17374-26-4 | Tbb

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$34.00	$24.00
250mg	98%	in stock	$67.00	$47.00
1g	98%	in stock	$155.00	$108.00
5g	98%	in stock	$449.00	$315.00

Description

• Catalog Number: AA92022
• Chemical Name: Tbb
• CAS Number: 17374-26-4
• Molecular Formula: C6HBr4N3
• Molecular Weight: 434.7082
• MDL Number: MFCD06411399
• SMILES: Brc1c(Br)c(Br)c2c(c1Br)[nH]nn2
• NSC Number: 231634

Computed Properties

• Complexity: 184
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 3.8

Literature

• Raf-1/CK2 and RhoA/ROCK signaling promote TNF-α-mediated endothelial apoptosis via regulating vimentin cytoskeleton.

  Toxicology 20170815

• CK2 activity is required for the interaction of FGF14 with voltage-gated sodium channels and neuronal excitability.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20160601

• BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice.

  Nature neuroscience 20151001

• Synthesis and physico-chemical properties in aqueous medium of all possible isomeric bromo analogues of benzo-1H-triazole, potential inhibitors of protein kinases.

  The journal of physical chemistry. B 20120621

• Protein kinase CK2 mediates peroxynitrite-induced heme oxygenase-1 expression in articular chondrocytes.

  International journal of molecular medicine 20120601

• Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.

  Bioorganic & medicinal chemistry 20120401

• Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7.

  Science signaling 20120207

• A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

  Toxicology and applied pharmacology 20120115

• Time schedule-dependent effect of the CK2 inhibitor TBB on PC-3 human prostate cancer cell viability.

  Oncology reports 20120101

• Influence of five potential anticancer drugs on wnt pathway and cell survival in human biliary tract cancer cells.

  International journal of biological sciences 20120101

• Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration.

  Scientific reports 20120101

• Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells.

  PloS one 20120101

• GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis.

  Nature chemical biology 20111201

• Multisite-directed inhibitors of protein kinase CK2: new challenges.

  Molecular and cellular biochemistry 20111001

• Design and synthesis of CK2 inhibitors.

  Molecular and cellular biochemistry 20111001

• Down-regulation of CK2 activity results in a decrease in the level of cdc25C phosphatase in different prostate cancer cell lines.

  Molecular and cellular biochemistry 20111001

• The kinase DYRKIA regulates pre-mRNA splicing in spermatogonia and proliferation of spermatogonia and Sertoli cells by phosphorylating a spliceosomal component, SAP155, in postnatal murine testes.

  Molecular and cellular biochemistry 20110901

• The protein kinase CK2 inhibitor TBB mediates up-regulation of MEK3/6 and p38δ activities, down-regulation of ERK1/2 activity and induction of G1/S arrest in normal human epidermal autocrine proliferating keratinocytes.

  Journal of dermatological science 20110801

• The cytosolic protein kinase CK2 phosphorylates cardiac calsequestrin in intact cells.

  Molecular and cellular biochemistry 20110701

• CK2 phosphorylates AP-2α and increases its transcriptional activity.

  BMB reports 20110701

• Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110601

• Brain-derived neurotrophic factor enhances Bcl-xL expression through protein kinase casein kinase 2-activated and nuclear factor kappa B-mediated pathway in rat hippocampus.

  Brain pathology (Zurich, Switzerland) 20110301

• Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton.

  Molecular and cellular biochemistry 20110301

• CK2 inhibition induces apoptosis via the ER stress response.

  Cellular signalling 20110101

• A specific inhibitor of protein kinase CK2 delays gamma-H2Ax foci removal and reduces clonogenic survival of irradiated mammalian cells.

  Radiation oncology (London, England) 20110101

• CK2 is acting upstream of MEK3/6 as a part of the signal control of ERK1/2 and p38 MAPK during keratinocytes autocrine differentiation.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20110101

• IL-6 stabilizes Twist and enhances tumor cell motility in head and neck cancer cells through activation of casein kinase 2.

  PloS one 20110101

• Downregulation of protein kinase CK2 activity facilitates tumor necrosis factor-α-mediated chondrocyte death through apoptosis and autophagy.

  PloS one 20110101

• Bromophenols in marine algae and their bioactivities.

  Marine drugs 20110101

• Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90.

  Molecular cancer 20110101

• CK2 phosphorylation of Schistosoma mansoni HMGB1 protein regulates its cellular traffic and secretion but not its DNA transactions.

  PloS one 20110101

• Label-free integrative pharmacology on-target of drugs at the β(2)-adrenergic receptor.

  Scientific reports 20110101

• Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.

  Neuron 20101209

• Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.

  Blood 20101007

• Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1alpha mediated transcription.

  The international journal of biochemistry & cell biology 20101001

• The inhibitory effect of acrylamide on NCAM expression in human neuroblastoma cells: involvement of CK2/Ikaros signaling pathway.

  Toxicology in vitro : an international journal published in association with BIBRA 20101001

• Relative role of halogen bonds and hydrophobic interactions in inhibition of human protein kinase CK2α by tetrabromobenzotriazole and some C5-substituted analogues.

  The journal of physical chemistry. B 20100819

• A medicinal chemist's guide to molecular interactions.

  Journal of medicinal chemistry 20100722

• Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.

  PLoS genetics 20100701

• Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines.

  Molecular and cellular biochemistry 20100501

• Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2.

  The Journal of biological chemistry 20100409

• A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease.

  Journal of enzyme inhibition and medicinal chemistry 20100401

• Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors.

  Haematologica 20100401

• p53 is dispensable for the induction of apoptosis after inhibition of protein kinase CK2.

  The Prostate 20100201

• Halogenated imidazole derivatives block RNA polymerase II elongation along mitogen inducible genes.

  BMC molecular biology 20100101

• A CE-based assay for human protein kinase CK2 activity measurement and inhibitor screening.

  Electrophoresis 20100101

• Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress.

  PloS one 20100101

• Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.

  Molecular cancer 20100101

• The 14-3-3ζ protein binds to the cell adhesion molecule L1, promotes L1 phosphorylation by CKII and influences L1-dependent neurite outgrowth.

  PloS one 20100101

• Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1.

  Molecular neurodegeneration 20100101

• Efficacy and mechanism of anti-tumor action of new potential CK2 inhibitors toward glioblastoma cells.

  International journal of oncology 20091101

• Selectivity analysis of protein kinase CK2 inhibitors DMAT, TBB and resorufin in cisplatin-induced stress responses.

  International journal of oncology 20091101

• Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells.

  Cancer research 20091015

• PACS-1 mediates phosphorylation-dependent ciliary trafficking of the cyclic-nucleotide-gated channel in olfactory sensory neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090826

• Inhibition of protein kinase CK2 induces E2F1 nuclear export, formation of p21/E2F1 complexes and suppression of DNA synthesis in normal human epidermal keratinocytes.

  Journal of dermatological science 20090801

• Involvement of reactive oxygen species in apoptosis induced by pharmacological inhibition of protein kinase CK2.

  Annals of the New York Academy of Sciences 20090801

• Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.

  Bioorganic & medicinal chemistry letters 20090601

• DMAT, an inhibitor of protein kinase CK2 induces reactive oxygen species and DNA double strand breaks.

  Oncology reports 20090601

• Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide--potential inhibitors of human protein kinase CK2.

  Bioorganic & medicinal chemistry 20090215

• Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression.

  European journal of immunology 20090101

• Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.

  BMC cancer 20090101

• The selectivity of inhibitors of protein kinase CK2: an update.

  The Biochemical journal 20081101

• Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells.

  Cellular signalling 20081101

• New inhibitors of protein kinase CK2, analogues of benzimidazole and benzotriazole.

  Molecular and cellular biochemistry 20080901

• Evaluating CK2 activity with the antibody specific for the CK2-phosphorylated form of a kinase-targeting cochaperone Cdc37.

  Molecular and cellular biochemistry 20080901

• Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells.

  Molecular and cellular biochemistry 20080901

• Role of heme oxygenase-2 in pial arteriolar response to acetylcholine in mice with and without transfusion of cell-free hemoglobin polymers.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080801

• Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity.

  Current neurovascular research 20080801

• Protein kinase CK2 modulates synaptic plasticity by modification of synaptic NMDA receptors in the hippocampus.

  The Journal of physiology 20080701

• An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets.

  Molecular & cellular proteomics : MCP 20080601

• Regulation of the epithelial Na+ channel by the protein kinase CK2.

  The Journal of biological chemistry 20080509

• Inhibition of casein kinase 2 enhances the death ligand- and natural kiler cell-induced hepatocellular carcinoma cell death.

  Clinical and experimental immunology 20080501

• A role for CK2 upon interkinetic nuclear migration in the cell cycle of retinal progenitor cells.

  Developmental neurobiology 20080401

• CK2beta gene silencing increases cell susceptibility to influenza A virus infection resulting in accelerated virus entry and higher viral protein content.

  Journal of molecular signaling 20080101

• Ecto-phosphorylation of CD98 regulates cell-cell interactions.

  PloS one 20080101

• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

  Proceedings of the National Academy of Sciences of the United States of America 20071218

• Inhibition of HCV replicon cell growth by 2-arylbenzofuran derivatives isolated from Mori Cortex Radicis.

  Planta medica 20071101

• The reverse in-gel kinase assay to profile physiological kinase substrates.

  Nature methods 20071101

• Organization and regulation of small conductance Ca2+-activated K+ channel multiprotein complexes.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070227

• Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070201

• Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors.

  Chembiochem : a European journal of chemical biology 20070102

• CK2 phosphorylation of SAG at Thr10 regulates SAG stability, but not its E3 ligase activity.

  Molecular and cellular biochemistry 20070101

• Differential regulation of mouse equilibrative nucleoside transporter 1 (mENT1) splice variants by protein kinase CK2.

  Molecular membrane biology 20070101

• A CK2-dependent mechanism for degradation of the PML tumor suppressor.

  Cell 20060728

• Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina.

  The American journal of pathology 20060501

• Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells.

  Molecular cancer research : MCR 20060501

• Role of protein kinase CK2 in the regulation of tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis in prostate cancer cells.

  Cancer research 20060215

• Adaptor heat shock protein complex formation regulates trafficking of the asialoglycoprotein receptor.

  American journal of physiology. Gastrointestinal and liver physiology 20060201

• Transcriptional analysis of calcium-dependent and calcium-independent signalling pathways induced by oligogalacturonides.

  Journal of experimental botany 20060101

• Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.

  Biochimica et biophysica acta 20051230

• CDK phosphorylation inhibits the DNA-binding and ATP-hydrolysis activities of the Drosophila origin recognition complex.

  The Journal of biological chemistry 20051202

• A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44.

  Traffic (Copenhagen, Denmark) 20051101

• Development and exploitation of CK2 inhibitors.

  Molecular and cellular biochemistry 20050601

• Phosphorylation of the acidic domain of Mdm2 by protein kinase CK2.

  Molecular and cellular biochemistry 20050601

• Spinal CK2 regulates nociceptive signaling in models of inflammatory pain.

  Pain 20050501

• Control of hepatitis C: a medicinal chemistry perspective.

  Journal of medicinal chemistry 20050113

• Synthesis and biological activity of 1H-benzotriazole and 1H-benzimidazole analogues--inhibitors of the NTpase/helicase of HCV and of some related Flaviviridae.

  Antiviral chemistry & chemotherapy 20050101

• Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.

  Journal of medicinal chemistry 20041202

• Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses.

  Acta poloniae pharmaceutica 20041201

• Flow-dependent regulation of endothelial Toll-like receptor 2 expression through inhibition of SP1 activity.

  Circulation research 20041001

• 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.

  Biochemical and biophysical research communications 20040903

• Expression of the Stp1 LMW-PTP and inhibition of protein CK2 display a cooperative effect on immunophilin Fpr3 tyrosine phosphorylation and Saccharomyces cerevisiae growth.

  Cellular and molecular life sciences : CMLS 20040501

• Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin.

  Biochemical and biophysical research communications 20040319

• TBBz but not TBBt discriminates between two molecular forms of CK2 in vivo and its implications.

  Biochemical and biophysical research communications 20031219

• Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA).

  The Biochemical journal 20030915

• Alternative binding modes of an inhibitor to two different kinases.

  European journal of biochemistry 20030801

• Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources.

  Biochemical and biophysical research communications 20030620

• Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses.

  European journal of biochemistry 20030401

• The role of calcium in oligogalacturonide-activated signalling in soybean cells.

  Planta 20020801

• Identification of protein kinase CK2 as a potent kinase of Epstein-Barr virus latent membrane protein 1.

  Biochemical and biophysical research communications 20020614

• Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.

  The Biochemical journal 20020515

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Toward the rational design of protein kinase casein kinase-2 inhibitors.

  Pharmacology & therapeutics 20020101

• Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole.

  Protein science : a publication of the Protein Society 20011101

• Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').

  FEBS letters 20010504