1783-96-6 | D-Aspartic acid

Packsize	Purity	Availability	Price	Discounted Price
25g	98%	in stock	$14.00	$10.00
100g	98%	in stock	$16.00	$11.00

Description

• Catalog Number: AB00803
• Chemical Name: D-Aspartic acid
• CAS Number: 1783-96-6
• Molecular Formula: C4H7NO4
• Molecular Weight: 133.1027
• MDL Number: MFCD00063081
• SMILES: OC(=O)C[C@H](C(=O)O)N

Computed Properties

• Complexity: 133
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3
• XLogP3: -2.8

Literature

• Central administration of L- and D-aspartate attenuates stress behaviors by social isolation and CRF in neonatal chicks.

  Amino acids 20121101

• New insights on the role of free D-aspartate in the mammalian brain.

  Amino acids 20121101

• D-Aspartate acts as a signaling molecule in nervous and neuroendocrine systems.

  Amino acids 20121101

• D-Amino acids in brain neurotransmission and synaptic plasticity.

  Amino acids 20121101

• D-Amino acids in the brain and mutant rodents lacking D-amino-acid oxidase activity.

  Amino acids 20121101

• Induced synthesis of P450 aromatase and 17β-estradiol by D-aspartate in frog brain.

  The Journal of experimental biology 20121015

• Ovarian teratoma associated with anti-N-methyl D-aspartate receptor encephalitis: a report of 5 cases documenting prominent intratumoral lymphoid infiltrates.

  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 20120901

• Discriminating D-amino acid-containing peptide epimers by radical-directed dissociation mass spectrometry.

  Analytical chemistry 20120807

• Co-localisation of advanced glycation end products and D-β-aspartic acid-containing proteins in gelatinous drop-like corneal dystrophy.

  The British journal of ophthalmology 20120801

• Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.

  Brain and behavior 20120701

• Increased [³H]D-aspartate release and changes in glutamate receptor expression in the hippocampus of the mnd mouse.

  Journal of neuroscience research 20120601

• Crystallization and preliminary crystallographic analysis of D-aspartate oxidase from porcine kidney.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20120601

• Conserved asparagine residue located in binding pocket controls cation selectivity and substrate interactions in neuronal glutamate transporter.

  The Journal of biological chemistry 20120518

• Activation of glutamate transport evokes rapid glutamine release from perisynaptic astrocytes.

  The Journal of physiology 20120515

• Oostatic peptides containing D-amino acids: synthesis, oostatic activity, degradation, accumulation in ovaries and NMR study.

  Amino acids 20120501

• A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior.

  Molecular psychiatry 20120501

• Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes.

  Glia 20120501

• In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate.

  Glia 20120501

• The density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNS.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120425

• Chemical activation of a high-affinity glutamate transporter in human erythrocytes and its implications for malaria-parasite-induced glutamate uptake.

  Blood 20120412

• The expanding spectrum of clinically-distinctive, immunotherapy-responsive autoimmune encephalopathies.

  Arquivos de neuro-psiquiatria 20120401

• Regulation of [³H]d-aspartate release by the 5-F(2t)-isoprostane and its 5-epimer in isolated bovine retina.

  Neurochemical research 20120301

• Unique ionotropic receptors for D-aspartate are a target for serotonin-induced synaptic plasticity in Aplysia californica.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120101

• HPLC methods for determination of D-aspartate and N-methyl-D-aspartate.

  Methods in molecular biology (Clifton, N.J.) 20120101

• Assays of D-amino acid oxidases.

  Methods in molecular biology (Clifton, N.J.) 20120101

• Anti-N-methyl-D-aspartate-receptor encephalitis: cognitive profile in two children.

  European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20120101

• A new splice variant of the glutamate-aspartate transporter: cloning and immunolocalization of GLAST1c in rat, pig and human brains.

  Journal of chemical neuroanatomy 20120101

• Steroidogenic gene expression following D-aspartate treatment in frog testis.

  General and comparative endocrinology 20120101

• The accessibility in the external part of the TM5 of the glutamate transporter EAAT1 is conformationally sensitive during the transport cycle.

  PloS one 20120101

• Brain glycogen-new perspectives on its metabolic function and regulation at the subcellular level.

  Frontiers in neuroenergetics 20120101

• Disruption of the serotonergic system after neonatal hypoxia-ischemia in a rodent model.

  Neurology research international 20120101

• Amyloid Beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: rethinking the current strategy.

  International journal of Alzheimer's disease 20120101

• Potassium dependent regulation of astrocyte water permeability is mediated by cAMP signaling.

  PloS one 20120101

• The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain.

  Frontiers in molecular neuroscience 20120101

• Negative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprotection?

  Frontiers in molecular neuroscience 20120101

• Metabolic turnover of hydrogen sulfide.

  Frontiers in physiology 20120101

• Characterization of an antibody that recognizes peptides containing D-β-aspartyl residues.

  Molecular vision 20120101

• Identifying context-specific gene profiles of social, reproductive, and mate preference behavior in a fish species with female mate choice.

  Frontiers in neuroscience 20120101

• Synaptic regulation of the hypothalamic-pituitary-adrenal axis and its modulation by glucocorticoids and stress.

  Frontiers in cellular neuroscience 20120101

• Astrocytic adenosine A2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake.

  Journal of Alzheimer's disease : JAD 20120101

• Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia.

  Parkinson's disease 20120101

• Increased D-aspartate brain content rescues hippocampal age-related synaptic plasticity deterioration of mice.

  Neurobiology of aging 20111201

• Hippocampal AMPA autoreceptors positively coupled to NMDA autoreceptors traffic in a constitutive manner and undergo adaptative changes following enriched environment training.

  Neuropharmacology 20111201

• Neuron-glia interactions in glutamatergic neurotransmission: roles of oxidative and glycolytic adenosine triphosphate as energy source.

  Journal of neuroscience research 20111201

• Higher free D-aspartate and N-methyl-D-aspartate levels prevent striatal depotentiation and anticipate L-DOPA-induced dyskinesia.

  Experimental neurology 20111201

• Emerging Pharmacological Properties of Cholinergic Synaptic Transmission: Comparison between Mammalian and Insect Synaptic and Extrasynaptic Nicotinic Receptors.

  Current neuropharmacology 20111201

• Persistent increase of D-aspartate in D-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay.

  Neurobiology of aging 20111101

• Simultaneous determination of D-aspartic acid and D-glutamic acid in rat tissues and physiological fluids using a multi-loop two-dimensional HPLC procedure.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• Determination of D-aspartate N-methyltransferase activity in the starfish by direct analysis of N-methyl-D-aspartate with high-performance liquid chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• D-Aspartate--an important bioactive substance in mammals: a review from an analytical and biological point of view.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• Effect of D-aspartate uptake on uncoupling protein-3 and α-tubulin expressions in rat Harderian gland.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• D-Asp: a new player in reproductive endocrinology of the amphibian Rana esculenta.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y(1) receptors.

  British journal of pharmacology 20111101

• HPLC determination of the distribution of D-amino acids and effects of ecdysis on alanine racemase activity in kuruma prawn Marsupenaeus japonicus.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• UV B-irradiation enhances the racemization and isomerizaiton of aspartyl residues and production of Nε-carboxymethyl lysine (CML) in keratin of skin.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• D-Amino acids in aged proteins: analysis and biological relevance.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• Computational investigation of the substrate recognition mechanism of protein D-aspartyl (L-isoaspartyl) O-methyltransferase by docking and molecular dynamics simulation studies and application to interpret size exclusion chromatography data.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• D-Amino acid metabolism in mammals: biosynthesis, degradation and analytical aspects of the metabolic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• Increased excitatory amino acid transport into murine prion protein knockout astrocytes cultured in vitro.

  Glia 20111101

• Signaling through EAAT-1/GLAST in cultured Bergmann glia cells.

  Neurochemistry international 20111101

• Comparison of molecular dynamics simulation methods for amyloid β(1-42) monomers containing D-aspartic acid residues for predicting retention times in chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• Substrate stereoselectivity of mammalian D-aspartyl endopeptidase.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• A sensitive and simple ultra-high-performance-liquid chromatography-tandem mass spectrometry based method for the quantification of D-amino acids in body fluids.

  Journal of chromatography. A 20111007

• Physiological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica neurons.

  Journal of neurophysiology 20111001

• Post-traumatic stress disorder: the neurobiological impact of psychological trauma.

  Dialogues in clinical neuroscience 20110901

• Substrate specificity of the aspartate:alanine antiporter (AspT) of Tetragenococcus halophilus in reconstituted liposomes.

  The Journal of biological chemistry 20110819

• Synthesis of alanine-based colorimetric sensors and enantioselective recognition of aspartate and malate anions.

  Organic & biomolecular chemistry 20110807

• Pain management in patients with cancer: focus on opioid analgesics.

  Current pain and headache reports 20110801

• Immunohistochemical localization of D-aspartate oxidase in porcine peripheral tissues.

  Amino acids 20110701

• Enriched environment and physical activity reduce microglia and influence the fate of NG2 cells in the amygdala of adult mice.

  Cell and tissue research 20110701

• Correction of furosemide-induced magnesium deficiency with different stereoisomers of organic magnesium salts: a comparative study.

  Bulletin of experimental biology and medicine 20110701

• The role of the cerebellum in schizophrenia: from cognition to molecular pathways.

  Clinics (Sao Paulo, Brazil) 20110601

• Cellular localization of glutamate and glutamine metabolism and transport pathways in the rat ciliary epithelium.

  Investigative ophthalmology & visual science 20110518

• Quantitative study of NPY-expressing GABAergic neurons and axons in rat spinal dorsal horn.

  The Journal of comparative neurology 20110415

• Fast and reversible stimulation of astrocytic glycolysis by K+ and a delayed and persistent effect of glutamate.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110323

• D-Aspartic acid is a novel endogenous neurotransmitter.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110301

• Expression of multiple glutamate transporter splice variants in the rodent testis.

  Asian journal of andrology 20110301

• Specificity of the volume-activated amino acid efflux pathway in cultured human breast cancer cells.

  General physiology and biophysics 20110301

• Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian D-aspartate oxidase.

  Amino acids 20110201

• Visible wavelength spectrophotometric assays of L-aspartate and D-aspartate using hyperthermophilic enzyme systems.

  Analytical biochemistry 20110201

• Functional NMDA receptors with atypical properties are expressed in podocytes.

  American journal of physiology. Cell physiology 20110101

• Distribution of D-aspartate-immunopositive cells in the ganglion cell layer of adult rat retina.

  Ophthalmic research 20110101

• MicroRNAs differentially expressed in postnatal aortic development downregulate elastin via 3' UTR and coding-sequence binding sites.

  PloS one 20110101

• Time course analysis of gene expression identifies multiple genes with differential expression in patients with in-stent restenosis.

  BMC medical genomics 20110101

• Link between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses.

  International journal of Alzheimer's disease 20110101

• Galanin-immunoreactivity identifies a distinct population of inhibitory interneurons in laminae I-III of the rat spinal cord.

  Molecular pain 20110101

• Proximity of transmembrane segments 5 and 8 of the glutamate transporter GLT-1 inferred from paired cysteine mutagenesis.

  PloS one 20110101

• Postnatal development of dendrodendritic inhibition in the Mammalian olfactory bulb.

  Frontiers in cellular neuroscience 20110101

• Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.

  Journal of neuroinflammation 20110101

• Immunohistochemical localization of endogenous D-Aspartate in the marine brown Alga Sargassum fusiforme.

  Bioscience, biotechnology, and biochemistry 20110101

• Ketamine-induced oscillations in the motor circuit of the rat basal ganglia.

  PloS one 20110101

• A role for glutamate transporters in the regulation of insulin secretion.

  PloS one 20110101

• Histaminergic mechanisms for modulation of memory systems.

  Neural plasticity 20110101

• Dynorphin is expressed primarily by GABAergic neurons that contain galanin in the rat dorsal horn.

  Molecular pain 20110101

• N-methyl D-aspartate receptor encephalitis: A new addition to the spectrum of autoimmune encephalitis.

  Annals of Indian Academy of Neurology 20110101

• Slice orientation and muscarinic acetylcholine receptor activation determine the involvement of N-methyl D-aspartate receptor subunit GluN2B in hippocampal area CA1 long-term depression.

  Molecular brain 20110101

• Preventive analgesia: Effect of small dose of ketamine on morphine requirement after renal surgery.

  Journal of anaesthesiology, clinical pharmacology 20110101

• Co-induction of cyclooxygenase-2 [correction of cyclooxyenase-2] and early growth response gene (Egr-1) in spinal cord in a clinical model of persistent inflammation and hyperalgesia.

  Molecular pain 20110101

• Chronic stress induces sex-specific alterations in methylation and expression of corticotropin-releasing factor gene in the rat.

  PloS one 20110101

• Comparative Structures and Evolution of Vertebrate Carboxyl Ester Lipase (CEL) Genes and Proteins with a Major Role in Reverse Cholesterol Transport.

  Cholesterol 20110101

• Dynamic development of the first synapse impinging on adult-born neurons in the olfactory bulb circuit.

  Neural systems & circuits 20110101

• Regulation of adult neurogenesis in the hippocampus by stress, acetylcholine and dopamine.

  Journal of natural science, biology, and medicine 20110101

• An introduction to sphingolipid metabolism and analysis by new technologies.

  Neuromolecular medicine 20101201

• Synthesis, accumulation, and release of d-aspartate in the Aplysia californica CNS.

  Journal of neurochemistry 20101201

• Age estimation by amino acid racemization in human teeth.

  Journal of forensic sciences 20101101

• AMPA- and P2X7-receptor-mediated facilitation of [3H]D-aspartate release from nerve terminals isolated from the rat caudal brainstem.

  Neurochemistry international 20101101

• D-aspartate oxidase localisation in pituitary and pineal glands of the female pig.

  Journal of neuroendocrinology 20101101

• On the catalytic role of the active site residue E121 of E. coli L-aspartate oxidase.

  Biochimie 20101001

• Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment.

  Biochimie 20101001

• Distribution of radiolabeled l-glutamate and d-aspartate from blood into peripheral tissues in naive rats: significance for brain neuroprotection.

  Biochemical and biophysical research communications 20100903

• Activation of a peroxisomal Pichia pastoris D-amino acid oxidase, which uses d-alanine as a preferred substrate, depends on pyruvate carboxylase.

  FEMS yeast research 20100901

• A locus for an auditory processing deficit and language impairment in an extended pedigree maps to 12p13.31-q14.3.

  Genes, brain, and behavior 20100801

• D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices.

  Neuroscience letters 20100712

• A conserved methionine residue controls the substrate selectivity of a neuronal glutamate transporter.

  The Journal of biological chemistry 20100709

• Changes in D-aspartate ion currents in the Aplysia nervous system with aging.

  Brain research 20100709

• Inhibition of brown adipose tissue thermogenesis by neurons in the ventrolateral medulla and in the nucleus tractus solitarius.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100701

• Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100701

• Interaction of PGHS-2 and glutamatergic mechanisms controlling the ovine fetal hypothalamus-pituitary-adrenal axis.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100701

• HIV gp41 engages gC1qR on CD4+ T cells to induce the expression of an NK ligand through the PIP3/H2O2 pathway.

  PLoS pathogens 20100701

• Methionine choline reverses lead-induced cognitive and N-methyl-d-aspartate receptor subunit 1 deficits.

  Toxicology 20100604

• Growth hormone rescues hippocampal synaptic function after sleep deprivation.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100601

• Pax2 is expressed in a subpopulation of Müller cells in the central chick retina.

  Developmental dynamics : an official publication of the American Association of Anatomists 20100601

• Collapse of homochirality of amino acids in proteins from various tissues during aging.

  Chemistry & biodiversity 20100601

• Influence of oxidative stress on D-aspartyl endopeptidase activity.

  Chemistry & biodiversity 20100601

• Molecular-dynamics simulations for amyloid beta 1-42 monomer with D-aspartic acid residues using continuous solvent.

  Chemistry & biodiversity 20100601

• Accumulation of D-beta-aspartic acid-containing proteins in age-related ocular diseases.

  Chemistry & biodiversity 20100601

• Structural consideration of mammalian D-aspartyl endopeptidase.

  Chemistry & biodiversity 20100601

• Oxidative stress induces the formation of D-aspartyl residues in the elastin mimic peptides.

  Chemistry & biodiversity 20100601

• Comparative characterization of three D-aspartate oxidases and one D-amino acid oxidase from Caenorhabditis elegans.

  Chemistry & biodiversity 20100601

• D-aspartate oxidase: the sole catabolic enzyme acting on free D-aspartate in mammals.

  Chemistry & biodiversity 20100601

• Effects of D-aspartate treatment on D-aspartate oxidase, superoxide dismutase, and caspase 3 activities in frog (Rana esculenta) tissues.

  Chemistry & biodiversity 20100601

• Thyroid hormones and D-aspartic acid, D-aspartate oxidase, D-aspartate racemase, H2O2, and ROS in rats and mice.

  Chemistry & biodiversity 20100601

• Translational neuroimaging research in pediatric obsessive-compulsive disorder.

  Dialogues in clinical neuroscience 20100601

• Evidence for the involvement of D-aspartic acid in learning and memory of rat.

  Amino acids 20100501

• Transportable and non-transportable inhibitors of L-glutamate uptake produce astrocytic stellation and increase EAAT2 cell surface expression.

  Neurochemical research 20100501

• Protective effects of the pyrolyzates derived from bamboo against neuronal damage and hematoaggregation.

  Journal of ethnopharmacology 20100421

• DL-Aspartic acid administration improves semen quality in rabbit bucks.

  Animal reproduction science 20100401

• Magnesium for treatment-resistant depression: a review and hypothesis.

  Medical hypotheses 20100401

• Muscarinic receptor stimulation of D-aspartate uptake into human SH-SY5Y neuroblastoma cells is attenuated by hypoosmolarity.

  The Journal of pharmacology and experimental therapeutics 20100401

• D-Aspartic acid induced oxidative stress and mitochondrial dysfunctions in testis of prepubertal rats.

  Amino acids 20100301

• Distribution of free D-aspartic acid and D-aspartate oxidase in frog Rana esculenta tissues.

  Journal of experimental zoology. Part A, Ecological genetics and physiology 20100301

• Inhibitory effects of (2S, 3S)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (TFB-TBOA) on the astrocytic sodium responses to glutamate.

  Brain research 20100226

• Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis.

  Proceedings of the National Academy of Sciences of the United States of America 20100216

• The maturation of oocyte follicular epithelium of Podarcis s. sicula is promoted by D-aspartic acid.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20100201

• Activation of presynaptic alpha7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study.

  British journal of pharmacology 20100201

• Structural remodeling of gray matter astrocytes in the neonatal pig brain after hypoxia/ischemia.

  Glia 20100115

• D-Aspartate binding sites in rat Harderian gland.

  Amino acids 20100101

• Glutamate spillover augments GABA synthesis and release from axodendritic synapses in rat hippocampus.

  Hippocampus 20100101

• Effects of extracellular pH reductions on [(3)H]D-aspartate and [(3)H]noradrenaline release by presynaptic nerve terminals isolated from rat cerebral cortex.

  Journal of neural transmission (Vienna, Austria : 1996) 20100101

• Linking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans.

  BMC systems biology 20100101

• Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.

  PloS one 20100101

• The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors.

  The open medicinal chemistry journal 20100101

• Predicted class-I aminoacyl tRNA synthetase-like proteins in non-ribosomal peptide synthesis.

  Biology direct 20100101

• Age and diet affect gene expression profiles in canine liver tissue.

  PloS one 20100101

• Trace eyeblink conditioning is impaired in α7 but not in β2 nicotinic acetylcholine receptor knockout mice.

  Frontiers in behavioral neuroscience 20100101

• Characterisation of the expression of NMDA receptors in human astrocytes.

  PloS one 20100101

• The emerging chondrocyte channelome.

  Frontiers in physiology 20100101

• Thrombin potentiates D-aspartate efflux from cultured astrocytes under conditions of K+ homeostasis disruption.

  Journal of neurochemistry 20091201

• Regulation of [3H] D-aspartate release from mammalian isolated retinae by hydrogen sulfide.

  Neurochemical research 20091101

• Angelman syndrome: current understanding and research prospects.

  Epilepsia 20091101

• Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells.

  Archives of biochemistry and biophysics 20091015

• D-Aspartate affects secretory activity in rat Harderian gland: molecular mechanism and functional significance.

  Amino acids 20091001

• Distribution of glutamate transporter GLAST in membranes of cultured astrocytes in the presence of glutamate transport substrates and ATP.

  Neurochemical research 20091001

• Rottlerin inhibits (Na+, K+)-ATPase activity in brain tissue and alters D-aspartate dependent redistribution of glutamate transporter GLAST in cultured astrocytes.

  Neurochemical research 20091001

• Quantitative analysis of the expression of the glutamate-aspartate transporter and identification of functional glutamate uptake reveal a role for cochlear fibrocytes in glutamate homeostasis.

  Neuroscience 20090915

• Release of [3H]D-aspartate induced by K+-stimulation is increased in the cervical spinal cord of the wobbler mouse: a model of motor neuron disease.

  Neurochemistry international 20090901

• Quantification of D-Asp and D-Glu in rat brain and human cerebrospinal fluid by microchip electrophoresis.

  Journal of separation science 20090901

• L-aspartate as an amino acid neurotransmitter: mechanisms of the depolarization-induced release from cerebrocortical synaptosomes.

  Journal of neurochemistry 20090801

• Axonal release of glutamate analog, d-2,3-3H-Aspartic acid and l-14C-proline from segments of sciatic nerve following electrical and magnetic stimulation.

  Neuroscience letters 20090710

• Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity.

  Glia 20090701

• Immunohistochemical localisation of D-beta-aspartic acid in pingueculae.

  The British journal of ophthalmology 20090701

• Immunohistochemical localisation of D-beta-aspartic acid-containing proteins in climatic droplet keratopathy.

  The British journal of ophthalmology 20090701

• HPLC determination of acidic D-amino acids and their N-methyl derivatives in biological tissues.

  Biomedical chromatography : BMC 20090601

• Neuropeptide S selectively inhibits the release of 5-HT and noradrenaline from mouse frontal cortex nerve endings.

  British journal of pharmacology 20090601

• The reproductive activity in the testis of Podarcis s. sicula involves D-aspartic acid: a study on c-kit receptor protein, tyrosine kinase activity and PCNA protein during annual sexual cycle.

  General and comparative endocrinology 20090501

• Localization of D-β-aspartyl residue-containing proteins in various tissues.

  International journal of molecular sciences 20090501

• Activation of pre-synaptic M-type K+ channels inhibits [3H]D-aspartate release by reducing Ca2+ entry through P/Q-type voltage-gated Ca2+ channels.

  Journal of neurochemistry 20090401

• Demequina lutea sp. nov., isolated from a high Arctic permafrost soil.

  International journal of systematic and evolutionary microbiology 20090401

• Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells.

  Environmental health perspectives 20090401

• Blockade of glutamate transporters facilitates cerebellar synaptic long-term depression.

  Neuroreport 20090325

• Excitatory amino acids in the forebrain of the Naples high-excitability rats: neurochemical and behavioural effects of subchronic D-aspartate and its diethyl ester prodrug.

  Behavioural brain research 20090302

• Elevated forebrain excitatory L-glutamate, L-aspartate and D-aspartate in the Naples high-excitability rats.

  Behavioural brain research 20090302

• Metabolic stress-like condition can be induced by prolonged strenuous exercise in athletes.

  Upsala journal of medical sciences 20090301

• The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats.

  PLoS genetics 20090301

• Recent advances in the treatment of amyotrophic lateral sclerosis. Emphasis on kynurenine pathway inhibitors.

  Central nervous system agents in medicinal chemistry 20090301

• No association between the D-aspartate oxidase locus and schizophrenia.

  Psychiatric genetics 20090201

• Molecular cloning and expression in Escherichia coli of an active fused Zea mays L. D-amino acid oxidase.

  Biochemistry. Biokhimiia 20090201

• Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents.

  Neuroscience 20090112

• Memantine (Namenda) for neuropathic pain.

  The American journal of hospice & palliative care 20090101

• Gene expression patterns in hypoxic and post-hypoxic adult rat retina with special reference to the NMDA receptor and its interactome.

  Molecular vision 20090101

• The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov.

  PloS one 20090101

• NMDA receptor stimulation induces reversible fission of the neuronal endoplasmic reticulum.

  PloS one 20090101

• Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes.

  Molecular pain 20090101

• Functional imaging of stimulus convergence in amygdalar neurons during Pavlovian fear conditioning.

  PloS one 20090101

• Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia.

  BMC neuroscience 20090101

• Enhancing m currents: a way out for neuropathic pain?

  Frontiers in molecular neuroscience 20090101

• NMDA receptor hypofunction leads to generalized and persistent aberrant gamma oscillations independent of hyperlocomotion and the state of consciousness.

  PloS one 20090101

• Signals, synapses, and synthesis: how new proteins control plasticity.

  Frontiers in neural circuits 20090101

• The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats.

  Reproductive biology and endocrinology : RB&E 20090101

• The functional consequences of cortical circuit abnormalities on gamma oscillations in schizophrenia: insights from computational modeling.

  Frontiers in human neuroscience 20090101

• NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia.

  Progress in brain research 20090101

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  Reviews in the neurosciences 20090101

• RANTES modulates the release of glutamate in human neocortex.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20081119

• A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2).

  Neuroscience 20081111

• L-glutamate enhances methylmercury toxicity by synergistically increasing oxidative stress.

  Journal of pharmacological sciences 20081101

• Glutamate transporter-mediated glutamate secretion in the mammalian pineal gland.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20081022

• D-aspartate prevents corticostriatal long-term depression and attenuates schizophrenia-like symptoms induced by amphetamine and MK-801.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20081008

• Functional glutamate transport in rodent optic nerve axons and glia.

  Glia 20080901

• Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings.

  Neuropharmacology 20080901

• Abundance and activity of Chloroflexi-type SAR202 bacterioplankton in the meso- and bathypelagic waters of the (sub)tropical Atlantic.

  Environmental microbiology 20080701

• Oxidative alterations induced by D-aspartic acid in prepubertal rat testis in vitro: a mechanistic study.

  Theriogenology 20080701

• Low-affinity excitatory amino acid uptake in hippocampal astrocytes: a possible role of Na+/dicarboxylate cotransporters.

  Glia 20080701

• The effects of acute intraocular pressure elevation on rat retinal glutamate transport.

  Acta ophthalmologica 20080601

• Hyperactive mutants of mouse D-aspartate oxidase: mutagenesis of the active site residue serine 308.

  Amino acids 20080601

• Collagen turnover in normal and degenerate human intervertebral discs as determined by the racemization of aspartic acid.

  The Journal of biological chemistry 20080404

• D-Aspartate and D-aspartate oxidase show selective and developmentally dynamic localization in mouse retina.

  Experimental eye research 20080401

• [Biochemical behavior and function of free D-aspartate in the mammalian body].

  Seikagaku. The Journal of Japanese Biochemical Society 20080401

• [Racemization of aspartyl residues of proteins in age-related disease].

  Seikagaku. The Journal of Japanese Biochemical Society 20080401

• [Distribution of free D-amino acids and their biosyntheses and physiological roles in aquatic animals].

  Seikagaku. The Journal of Japanese Biochemical Society 20080401

• In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080301

• Structure of aspartate racemase complexed with a dual substrate analogue, citric acid, and implications for the reaction mechanism.

  Proteins 20080301

• Cloning and functional characterization of Arabidopsis thaliana D-amino acid aminotransferase--D-aspartate behavior during germination.

  The FEBS journal 20080301

• Treatment of COPD: a matrix perspective.

  International journal of chronic obstructive pulmonary disease 20080301

• Increased levels of d-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility.

  Molecular and cellular neurosciences 20080201

• Na(+)-Ca(2+) cosignaling in the stimulation of the glucose transporter GLUT1 in cultured astrocytes.

  Glia 20080101

• Latitudinal trends of Crenarchaeota and Bacteria in the meso- and bathypelagic water masses of the Eastern North Atlantic.

  Environmental microbiology 20080101

• [Potassium magnesium homeostasis: physiology, pathophysiology, clinical consequences of deficiency and pharmacological correction].

  Uspekhi fiziologicheskikh nauk 20080101

• Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme.

  BMC biochemistry 20080101

• Opposing effects of D-aspartic acid and nitric oxide on tuning of testosterone production in mallard testis during the reproductive cycle.

  Reproductive biology and endocrinology : RB&E 20080101

• Altered Excitatory-Inhibitory Balance in the NMDA-Hypofunction Model of Schizophrenia.

  Frontiers in molecular neuroscience 20080101

• Comparison of [(3)H]-(2S,4R)-4-methylglutamate and [(3)H]D-aspartate as ligands for binding and autoradiographic analyses of glutamate transporters.

  Neurochemistry international 20071201

• Reproductive implication of D-aspartic acid in human pre-ovulatory follicular fluid.

  Human reproduction (Oxford, England) 20071201

• [Role of isomerized protein repair enzyme, PIMT, in cellular functions].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20071201

• Upregulation of elastin expression in constrictive bronchiolitis obliterans.

  International journal of chronic obstructive pulmonary disease 20071201

• Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by 'pathologically' elevated extraterminal K+ concentrations.

  Journal of neurochemistry 20071101

• Adult astroglia is competent for Na+/Ca2+ exchanger-operated exocytotic glutamate release triggered by mild depolarization.

  Journal of neurochemistry 20071101

• Ammonium scanning in an enzyme active site. The chiral specificity of aspartyl-tRNA synthetase.

  The Journal of biological chemistry 20071019

• Cytoskeletal anchoring of GLAST determines susceptibility to brain damage: an identified role for GFAP.

  The Journal of biological chemistry 20071005

• Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia.

  Biological psychiatry 20071001

• Accumulation of altered aspartyl residues in erythrocyte proteins from patients with Down's syndrome.

  The FEBS journal 20071001

• Effect of the L- or D-aspartate on ecto-5'nucleotidase activity and on cellular viability in cultured neurons: participation of the adenosine A(2A) receptors.

  Amino acids 20070901

• Localization of D-beta-aspartic acid-containing proteins in human eyes.

  Investigative ophthalmology & visual science 20070901

• Ethanolamine and related amino alcohols increase basal and evoked release of [3H]-D-aspartic acid from synaptosomes by enhancing the filling of synaptic vesicles.

  European journal of pharmacology 20070702

• Evidence that alpha7 nicotinic receptor modulates glutamate release from mouse neocortical gliosomes.

  Neurochemistry international 20070701

• Exocytosis of D-aspartate from INS-1E clonal beta cells.

  Biological & pharmaceutical bulletin 20070701

• Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytes.

  Biochemical pharmacology 20070615

• Glutamate transporter GLAST/EAAT1 directs cell surface expression of FXYD2/gamma subunit of Na, K-ATPase in human fetal astrocytes.

  Neurochemistry international 20070601

• D-amino acid formation in sterilized alkali-treated olives.

  Journal of agricultural and food chemistry 20070502

• Membrane currents and cytoplasmic sodium transients generated by glutamate transport in Bergmann glial cells.

  Pflugers Archiv : European journal of physiology 20070501

• Overproduction and characterization of a recombinant D-amino acid oxidase from Arthrobacter protophormiae.

  Applied microbiology and biotechnology 20070401

• Can levorphanol be used like methadone for intractable refractory pain?

  Journal of palliative medicine 20070401

• Age-dependent changes in the racemisation ratio of aspartic acid in human alveolar bone.

  Archives of oral biology 20070301

• Investigating the role of active site residues of Rhodotorula gracilis D-amino acid oxidase on its substrate specificity.

  Biochimie 20070301

• Serotonin modulation of cell excitability and of [3H]GABA and [3H]D-aspartate efflux in primary cultures of rat cortical neurons.

  Neuropharmacology 20070301

• Functional and structural characterization of D-aspartate oxidase from porcine kidney: non-Michaelis kinetics due to substrate activation.

  Journal of biochemistry 20070301

• D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role.

  Brain research reviews 20070201

• Protein kinase C-mediated modulation of glutamate transporter activity in rat retina.

  Current eye research 20070201

• Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.

  Nature 20070125

• D-Aspartic acid and nitric oxide as regulators of androgen production in boar testis.

  Theriogenology 20070115

• Biochemistry of D-aspartate in mammalian cells.

  Amino acids 20070101

• Effects of D-amino acids on lipoperoxidation in rat liver and kidney mitochondria.

  Amino acids 20070101

• Advances in immunoanalysis of single cells with capillary electrophoresis.

  Analytical and bioanalytical chemistry 20070101

• Isolation and characterization of mammalian D-aspartyl endopeptidase.

  Amino acids 20070101

• Caenorhabditis elegans has two genes encoding functional d-aspartate oxidases.

  The FEBS journal 20070101

• D-aspartic acid and L-amino acids in the neural system of the amphioxus Branchiostoma lanceolatum.

  Amino acids 20070101

• Is there a correlation between age and D-aspartic acid in human knee cartilage?

  Amino acids 20070101

• Involvement of D-Asp in P450 aromatase activity and estrogen receptors in boar testis.

  Amino acids 20070101

• Modulation of an AMPA-like glutamate receptor (SqGluR) gating by L- and D-aspartic acids.

  Amino acids 20070101

• Molecular cloning of a cDNA encoding mouse D-aspartate oxidase and functional characterization of its recombinant proteins by site-directed mutagenesis.

  Amino acids 20070101

• Species differences in brain gene expression profiles associated with adult behavioral maturation in honey bees.

  BMC genomics 20070101

• Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia.

  Theoretical biology & medical modelling 20070101

• N-methyl-D-aspartic acid (NMDA) in the nervous system of the amphioxus Branchiostoma lanceolatum.

  BMC neuroscience 20070101

• 5-Hydroxytryptamine-mediated increase in glutamate uptake by the leech giant glial cell.

  Glia 20061201

• Biochemistry of amino acid racemization and clinical application to musculoskeletal disease.

  Clinical biochemistry 20061201

• Identification of an essential gene responsible for D-Asp incorporation in the Lactococcus lactis peptidoglycan crossbridge.

  Molecular microbiology 20061201

• Modulation of the function of presynaptic alpha7 and non-alpha7 nicotinic receptors by the tryptophan metabolites, 5-hydroxyindole and kynurenate in mouse brain.

  British journal of pharmacology 20061101

• The substrate specificity of a neuronal glutamate transporter is determined by the nature of the coupling ion.

  Journal of neurochemistry 20061001

• Behavioural alterations in male mice lacking the gene for D-aspartate oxidase.

  Behavioural brain research 20060810

• Occurrence of D-aspartate in the harderian gland of Podarcis s. sicula and its effect on gland secretion.

  Journal of experimental zoology. Part A, Comparative experimental biology 20060801

• Cryptic expression of functional glutamate transporters in the developing rodent brain.

  Neuron glia biology 20060801

• Metabolic properties of astrocytes differentiated from rat neurospheres.

  Brain research 20060726

• The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060719

• Taurine attenuates D-[3H]aspartate release evoked by depolarization in ischemic corticostriatal slices.

  Brain research 20060712

• Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport.

  Glia 20060701

• A physiological mechanism to regulate D-aspartic acid and NMDA levels in mammals revealed by D-aspartate oxidase deficient mice.

  Gene 20060607

• Immunohistochemical localization of D-aspartate in islets of Langerhans.

  Biological & pharmaceutical bulletin 20060601

• The influence of manufacture on the free D-amino acid content of Cheddar cheese.

  Amino acids 20060601

• Differential analysis of D-beta-Asp-containing proteins found in normal and infrared irradiated rabbit lens.

  Biochemical and biophysical research communications 20060526

• Engineering the substrate specificity of porcine kidney D-amino acid oxidase by mutagenesis of the 'active-site lid'.

  Journal of biochemistry 20060501

• Aslfm, the D-aspartate ligase responsible for the addition of D-aspartic acid onto the peptidoglycan precursor of Enterococcus faecium.

  The Journal of biological chemistry 20060428

• D-aspartate and reproductive activity in sheep.

  Theriogenology 20060415

• D-Aspartate as a putative cell-cell signaling molecule in the Aplysia californica central nervous system.

  Journal of neurochemistry 20060401

• D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060308

• Mini-alphaB-crystallin: a functional element of alphaB-crystallin with chaperone-like activity.

  Biochemistry 20060307

• The presence of high concentrations of free D-amino acids in human saliva.

  Life sciences 20060306

• D-aspartic acid in the nervous system of Aplysia limacina: possible role in neurotransmission.

  Journal of cellular physiology 20060301

• Mercuric chloride inhibits the in vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells.

  Biological trace element research 20060301

• Confirmation of peak assignments in capillary electrophoresis using immunoprecipitation. Application to D-aspartate measurements in neurons.

  Journal of chromatography. A 20060217

• Cytoplasmic localization and efflux of endogenous D-aspartate in pheochromocytoma 12 cells.

  Archives of biochemistry and biophysics 20060215

• Oxidative metabolism in cultured rat astroglia: effects of reducing the glucose concentration in the culture medium and of D-aspartate or potassium stimulation.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20060201

• Glia re-sealed particles freshly prepared from adult rat brain are competent for exocytotic release of glutamate.

  Journal of neurochemistry 20060201

• Endogenous testicular D-aspartic acid regulates gonadal aromatase activity in boar.

  Journal of endocrinological investigation 20060201

• Release of tritiated agmatine from spinal synaptosomes.

  Neuroreport 20060123

• High glucose and diabetes increase the release of [3H]-D-aspartate in retinal cell cultures and in rat retinas.

  Neurochemistry international 20060101

• High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes.

  Neurochemistry international 20060101

• Domain-based small molecule binding site annotation.

  BMC bioinformatics 20060101

• EAAC1 is expressed in rat and human prostate epithelial cells; functions as a high-affinity L-aspartate transporter; and is regulated by prolactin and testosterone.

  BMC biochemistry 20060101

• Free amino acids in the nervous system of the amphioxus Branchiostoma lanceolatum. A comparative study.

  International journal of biological sciences 20060101

• Inhibition of potassium- and ischemia-evoked [3H] D-aspartate release from isolated bovine retina by cannabinoids.

  Current eye research 20060101

• [Comparative study of the antiarrhythmic activity of magnesium aspartate L-, D- and DL-aspartate stereoisomers].

  Kardiologiia 20060101

• S1 gene sequence analysis of a nephropathogenic strain of avian infectious bronchitis virus in Egypt.

  Virology journal 20060101

• Occurrence and functions of free D-aspartate and its metabolizing enzymes.

  Chemical record (New York, N.Y.) 20060101

• Mathematical modeling of intracellular signaling pathways.

  BMC neuroscience 20060101

• The in vitro uptake of glutamate in GLAST and GLT-1 transfected mutant CHO-K1 cells is inhibited by manganese.

  Biological trace element research 20051201

• Endocrine roles of D-aspartic acid in the testis of lizard Podarcis s. sicula.

  The Journal of endocrinology 20051201

• Subcellular analysis of D-aspartate.

  Analytical chemistry 20051115

• Pharmacological consequences of oxidative stress in ocular tissues.

  Mutation research 20051111

• Ncm-D-aspartate: a novel caged D-aspartate suitable for activation of glutamate transporters and N-methyl-D-aspartate (NMDA) receptors in brain tissue.

  Neuropharmacology 20051101

• Physiological role of D-aspartate oxidase in the assimilation and detoxification of D-aspartate in the yeast Cryptococcus humicola.

  Yeast (Chichester, England) 20051101

• An application of D- and L-aspartic acid mixtures as standard specimens for the chronological age estimation.

  Journal of forensic sciences 20051101

• Glutamate release induced by activation of glycine and GABA transporters in spinal cord is enhanced in a mouse model of amyotrophic lateral sclerosis.

  Neurotoxicology 20051001

• Characterization of new D-beta-aspartate-containing proteins in a lens-derived cell line.

  Biochemical and biophysical research communications 20050909

• Effects of glutamate transporter and receptor ligands on neuronal glutamate uptake.

  Neuroscience research 20050901

• Free D-aspartate in mammals.

  Biological & pharmaceutical bulletin 20050901

• Physiological function and metabolism of free D-alanine in aquatic animals.

  Biological & pharmaceutical bulletin 20050901

• Modification of the synaptic glutamate turnover in the hippocampal tissue exposed to low-frequency, pulsed magnetic fields.

  Brain research 20050809

• D-aspartate modulates transcriptional activity in Harderian gland of frog, Rana esculenta: Morphological and molecular evidence.

  Journal of cellular physiology 20050801

• Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2B.

  The Journal of biological chemistry 20050715

• Retinal bipolar cell input mechanisms in giant danio. III. ON-OFF bipolar cells and their color-opponent mechanisms.

  Journal of neurophysiology 20050701

• Substrate-induced modulation of glutamate uptake in human platelets.

  British journal of pharmacology 20050701

• D-amino acids in the central nervous system in health and disease.

  Molecular genetics and metabolism 20050701

• Presynaptic alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate [3H]d-aspartate release from rat frontal cortex in vitro.

  Neuropharmacology 20050701

• D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons.

  British journal of pharmacology 20050601

• Chronic nicotine differentially affects the function of nicotinic receptor subtypes regulating neurotransmitter release.

  Journal of neurochemistry 20050601

• A novel L-glutamate transporter inhibitor reveals endogenous D-aspartate homeostasis in rat pheochromocytoma MPT1 cells.

  Life sciences 20050506

• Activation of gamma-aminobutyric acid GAT-1 transporters on glutamatergic terminals of mouse spinal cord mediates glutamate release through anion channels and by transporter reversal.

  Journal of neuroscience research 20050501

• Effects of hypoxic and osmotic stress on the free D-aspartate level in the muscle of blood shell Scapharca broughtonii.

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  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20050501

• Esterification of Escherichia coli tRNAs with D-histidine and D-lysine by aminoacyl-tRNA synthetases.

  Bioscience, biotechnology, and biochemistry 20050501

• Synthesis and characterization of 4-methoxy-7-nitroindolinyl-D-aspartate, a caged compound for selective activation of glutamate transporters and N-methyl-D-aspartate receptors in brain tissue.

  Biochemistry 20050308

• Cephalopod vision involves dicarboxylic amino acids: D-aspartate, L-aspartate and L-glutamate.

  The Biochemical journal 20050301

• Racemization in enamel among different types of teeth from the same individual.

  International journal of legal medicine 20050301

• Calcium regulates the mode of exocytosis induced by hypotonic shock in isolated neuronal presynaptic endings.

  Neurochemistry international 20050201

• Glutamate transport by retinal Muller cells in glutamate/aspartate transporter-knockout mice.

  Glia 20050115

• Retinal bipolar cell input mechanisms in giant danio. II. Patch-clamp analysis of on bipolar cells.

  Journal of neurophysiology 20050101

• Glycine taken up through GLYT1 and GLYT2 heterotransporters into glutamatergic axon terminals of mouse spinal cord elicits release of glutamate by homotransporter reversal and through anion channels.

  Biochemical pharmacology 20050101

• Glutamate uptake by rat brain astroglia incubated in human cerebrospinal fluid.

  Medical science monitor : international medical journal of experimental and clinical research 20050101

• Regulation of glutamate transporters in astrocytes: evidence for a relationship between transporter expression and astrocytic phenotype.

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• Dual effect of isoprostanes on the release of [3H]D-aspartate from isolated bovine retinae: role of arachidonic acid metabolites.

  Neurochemical research 20050101

• Vitamin A deficiency alters the pulmonary parenchymal elastic modulus and elastic fiber concentration in rats.

  Respiratory research 20050101

• In vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells is inhibited by the ethylmercury-containing preservative thimerosal.

  Biological trace element research 20050101

• [Lanthanides induce neurotransmitter release from the vesicular pool in rat brain synaptosomes].

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• Potentiation of the osmosensitive release of taurine and D-aspartate from SH-SY5Y neuroblastoma cells after activation of M3 muscarinic cholinergic receptors.

  The Journal of pharmacology and experimental therapeutics 20041201

• Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study.

  Neurochemistry international 20041201

• Molecular identification of monomeric aspartate racemase from Bifidobacterium bifidum.

  European journal of biochemistry 20041201

• [Degradation of biomolecules: a comparative study of diagenesis of DNA and proteins in human bone tissue].

  Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur 20041201

• Retinal glutamate transporter activity persists under simulated ischemic conditions.

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• In vitro differentiated neural stem cells express functional glial glutamate transporters.

  Neuroscience letters 20041111

• Effects of nociceptin/orphanin FQ and endomorphin-1 on glutamate and GABA release, intracellular [Ca2+] and cell excitability in primary cultures of rat cortical neurons.

  Neuropharmacology 20041101

• Glutamate efflux from human cerebrocortical slices during ischemia: vesicular-like mode of glutamate release and sensitivity to A(2A) adenosine receptor blockade.

  Neuropharmacology 20041101

• Effects of glutamate transport substrates and glutamate receptor ligands on the activity of Na-/K(+)-ATPase in brain tissue in vitro.

  Clinical and experimental pharmacology & physiology 20041101

• Formation of D-tyrosyl-tRNATyr accounts for the toxicity of D-tyrosine toward Escherichia coli.

  The Journal of biological chemistry 20041008

• 5-HT control of ischemia-evoked glutamate efflux from human cerebrocortical slices.

  Neurochemistry international 20041001

• Glutamate transporter localization does not correspond to the temporary functional recovery and late degeneration after acute ocular ischemia in rats.

  Experimental eye research 20041001

• Continuous on-line derivatization and selective separation of D-aspartic acid by a capillary electrophoresis system with a continuous sample introduction interface.

  Electrophoresis 20041001

• Determination of amino acids in rat vitreous perfusates by capillary electrophoresis.

  Electrophoresis 20040901

• Inhibition by anandamide and synthetic cannabimimetics of the release of [3H]D-aspartate and [3H]GABA from synaptosomes isolated from the rat hippocampus.

  Neurochemical research 20040801

• Interaction between intrathecal gabapentin and adenosine in the formalin test of rats.

  Journal of Korean medical science 20040801

• Cannabinoid signaling in rat cerebellar granule cells: G-protein activation, inhibition of glutamate release and endogenous cannabinoids.

  Neuropharmacology 20040701

• NMDA preconditioning protects against seizures and hippocampal neurotoxicity induced by quinolinic acid in mice.

  Epilepsia 20040701

• Measurement of glutamate uptake and reversed transport by rat synaptosome transporters.

  Biological & pharmaceutical bulletin 20040601

• Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface trafficking.

  Brain research. Molecular brain research 20040519

• Excessive and precocious glutamate release in a mouse model of amyotrophic lateral sclerosis.

  Neuropharmacology 20040501

• Comparison of age estimated from degree of racemization of aspartic acid, glutamic acid and alanine in the femur.

  Journal of forensic sciences 20040501

• Arachidonic acid metabolites and peroxide-induced inhibition of [3H]D-aspartate release from bovine isolated retinae.

  Current eye research 20040501

• L-Glutamate in the extracellular space regulates endogenous D-aspartate homeostasis in rat pheochromocytoma MPT1 cells.

  Archives of biochemistry and biophysics 20040401

• Effects of L-glutamate/D-aspartate and monensin on lactic acid production in retina and cultured retinal Müller cells.

  Journal of neurochemistry 20040401

• Effect of peroxides on [3H]D-aspartate release from bovine isolated retinae.

  Neurochemical research 20040401

• Cloning and expression in Escherichia coli of the D-aspartate oxidase gene from the yeast Cryptococcus humicola and characterization of the recombinant enzyme.

  Journal of biochemistry 20040401

• Binding and transport of [3H](2S,4R)- 4-methylglutamate, a new ligand for glutamate transporters, demonstrate labeling of EAAT1 in cultured murine astrocytes.

  Journal of neuroscience research 20040315

• Somatostatin inhibits glutamate release from mouse cerebrocortical nerve endings through presynaptic sst2 receptors linked to the adenylyl cyclase-protein kinase A pathway.

  Neuropharmacology 20040301

• Noise trauma alters D-[3H]aspartate release and AMPA binding in chinchilla cochlear nucleus.

  Journal of neuroscience research 20040215

• Diversity of functional astroglial properties in the respiratory network.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040211

• M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040121

• Immunohistochemical study of chronological and photo-induced aging skins using the antibody raised against D-aspartyl residue-containing peptide.

  Journal of cutaneous pathology 20040101

• Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress.

  Journal of neurochemistry 20040101

• Neurotransmitter release in experimental stroke models: the role of glutamate-GABA interaction.

  Advances in experimental medicine and biology 20040101

• Glutamate-induced inhibition of D-aspartate uptake in Müller glia from the retina.

  Neurochemical research 20040101

• [Influence of calcium ionophore A23187 on neurotransmitter release in rat brain synaptosomes].

  Biofizika 20040101

• Free D-aspartic acid in rat salivary glands.

  Archives of biochemistry and biophysics 20031201

• Molecular characterization of D-amino acid oxidase from common carp Cyprinus carpio and its induction with exogenous free D-alanine.

  Archives of biochemistry and biophysics 20031201

• Regulation of the Na+-dependent glutamate/aspartate transporter in rodent cerebellar astrocytes.

  Neurochemical research 20031201

• Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201

• WAY-855 (3-amino-tricyclo[2.2.1.02.6]heptane-1,3-dicarboxylic acid): a novel, EAAT2-preferring, nonsubstrate inhibitor of high-affinity glutamate uptake.

  British journal of pharmacology 20031101

• First evidence on induced topological changes in supercoiled DNA by an aluminium D-aspartate complex.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20031101

• Effect of hydrogen peroxide on amino acid concentrations in bovine retina and vitreous humor, ex vivo.

  Methods and findings in experimental and clinical pharmacology 20031101

• Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices.

  Journal of neurochemistry 20030901

• Location of putative glutamatergic neurons projecting to the medial preoptic area of the rat hypothalamus.

  Brain research bulletin 20030830

• The mcyF gene of the microcystin biosynthetic gene cluster from Microcystis aeruginosa encodes an aspartate racemase.

  The Biochemical journal 20030801

• Changes in NPY-mediated modulation of hippocampal [3H]D-aspartate outflow in the kindling model of epilepsy.

  Synapse (New York, N.Y.) 20030801

• Thiamine deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytes.

  Glia 20030801

• A receptor for presynaptic glutamatergic autoinhibition is a glutamate transporter.

  The European journal of neuroscience 20030801

• Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells.

  Neurochemistry international 20030701

• Functional characterization of a glutamate/aspartate transporter from the mosquito Aedes aegypti.

  The Journal of experimental biology 20030701

• Stimulation of sodium pump restores membrane potential to neurons excited by glutamate in zebrafish distal retina.

  The Journal of physiology 20030615

• Differences in the D/L aspartic acid ratios in dentin among different types of teeth from the same individual and estimated age.

  International journal of legal medicine 20030601

• An investigation into the role of calcium in the modulation of rat synaptosomal D-[3H]aspartate transport by docosahexaenoic acid.

  Brain research 20030523

• Immunological detection of D-beta-aspartate-containing protein in lens-derived cell lines.

  Molecular vision 20030522

• An NMR study of alterations in [1-13C]glucose metabolism in C6 glioma cells by gliotoxic amino acids.

  Neurochemistry international 20030501

• The possible role of glutamate uptake in metaphit-induced seizures.

  Neurochemical research 20030501

• Metabotropic glutamate receptor-mediated hetero-synaptic interaction of red- and green-cone inputs to LHC of carp retina.

  Brain research bulletin 20030415

• Nucleotides modulate the activity of aspartate racemase of Scapharca broughtonii.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20030401

• Adenosine-induced modulation of excitatory amino acid transport across isolated brain arterioles.

  Journal of neurosurgery 20030301

• Activation of a glycine transporter on spinal cord neurons causes enhanced glutamate release in a mouse model of amyotrophic lateral sclerosis.

  British journal of pharmacology 20030301

• P2X7 receptor-mediated release of excitatory amino acids from astrocytes.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030215

• Distribution and characteristics of D-amino acid and D-aspartate oxidases in fish tissues.

  Journal of experimental zoology. Part A, Comparative experimental biology 20030201

• The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings.

  Journal of neurochemistry 20030201

• Purification and characterization of aspartate racemase from the bivalve mollusk Scapharca broughtonii.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20030201

• Presence of free D-amino acids in microalgae.

  Bioscience, biotechnology, and biochemistry 20030201

• N-methyl-D-glutamate and N-methyl-L-glutamate in Scapharca broughtonii (Mollusca) and other invertebrates.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20030101

• Effect of D-amino acids on some mitochondrial functions in rat liver.

  Amino acids 20030101

• Asymmetry of glutamine transporters in cultured neural cells.

  Neurochemistry international 20030101

• Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems.

  Bioconjugate chemistry 20030101

• Inhibitory effect of some neuroactive steroids on cocaine-induced kindling in mice.

  Polish journal of pharmacology 20030101

• Activation of glutamate transporters in rods inhibits presynaptic calcium currents.

  Visual neuroscience 20030101

• Amino acid racemases: functions and mechanisms.

  Journal of bioscience and bioengineering 20030101

• The effect of D-aspartate on luteinizing hormone-releasing hormone, alpha-melanocyte-stimulating hormone, GABA and dopamine release.

  Neuroreport 20021203

• Mechanism of nicotine-evoked release of 3H-noradrenaline in human cerebral cortex slices.

  British journal of pharmacology 20021201

• The consequences of methylmercury exposure on interactive functions between astrocytes and neurons.

  Neurotoxicology 20021201

• Technical notes for age estimation using the femur: influence of various analytical conditions on D-aspartic acid contents.

  International journal of legal medicine 20021201

• Mechanism of superoxide and hydrogen peroxide formation by fumarate reductase, succinate dehydrogenase, and aspartate oxidase.

  The Journal of biological chemistry 20021108

• Dose-dependent effects of prenatal ethanol exposure on synaptic plasticity and learning in mature offspring.

  Alcoholism, clinical and experimental research 20021101

• D-Aspartic acid in bovine dentine non-collagenous phosphoprotein.

  Archives of oral biology 20021101

• Tyrosine kinases and amino acid efflux under hyposmotic and ischaemic conditions in the chicken retina.

  Pflugers Archiv : European journal of physiology 20021001

• [Studies on the cytological function of the biomembrane and the neurons].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20021001

• Cellular architecture of the nucleus reuniens thalami and its putative aspartatergic/glutamatergic projection to the hippocampus and medial septum in the rat.

  The European journal of neuroscience 20021001

• Ferrous-iron-dependent uptake of L-glutamate by a mesophilic, mixotrophic iron-oxidizing bacterium strain OKM-9.

  Bioscience, biotechnology, and biochemistry 20021001

• A specific enzymatic high-performance liquid chromatography method to determine N-methyl-D-aspartic acid in biological tissues.

  Analytical biochemistry 20020901

• Glutamate uptake is inhibited by tamoxifen and toremifene in cultured retinal pigment epithelial cells.

  Pharmacology & toxicology 20020901

• Cellular and subcellular distribution of D-aspartate oxidase in human and rat brain.

  The Journal of comparative neurology 20020826

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  Brain research 20020816

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  Archives of biochemistry and biophysics 20020801

• Engineering the substrate specificity of D-amino-acid oxidase.

  The Journal of biological chemistry 20020726

• The presence of D-beta-aspartic acid-containing peptides in elastic fibers of sun-damaged skin: a potent marker for ultraviolet-induced skin aging.

  Biochemical and biophysical research communications 20020628

• Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes.

  British journal of pharmacology 20020601

• A novel method for in vitro production of human glial-like cells from neurosurgical resection tissue.

  Laboratory investigation; a journal of technical methods and pathology 20020601

• Effect of allopregnanolone on d-[3H]-aspartate release and [3H]-glutamate uptake in the hippocampus of kainate-treated mice.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20020601

• Protein kinase C regulates [3H]D-aspartate release in auditory brain stem nuclei.

  Experimental neurology 20020501

• Effect of ionotropic and metabotropic glutamate agonists and D-aspartate on prolactin release from anterior pituitary cells.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20020501

• Antagonists of protein kinase C inhibit rat retinal glutamate transport activity in situ.

  Journal of neurochemistry 20020501

• Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter.

  The Journal of biological chemistry 20020419

• Benzodiazepines differently modulate EAAT1/GLAST and EAAT2/GLT1 glutamate transporters expressed in CHO cells.

  Neurochemistry international 20020401

• Insulin-like growth factor-1 increases activity and surface levels of the GLAST subtype of glutamate transporter.

  Neurochemistry international 20020401

• Glutamate uptake controls expression of a slow postsynaptic current mediated by mGluRs in cerebellar Purkinje cells.

  Journal of neurophysiology 20020401

• D-amino acids in living higher organisms.

  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20020401

• Differences between D- and L-aspartate binding to the Na+-dependent binding sites on glutamate transporters in frozen sections of rat brain.

  Life sciences 20020118

• Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology.

  Journal of medicinal chemistry 20020103

• Naturally occurring free D-aspartate is a nuclear component of cells in the mammalian hypothalamo-neurohypophyseal system.

  Neuroscience 20020101

• Modulation of glial glutamate transport through cell interactions with the extracellular matrix.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20020101

• Age-related changes in the D-aspartic acid content of the cranial bones in senescence-accelerated mice (SAM).

  Growth, development, and aging : GDA 20020101

• In vivo cellular uptake of glutamate is impaired in the rat hippocampus during and after transient cerebral ischemia: a microdialysis extraction study.

  Journal of neuroscience research 20011215

• Occurrence of N-methyl-L-aspartate in bivalves and its distribution compared with that of N-methyl-D-aspartate and D,L-aspartate.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20011201

• Activation of alpha 6 GABAA receptors on depolarized cerebellar parallel fibers elicits glutamate release through anion channels.

  Neuropharmacology 20011201

• Substrate exchange properties of the high-affinity glutamate transporter EAAT2.

  Journal of neuroscience research 20011101

• Effects of metabotropic glutamate receptor agonists and antagonists on D-aspartate release from mouse cerebral cortical and striatal slices.

  Neurochemical research 20011101

• Hypoxia-induced [(3)H]D-aspartate release from isolated bovine retina: modulation by calcium-channel blockers and glutamatergic agonists and antagonists.

  Current eye research 20011101

• Differential perturbation of neuronal and glial glutamate transport systems in retinal ischaemia.

  Neurochemistry international 20011001

• Characteristics of L-aspartate transport and expression of EAAC-1 in sarcolemmal vesicles and isolated cells from rat heart.

  Cardiovascular research 20011001

• Metabolic consequences of hyperhomocysteinemia in uremia.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20011001

• Physiological relevance of endogenous free D-serine in the mammalian brain: are scientists on a royal road for the treatment of glutamatergic-related brain disorders?

  Pathologie-biologie 20011001

• D-Aspartate oxidase and D-amino acid oxidase are localised in the peroxisomes of terrestrial gastropods.

  European journal of cell biology 20011001

• Determination of D- and L-aspartate in cell culturing medium, within cells of MPT1 cell line and in rat blood by a column-switching high-performance liquid chromatogrpahic method.

  Journal of chromatography. B, Biomedical sciences and applications 20010915

• Synaptosomal and vesicular accumulation of L-glutamate, L-aspartate and D-aspartate.

  Neurochemistry international 20010901

• Brain aging research at the close of the 20th century: from bench to bedside.

  Dialogues in clinical neuroscience 20010901

• Effect of acute exposure to ammonia on glutamate transport in glial cells isolated from the salamander retina.

  Journal of neurophysiology 20010801

• Evidence for two mechanisms of amino acid osmolyte release from hippocampal slices.

  Pflugers Archiv : European journal of physiology 20010801

• Differential effects of glutamate agonists and D-aspartate on oxytocin release from hypothalamus and posterior pituitary of male rats.

  Endocrine 20010801

• D-Aspartate is stored in secretory granules and released through a Ca(2+)-dependent pathway in a subset of rat pheochromocytoma PC12 cells.

  The Journal of biological chemistry 20010713

• Comparison of effects of DL-threo-beta-benzyloxyaspartate (DL-TBOA) and L-trans-pyrrolidine-2,4-dicarboxylate (t-2,4-PDC) on uptake and release of [3h]D-aspartate in astrocytes and glutamatergic neurons.

  Neurochemical research 20010601

• Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase.

  Brain research 20010525

• Regulation of mitochondrial glutamine/glutamate metabolism by glutamate transport: studies with (15)N.

  American journal of physiology. Cell physiology 20010501

• A Na+-dependent electrogenic glutamate transporter current in voltage-clamped cells of corpora allata in the cricket Gryllus bimaculatus.

  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20010501

• Altered expression of glutamate transporters under hypoxic conditions in vitro.

  Journal of neuroscience research 20010415

• Effects of L-glutamate, D-aspartate, and monensin on glycolytic and oxidative glucose metabolism in mouse astrocyte cultures: further evidence that glutamate uptake is metabolically driven by oxidative metabolism.

  Neurochemistry international 20010401

• Characterization of electrically evoked [3H]-D-aspartate release from hippocampal slices.

  Neurochemistry international 20010301

• Occurrence of D-Amino Acids and a pyridoxal 5'-phosphate-dependent aspartate racemase in the acidothermophilic archaeon, Thermoplasma acidophilum.

  Biochemical and biophysical research communications 20010223

• FK960, a novel potential anti-dementia drug, enhances high K(+)-evoked release of somatostatin from rat hippocampal slices.

  Brain research 20010216

• Anesthetic concentrations of propofol protect against oxidative stress in primary astrocyte cultures: comparison with hypothermia.

  Anesthesiology 20010201

• N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures.

  The Journal of biological chemistry 20010126

• Localization, transport, and uptake of D-aspartate in the rat adrenal and pituitary glands.

  Archives of biochemistry and biophysics 20010115

• Substrate translocation kinetics of excitatory amino acid carrier 1 probed with laser-pulse photolysis of a new photolabile precursor of D-aspartic acid.

  Biochemistry 20010109

• Matrix metalloproteinases in lung biology.

  Respiratory research 20010101

• Transport of D-aspartate in cerebellar granule cells under cell-damaging conditions.

  Proceedings of the Western Pharmacology Society 20010101

• A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.

  Journal of medicinal chemistry 19960802