165450-17-9 | Neotame

Packsize	Purity	Availability	Price	Discounted Price
5g	99%	in stock	$10.00	$7.00
10g	99%	in stock	$13.00	$9.00
25g	99%	in stock	$19.00	$13.00
100g	99%	in stock	$56.00	$39.00
500g	99%	in stock	$235.00	$164.00

Description

• Catalog Number: AA88131
• Chemical Name: Neotame
• CAS Number: 165450-17-9
• Molecular Formula: C20H30N2O5
• Molecular Weight: 378.4626
• MDL Number: MFCD09039056
• SMILES: COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NCCC(C)(C)C

Computed Properties

• Complexity: 495
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 12
• XLogP3: -0.1

Literature

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  Journal of chromatography. A 20121109

• Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.

  Biochemical and biophysical research communications 20121019

• Artificial sweeteners--a recently recognized class of emerging environmental contaminants: a review.

  Analytical and bioanalytical chemistry 20120701

• Position of the Academy of Nutrition and Dietetics: use of nutritive and nonnutritive sweeteners.

  Journal of the Academy of Nutrition and Dietetics 20120501

• Nonnutritive, low caloric substitutes for food sugars: clinical implications for addressing the incidence of dental caries and overweight/obesity.

  International journal of dentistry 20120101

• Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds.

  PloS one 20120101

• Taste quality and intensity of 100 stimuli as reported by rats: the taste-location association task.

  Frontiers in behavioral neuroscience 20120101

• The content of high-intensity sweeteners in different categories of foods available on the Polish market.

  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120101

• Analysis of nine food additives in red wine by ion-suppression reversed-phase high-performance liquid chromatography using trifluoroacetic acid and ammonium acetate as ion-suppressors.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20120101

• Stimulation of the extracellular Ca²⁺-sensing receptor by denatonium.

  Biochemical and biophysical research communications 20111216

• Advantame--an overview of the toxicity data.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101

• Pharmacokinetics and metabolism of N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-α-aspartyl]-L-phenylalanine 1-methyl ester, monohydrate (advantame) in the rat, dog, and man.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101

• [Influences of ion-suppressors on retention behaviors of nine food additives in reversed-phase high performance liquid chromatographic separation].

  Se pu = Chinese journal of chromatography 20111001

• Molecular mechanism of species-dependent sweet taste toward artificial sweeteners.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110727

• Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection.

  Analytical and bioanalytical chemistry 20110601

• Nonnutritive sweeteners, fructose, and other aspects of diet.

  Diabetes care 20110501

• Sugar substitutes: Health controversy over perceived benefits.

  Journal of pharmacology & pharmacotherapeutics 20110101

• [Simultaneous determination of six synthetic sweeteners in food by high performance liquid chromatography-tandem mass spectrometry].

  Se pu = Chinese journal of chromatography 20101101

• Retention behaviour of some high-intensity sweeteners on different SPE sorbents.

  Talanta 20101015

• Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16.

  The Journal of biological chemistry 20100903

• Determination of neotame in beverages, cakes and preserved fruits by column-switching high-performance liquid chromatography.

  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20100901

• [Determination of five synthetic sweeteners in wines using high performance liquid chromatography-tandem mass spectrometry].

  Se pu = Chinese journal of chromatography 20100801

• Gain weight by 'going diet?' Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010.

  The Yale journal of biology and medicine 20100601

• Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor.

  Journal of molecular biology 20100514

• Positive allosteric modulators of the human sweet taste receptor enhance sweet taste.

  Proceedings of the National Academy of Sciences of the United States of America 20100309

• Standards of medical care in diabetes--2010.

  Diabetes care 20100101

• Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT).

  Analytical and bioanalytical chemistry 20090701

• Simultaneous determination of nonnutritive sweeteners in foods by HPLC/ESI-MS.

  Journal of agricultural and food chemistry 20090422

• Standards of medical care in diabetes--2009.

  Diabetes care 20090101

• Analyses of sweet receptor gene (Tas1r2) and preference for sweet stimuli in species of Carnivora.

  The Journal of heredity 20090101

• Determination of nine intense sweeteners in foodstuffs by high-performance liquid chromatography and evaporative light-scattering detection: interlaboratory study.

  Journal of AOAC International 20090101

• [Simultaneous determination of artificial sweeteners in beverage by ultra performance liquid chromatography].

  Se pu = Chinese journal of chromatography 20090101

• Development of rebiana, a natural, non-caloric sweetener.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701

• The potential toxicity of artificial sweeteners.

  AAOHN journal : official journal of the American Association of Occupational Health Nurses 20080601

• [Simultaneous determination of neotame, alitame and aspartame in foods by HPLC].

  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20080201

• Simultaneous determination of nine intense sweeteners in foodstuffs by high performance liquid chromatography and evaporative light scattering detection--development and single-laboratory validation.

  Journal of chromatography. A 20070720

• The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.

  BMC structural biology 20070101

• Taste responses to sweet stimuli in alpha-gustducin knockout and wild-type mice.

  Chemical senses 20060701

• The G protein-coupled receptor subset of the chicken genome.

  PLoS computational biology 20060601

• The heterodimeric sweet taste receptor has multiple potential ligand binding sites.

  Current pharmaceutical design 20060101

• Artificial sweeteners: no calories...sweet!

  FDA consumer 20060101

• Quantitation of crystalline and amorphous forms of anhydrous neotame using 13C CPMAS NMR spectroscopy.

  Journal of pharmaceutical sciences 20051201

• Artificial sweeteners--do they bear a carcinogenic risk?

  Annals of oncology : official journal of the European Society for Medical Oncology 20041001

• Different functional roles of T1R subunits in the heteromeric taste receptors.

  Proceedings of the National Academy of Sciences of the United States of America 20040928

• Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners.

  Journal of the American Dietetic Association 20040201

• Evaluation of certain food additives and contaminants.

  World Health Organization technical report series 20040101

• [Effect of food additive Neotame (N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine-1-methyl) on glucose level in blood of patients with diabetes mellitus type 2].

  Voprosy pitaniia 20040101

• Food consumption and body weight changes with neotame, a new sweetener with intense taste: differentiating effects of palatability from toxicity in dietary safety studies.

  Regulatory toxicology and pharmacology : RTP 20031001

• Long-term food consumption and body weight changes in neotame safety studies are consistent with the allometric relationship observed for other sweeteners and during dietary restrictions.

  Regulatory toxicology and pharmacology : RTP 20031001

• Crystal structure of neotame anhydrate polymorph G.

  Pharmaceutical research 20021001

• Conformational flexibility and hydrogen-bonding patterns of the neotame molecule in its various solid forms.

  Journal of pharmaceutical sciences 20020901

• Neotame anhydrate polymorphs. II: Quantitation and relative physical stability.

  Pharmaceutical research 20020901

• Neotame - a new artificial sweetener.

  The Medical letter on drugs and therapeutics 20020819

• Dehydration kinetics of neotame monohydrate.

  Journal of pharmaceutical sciences 20020601

• Neotame anhydrate polymorphs I: preparation and characterization.

  Pharmaceutical research 20020301

• Structure, dynamics, and stability of beta-cyclodextrin inclusion complexes of aspartame and neotame.

  Journal of agricultural and food chemistry 20010401

• Modifying the temporal profile of the high-potency sweetener neotame.

  Journal of agricultural and food chemistry 20010201