1617-53-4 | Amentoflavone

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$20.00	$14.00
10mg	98%	in stock	$30.00	$21.00
25mg	98%	in stock	$48.00	$34.00
100mg	98%	in stock	$124.00	$87.00

Description

• Catalog Number: AA87688
• Chemical Name: Amentoflavone
• CAS Number: 1617-53-4
• Molecular Formula: C30H18O10
• Molecular Weight: 538.4579
• MDL Number: MFCD00017470
• SMILES: Oc1ccc(cc1)c1cc(=O)c2c(o1)c(c(cc2O)O)c1cc(ccc1O)c1cc(=O)c2c(o1)cc(cc2O)O
• NSC Number: 295677

Computed Properties

• Complexity: 1050
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 40
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 6
• Rotatable Bond Count: 3
• XLogP3: 5

Literature

• Amentoflavone is a potent broad-spectrum inhibitor of human UDP-glucuronosyltransferases.

  Chemico-biological interactions 20180325

• Amentoflavone protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through PI3K/Akt and ERK signaling pathways.

  Toxicology and applied pharmacology 20170315

• Modification of fatty acid, essential oil and phenolic contents of salt-treated sweet marjoram (Origanum majorana L.) according to developmental stage.

  Journal of food science 20121001

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• Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.

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• Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy.

  European journal of medicinal chemistry 20120601

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  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

• Amentoflavone stimulates mitochondrial dysfunction and induces apoptotic cell death in Candida albicans.

  Mycopathologia 20120401

• The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3.

  Phytochemistry 20120401

• Amentoflavone inhibits UVB-induced matrix metalloproteinase-1 expression through the modulation of AP-1 components in normal human fibroblasts.

  Applied biochemistry and biotechnology 20120301

• Inhibition of fatty acid synthase by amentoflavone reduces coxsackievirus B3 replication.

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  Chemistry Central journal 20120101

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• Protective effects of amentoflavone on Lamin A-dependent UVB-induced nuclear aberration in normal human fibroblasts.

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• New 3',8''-linked biflavonoids from Selaginella uncinata displaying protective effect against anoxia.

  Molecules (Basel, Switzerland) 20110725

• The biflavonoid amentoflavone inhibits neovascularization preventing the activity of proangiogenic vascular endothelial growth factors.

  The Journal of biological chemistry 20110603

• Biflavonoids are superior to monoflavonoids in inhibiting amyloid-β toxicity and fibrillogenesis via accumulation of nontoxic oligomer-like structures.

  Biochemistry 20110405

• Anti-acetylcholinesterase and antioxidant assets of the major components (salicin, amentoflavone, and chlorogenic acid) and the extracts of Viburnum opulus and Viburnum lantana and their total phenol and flavonoid contents.

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• Development of an LC-MS method for simultaneous quantitation of amentoflavone and biapigenin, the minor and major biflavones from Hypericum perforatum L., in human plasma and its application to real blood.

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• The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

  International journal of molecular sciences 20110101

• The biflavonoid amentoflavone induces apoptosis via suppressing E7 expression, cell cycle arrest at sub-G₁ phase, and mitochondria-emanated intrinsic pathways in human cervical cancer cells.

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  Neurochemistry international 20101201

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  Natural product communications 20091001

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• Brain-to-plasma distribution ratio of the biflavone amentoflavone in the mouse.

  Drug metabolism letters 20080401

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  Bioorganic & medicinal chemistry 20080115

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  Phytochemistry 20080101

• Amentoflavone inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, NM23 and cytokines in lung tissues of C57BL/6 mice.

  Immunopharmacology and immunotoxicology 20080101

• Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages.

  Journal of experimental therapeutics & oncology 20080101

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