP2E1 and other CYPs leads to distinct lethal and vestibulotoxic effects in the mouse.
Toxicological sciences : an official journal of the Society of Toxicology 20090201
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Ability of white-rot fungi to remove selected pharmaceuticals and identification of degradation products of ibuprofen by Trametes versicolor.
Chemosphere 20090201
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Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?
Drug metabolism and disposition: the biological fate of chemicals 20090101
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Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes.
Autonomic & autacoid pharmacology 20090101
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Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice.
Scandinavian journal of gastroenterology 20090101
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Involvement of cytochrome P450-mediated metabolism in tienilic acid hepatotoxicity in rats.
Toxicology letters 20081215
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Nonenzymatic formation of a novel hydroxylated sulfamethoxazole derivative in human liver microsomes: implications for bioanalysis of sulfamethoxazole metabolites.
Drug metabolism and disposition: the biological fate of chemicals 20081201
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Inhibition of rat aortic smooth muscle contraction by 2-methoxyestradiol.
American journal of physiology. Heart and circulatory physiology 20081101
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Validation of the use of nonnaive surgically catheterized rats for pharmacokinetics studies.
Journal of the American Association for Laboratory Animal Science : JAALAS 20081101
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Responses to clomazone and 5-ketoclomazone by Echinochloa phyllopogon resistant to multiple herbicides in Californian rice fields.
Pest management science 20081001
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Mechanistic investigation of the noncytochrome P450-mediated metabolism of triadimefon to triadimenol in hepatic microsomes.
Chemical research in toxicology 20081001
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Role of biotransformation in 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione-induced hepatotoxicity in Fischer 344 rats.
Toxicology 20080904
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Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash.
Chemical research in toxicology 20080901
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Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes.
Mutation research 20080825
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Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.
The Journal of pharmacology and experimental therapeutics 20080801
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Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726.
Drug metabolism letters 20080801
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Estradiol and the estradiol metabolite, 2-hydroxyestradiol, activate AMP-activated protein kinase in C2C12 myotubes.
Obesity (Silver Spring, Md.) 20080601
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Role of hydrazine in isoniazid-induced hepatotoxicity in a hepatocyte inflammation model.
Toxicology and applied pharmacology 20080515
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Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 20080501
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Accelerated cytotoxic mechanism screening of hydralazine using an in vitro hepatocyte inflammatory cell peroxidase model.
Chemical research in toxicology 20080401
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The use of 1-aminobenzotriazole in differentiating the role of CYP-mediated first pass metabolism and absorption in limiting drug oral bioavailability: a case study.
Drug metabolism letters 20080401
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Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.
The AAPS journal 20080301
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1-Phenyl-4-(triphenyl-phosphanyl-idene)pyrrolidine-2,3,5-trione.
Acta crystallographica. Section E, Structure reports online 20080301
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Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats.
Xenobiotica; the fate of foreign compounds in biological systems 20080201
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Mechanistics of trichloroethylene mineralization by the white-rot fungus Trametes versicolor.
Chemosphere 20080101
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In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers.
Molecular pharmacology 20071201
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CYP3A4 and CYP3A5 catalyse the conversion of the N-methyl-D-aspartate (NMDA) antagonist CJ-036878 to two novel dimers.
Xenobiotica; the fate of foreign compounds in biological systems 20071201
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Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase.
Bioorganic & medicinal chemistry letters 20071115
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The cytochrome p450 inhibitor ketoconazole potentiates 5-hydroxytryptamine-induced contraction in rat aorta.
The Journal of pharmacology and experimental therapeutics 20071101
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Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.
Drug metabolism and disposition: the biological fate of chemicals 20071101
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Degradation of 2,5-dimethylpyrazine by Rhodococcus erythropolis strain DP-45 isolated from a waste gas treatment plant of a fishmeal processing company.
Biodegradation 20071001
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Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites.
Chemical research in toxicology 20071001
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The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore.
The Journal of pharmacology and experimental therapeutics 20070901
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Induction of DNA strand breaks and oxidative stress in HeLa cells by ethanol is dependent on CYP2E1 expression.
Mutagenesis 20070501
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Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling.
Journal of immunology (Baltimore, Md. : 1950) 20070501
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Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.
Hypertension (Dallas, Tex. : 1979) 20070301
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Reactivity of dehydrometallophthalocyanines and -porphyrazines.
Chemistry (Weinheim an der Bergstrasse, Germany) 20070101
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Effects of ATP on rat renal haemodynamics and excretion: role of sodium intake, nitric oxide and cytochrome P450.
Acta physiologica (Oxford, England) 20070101
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Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats.
Vascular pharmacology 20070101
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Novel aerobic perchloroethylene degradation by the white-rot fungus Trametes versicolor.
Environmental science & technology 20061215
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Comparative metabolism and disposition of trichloroethylene in Cyp2e1-/-and wild-type mice.
Drug metabolism and disposition: the biological fate of chemicals 20061201
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Hydroxyeicosatetraenoic acids released through the cytochrome P-450 pathway regulate 3T6 fibroblast growth.
Journal of lipid research 20061201
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CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].
Drug metabolism and disposition: the biological fate of chemicals 20061201
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Effects of quercetin on beta-apo-8'-carotenal-induced DNA damage and cytochrome P1A2 expression in A549 cells.
Chemico-biological interactions 20061107
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Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101
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Acrylonitrile-induced oxidative DNA damage in rat astrocytes.
Environmental and molecular mutagenesis 20061001
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Nitric oxide/cytochrome P450 interactions in cyclosporin A-induced effects in the rat.
Journal of hypertension 20060901
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Metabolism and disposition of 1-bromopropane in rats and mice following inhalation or intravenous administration.
Toxicology and applied pharmacology 20060815
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Regioselective hydroxylation of adamantane by Streptomyces griseoplanus cells.
Applied microbiology and biotechnology 20060701
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Activation of T cells by carbamazepine and carbamazepine metabolites.
The Journal of allergy and clinical immunology 20060701
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In vivo use of the P450 inactivator 1-aminobenzotriazole in the rat: varied dosing route to elucidate gut and liver contributions to first-pass and systemic clearance.
Journal of pharmaceutical sciences 20060601
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Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Growth of Phanerochaete chrysosporium on diesel fuel hydrocarbons at neutral pH.
Chemosphere 20060401
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Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone.
Toxicological sciences : an official journal of the Society of Toxicology 20060401
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Flavonoids suppresses the enhancing effect of beta-carotene on DNA damage induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A549 cells.
Chemico-biological interactions 20060325
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Inhibition by nitric oxide of cytochrome P450 4A activity contributes to endotoxin-induced hypotension in rats.
Nitric oxide : biology and chemistry 20060201
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Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus.
American journal of physiology. Renal physiology 20051201
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Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver.
Life sciences 20051021
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Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME.
Autonomic & autacoid pharmacology 20051001
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In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A.
Drug metabolism and pharmacokinetics 20051001
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Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery.
Pharmacological research 20050901
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Effect of 1-aminobenzotriazole on the in vitro metabolism and single-dose pharmacokinetics of chlorzoxazone, a selective CYP2E1 substrate in Wistar rats.
Xenobiotica; the fate of foreign compounds in biological systems 20050801
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Comparative metabolism of methacrylonitrile and acrylonitrile to cyanide using cytochrome P4502E1 and microsomal epoxide hydrolase-null mice.
Toxicology and applied pharmacology 20050601
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Extrahepatic metabolism of carbamate and organophosphate thioether compounds by the flavin-containing monooxygenase and cytochrome P450 systems.
Drug metabolism and disposition: the biological fate of chemicals 20050201
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Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver.
Hepatology (Baltimore, Md.) 20050201
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Preparation of tertiary alkyl carbinamines, propargylamines, and alpha-heteroarylamines by ketone-based aminoalkylation.
The Journal of organic chemistry 20050107
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A role for one or more p450 enzymes in the response to sepsis.
Critical care medicine 20050101
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The use of the suicide CYP450 inhibitor ABT for distinguishing absorption and metabolism processes in in-vivo pharmacokinetic screens.
European journal of drug metabolism and pharmacokinetics 20050101
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Expression and activities of several drug-metabolizing enzymes in LLC-PK1 cells.
Toxicology in vitro : an international journal published in association with BIBRA 20041201
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Subchronic acrylamide treatment induces a tissue-specific increase in DNA synthesis in the rat.
Toxicology letters 20041201
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Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial sampling.
Drug metabolism and disposition: the biological fate of chemicals 20041001
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Endothelial cytochrome P450 contributes to the acetylcholine-induced cardiodepression in isolated rat hearts.
Acta physiologica Scandinavica 20040901
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Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis.
American journal of physiology. Regulatory, integrative and comparative physiology 20040701
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The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6.
Drug metabolism and disposition: the biological fate of chemicals 20040401
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Cytochrome P-450 inhibition attenuates hypertension induced by reductions in uterine perfusion pressure in pregnant rats.
Hypertension (Dallas, Tex. : 1979) 20040301
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Cytochrome P450-catalyzed brassinosteroid pathway activation through synthesis of castasterone and brassinolide in Phaseolus vulgaris.
Phytochemistry 20040301
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Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
Chemical research in toxicology 20040301
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Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis.
Critical care medicine 20040201
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The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice.
Free radical biology & medicine 20031215
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Studies on the metabolism of the thiofurans furfuryl mercaptan and 2-methyl-3-furanthiol in rat liver.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20031201
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Inhibitors of 20-HETE formation promote salt-sensitive hypertension in rats.
Hypertension (Dallas, Tex. : 1979) 20031001
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Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in peripheral human lung microsomes.
Drug metabolism and disposition: the biological fate of chemicals 20030901
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Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats.
American journal of physiology. Renal physiology 20030801
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Effect of cytochrome P-450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female mice.
Archives of toxicology 20030801
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NO inhibits Na+-K+-2Cl- cotransport via a cytochrome P-450-dependent pathway in renal epithelial cells (MMDD1).
American journal of physiology. Renal physiology 20030601
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The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats.
Free radical biology & medicine 20030601
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CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis.
American journal of physiology. Heart and circulatory physiology 20030501
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Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes.
Drug metabolism and disposition: the biological fate of chemicals 20030501
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Cytochrome P450 2E1 (CYP2E1) is the principal enzyme responsible for urethane metabolism: comparative studies using CYP2E1-null and wild-type mice.
The Journal of pharmacology and experimental therapeutics 20030501
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Biodegradation of chloronaphthalenes and polycyclic aromatic hydrocarbons by the white-rot fungus Phlebia lindtneri.
Applied microbiology and biotechnology 20030501
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Concurrent corticosteroid and phenanthrene transformation by filamentous fungus Cunninghamella elegans.
The Journal of steroid biochemistry and molecular biology 20030501
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[Effects of acrylamide on DNA damage in human keratinocytes].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20030401
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Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
Chemical research in toxicology 20030301
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3-methylindole-induced toxicity to human bronchial epithelial cell lines.
Toxicological sciences : an official journal of the Society of Toxicology 20030201
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In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.
Drug metabolism and pharmacokinetics 20030101
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Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeys.
Drug metabolism and disposition: the biological fate of chemicals 20021001
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Oxidation of dibenzo- p-dioxin, dibenzofuran, biphenyl, and diphenyl ether by the white-rot fungus Phlebia lindtneri.
Applied microbiology and biotechnology 20021001
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Investigation of the role of lipoxygenase in bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung.
Chemical research in toxicology 20021001
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NTP Technical Report on the metabolism, toxicity and predicted carcinogenicity of diazoaminobenzene (CAS No. 136-35-6).
Toxicity report series 20020901
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Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II.
American journal of physiology. Regulatory, integrative and comparative physiology 20020701
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Mechanisms for the induction of oxidative stress in Syrian hamster embryo cells by acrylonitrile.
Toxicological sciences : an official journal of the Society of Toxicology 20020601
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Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
The Journal of biological chemistry 20020419
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Methoxyestradiols mediate estradiol-induced antimitogenesis in human aortic SMCs.
Hypertension (Dallas, Tex. : 1979) 20020401
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Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy.
American journal of physiology. Regulatory, integrative and comparative physiology 20020201
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Acrylamide-induced cellular transformation.
Toxicological sciences : an official journal of the Society of Toxicology 20020201
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Renal damage, metabolism and covalent binding following administration of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide (NDPS) to male Fischer 344 rats.
Toxicology 20020125
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Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor.
Bioorganic & medicinal chemistry letters 20011203
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Role of guanylyl cyclase and cytochrome P-450 on renal response to nitric oxide.
American journal of physiology. Renal physiology 20010901
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State-dependent block of rabbit vascular smooth muscle delayed rectifier and Kv1.5 channels by inhibitors of cytochrome P450-dependent enzymes.
The Journal of pharmacology and experimental therapeutics 20010801
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Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes).
Toxicological sciences : an official journal of the Society of Toxicology 20010601
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Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect.
American journal of physiology. Heart and circulatory physiology 20010601
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An evaluation of the mutagenicity, metabolism, and DNA adduct formation of 5-nitrobenzo[b]naphtho[2,1-d]thiophene.
Chemical research in toxicology 20010601
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Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors.
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The contribution of oxidation and deacetylation to acetaminophen nephrotoxicity in female Sprague-Dawley rats.
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Benzoic acid 2-hydroxylase, a soluble oxygenase from tobacco, catalyzes salicylic acid biosynthesis.
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Purification and properties of isoenzymes of cinnamyl-alcohol dehydrogenase from soybean-cell-suspension cultures.
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