1642300-52-4 | KPT-8602

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$48.00	$34.00
10mg	98%	in stock	$71.00	$50.00
50mg	98%	in stock	$204.00	$143.00
100mg	98%	in stock	$345.00	$241.00

Description

• Catalog Number: AE81645
• Chemical Name: KPT-8602
• CAS Number: 1642300-52-4
• Molecular Formula: C17H10F6N6O
• Molecular Weight: 428.2913
• MDL Number: MFCD30489739
• SMILES: NC(=O)/C(=C/n1cnc(n1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)/c1cncnc1

Computed Properties

• Complexity: 626
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 11
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 2.5

Literature

• The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20170515

• KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells.

  Leukemia 20170101

• Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.

  Leukemia 20161201