169332-60-9 | (4S,7S,10S,13S)-7-(2-Carboxyethyl)-4-(carboxymethyl)-13-formyl-10-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$87.00	$61.00
5mg	97%	in stock	$272.00	$190.00

Description

• Catalog Number: AE82124
• Chemical Name: (4S,7S,10S,13S)-7-(2-Carboxyethyl)-4-(carboxymethyl)-13-formyl-10-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid
• CAS Number: 169332-60-9
• Molecular Formula: C20H30N4O11
• Molecular Weight: 502.4724
• MDL Number: MFCD00671412
• SMILES: O=CC(NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(NC(=O)C)CC(=O)O)CCC(=O)O)CC(=O)O

Computed Properties

• Complexity: 843
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 11
• Hydrogen Bond Donor Count: 7
• Rotatable Bond Count: 16
• XLogP3: -2.6

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  Arthritis research & therapy 20040101

• Cytoskeletal actin degradation induced by lovastatin in cardiomyocytes is mediated through caspase-2.

  Cell biology international 20040101

• Role of mitochondria in neuron apoptosis during ischemia-reperfusion injury.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101

• Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors.

  Toxicology and applied pharmacology 20031215

• Oligonucleosomal DNA fragmentation in MCF-7 cells undergoing palmitate-induced apoptosis.

  Biochemistry. Biokhimiia 20031201

• Cisplatin-induced apoptosis in melanoma cells: role of caspase-3 and caspase-7 in Apaf-1 proteolytic cleavage and in execution of the degradative phases.

  Annals of the New York Academy of Sciences 20031201

• Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells.

  Cancer research 20031101

• JNK/SAPK is required in nitric oxide-induced apoptosis in osteoblasts.

  Archives of pharmacal research 20031101

• [Effect of tumor necrosis factor-alpha and interleukin-1beta on bovine pulmonary arterial endothelial cell apoptosis].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20031101

• Involvement of nucleophosmin/B23 in TPA-induced megakaryocytic differentiation of K562 cells.

  British journal of cancer 20031006

• Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway.

  Radiation research 20031001

• Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability.

  The Journal of biological chemistry 20030912

• Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030903

• The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

  The Journal of pharmacology and experimental therapeutics 20030901

• Mechanisms of sodium nitroprusside-induced death in human chondrocytes.

  Rheumatology international 20030901

• Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells.

  Blood 20030801

• Caspase-independent cell death by low concentrations of nitric oxide in PC12 cells: involvement of cytochrome C oxidase inhibition and the production of reactive oxygen species in mitochondria.

  Journal of neuroscience research 20030801

• Enhancement of sensitivity to cisplatin by orobol is associated with increased mitochondrial cytochrome c release in human ovarian carcinoma cells.

  Gynecologic oncology 20030801

• Caspase-mediated cleavage of JNK during stress-induced apoptosis.

  Biochemical and biophysical research communications 20030711

• Nicotinyl aspartyl ketones as inhibitors of caspase-3.

  Bioorganic & medicinal chemistry letters 20030707

• Proteasome inhibitors induce growth inhibition and apoptosis in myeloma cell lines and in human bone marrow myeloma cells irrespective of chromosome 13 deletion.

  Journal of cancer research and clinical oncology 20030701

• Caspase-3 and its inhibitor Ac-DEVD-CHO in rat lens epithelial cell apoptosis induced by hydrogen in vitro.

  Chinese medical journal 20030701

• beta-Phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells.

  Cellular and molecular life sciences : CMLS 20030701

• Differential modulation of apoptosis-associated proteins by ethanol in rat cerebral cortex and cerebellum.

  European journal of pharmacology 20030606

• Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats.

  Experimental neurology 20030601

• High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030501

• Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis.

  Acta neuropathologica 20030501

• Activation of caspases-3/7 is dispensable for idarubicin-induced apoptotic DNA fragmentation in human leukemia cells.

  International journal of oncology 20030501

• Protective effect of S-allyl-L-cysteine, a garlic compound, on amyloid beta-protein-induced cell death in nerve growth factor-differentiated PC12 cells.

  Neuroscience research 20030501

• Herba houttuyniae extract induces apoptotic death of human promyelocytic leukemia cells via caspase activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release.

  Experimental & molecular medicine 20030430

• Oxidative stress-induced cell death of human oral neutrophils.

  American journal of physiology. Cell physiology 20030401

• Molecular dynamics studies of caspase-3.

  Biophysical journal 20030401

• Expression of dominant-negative Fas-associated death domain blocks human keratinocyte apoptosis and vesication induced by sulfur mustard.

  The Journal of biological chemistry 20030307

• Apoptosis of bladder cancer cells induced by short-term and low-dose Mitomycin-C: potential molecular mechanism and clinical implication.

  International journal of molecular medicine 20030301

• Apoptotic cell death induction by F 11782 a novel dual catalytic inhibitor of topoisomerases I and II.

  Biochemical pharmacology 20030301

• Caspase-mediated apoptosis in sponges: cloning and function of the phylogenetic oldest apoptotic proteases from Metazoa.

  Biochimica et biophysica acta 20030217

• Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells.

  International journal of cancer 20030210

• Mechanisms of glucocorticoid-induced Leydig cell apoptosis.

  Molecular and cellular endocrinology 20030131

• Caspase-9 takes part in programmed cell death in developing mouse kidney.

  Nephron. Experimental nephrology 20030101

• Interleukin-2 activated NK cells do not use the CD95L- and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells.

  Immunobiology 20030101

• A common pathway for chemotherapy-induced apoptosis in human squamous cell carcinoma lines distinct from that of receptor-mediated cell death.

  Anticancer research 20030101

• Delineation of signalling pathway leading to antioxidant-dependent inhibition of dexamethasone-mediated muscle cell death.

  Journal of muscle research and cell motility 20030101

• Calpain and caspase-3 inhibitors reduce infarct size and post-ischemic apoptosis in rat heart without modifying contractile recovery.

  Cellular and molecular biology (Noisy-le-Grand, France) 20030101

• Ordering ceramide-induced cell detachment and apoptosis in human neuroepithelioma.

  Neuroscience letters 20021216

• Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.

  Biochemical pharmacology 20021215

• Purging effect of dibutyl phthalate on leukemia cells involves fas independent activation of caspase-3/CPP32 protease.

  Cancer letters 20021205

• Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase.

  Journal of cell science 20021201

• Time sequence analysis of caspase-3-independent programmed cell death and apoptosis in X-irradiated human leukemic MOLT-4 cells.

  Cell and tissue research 20021201

• Caspase-3-dependent pathway mediates apoptosis of human mononuclear cells induced by cellulosic haemodialysis membranes.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20021101

• Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer.

  Experimental cell research 20021101

• Amylin-induced cytotoxicity is associated with activation of caspase-3 and MAP kinases.

  Biological chemistry 20021101

• Phosphorylation of Fas-associated death domain contributes to enhancement of etoposide-induced apoptosis in prostate cancer cells.

  Japanese journal of cancer research : Gann 20021001

• Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis.

  The Journal of biological chemistry 20020913

• Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion.

  FEBS letters 20020911

• Inhibitor specificity of recombinant and endogenous caspase-9.

  The Biochemical journal 20020901

• Hydrogen peroxide induces apoptosis of osteocytes: involvement of calcium ion and caspase activity.

  Calcified tissue international 20020901

• Nitric oxide interferes with salivary mucin synthesis: involvement of ERK and p38 mitogen-activated protein kinase.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20020901

• Avian encephalomyelitis virus induces apoptosis via major structural protein VP3.

  Virology 20020815

• Bcl-2 blocks apoptosis caused by pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly.

  Biochemical and biophysical research communications 20020809

• Involvement of human heat shock protein 90 alpha in nicotine-induced apoptosis.

  International journal of cancer 20020701

• Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation.

  Human molecular genetics 20020615

• Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forces.

  The Journal of biological chemistry 20020614

• Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesis.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020601

• Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.

  Archives of toxicology 20020601

• Caspase inhibition protects nerve terminals from in vitro degradation.

  Neurochemical research 20020601

• The protection of hybridoma cells from apoptosis by caspase inhibition allows culture recovery when exposed to non-inducing conditions.

  Journal of biotechnology 20020523

• Ca(2+)-independent caspase-3 but not Ca(2+)-dependent caspase-2 activation induced by oxidative stress leads to SH-SY5Y human neuroblastoma cell apoptosis.

  Journal of neuroscience research 20020515

• Involvement of caspase and reactive oxygen species in cyanobacterial toxin anatoxin-a-induced cytotoxicity and apoptosis in rat thymocytes and Vero cells.

  Archives of toxicology 20020501

• Apoptosis during ectromelia orthopoxvirus infection is DEVDase dependent: in vitro and in vivo studies.

  Microbes and infection 20020501

• Inhibition of sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase-3.

  Biotechnology and bioengineering 20020420

• Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells.

  Molecular and cellular biology 20020401

• D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells.

  Experimental & molecular medicine 20020331

• Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells.

  Oncogene 20020327

• Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells.

  Journal of neuroscience research 20020315

• Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.

  The Journal of pharmacology and experimental therapeutics 20020301

• Kainic acid-induced neuronal cell death in cerebellar granule cells is not prevented by caspase inhibitors.

  British journal of pharmacology 20020301

• Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020301

• Caspase-3 inhibitor transiently delays inherited retinal degeneration in C3H mice carrying the rd gene.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20020301

• Caspase activation in equine influenza virus induced apoptotic cell death.

  Veterinary microbiology 20020204

• Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target.

  Journal of neurochemistry 20020201

• Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease.

  Biochemical pharmacology 20020115

• Characterization of cell death induced by vinflunine, the most recent Vinca alkaloid in clinical development.

  British journal of cancer 20020107

• Role of caspase 3-dependent Bcl-2 cleavage in potentiation of apoptosis by Bcl-2.

  Molecular pharmacology 20020101

• Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation.

  Neuro-oncology 20020101

• Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases.

  Haematologica 20020101

• Blockade of maitotoxin-induced oncotic cell death reveals zeiosis.

  BMC physiology 20020101

• The antimicrotubule drug estramustine but not irradiation induces apoptosis in malignant glioma involving AKT and caspase pathways.

  Journal of neuro-oncology 20020101

• Lactacystin, a proteasome inhibitor, potentiates the apoptotic effect of parthenolide, an inhibitor of NFkappaB activation, on drug-resistant mouse leukemia L1210 cells.

  Anticancer research 20020101

• Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2-infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage.

  Blood 20011215

• Vibrio vulnificus cytolysin induces superoxide anion-initiated apoptotic signaling pathway in human ECV304 cells.

  The Journal of biological chemistry 20011214

• Inhibition of caspase-3 improves contractile recovery of stunned myocardium, independent of apoptosis-inhibitory effects.

  Journal of the American College of Cardiology 20011201

• Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria.

  Cell death and differentiation 20011201

• Roles of caspases in the programmed cell death of motoneurons in vivo.

  Archives of histology and cytology 20011201

• Involvement of TLCK-sensitive serine protease in colchicine-induced cell death of sympathetic neurons in culture.

  Journal of neuroscience research 20011115

• Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell.

  British journal of pharmacology 20011101

• Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway.

  British journal of cancer 20011101

• Platelet-activating factor (PAF) enhances apoptosis induced by ultraviolet radiation in corneal epithelial cells through cytochrome c-caspase activation.

  Current eye research 20011101

• Limited proteolysis of filamin is catalyzed by caspase-3 in U937 and Jurkat cells.

  Journal of biochemistry 20011001

• Apaf-1 overexpression partially overcomes apoptotic resistance in a cisplatin-selected HeLa cell line.

  FEBS letters 20010914

• Fas-mediated apoptosis in a rat acinar cell line is dependent on caspase-1 activity.

  Cellular signalling 20010901

• Attenuation of staurosporine-induced apoptosis, oxidative stress, and mitochondrial dysfunction by synthetic superoxide dismutase and catalase mimetics, in cultured cortical neurons.

  Experimental neurology 20010901

• Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation.

  Oncogene 20010816

• p53 activates the mitochondrial death pathway and apoptosis of ventricular myocytes independent of de novo gene transcription.

  Journal of molecular and cellular cardiology 20010801

• Infection with Langat Flavivirus or expression of the envelope protein induces apoptotic cell death.

  Virology 20010801

• Caspase activity is involved in, but is dispensable for, early motoneuron death in the chick embryo cervical spinal cord.

  Molecular and cellular neurosciences 20010801

• Caspase-3-mediated cleavage of the NF-kappa B subunit p65 at the NH2 terminus potentiates naphthoquinone analog-induced apoptosis.

  The Journal of biological chemistry 20010706

• Cocaine-mediated apoptosis in bovine coronary artery endothelial cells: role of nitric oxide.

  The Journal of pharmacology and experimental therapeutics 20010701

• Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis.

  Journal of neuroscience research 20010701

• [Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20010701

• Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis.

  Experimental cell research 20010610

• Caspase activity in newt spermatogonial apoptosis induced by prolactin and cycloheximide.

  Molecular reproduction and development 20010601

• Time course of the apoptotic cascade and effects of caspase inhibitors in adult rat ventricular cardiomyocytes.

  Journal of molecular and cellular cardiology 20010501

• Sodium nitroprusside induces apoptosis of H9C2 cardiac muscle cells in a c-Jun N-terminal kinase-dependent manner.

  International immunopharmacology 20010501

• Quinacrine induces cytochrome c-dependent apoptotic signaling in human cervical carcinoma cells.

  Archives of pharmacal research 20010401

• Caspase inhibitors promote the survival of avulsed spinal motoneurons in neonatal rats.

  Neuroreport 20010305

• Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease.

  Journal of neuroscience research 20010301

• Virus infection induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation.

  European journal of immunology 20010301

• Initiation of apoptosis by actin cytoskeletal derangement in human airway epithelial cells.

  American journal of respiratory cell and molecular biology 20010301

• Caspase-dependent cleavage of cadherins and catenins during osteoblast apoptosis.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010301

• Homology modeling of nematode Caenorhabditis elegans CED3 protein-inhibitor complex.

  Biochemical and biophysical research communications 20010216

• Insulin-like growth factor-I and Bcl-X(L) inhibit c-jun N-terminal kinase activation and rescue Schwann cells from apoptosis.

  Journal of neurochemistry 20010201

• Effects of a novel hepatoprotective drug, ZNC-2381, on fas-induced hepatocellular caspase-3 activity and apoptosis in mice.

  Pharmacology 20010201

• Growth inhibition and apoptosis of gastric cancer cell lines by Anemarrhena asphodeloides Bunge.

  Journal of gastroenterology 20010201

• [Induction of apoptosis of splenic lymphocytes in mice by accelerated carbon ions].

  Canadian journal of physiology and pharmacology 20010201

• Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis.

  The Journal of biological chemistry 20010126

• Design and synthesis of rhodamine 110 derivative and caspase-3 substrate for enzyme and cell-based fluorescent assay.

  Bioorganic & medicinal chemistry letters 20010108

• Reactive oxygen species and caspase activation mediate silica-induced apoptosis in alveolar macrophages.

  American journal of physiology. Lung cellular and molecular physiology 20010101

• DNA-dependent protein kinase catalytic subunit is cleaved during UV-induced apoptosis.

  Journal of dermatological science 20010101

• Increased sensitivity to sodium salicylate-induced apoptosis in drug-resistant leukemia L1210 cells.

  Anticancer research 20010101

• Deciphering the plasma membrane hallmarks of apoptotic cells: phosphatidylserine transverse redistribution and calcium entry.

  BMC cell biology 20010101

• Inhibitors of caspase homologues suppress an apoptotic phenotype in cultured rabbit corpora lutea.

  Reproduction, fertility, and development 20010101

• New concepts in radiation-induced apoptosis: 'premitotic apoptosis' and 'postmitotic apoptosis'.

  Journal of cellular and molecular medicine 20010101

• The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32.

  Proceedings of the National Academy of Sciences of the United States of America 20001121

• Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells.

  Cancer research 20001101

• Organophosphorus compound-induced apoptosis in SH-SY5Y human neuroblastoma cells.

  Toxicology and applied pharmacology 20001015

• Different mechanisms between premitotic apoptosis and postmitotic apoptosis in X-irradiated U937 cells.

  International journal of radiation oncology, biology, physics 20000601

• Paclitaxel-induced apoptosis in non-small cell lung cancer cell lines is associated with increased caspase-3 activity.

  The Journal of thoracic and cardiovascular surgery 20000401

• Induction of apoptosis by the O-hydroxyethyl-D(Ser)(8)-cyclosporine A derivative SDZ IMM 125 in rat hepatocytes.

  The Journal of pharmacology and experimental therapeutics 20000401

• Cocaine induces apoptosis in human coronary artery endothelial cells.

  Journal of cardiovascular pharmacology 20000401

• Cocaine induces apoptosis in fetal myocardial cells through a mitochondria-dependent pathway.

  The Journal of pharmacology and experimental therapeutics 20000101

• Involvement of activated caspase-3-like proteases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons.

  Journal of neurochemistry 20000101

• The lipid peroxidation product 4-hydroxy-2,3-nonenal increases AP-1-binding activity through caspase activation in neurons.

  Journal of neurochemistry 20000101

• Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20000101

• Effect of heat stress on serotonin-2A receptor-mediated intracellular calcium mobilization in rat C6 glioma cells.

  Journal of neural transmission (Vienna, Austria : 1996) 20000101

• Prevention of cycloheximide-induced apoptosis in hepatocytes by adenosine and by caspase inhibitors.

  Biochemical pharmacology 19991215

• The apoptotic effects and synergistic interaction of sodium butyrate and MG132 in human retinoblastoma Y79 cells.

  Cancer research 19991101

• Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53.

  Cancer research 19991001

• Effects of BAPTA-AM and forskolin on apoptosis and cytochrome c release in photosensitized Chinese hamster V79 cells.

  Photochemistry and photobiology 19991001

• Induction of apoptosis by penta-O-galloyl-beta-D-glucose through activation of caspase-3 in human leukemia HL-60 cells.

  European journal of pharmacology 19990924

• Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 19990815

• Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 19990815

• Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes.

  Oncogene 19990708

• A predominant apoptotic death pathway of neuronal PC12 cells induced by activated microglia is displaced by a non-apoptotic death pathway following blockage of caspase-3-dependent cascade.

  The Journal of biological chemistry 19990528

• Caspase-3 activation during apoptosis caused by glutathione-doxorubicin conjugate.

  British journal of cancer 19990501

• Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3.

  The Journal of biological chemistry 19990409

• Induction of apoptosis and changes in nuclear G-actin are mediated by different pathways: the effect of inhibitors of protein and RNA synthesis in isolated rat hepatocytes.

  Toxicology and applied pharmacology 19990401

• Caspase-dependent activation of calpain during drug-induced apoptosis.

  The Journal of biological chemistry 19990319

• Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3.

  Cell proliferation 19990201

• Menadione-induced apoptosis and the degradation of lamin-like proteins in tobacco protoplasts.

  Cellular and molecular life sciences : CMLS 19990201

• Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation.

  Free radical research 19990101

• Evidence that non-caspase proteases are required for chromatin degradation during apoptosis.

  Cell death and differentiation 19981201

• Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3.

  Cell death and differentiation 19981201

• Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 19981015

• Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine.

  Journal of neuroscience research 19981015

• Caspase-3-like activity is necessary for IL-2 release in activated Jurkat T-cells.

  Experimental cell research 19981010

• Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide.

  Cell death and differentiation 19981001

• Proteolytic activation of PKN by caspase-3 or related protease during apoptosis.

  Proceedings of the National Academy of Sciences of the United States of America 19980929

• Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways.

  Journal of immunology (Baltimore, Md. : 1950) 19980815

• Distinct steps in DNA fragmentation pathway during camptothecin-induced apoptosis involved caspase-, benzyloxycarbonyl- and N-tosyl-L-phenylalanylchloromethyl ketone-sensitive activities.

  Cancer research 19980715

• Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 19980615

• Dissection of pathways leading to antigen receptor-induced and Fas/CD95-induced apoptosis in human B cells.

  Journal of immunology (Baltimore, Md. : 1950) 19980615

• Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases.

  Hepatology (Baltimore, Md.) 19980601

• Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 19980515

• The intracellular domain of p55 tumor necrosis factor receptor induces apoptosis which requires different caspases in naive and neuronal PC12 cells.

  Journal of neuroscience research 19980515

• Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene.

  Cancer research 19980515

• Proteolytic cleavage of HsRad51 during apoptosis.

  FEBS letters 19980508

• Peroxynitrite induces apoptosis of HL-60 cells by activation of a caspase-3 family protease.

  The American journal of physiology 19980401

• Preparation and imaging of nuclear spreads from cells of the zebrafish embryo. Evidence for large degradation intermediates in apoptosis.

  Chromosoma 19980301

• Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.

  Cancer research 19980201

• Apoptotic cell death and CPP32-like activation induced by thapsigargin and their prevention by nerve growth factor in PC12 cells.

  Biochimica et biophysica acta 19980102

• Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms.

  The Journal of biological chemistry 19971205

• Cooperative interception of neuronal apoptosis by BCL-2 and BAG-1 expression: prevention of caspase activation and reduced production of reactive oxygen species.

  Journal of neurochemistry 19971101

• Need for caspases in apoptosis of trophic factor-deprived PC12 cells.

  Journal of neuroscience research 19971001

• Activation of caspase-2 in apoptosis.

  The Journal of biological chemistry 19970822

• Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A.

  Kidney international 19970801

• Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis.

  Proceedings of the National Academy of Sciences of the United States of America 19970513

• Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases.

  The Journal of biological chemistry 19970314

• Inhibition of CPP32-like proteases prevents granzyme B- and Fas-, but not granzyme A-based cytotoxicity exerted by CTL clones.

  Journal of immunology (Baltimore, Md. : 1950) 19970301

• Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis.

  Biochemical and biophysical research communications 19970103

• Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease.

  The Journal of biological chemistry 19961206

• Involvement of CPP32/Yama-like protease in CPT-11-induced death signal transduction pathway.

  Toxicology in vitro : an international journal published in association with BIBRA 19961201

• Intracellular IL-1beta is an inhibitor of Fas-mediated apoptosis.

  Journal of immunology (Baltimore, Md. : 1950) 19961101