168828-58-8 | Sutezolid

Packsize	Purity	Availability	Price	Discounted Price
5mg	≥98%	in stock	$111.00	$78.00
10mg	≥98%	in stock	$196.00	$137.00
25mg	95%	in stock	$378.00	$264.00
50mg	95%	in stock	$592.00	$414.00
100mg	95%	in stock	$719.00	$504.00
250mg	95%	in stock	$1,795.00	$1,257.00

Description

• Catalog Number: AA90926
• Chemical Name: Sutezolid
• CAS Number: 168828-58-8
• Molecular Formula: C16H20FN3O3S
• Molecular Weight: 353.4117
• MDL Number: MFCD00937821
• SMILES: CC(=O)NC[C@@H]1OC(=O)N(C1)c1ccc(c(c1)F)N1CCSCC1
• NSC Number: 742407

Computed Properties

• Complexity: 476
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 1.5

Literature

• In vitro activities of PNU-100480 and linezolid against drug-susceptible and drug-resistant Mycobacterium tuberculosis isolates.

  International journal of antimicrobial agents 20130701

• SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro.

  The Journal of antimicrobial chemotherapy 20120501

• Tuberculosis: the drug development pipeline at a glance.

  European journal of medicinal chemistry 20120501

• Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide.

  PloS one 20120101

• Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers.

  The Journal of infectious diseases 20100901

• Addition of PNU-100480 to first-line drugs shortens the time needed to cure murine tuberculosis.

  American journal of respiratory and critical care medicine 20090815

• Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.

  Journal of medicinal chemistry 20080410

• New small-molecule synthetic antimycobacterials.

  Antimicrobial agents and chemotherapy 20050601

• Short-course treatment regimen to identify potential antituberculous agents in a murine model of tuberculosis.

  The Journal of antimicrobial chemotherapy 20040401

• Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480.

  Bioorganic & medicinal chemistry letters 20040322

• Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model.

  Antimicrobial agents and chemotherapy 19990501

• Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity.

  Journal of medicinal chemistry 19960202