177355-84-9 | DBeQ

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$15.00	$10.00
5mg	95%	in stock	$35.00	$24.00
10mg	95%	in stock	$50.00	$35.00
25mg	95%	in stock	$60.00	$42.00
50mg	95%	in stock	$73.00	$51.00
250mg	95%	in stock	$322.00	$225.00

Description

• Catalog Number: AF00495
• Chemical Name: DBeQ
• CAS Number: 177355-84-9
• Molecular Formula: C22H20N4
• Molecular Weight: 340.42100000000005
• MDL Number: MFCD03691820
• SMILES: c1ccc(cc1)CNc1nc(NCc2ccccc2)c2c(n1)cccc2

Computed Properties

• Complexity: 403
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6
• XLogP3: 5.3

Literature

• Dendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and Progression.

  PloS one 20160101

• Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

  Journal of molecular biology 20140729

• Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.

  Nature chemical biology 20130901

• Development of p97 AAA ATPase inhibitors.

  Autophagy 20110901

• New insights into the structural requirements for pro-apoptotic agents based on 2,4-diaminoquinazoline, 2,4-diaminopyrido[2,3-d]pyrimidine and 2,4-diaminopyrimidine derivatives.

  European journal of medicinal chemistry 20110901

• New symmetrical quinazoline derivatives selectively induce apoptosis in human cancer cells.

  Cancer biology & therapy 20060701