-
Endothelin in hypertension: an update.
Current opinion in nephrology and hypertension 20120301
-
Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure.
International journal of hypertension 20120101
-
Antidiuretic effects of the endothelin receptor antagonist avosentan.
Frontiers in physiology 20120101
-
Therapeutic perspectives in hypertension: novel means for renin-angiotensin-aldosterone system modulation and emerging device-based approaches.
European heart journal 20111101
-
Macitentan: entry-into-humans study with a new endothelin receptor antagonist.
European journal of clinical pharmacology 20111001
-
Determination of darusentan enantiomers in rat plasma by enantioselective liquid chromatography with tandem mass spectrometry using cellulose-based chiral stationary phase.
Journal of separation science 20111001
-
Bosentan and oral anticoagulants in HIV patients: what we can learn of cases reported so far.
Hematology reports 20110831
-
Selective endothelin receptor blockade in resistant hypertension: results of the DORADO trial.
Expert opinion on pharmacotherapy 20110101
-
Benefits from treatment and control of patients with resistant hypertension.
International journal of hypertension 20110101
-
Resistant hypertension workup and approach to treatment.
International journal of hypertension 20110101
-
Aortocaval fistula in rat: a unique model of volume-overload congestive heart failure and cardiac hypertrophy.
Journal of biomedicine & biotechnology 20110101
-
Common secondary causes of resistant hypertension and rational for treatment.
International journal of hypertension 20110101
-
Role of the kidneys in resistant hypertension.
International journal of hypertension 20110101
-
Pulmonary hypertension related to left-sided cardiac pathology.
Pulmonary medicine 20110101
-
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.
Respiratory research 20110101
-
Endothelin antagonism in patients with resistant hypertension and hypertension nephropathy.
Contributions to nephrology 20110101
-
Endothelial dysfunction in the apolipoprotein E-deficient mouse: insights into the influence of diet, gender and aging.
Lipids in health and disease 20110101
-
TRC120038, a Novel Dual AT(1)/ET(A) Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 Rats.
International journal of hypertension 20110101
-
Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet.
Kidney international 20101201
-
Divergent results using clinic and ambulatory blood pressures: report of a darusentan-resistant hypertension trial.
Hypertension (Dallas, Tex. : 1979) 20101101
-
Gene expression of endothelin-1 and endothelin receptor a on monocrotaline-induced pulmonary hypertension in rats after bosentan treatment.
Korean circulation journal 20100901
-
How are stressed prehypertensive rats pressured? Endothelin pleads guilty.
Hypertension (Dallas, Tex. : 1979) 20100801
-
Darusentan, a selective endothelin A receptor antagonist, for the oral treatment of resistant hypertension.
Therapeutic advances in cardiovascular disease 20100801
-
Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries.
Canadian journal of physiology and pharmacology 20100801
-
Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes.
Canadian journal of physiology and pharmacology 20100601
-
Best strategies for hypertension management in type 2 diabetes and obesity.
Current diabetes reports 20100401
-
Darusentan in resistant hypertension: lost in translation.
Current hypertension reports 20100201
-
A signal processing-based bioinformatics approach to assessing drug resistance: human immunodeficiency virus as a case study.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20100101
-
Vasodilators in the treatment of acute heart failure: what we know, what we don't.
Heart failure reviews 20091201
-
A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial.
Lancet (London, England) 20091024
-
Clinical approach in treatment of resistant hypertension.
Integrated blood pressure control 20090101
-
Dietary alkalinization and darusentan for prevention of decline in glomerular filtration rate in rats fed a casein diet.
Kidney international 20081201
-
Darusentan: a new perspective for treatment of resistant hypertension?
Expert opinion on investigational drugs 20080801
-
Efficacy and safety of darusentan: a novel endothelin receptor antagonist.
The Annals of pharmacotherapy 20080701
-
Ambrisentan for the treatment of pulmonary arterial hypertension.
Drug design, development and therapy 20080101
-
Reversal of isoproterenol-induced downregulation of phospholamban and FKBP12.6 by CPU0213-mediated antagonism of endothelin receptors.
Acta pharmacologica Sinica 20071101
-
Efficacy and safety of darusentan in patients with resistant hypertension: results from a randomized, double-blind, placebo-controlled dose-ranging study.
Journal of clinical hypertension (Greenwich, Conn.) 20071001
-
Modulation of the transient outward K+ current by inhibition of endothelin-A receptors in normal and hypertrophied rat hearts.
Pflugers Archiv : European journal of physiology 20070701
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20070301
-
Dietary protein induces endothelin-mediated kidney injury through enhanced intrinsic acid production.
Kidney international 20070201
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20061201
-
Up-regulated inflammatory factors endothelin, NFkappaB, TNFalpha and iNOS involved in exaggerated cardiac arrhythmias in l-thyroxine-induced cardiomyopathy are suppressed by darusentan in rats.
Life sciences 20061004
-
New drugs for hypertension: what do they offer?
Current hypertension reports 20061001
-
Endothelin-1 receptor antagonist (LU-135252) improves the microcirculation and course of TNBS colitis in rats.
Digestive diseases and sciences 20060801
-
[Trend of research and development of antihypertensive agents].
Nihon rinsho. Japanese journal of clinical medicine 20060701
-
Endothelin receptor antagonists.
Pharmacology & therapeutics 20060601
-
Profile of past and current clinical trials involving endothelin receptor antagonists: the novel '-sentan' class of drug.
Experimental biology and medicine (Maywood, N.J.) 20060601
-
Downregulation of renal endothelin-converting enzyme 2 expression in early autoimmune diabetes.
Experimental biology and medicine (Maywood, N.J.) 20060601
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20060601
-
Spironolactone preserves cardiac norepinephrine reuptake in salt-sensitive Dahl rats.
Endocrinology 20060501
-
Endothelin ETA receptor blockade with darusentan increases sodium and potassium excretion in aging rats.
Journal of cardiovascular pharmacology 20060301
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20051201
-
The endothelin/nitric oxide balance determines small-for-size liver injury after reduced-size rat liver transplantation.
Virchows Archiv : an international journal of pathology 20051001
-
Regression of medial elastocalcinosis in rat aorta: a new vascular function for carbonic anhydrase.
Circulation 20050913
-
Endothelin-1 inhibits the neuronal norepinephrine transporter in hearts of male rats.
Cardiovascular research 20050801
-
Endothelin-1 exerts a preconditioning-like cardioprotective effect against ischaemia/reperfusion injury via the ET(A) receptor and the mitochondrial K(ATP) channel in the rat in vivo.
British journal of pharmacology 20050201
-
[New choice of therapy of pulmonary hypertension: endothelin receptor antagonist].
Zhonghua yi xue za zhi 20050126
-
Endothelin A antagonist LU-135252 and trandolapril in the treatment of the Cohen-Rosenthal diabetic hypertensive rat.
Blood pressure 20050101
-
Effects of chronic endothelin ET(A) receptor blockade on blood pressure and vascular formation of cyclic guanosine-3',5'-monophosphate in spontaneously hypertensive rats.
Arzneimittel-Forschung 20050101
-
Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibition.
Hypertension (Dallas, Tex. : 1979) 20041201
-
Effects of systemic endothelin A receptor antagonism in various vascular beds in men: in vivo interactions of the major blood pressure-regulating systems and associations with the GNB3 C825T polymorphism.
Clinical pharmacology and therapeutics 20041101
-
Phenotypic modulation of vascular smooth muscle cells during medial arterial calcification: a role for endothelin?
Journal of cardiovascular pharmacology 20041101
-
Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial.
Lancet (London, England) 20040701
-
Endothelin receptor antagonists are not beneficial in the therapy of acute experimental pancreatitis.
Langenbeck's archives of surgery 20040601
-
Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.
Journal of medicinal chemistry 20040408
-
ACE-inhibition is superior to endothelin A receptor blockade in preventing abnormal capillary supply and fibrosis of the heart in experimental diabetes.
Diabetologia 20040201
-
Neurohumoral and hemodynamic effects of the selective endothelin antagonist darusentan in advanced chronic heart failure.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20040101
-
Endothelin receptor antagonists in heart failure: current status and future directions.
Drugs 20040101
-
Activation of the right ventricular endothelin (ET) system in the monocrotaline model of pulmonary hypertension: response to chronic ETA receptor blockade.
Clinical science (London, England : 1979) 20031201
-
Renal damage is not improved by blockade of endothelin receptors in primary renin-dependent hypertension.
Journal of hypertension 20031201
-
Endothelin-A receptor antagonist reduces microcirculatory disturbances and transplant dysfunction after partial liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20030901
-
Renal damage in the SHR/N-cp type 2 diabetes model: comparison of an angiotensin-converting enzyme inhibitor and endothelin receptor blocker.
Laboratory investigation; a journal of technical methods and pathology 20030901
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20030901
-
Endothelin receptor blockade and exacerbation of heart failure.
Circulation 20030610
-
Effects of the endothelin a receptor antagonist darusentan on blood pressure and vascular contractility in type 2 diabetic Goto-Kakizaki rats.
Journal of cardiovascular pharmacology 20030601
-
ACE-inhibitors but not endothelin receptor blockers prevent podocyte loss in early diabetic nephropathy.
Diabetologia 20030601
-
Nephroprotective effects of the endothelin ET(A) receptor antagonist darusentan in salt-sensitive genetic hypertension.
European journal of pharmacology 20030516
-
Enalaprilat, losartan and LU 135252 in coronary blood flow regulation.
European journal of clinical investigation 20030501
-
Trandolapril and endothelin antagonist LU-135252 in the treatment of the fructose-induced hypertensive, hyperinsulinemic, hypertriglyceridemic rat.
American journal of hypertension 20030401
-
Will endothelin receptor antagonists have a role in heart failure?
The Medical clinics of North America 20030301
-
Gateways to clinical trials. March 2003.
Methods and findings in experimental and clinical pharmacology 20030301
-
Effects of ET-A receptor blockade on eNOS gene expression in chronic hypoxic rat lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 20030201
-
Erythropoietin-induced excessive erythrocytosis activates the tissue endothelin system in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201
-
RES function and liver microcirculation in the early stage of acute experimental pancreatitis.
Hepato-gastroenterology 20030101
-
Effect of endothelin blockade on early cardiovascular remodeling in the one-clip-two-kidney hypertension of the rat.
Kidney & blood pressure research 20030101
-
Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade Trial (HEAT).
Circulation 20021119
-
Endothelin-A receptor blockade prevents left ventricular hypertrophy and dysfunction in salt-sensitive experimental hypertension.
Circulation 20021029
-
Angiotensin-converting enzyme inhibition and endothelin antagonism for endothelial dysfunction in heart failure: mono-or combination therapy.
Journal of cardiovascular pharmacology 20021001
-
Selective endothelin receptor blockade reverses mitochondrial dysfunction in canine heart failure.
Journal of cardiac failure 20021001
-
Long-term survival and hemodynamics after endothelin-a receptor antagonism and angiotensin-converting enzyme inhibition in rats with chronic heart failure: monotherapy versus combination therapy.
Circulation 20020827
-
Endothelin A but not endothelin B receptor blockade reduces capillary permeability in severe experimental pancreatitis.
Pancreas 20020801
-
Pharmacological prevention and regression of arterial remodeling in a rat model of isolated systolic hypertension.
Journal of hypertension 20020801
-
Effects of obesity on endothelium-dependent reactivity during acute nitric oxide synthase inhibition: modulatory role of endothelin.
Clinical science (London, England : 1979) 20020801
-
ET(A) receptor blockade protects the small intestine against ischaemia/reperfusion injury in dogs via an enhancement of antioxidant defences.
Clinical science (London, England : 1979) 20020801
-
Treatment with darusentan over 21 days improved cGMP generation in patients with chronic heart failure.
Clinical science (London, England : 1979) 20020801
-
Endothelin A-receptor antagonist administration immediately after experimental myocardial infarction with reperfusion does not affect scar healing in dogs.
Cardiovascular research 20020701
-
Increased pulmonary prostacyclin synthesis in rats with chronic hypoxic pulmonary hypertension.
Cardiovascular research 20020701
-
Darusentan: an effective endothelinA receptor antagonist for treatment of hypertension.
American journal of hypertension 20020701
-
Endothelin A receptor antagonist LU 135252 inhibits hypercholesterolemia-induced, but not deendothelialization-induced, atherosclerosis in rabbit arteries.
Investigative radiology 20020601
-
Predominant activation of endothelin-dependent cardiac hypertrophy by norepinephrine in rat left ventricle.
American journal of physiology. Regulatory, integrative and comparative physiology 20020501
-
Cardioprotection by long-term ET(A) receptor blockade and ACE inhibition in rats with congestive heart failure: mono- versus combination therapy.
Cardiovascular research 20020401
-
Chronic ET(A) receptor blockade prevents endothelial dysfunction of small arteries in apolipoprotein E-deficient mice.
Cardiovascular research 20020201
-
The design and synthesis of a novel series of indole derived selective ET(A) antagonists.
Bioorganic & medicinal chemistry letters 20020121
-
Chronic exposure to carbon monoxide and nicotine: endothelin ET(A) receptor antagonism attenuates carbon monoxide-induced myocardial hypertrophy in rat.
Toxicology and applied pharmacology 20020101
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20020101
-
Norepinephrine-induced aortic hyperplasia and extracellular matrix deposition are endothelin-dependent.
Journal of hypertension 20011101
-
Influence of aldosterone vs. endothelin receptor antagonism on renovascular function in liquorice-induced hypertension.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20011101
-
Darusentan (Abbott Laboratories).
IDrugs : the investigational drugs journal 20011101
-
Endothelin receptor blockade in congestive heart failure.
Circulation 20011030
-
Transient involvement of endothelin in hypertrophic remodeling of small arteries.
Journal of hypertension 20011001
-
Endothelin 1 type a receptor antagonism prevents vascular dysfunction and hypertension induced by 11beta-hydroxysteroid dehydrogenase inhibition: role of nitric oxide.
Circulation 20010626
-
Hemodynamic, renal, and endocrine responses to acute ET(A) blockade at different ANG II plasma levels.
American journal of physiology. Regulatory, integrative and comparative physiology 20010501
-
Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future?
Journal of the American College of Cardiology 20010501
-
Role of the astrocytic ET(B) receptor in the regulation of extracellular endothelin-1 during hypoxia.
Glia 20010401
-
Therapeutic administration of an endothelin-A receptor antagonist after acute ischemic renal failure dose-dependently improves recovery of renal function.
Journal of cardiovascular pharmacology 20010401
-
Involvement of nitric oxide in cardioprotective effect of endothelin receptor antagonist during ischemia-reperfusion.
American journal of physiology. Heart and circulatory physiology 20010301
-
Effects of endothelin a receptor blockade on endothelial function in patients with chronic heart failure.
Circulation 20010220
-
Effectiveness of a nonselective ET(A/B) and a selective ET(A) antagonist in rats with monocrotaline-induced pulmonary hypertension.
Circulation 20010116
-
Effect of ET(A) receptor antagonist on pulmonary hypertension and vascular reactivity in rats with congestive heart failure.
Pulmonary pharmacology & therapeutics 20010101
-
Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists.
Journal of medicinal chemistry 19960524
