169274-78-6 | Ro 25-6981

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	1 week	$53.00	$37.00
2mg	95%	1 week	$75.00	$53.00
5mg	95%	1 week	$101.00	$71.00
10mg	95%	1 week	$142.00	$100.00
25mg	95%	1 week	$305.00	$214.00
50mg	95%	1 week	$481.00	$337.00
100mg	95%	1 week	$711.00	$498.00

Description

• Catalog Number: AE81393
• Chemical Name: Ro 25-6981
• CAS Number: 169274-78-6
• Molecular Formula: C22H29NO2
• Molecular Weight: 339.4712
• MDL Number: MFCD06798375
• SMILES: C[C@H]([C@H](c1ccc(cc1)O)O)CN1CCC(CC1)Cc1ccccc1

Computed Properties

• Complexity: 366
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6
• XLogP3: 4.2

Literature

• Effect of oestrogen receptors on brain NMDA receptors of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice.

  Journal of neuroendocrinology 20121101

• Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.

  Neuropharmacology 20121101

• Involvement of the anterior cingulate cortex in formation, consolidation, and reconsolidation of recent and remote contextual fear memory.

  Learning & memory (Cold Spring Harbor, N.Y.) 20120914

• NMDARs mediate the role of monoamine oxidase A in pathological aggression.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120620

• NMDA receptor mediated phosphorylation of GluR1 subunits contributes to the appearance of calcium-permeable AMPA receptors after mechanical stretch injury.

  Neurobiology of disease 20120601

• Investigation of the antidyskinetic site of action of metabotropic and ionotropic glutamate receptor antagonists. Intracerebral infusions in 6-hydroxydopamine-lesioned rats with levodopa-induced dyskinesia.

  European journal of pharmacology 20120515

• Hippocampus versus entorhinal cortex decoupling by an NR2 subunit-specific block of NMDA receptors in a rat in vitro model of temporal lobe epilepsy.

  Epilepsia 20120501

• Reduction of inflammatory pain in female rats after NR2B NMDA cortical antagonism.

  Psicothema 20120501

• Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models.

  Pain 20120501

• Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons.

  Naunyn-Schmiedeberg's archives of pharmacology 20120201

• Isoflurane/nitrous oxide anesthesia induces increases in NMDA receptor subunit NR2B protein expression in the aged rat brain.

  Brain research 20120111

• Inhibition of Ca2+/calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in rats.

  Molecular pain 20120101

• Genetic, pharmacological and lesion analyses reveal a selective role for corticohippocampal GLUN2B in a novel repeated swim stress paradigm.

  Neuroscience 20111013

• Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain.

  Brain, behavior, and immunity 20111001

• Blockade of NMDA receptors 2A subunit in the dorsal striatum impairs the learning of a complex motor skill.

  Behavioral neuroscience 20111001

• Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110831

• Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning.

  Psychopharmacology 20110801

• Involvement of synaptic NR2B-containing NMDA receptors in long-term depression induction in the young rat visual cortex in vitro.

  The Chinese journal of physiology 20110630

• Peripheral administration of NR2 antagonists attenuates orofacial formalin-induced nociceptive behavior in rats.

  Progress in neuro-psychopharmacology & biological psychiatry 20110601

• A silent synapse-based mechanism for cocaine-induced locomotor sensitization.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110601

• Dopamine induces a GluN2A-dependent form of long-term depression of NMDA synaptic responses in the nucleus accumbens.

  Neuropharmacology 20110501

• Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices.

  Neuropharmacology 20110501

• NR2B subunit blockade does not affect motor symptoms induced by 3-nitropropionic acid.

  Neurological research 20110501

• Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure.

  Biological psychiatry 20110415

• The effects of NMDA receptor antagonists on attentional set-shifting task performance in mice.

  Psychopharmacology 20110401

• NR2B subunit-specific NMDA antagonist Ro25-6981 inhibits the expression of conditioned fear: a comparison with the NMDA antagonist MK-801 and fluoxetine.

  Behavioural pharmacology 20110401

• Nickel modulates the electrical activity of cultured cortical neurons through a specific effect on N-methyl-D-aspartate receptor channels.

  Neuroscience 20110317

• Cyclic adenosine monophosphate-independent tyrosine phosphorylation of NR2B mediates cocaine-induced extracellular signal-regulated kinase activation.

  Biological psychiatry 20110201

• [Effects of the neurogenesis stimulator Ro 25-6981 upon formation of spatial skill in adult rats depend on the term of its administration and the animals' ability to learn].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20110201

• An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine.

  Psychopharmacology 20110101

• Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats.

  Molecular pain 20110101

• Intracisternal administration of NR2 subunit antagonists attenuates the nociceptive behavior and p-p38 MAPK expression produced by compression of the trigeminal nerve root.

  Molecular pain 20110101

• Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease.

  Experimental neurology 20101001

• Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach.

  Bioorganic & medicinal chemistry letters 20100915

• mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.

  Science (New York, N.Y.) 20100820

• Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100728

• Inverse relationship between seizure expression and extrasynaptic NMDAR function following chronic NMDAR inhibition.

  Epilepsia 20100701

• Stoichiometry of N-methyl-D-aspartate receptors within the suprachiasmatic nucleus.

  Journal of neurophysiology 20100601

• Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation.

  Experimental neurology 20100401

• Effects of agents targeting glutamatergic systems on marble-burying behavior.

  Neuroscience letters 20100303

• NMDA NR2B subtype-selective receptor antagonists fail to antagonize electrically-precipitated seizures and elicit popping in mice.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100301

• Effects of acute stress and GluN2B-containing NMDA receptor antagonism on object and object-place recognition memory.

  Neurobiology of learning and memory 20100201

• Intracisternal administration of NR2 antagonists attenuates facial formalin-induced nociceptive behavior in rats.

  Journal of orofacial pain 20100101

• Postsynaptic response to stimulation of the Schaffer collaterals with properties similar to those of synaptosomal aspartate release.

  Brain research 20091027

• NR2A-containing NMDA receptors are required for L-LTP induction and depotentiation in CA1 region of hippocampal slices.

  The European journal of neuroscience 20090601

• A novel protein complex in membrane rafts linking the NR2B glutamate receptor and autophagy is disrupted following traumatic brain injury.

  Journal of neurotrauma 20090501

• Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons.

  The Journal of biological chemistry 20090320

• Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus.

  Neuroscience 20090303

• Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists.

  Bioorganic & medicinal chemistry 20090215

• Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain.

  Experimental neurology 20090201

• Fear memory impairing effects of systemic treatment with the NMDA NR2B subunit antagonist, Ro 25-6981, in mice: attenuation with ageing.

  Pharmacology, biochemistry, and behavior 20090101

• A role of periaqueductal grey NR2B-containing NMDA receptor in mediating persistent inflammatory pain.

  Molecular pain 20090101

• D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs.

  Neuropharmacology 20081001

• Differential effect of NR2A and NR2B subunit selective NMDA receptor antagonists on striato-pallidal neurons: relationship to motor response in the 6-hydroxydopamine model of parkinsonism.

  Journal of neurochemistry 20080701

• Cerebellar granule cells cultured from adolescent rats express functional NMDA receptors: an in vitro model for studying the developing cerebellum.

  Journal of neurochemistry 20080701

• D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080401

• Spinal cord long-term potentiation is attenuated by the NMDA-2B receptor antagonist Ro 25-6981.

  Acta physiologica (Oxford, England) 20080301

• Tonic facilitation of glutamate release by glycine binding sites on presynaptic NR2B-containing NMDA autoreceptors in the rat visual cortex.

  Neuroscience letters 20080227

• Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors.

  European journal of pharmacology 20080226

• Brain-derived neurotrophic factor activation of extracellular signal-regulated kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular signal-regulated kinase shutoff pathway.

  Neuroscience 20080124

• Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine.

  The Journal of pharmacology and experimental therapeutics 20070501

• Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides.

  Journal of medicinal chemistry 20070308

• Contribution of NMDA receptor NR2B subunit to synaptic plasticity during associative learning in behaving rats.

  The European journal of neuroscience 20070201

• Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression.

  Neuropharmacology 20070101

• Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus.

  Neuropharmacology 20070101

• NR2B antagonists restrict spatiotemporal spread of activity in a rat model of cortical dysplasia.

  Epilepsy research 20061201

• N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subunits and associated proteins in the whole hippocampus.

  Neuroscience 20060901

• Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists.

  Bioorganic & medicinal chemistry letters 20060901

• NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo.

  Neuroreport 20060821

• Estradiol-induced increase in the magnitude of long-term potentiation is prevented by blocking NR2B-containing receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060816

• An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.

  European journal of pain (London, England) 20060801

• Effects of N-methyl-D-aspartate receptor antagonism on neuroleptic-induced orofacial dyskinesias.

  Psychopharmacology 20060401

• Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060315

• Glutamate-based therapeutic approaches: NR2B receptor antagonists.

  Current opinion in pharmacology 20060201

• Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060125

• Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060111

• Role of neuronal NR2B subunit-containing NMDA receptor-mediated Ca2+ influx and astrocytic activation in cultured mouse cortical neurons and astrocytes.

  Synapse (New York, N.Y.) 20060101

• Contribution of NR2A and NR2B NMDA subunits to bidirectional synaptic plasticity in the hippocampus in vivo.

  Hippocampus 20060101

• Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo.

  Hippocampus 20060101

• Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory.

  Neuron 20050915

• Functional roles of NMDA receptor NR2A and NR2B subunits in the acute intoxicating effects of ethanol in mice.

  Synapse (New York, N.Y.) 20050615

• Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices.

  Experimental brain research 20050401

• BDNF enhancement of postsynaptic NMDA receptors is blocked by ethanol.

  Synapse (New York, N.Y.) 20050101

• The NR2B-selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 [(+/-)-(R*,S*)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and dopamine release in the nucleus accumbens.

  The Journal of pharmacology and experimental therapeutics 20041101

• Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040908

• Oxamides as novel NR2B selective NMDA receptor antagonists.

  Bioorganic & medicinal chemistry letters 20040802

• Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time.

  Pain 20040601

• Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity.

  Science (New York, N.Y.) 20040514

• Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease.

  Experimental neurology 20040501

• The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies.

  Current medicinal chemistry 20040201

• Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket.

  The Journal of pharmacology and experimental therapeutics 20031201

• Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists.

  Bioorganic & medicinal chemistry letters 20031103

• Asymmetrical allocation of NMDA receptor epsilon2 subunits in hippocampal circuitry.

  Science (New York, N.Y.) 20030509

• Role of the NMDA receptor NR2B subunit in the discriminative stimulus effects of ketamine.

  Behavioural pharmacology 20030501

• 2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.

  Bioorganic & medicinal chemistry letters 20030310

• Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists.

  Bioorganic & medicinal chemistry letters 20030224

• The NMDA receptor NR2B subtype selective antagonist Ro 25-6981 aggravates paroxysmal dyskinesia in the dt(sz) mutant.

  European journal of pharmacology 20030101

• Blockade of NMDA receptor subtype NR2B prevents seizures but not apoptosis of dentate gyrus neurons in bacterial meningitis in infant rats.

  BMC neuroscience 20030101

• Role of NR2B-containing N-methyl-D-aspartate receptors in haloperidol-induced c-Fos expression in the striatum and nucleus accumbens.

  Neuroscience 20030101

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist.

  Bioorganic & medicinal chemistry letters 20010820

• Estrogen-like activity of tamoxifen and raloxifene on NMDA receptor binding and expression of its subunits in rat brain.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010801

• NMDA receptor antagonists do not block the development of sensitization of catalepsy, but make its expression state-dependent.

  Behavioural pharmacology 20010401

• Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.

  European journal of pharmacology 20010330